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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Individual patient data meta-analysis of docetaxel administered once every 3 weeks compared with once every week second line treat- ment of advanced non-small-cell lung cancer 显示文摘 | Di Maio M Pernme F Chiodini P | 2007 | J Clin Oncol2007，25，11： | 1 |
| 3 | Meta-analysis of sin-gle-agent chemotherapy compared with combination chemothera-py as second-line treatment of advanced non-small-cell lung canc-er显示文摘 | Di Maio M Chiodini P Georgoulias V | 2009 | J Clin Oncol2009，27，11： | 1 |
| 4 | Carboplatin-or cisplatin-based chemotherapy in first-line treatment of small-cell lung cancer:the COCIS meta-analysis of individual patient data显示文摘 | Rossi A Di Maio M Chiodini P | 2012 | J Clin Oncol2012，30，14： | 1 |
| 5 | Needle Artifact Localization in 3T MR Images显示文摘 | Di Maio S P Kacher D F Ellis R E | 2006 | Stud Health Teehnol Inform2006，119，： | 1 |
| 6 | How much do you like your name? An implicit measure of global self-esteem 显示文摘 | Gebauer JE Riketta M Broemer P & Maio GR | 2008 | Journal of Experimental Social Psychology2008，44，： | 1 |
| 7 | Carboplatin or cisplatinbased chemotherapy in first-line treatment of small-cell lung cancer:the COCIS meta-analysis of individual patient data显示文摘 | Rossi A Di Maio M Chiodini P | 2012 | J Clin Oncol2012，30，： | 1 |
| 8 | “All-on-Four” immediate-function concept withBranemark System implants for com-pletely edentulous mandibles : a retrospective clinical study 显示文摘 | Maio P Rangert B Nobre M | 2003 | Clin Implant Dent Relat Res2003，5，1： | 1 |
| 9 | An improvedinte gral non-linear model for the contact of particles in distinct element simulations显示文摘 | Di Renzo A Di Maio F P | 2005 | Chemical Engineering Science2005，60，： | 1 |
| 10 | Structure and rheology of recycled PET modified by reactive extrusion 显示文摘 | INCARNATO L SCARFATO P DI MAIO L | 2000 | Polymer2000，41，： | 1 |
| 11 | Film blowing of recycled PET modified by reactive extrusion 显示文摘 | DI MAIO L INCARNATO L SCARFATO P | 2001 | Polymer Recycling2001，6，： | 1 |
| 12 | Carboplatin- or cisplatin-based chemotherapy in first-line treatment of small- cell lung cancer: the COCIS meta-analysis of individual patient data 显示文摘 | Rossi A di Maio M Chiodini P | 2012 | J Clin Oncol2012，30，14： | 1 |
| 13 | Is the impedance cardiogram a potential indicator of effective external cardiac massage in a human model a study to establish if there is a linear correlation between the impedance cardiogram and depth in a cardiac arrest setting显示文摘 | Di Maio R Howe A McCanny P | 2012 | Resuscitation2012，83，81： | 1 |
| 14 | Structure and rheolo- gy of recycled PET modified by reactive extrusion 显示文摘 | Incarnato L Scarfato P Maio L D | 2000 | Poly- mer2000，41，18： | 1 |
| 15 | Structure and rh- eology of recycled PET modified by reactive extrusion 显示文摘 | L Incarnato P Scarfato L Di Maio | 2000 | Polymer2000，41，： | 1 |
| 16 | Analytical solution for the problem of frictional-elastic collisions of spherical parti- cles using the linear model显示文摘 | Di Maio F P Di Renzo A | 2004 | Chemical Engineering Science2004，59，16： | 1 |
| 17 | Volume Change Behaviour of Clays:the Influence of Mineral Com-position,Pore Fluid Composition and Stress State 显示文摘 | DI MAIO C SANTOLI L SCHIAVONE P | 2004 | Me-chanics of Materials2004，36，56： | 1 |
| 18 | Estimation of compressive strengh of recycled concrete with the uhrasonnic method 显示文摘 | Maio A A Zega C J Traversa L P | 2005 | Journal of ASTM International2005，2，5： | 1 |
| 19 | Volume change behavior of clay: The influence of mineral composition, pore fluid composition and stress state显示文摘 | MAIO C D SANTOLI L SCHIAVONE P | 2010 | Mechanics of Materials2010，36，： | 1 |
| 20 | Individual patient data meta-analysis of docetaxel administered once every 3 weeks compared with once every weeks secong-line treatment of advanced non-snail-cell lung cancer 显示文摘 | Di Maio M Perrone F Chiodini P | 2007 | JClin Oncol2007，25，11： | 1 |
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