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| 1 | Helicobacter pylori associated chronic gastritis,clinical syndromes,precancerous lesions,and pathogenesis of gastric cancer development显示文摘Helicobacter pylori(H.pylori)infection is well known to be associated with the development of precancerous lesions such as chronic atrophic gastritis(AG),or gastric intestinal metaplasia(GIM),and cancer.Various molecular alterations are identified not only in gastric cancer(GC)but also in precancerous lesions.H.pylori treatment seems to improve AG and GIM,but still remains controversial.In contrast,many studies,including meta-analysis,show that H.pylori eradication reduces GC.Molecular markers detected by genetic and epigenetic alterations related to carcinogenesis reverse following H.pylori eradication.This indicates that these changes may be an important factor in the identification of high risk patients for cancer development.Patients who underwent endoscopic treatment of GC are at high risk for development of metachronous GC.A randomized controlled trial from Japan concluded that prophylactic eradication of H.pylori after endoscopic resection should be used to prevent the development of metachronous GC,but recent retrospective studies did not show the tendency.Patients with precancerous lesions(molecular alterations)that do not reverse after H.pylori treatment,represent the'point of no return'and may be at high risk for the development of GC.Therefore,earlier H.pylori eradication should be considered for preventing GC development prior to the appearance of precancerous lesions. | Jiro Watari Nancy Chen Peter S Amenta Hirokazu Fukui Tadayuki Oshima Toshihiko Tomita Hiroto Miwa Kheng-Jim Lim Kiron M Das | 2014 | World Journal of Gastroenterology2014，20，18： | 60 |
| 2 | Identification of novel hypocholesterolemic peptides derived from bovine milk β -Lactoglobulin 显示文摘 | NAGAOKA S FUTAMURA Y MIWA K | 2001 | Biochemical and Biophysical Research Communication2001，281，： | 1 |
| 3 | Involvement of claudin-1 in the β-catenin/TCF signaling pathway and its frequent upregulation in human colorectal cancers显示文摘 | Miwa N Furuse M Tsukita S | 2001 | Oncol Res2001，12，1112： | 1 |
| 4 | Thyroid hormone inducesmetamorphosis of flounder larvae显示文摘 | INUI Y MIWA S | 1985 | General and Comparative Endocrinology1985，60，3： | 1 |
| 5 | Continual remodeling of postsynaptic density and itsregulation by synaptic activity 显示文摘 | Kim H D Okabe S Miwa A | 1999 | Nature Nell1999，2，9： | 1 |
| 6 | Application of fuzzy reasoning in an experl system for ultra - sonographt 显示文摘 | Tanaka T Miwa K Kanda S | 1997 | Dentomaxillofac Radiol1997，26，： | 1 |
| 7 | Caffeine induces apoptosis of osteosarcoma ceils by inhibiting AKT/mTOR/S6K, NF-KB and MAPKpathways 显示文摘 | Miwa S Sugimoto N Yamamoto N | 2012 | Anticancer Res2012，32，9： | 1 |
| 8 | Selection Criteria for Simultaneous Resection in Patients With Synchronous Liver Metastasis显示文摘 | Minagawa M Yamamoto J Miwa S | | 0，，10： | 1 |
| 9 | Cyclooxygenase-2 downregulates inducible nitric oxide synthase in rat intestinal epi- thelial cells显示文摘 | Kobayashi O Miwa H Watanabe S | 2001 | Am J Physiol Gastrointest Liver Physiol2001，281，3： | 1 |
| 10 | Reduction of gap junction protein connexin 32 in rat atrophic gastric mucosa as an early event in carcinogenesis显示文摘 | Nagahara A Watanabe S Miwa H | 1996 | J Gastroenterology1996，31，： | 1 |
| 11 | Mass mortalities of cultured kuruma shrimp Penaeus japonicus in Japanicus in Japan in 1993 : Electron microscopic evidence of the causative virus 显示文摘 | INOUYE K S MIWA | 1994 | Fish Pathology1994，29，： | 1 |
| 12 | Autoimmune hem- olytic anemia (AIHA) in an infant rhesus macaque (Macaca mulatta) 显示文摘 | Suzuki J Gotoh S Miwa N Terao K Nakayama H | 2000 | J Med Primatol2000，29，2： | 1 |
| 13 | Destabilization and enhanced dehydriding reaction of LiNH 2:an electronic structure viewpoint显示文摘 | Orimo S Nakamori Y Kitahara G Miwa K. Ohba N. Noritake T. Towata S | | 0，，79： | 1 |
| 14 | Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy 显示文摘 | Li M Miwa S Kobayashi Y | 1998 | Ann Neurol1998，44，2： | 1 |
| 15 | Inhibitions by hydrogen-occluding silica microcluster to melanogenesis in human pigment ceils and tyrosinase reaction显示文摘 | Kato S Saitoh Y Miwa N | 2013 | J Nanosci Nanotechnol2013，13，： | 1 |
| 16 | Effects of hypoxia on the activities of noradrenergic and dopaminergic neurons in the rat brain显示文摘 | Miwa S Fujiwara M Inoue M | 1986 | J Neurochem1986，47，1： | 1 |
| 17 | Diagnostic value of carotid intima-media thickness and plaque score for predicting target organ damage in patients with essential hypertension 显示文摘 | Takiuehi S Kamide K Miwa Y | 2004 | J Hum Hypertens2004，18，1： | 1 |
| 18 | Alternative splicing of the C-terminal domain regulates cell surface expression of the NMDA receptor NR1 subunit 显示文摘 | MIWA A OKADO H | 1999 | Jour of Neurosci1999，19，18： | 1 |
| 19 | Synergistic effects of hydrogen and helium on microstructural evolution in vanadium alloys by triple ion beam irradiation 显示文摘 | Sekimura N Iwai T Awai Y Yonamine S Naito A Miwa Y Hamada S | 2000 | Journal of Nuclear Materials2000，，283287： | 1 |
| 20 | Loss of imprinting in IGF2 in colorectal carcinoma assessed by microdissection显示文摘 | Maenaka S Hikichi T Imai Miwa A | 2006 | Oncology Reports2006，15，4： | 1 |
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