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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Expression of gap junction genes connexin 32,connexin 43 and their proteins in hepatocellular carcinoma and normal liver tissues显示文摘AIM To investigate the significance andmechanism of cx32 mRNA,cx43 mRNA and theirproteins in hepatocarcinogenesis.METHODS Sixty-one cases of HCC and 14cases of normal liver tissues were detected byimmunohistochemical and in situ hybridization(ISH)methods.RESULTS In HCC grades Ⅰ,Ⅱ,Ⅲ and normalliver tissues,the positive rates of Cx32 proteinwere 55.6%,42.1%,18.2% and 92.9%,respectively.The detection rates of Cx43 proteinwere 44.4%,26.3%,12.1% and 78.6%,respectively.There was significant difference inCx32 and Cx43 protein between HCC and normalliver tissues(P<0.01).ISH the positive rates ofcx32 mRNA shown by ISH in HCC grades Ⅰ,Ⅱ,Ⅲ and normal liver tissues were 88.9%,84.2%,87.9% and 92.9%,respectively.Those of cx43mRNA were 77.8%,78.6%,78.8% and 85.7%,respectively.There was no statistical differencein the positive rates of cx32 mRNA and cx43mRNA between HCC and normal liver tissue(P>0.05).CONCLUSION The aberrant location of Cx32and Cx43 proteins could be responsible forprogression of hepatocarcinogenesis,and thedefect of cx genes in post-translationalprocessing might be the possible mechanism. | Ma XD Sui YF Wang WL | 2000 | World Journal of Gastroenterology2000，6，1： | 9 |
| 3 | A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis 显示文摘 | Ma QH Futagawa T Yang WL | 2008 | Nat Cell Biol2008，10，3： | 1 |
| 4 | Peripheral blood stem cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia?显示文摘 | Vellenga E van Putten WL Boogaerts MA | 1999 | Bone Marrow Transplant1999，23，12： | 1 |
| 5 | A comparision of traditional textbook and interactive computer learning of neuromuscular block显示文摘 | Ohm MA Van Oostrom JH Van Meurs WL | 1997 | Anesth Analg1997，84，3： | 1 |
| 6 | Stereo- logy of cerebral cortex after traumatic brain injury matched to the Glasgow outcome score显示文摘 | Maxwell WL MacKinnon MA Stewart JE | 2010 | Brain2010，133，1： | 1 |
| 7 | Lack of association between BARD1 Cys557Ser variant and breast cancer risk: a meta-analysis of 11,870 cases and 7, 687 controls显示文摘 | Ding DP Zhang Y Ma WL | 2011 | J Cancer Res Clin Oncol2011，137，10： | 1 |
| 8 | Patterns of nodal metastasis and surgical management of the neck in supraglottic laryngeal carcinoma显示文摘 | Hicks WL Jr Kollmorgen DR Kuriakose MA | 1999 | Otolaryngol Head Neck Surg1999，121，： | 1 |
| 9 | Madelung's deformity: diagnostic thresholds of radiographic measurements 显示文摘 | McCarroll HR Jr James MA Newmeyer WL 3rd | 2010 | J Hand Surg Am2010，35，5： | 1 |
| 10 | A modified restriction display PCR method in sample - labelling of DNA microarray 显示文摘 | Li L Ma WL Zhu J | 2003 | J Virol Meth2003，67，： | 1 |
| 11 | Fibrin fragment induction of plasminogen activator inhibitor transcription is mediated by activator protein-1 through a highly conserved element显示文摘 | Olman MA Hagood JS Simmons WL | 1999 | Blood1999，94，6： | 1 |
| 12 | Surgery versus radiation therapy as single-modality treatment of tonsillar fossa carcinoma;the roswell park cancer institute experience(1917-1991)显示文摘 | Hicks WL Jr Kuriakose MA Loree TR | 1998 | Laryngoscope1998，108，： | 1 |
| 13 | Multi-band muscosectomy for endoscopic resection of Barrett’s esophagus:feasibility study with matched historical controls显示文摘 | Peter FP Kara MA Curvers WL | 2007 | Eur J Gastroenterol Hepatol2007，19，4： | 1 |
| 14 | NaoXinQing,anantistroke herbal medicine,reduces hydrogen peroxide-induced injury in NG108-15 cells显示文摘 | Bei WJ Peng WL Ma Y | | 0，，03： | 1 |
| 15 | Resistance ex- ercise in individuals with and without cardiovascular disease:2007 update:a scientific statement from the American Heart Association Council on Clinical Cardiology and Coun- cil on Nutrition,Physical Activity,and Metabolism显示文摘 | Williams MA Haskell WL Ades PA | 2007 | Circulation''2007，116，5： | 1 |
| 16 | The short term effect of heat waves on mortality and its modifiers in China: an analysis from 66 communities显示文摘 | Ma W J Zen WL Zhou MG | 2015 | Environ Int2015，75，： | 1 |
| 17 | Hypoxia and stem cell-based engineering of mesenchymal tissues 显示文摘 | Ma T Grayson WL Frohlich M | 2009 | Biotechnol Prog2009，25，1： | 1 |
| 18 | Binding of small molecules to an adaptive protein-protein interface显示文摘 | Arkin MA Randal M De Lano WL | 2003 | Proc Natl Acad Sci2003，100，： | 1 |
| 19 | Diagnosis and treatment of retained foreign bodies in the hand显示文摘 | Anderson MA Newmeyer WL 3rd Kilgore ES Jr | | 0，，01： | 1 |
| 20 | Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome显示文摘 | Nichols WL | 2001 | Mayo Clin Proc2001，76，11： | 1 |
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