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| 1 | Endoscopic ultrasound guided radiofrequency ablation,for pancreatic cystic neoplasms and neuroendocrine tumors显示文摘AIM: To outline the feasibility, safety, adverse events and early results of endoscopic ultrasound(EUS)-radiofrequency ablation(RFA) in pancreatic neoplasms using a novel probe. METHODS: This is a multi-center, pilot safety feasibility study. The intervention described was radiofrequency ablation(RF) which was applied with an innovative monopolar RF probe(1.2 mm Habib EUS-RFA catheter) placed through a 19 or 22 gauge fine needle aspiration(FNA) needle once FNA was performed in patients with a tumor in the head of the pancreas. The HabibTM EUSRFA is a 1 Fr wire(0.33 mm, 0.013') with a working length of 190 cm, which can be inserted through the biopsy channel of an echoendoscope. RF power is applied to the electrode at the end of the wire to coagulate tissue in the liver and pancreas.RESULTS: Eight patients [median age of 65(range 27-82) years; 7 female and 1 male] were recruited in a prospective multicenter trial. Six had a pancreatic cysticneoplasm(four a mucinous cyst, one had intraductal papillary mucinous neoplasm and one a microcystic adenoma) and two had a neuroendocrine tumors(NET) in the head of pancreas. The mean size of the cystic neoplasm and NET were 36.5 mm(SD ± 17.9 mm) and 27.5 mm(SD ± 17.7 mm) respectively. The EUSRFA was successfully completed in all cases. Among the 6 patients with a cystic neoplasm, post procedure imaging in 3-6 mo showed complete resolution of the cysts in 2 cases, whilst in three more there was a 48.4% reduction [mean pre RF 38.8 mm(SD ± 21.7 mm) vs mean post RF 20 mm(SD ± 17.1 mm)] in size. In regards to the NET patients, there was a change in vascularity and central necrosis after EUS-RFA. No major complications were observed within 48 h of the procedure. Two patients had mild abdominal pain that resolved within 3 d. CONCLUSION: EUS-RFA of pancreatic neoplasms with a novel monopolar RF probe was well tolerated in all cases. Our preliminary data suggest that the procedure is straightforward and safe. The response ranged from complete resolution to a 50% reduction in size. | Madhava Pai Nagy Habib Hakan Senturk Sundeep Lakhtakia Nageshwar Reddy Vito R Cicinnati Iyad Kaba Susanne Beckebaum Panagiotis Drymousis Michel Kahaleh William Brugge | 2015 | World Journal of Gastrointestinal Surgery2015，7，4： | 23 |
| 2 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 6 |
| 3 | Radiofrequency combined with immunomodulation for hepatocellular carcinoma: State of the art and innovations显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver tumor and has been considered a very immunogenic tumor.The treatment with radiofrequency ablation(RFA)has been established as the standard ablative therapy for early HCC,and is currently recognized as the main ablative tool for HCC tumors<5 cm in size;however,progression and local recurrence remain the main disadvantages of this approach.To solve this clinical problem,recent efforts were concentrated on multimodal treatment,combining different strategies,including the combination of RFA and immunotherapy.This article reviewed the combination treatment of RFA with immunotherapy and found that this treatment strategy leads to an increased response of anti-tumor T cells,significantly reduces the risk of recurrence and improves survival rates compared to RFA alone.This review highlighted scientific evidence that supports the current recommendations for pre-clinical studies,and discuss the need for further research on this topic. | Adriano Carneiro da Costa Mikael Sodergren Kumar Jayant Fernando Santa Cruz Duncan Spalding Madhava Pai Nagy Habib | 2020 | World Journal of Gastroenterology2020，26，17： | 5 |
| 4 | Costs of laparoscopic and open liver and pancreatic resection:A systematic review显示文摘AIM:To study costs of laparoscopic and open liver and pancreatic resections,all the compiled data from available observational studies were systematically reviewed.METHODS:A systematic review of the literature was performed using the Medline,Embase,Pub Med,and Cochrane databases to identify all studies published up to 2013 that compared laparoscopic and open liver[laparoscopic hepatic resection(LLR)vs open liver resection(OLR)]and pancreatic[laparoscopic pancreatic resection(LPR)vs open pancreatic resection]resection.The last search was conducted on October 30,2013.RESULTS:Four studies reported that LLR was associated with lower ward stay cost than OLR(2972 USD vs 5291 USD).The costs related to equipment(3345USD vs 2207 USD)and theatre(14538 vs 11406)were reported higher for LLR.The total cost was lower in patients managed by LLR(19269 USD)compared to OLR(23419 USD).Four studies reported that LPR was associated with lower ward stay cost than OLR(6755vs 9826 USD).The costs related to equipment(2496USD vs 1630 USD)and theatre(5563 vs 4444)were reported higher for LPR.The total cost was lower in the LPR(8825 USD)compared to OLR(13380 USD).CONCLUSION:This systematic review support the economic advantage of laparoscopic over open approach to liver and pancreatic resection. | Paolo Limongelli Chiara Vitiello Andrea Belli Madhava Pai Salvatore Tolone Gianmattia del Genio Luigi Brusciano Giovanni Docimo Nagy Habib Giulio Belli Long Richard Jiao Ludovico Docimo | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 5 | Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate显示文摘Pantoprazole sodium, a substituted