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165篇 您的检索式：作者名="Makela J"

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	题名	作者	年代	出处	被引量
1	Divergent expression of bacterial wall sensing toll-like receptors 2 and 4 in colorectal cancer显示文摘AIM To characterize the expression of toll-like receptors(TLR) 2 and 4 in colorectal cancer(CRC) and in normal colorectal mucosa.METHODS We analysed tissue samples from a prospective series of 118 unselected surgically treated patients with CRC. Sections from formalin fixed, paraffin embedded specimens were analysed for TLR2 and TLR4 expression by immunohistochemistry. Two independent assessors evaluated separately expression at the normal mucosa, at the invasive front and the bulk of the carcinoma, and in the lymph node metastases when present. Expression levels in different locations were compared and their associations with clinicopathological features including TNM-stage and the grade of the tumour and 5-year follow-up observations were analysed.RESULTS Normal colorectal epithelium showed a gradient of expression of both TLR2 and TLR4 with low levels in the crypt bases and high levels in the surface. In CRC, expression of both TLRs was present in all cases and in the major proportion of tumour cells. Compared to normal epithelium, TLR4 expression was significantly weaker but TLR2 expression stronger in carcinoma cells. Weak TLR4 expression in the invasive front was associated with distant metastases and worse cancerspecific survival at 5 years. In tumours of the proximal colon the cancer-specific survival at 5 years was 36.9% better with strong TLR4 expression as compared with those with weak expression(P = 0.044). In contrast, TLR2 expression levels were not associated with prognosis. Tumour cells in the lymph node metastases showed higher TLR4 expression and lower TLR2 expression than cells in primary tumours.CONCLUSION Tumour cells in CRC show downregulation of TLR4 and upregulation of TLR2. Low expression of TLR4 in the invasive front predicts poor prognosis and metastatic disease.	Karoliina Paarnio Sara Vayrynen Kai Klintrup Pasi Ohtonen Markus J Makinen Jyrki Makela Tuomo J Karttunen	2017	World Journal of Gastroenterology2017，23，26：	8
2	IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization显示文摘	MAKELA M J KANEHIRO A BORISH L	2000	Proc Natl Acad Sci USA2000，97，11：	1
3	Effects of pH management during selective antegrade cerebral perfusion on cerebral microcirculation and metabolism:alpha-stat versus pH-stat显示文摘	Dahlbacka S Alaoja H Makela J	2007	Ann Thorac Surg2007，84，3：	1
4	HF radiation emitted by chaotic leader processes 显示文摘	MAKELA J S EDIRISINGHE M FERNANDO M	2007	Journal of Atmospheric and Solar-Terrestrial Physics2007，69，6：	1
5	Towards evidence-based clinical practice:an international survey of 18 clinical guideline programes显示文摘	Burgers JS Grol R Klazinga NS Makela M Zaat J AGREE Collaboration	2003	Int J Qual Health Care2003，15，1：	1
6	Stable Sulphate Clus- ters as a Source of New Atmospheric Particles 显示文摘	Kulmala M Pirjola L Makela J M	2000	Nature2000，404，：	1
7	Magnetoenceph- alography in neurosurgery 显示文摘	Makela JP Forss N Jaaskelainen J	2006	Neurosurgery2006，59，49：	1
8	Mechanical properties and strength retention of carbon fibre-reinforced liquid crystalline polymer(LCP/CF) composite : An experiment study on rabbits 显示文摘	Kettunen J Makela E A Miettinen H	1998	Biomater1998，19，14：	1
9	The pathogenesis of nephmpathia epidemica: new knowledge and unanswered questions 显示文摘	Mustonen J Makela S Outinen T	2013	Antiviral Res2013，100，3：	1
10	WHO recommendations on pneumococcal vaccination:immunization of elderly people with polyvalent pneumococcal vaccine显示文摘	Fedson D Henrichsen J Makela PH	1989	Infection1989，17，6：	1
11	Postoperative inte~vertebral dis-citis显示文摘	Puranen J Makela J Lahdes	1984	Acta Orthop Scand1984，55，4：	1
12	Cloning of Human T Cells Specific for Measles Vires Haemagglutinin and Nucleocapsid显示文摘	Ilonen J Makela M J Ziola B	1990	Clin Exp Immunol1990，81，：	1
13	A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains 显示文摘	Partanen J Armstrong E Makela T P	1992	Mol Cell Biol1992，12，4：	1
14	Interplay between PT- PN22 C1858T polymorphism and cow' s milk formula exposure in type 1 diabetes显示文摘	Lempainen J Vaarala O Makela M	2009	J Autoimmun2009，33，：	1
15	Different combinations of formic, propionic and benzoic acids in slaughter offal preservation for feeding to fur animals显示文摘	Polonen I Toivonen V Makela J	1998	Animal Feed Science and Technology1998，70，：	1
16	Survival of ropyslime-producing lactic acid bacteria in heat processes used in the meatindustry显示文摘	MAKELA P M KORKEALA H J LAINE J J	1992	Meat Science1992，31，：	1
17	Novel avian influenza A (H7N9) virus induces impaired interferon responses in human dendriticeells显示文摘	Arilahti V Makela SM Tynell J	2014	PLoSOne2014，9，96：	1
18	Immunization of eld- erly people with polyvalent pneumococcal vaccine 显示文摘	Fedson D Henrichsen J Makela PH	1989	Infection1989，17，6：	1
19	Effect of glycinebetaine on chloroplast ultrastructure, chlorophyll and protein content,and RuBPCO activities in tomato grown under drought or salinity显示文摘	Makela P Karkkainen J Somersalo S	2000	Biologia Plantarum2000，43，3：	1
20	Long-term persistence of immunity after immunisation with Haemophilus influenzae type b conjugate vaccine 显示文摘	Makela PH Kayhty H Leino T Auranen K Peltola H Ekstrom N Eskola J	2003	Vaccine2003，22，：	1

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