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| 1 | Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors. | Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 2 | Prescriptionpattern of benzodiazepines for inpatients at a tertiary care university hospital in Pakistan显示文摘 | Khawaja M R Majeed A Maik F | 2005 | J Pak Med Assoc2005，55，： | 1 |
| 3 | Endothelin-A receptor blockade prevents left ventricular hypertrophy and dysfunction in salt-sensitive experimental hypertension显示文摘 | Lars R Roland V Maike D | 2002 | Circulation2002，106，： | 1 |
| 4 | Endothelin-A receptor blockade prevents left ventricular hypertrophy and dysfunction in salt-sensitive experimental hypertension显示文摘 | Lars R Roland V Maike D | 2002 | Circulation2002，106，： | 1 |
| 5 | Endothelin-A receptor blockade prevents left ventricular hypertrophy and dysfunction in salt-sensitive experimental hypertension 显示文摘 | LARS R ROLAND V MAIKE D | 2002 | Circulation2002，106，： | 1 |
| 6 | The Bombyxmori sex phero- mone biosynthetic pathway is not mediated by cAMP显示文摘 | Hull JJ Kajigaya R Maik etal | 2007 | Jour- nal of Insect Physiology2007，53，： | 1 |
| 7 | FasLexpression on epithelial cells 显示文摘 | Dayan C M Elsegood K A Maik R | 1997 | Immunol Today1997，18，： | 1 |
| 8 | Genotypic and phenotypic characterization of Pseudomonas aeruginosa isolates from urinary tract infections显示文摘 | Petra Tielen Maike Narten Nathalie Rosin Ilona Biegler Isam Haddad Michael Hogardt Rüdiger Neubauer Max Schobert Lutz Wiehlmann Dieter Jahn | 2010 | International Journal of Medical Microbiology2010，，4： | 1 |
| 9 | Oxidative Stress-Induced Calcium Signaling in Arabidopsis显示文摘 | Maike C Rentel Marc R Knight | 2004 | Plant Physiol2004，135，： | 1 |
| 10 | L, take two! Reflections from the second attempt at lean implementation 显示文摘 | MAIKE S R TODD A B PATRICIA D | 2009 | Business Horizons2009，，52： | 1 |
| 11 | An Investygation of the Mechanisms of Flue Gas Desulfuryzation by In-Duet Dry Sorbent Injection Ind Eng Chem显示文摘 | Maik R Stouffer et | 1989 | Res1989，，28： | 1 |
| 12 | Chronic therapy with isosorbide-5-mononitrate causes endothelial dysfunction, oxidative stress, and a marked increase in vascular endothelin-1 expression显示文摘 | Matthias Oelze Maike Knorr Swenja Kr?ller-Sch?n Sabine Kossmann Anna Gottschlich Robert Rümmler Alexandra Schuff Steffen Daub Christopher Doppler Hartmut Kleinert Tommaso Gori Andreas Daiber Thomas Münzel | 2013 | European Heart Journal2013，，41： | 1 |
| 13 | FasLexpression on epithelial cells 显示文摘 | Dayan C M Elsegood K A Maik R | 1997 | Immunol Today1997，18，： | 1 |
| 14 | Dye effluents:a-Natural remedy显示文摘 | PAUL R THAMPI J MAIK S R | 1996 | Indian Textile Journal1996，106，4： | 1 |
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