benzimidazole derivative, is an irreversible proton pump inhibitor which is primarily used for the treatment of duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD). The monographs of European Pharmacopoeia (Ph. Eur.) and United States Pharmacopoeia (USP) specify six impurities, viz.;impurities A, B, C, D, E and F, respectively for its active pharmaceutical ingredient (API). The identification and synthesis of all impurities except impurity E are well described in the literature;however, there is no report related to impurity E. The prospects to the formation and controlling of impurity E up to -0.03% in the synthesis of pantoprazole sodium sesquihydrate (PAN) were discussed in detail for the first time. The present work described the journey towards the successful development of an optimal preparation procedure of dimer impurity E. The most plausible mechanism involved in the formation of impurity E has been proposed. | Arun Kumar Awasthi Lalit Kumar Punit Tripathi Madhava Golla Cirandur Suresh Reddy Pramod Kumar | 2019 | Journal of Pharmaceutical Analysis2019，9，3： | 4 |
| 6 | Percutaneous Intraductal Radiofrequency Ablation is a Safe Treatment for Malignant Biliary Obstruction: Feasibility and Early Results显示文摘 | Malkhaz Mizandari Madhava Pai Feng Xi Vlastimil Valek Andrasina Tomas Pietro Quaretti Rita Golfieri Cristina Mosconi Ao Guokun Charis Kyriakides Robert Dickinson Joanna Nicholls Nagy Habib | 2013 | CardioVascular and Interventional Radiology2013，，3： | 3 |
| 7 | Percutaneous Intraductal Radiofrequency Ablation for Clearance of Occluded Metal Stent in Malignant Biliary Obstruction: Feasibility and Early Results显示文摘 | Madhava Pai Vlastimil Valek Andrasina Tomas Attila Doros Pietro Quaretti Rita Golfieri Cristina Mosconi Nagy Habib | 2014 | CardioVascular and Interventional Radiology2014，，1： | 2 |
| 8 | 有 laparoscopic Habib 4 × radiofrequency 设备的巨大的 exophytic 肝 haemangioma 的 Laparoscopic 切除术显示文摘 Haemangiomas are the most common solitary benign neoplasm of the liver with an incidence ranging from 5% to 20%. Although usually small and asymptomatic, they may reach considerable proportions and rarely give rise to life-threatening complications. Surgical intervention is required for incapacitating symptoms, established complications, and diagnostic uncertainty. The resection of haemangiomas demands meticulous surgical technique, owing to their high vascularity and the concomitant risk of intra-operative haemorrhage. Laparoscopic resection of giant haemangiomas is even more challenging, and has only been reported twice. We here report the case of a giant 10 cm liver haemangioma which was successfully resected laparoscopically using the laparoscopic HabibTM 4×, a bipolar radiofrequency device, without clamping major vessels and with minimal blood loss. Transfusion of blood or blood products was not required. The patient had an uneventful recovery and was asymptomatic at 7-mo follow-up. | Metesh Acharya Nikolaos Panagiotopoulos Premjithlal Bhaskaran Charis Kyriakides Madhava Pai Nagy Habib | 2012 | World Journal of Gastrointestinal Surgery2012，4，8： | 2 |
| 9 | Antioxidative parameters in the seedlings of pigeonpea ( Cajanus cajan (L.) Millspaugh) in response to Zn and Ni stresses显示文摘 | K.V Madhava Rao T.V.S Sresty | 2000 | Plant Science2000，，1： | 2 |
| 10 | Removal of mercury from aqueous solutions using activated carbon prepared from agricultural by-product/waste显示文摘 | M Madhava Rao Kumar Reddy D H K Padala Venkateswarlu | 2009 | Journal of Environmental Management2009，90，： | 1 |
| 11 | Studies on the antioxidant activities of natural vanilla extract and its constituent compounds through in vitro models显示文摘 | Shyamala BN Madhava NM Ulochanamma GS | 2007 | Journal Agriculture Food Chemistry2007，55，19： | 1 |
| 12 | Biosorption of Pb 2+ from aqueous solutions by Moringa oleifera bark: Equilibrium and kinetic studies显示文摘 | D. Harikishore Kumar Reddy K. Seshaiah A.V.R. Reddy M. Madhava Rao M.C. Wang | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 13 | Behavior of Internally Ring-Stiffened Joints of Offshore Platforms显示文摘 | Thandavamoortgy T S Madhava Rao A G Santhakumar A R | 1998 | Journal of Structural Engineering1998，125，11： | 1 |
| 14 | Lipid changes during accelerated aging of seeds of pigeonpea cultivars显示文摘 | Kalpana R Madhava Rao K V | 1996 | Seed Science and Technology1996，24，： | 1 |
| 15 | Behavior of internally ring-stiffened joints of offshore platforms 显示文摘 | THANDAVAMOORTHY T S MADHAVA A G SANTHAKUMAR A R | 1999 | Journal of Structural Engineering ASCE1999，125，11： | 1 |
| 16 | Behavior of internally ring-stiffened joints of offshore platforms显示文摘 | THANDAVAMOORTGY T S MADHAVA RAO A G SANTHAKUMAR A R | 1998 | Journal of Structural Engineering1998，125，11： | 1 |
| 17 | The significance of collector colloids in alkali halide flotation systems 显示文摘 | Madhava Rao Yalamanchili | 1993 | Department of Metallurgical Engineering The University of Utah1993，，5： | 1 |
| 18 | Structural efficiency of internally ring stiffened steel tubular joints显示文摘 | MADHAVA D S GANDHI P PANT P K | 1992 | J Struct Eng1992，118，11： | 1 |
| 19 | Autologous Bone Marrow Stem Cells in the Treatment of Chronic Liver Disease显示文摘 | Madhava Pai Duncan Spalding Feng Xi Nagy Habib Angela Dolganiuc | 2011 | International Journal of Hepatology2011，，： | 1 |
| 20 | Behavior of internally ring-stiffened joints of offshore platforms显示文摘 | Thandavamoorthy T S Madhava Rao A G Santhakumar A R | | 0，，11： | 1 |
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