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| 1 | Genetic epidemiology of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS) is the most common functional gastrointestinal disorder characterized by presence of abdominal pain or discomfort associated with altered bowel habits. It has three main subtypes- constipation predominant IBS(C-IBS),diarrhea predominant IBS(D-IBS) and IBS with mixed featuresof both diarrhea as well as constipation(M-IBS). Its pathophysiology and underlying mechanisms remain elusive. It is traditionally believed that IBS is a result of multiple factors including hypersensitivity of the bowel,altered bowel motility,inflammation and stress. Initial studies have shown familial aggregation of IBS suggesting shared genetic or environmental factors. Twin studies of IBS from different parts of world have shown higher concordance rates among monozygotic twins than dizygotic twins,and thus suggesting a genetic component to this disorder. Multiple studies have tried to link single-nucleotide polymorphisms(SNPs) to IBS but there is little evidence that these SNPs are functional. Various molecules have been studied and investigated by the researchers. Serotonin,a known neurotransmitter and a local hormone in the enteric nervous system,has been most extensively explored. At this time,the underlying gene pathways,genes and functional variants linked with IBS remain unknown and the promise of genetically-determined risk prediction and personalize medicine remain unfulfilled. However,molecular biological technologies continue to evolve rapidly and genetic investigations offer much promise in the intervention,treatment and prevention of IBS. | Jasbir Makker Sridhar Chilimuri Jonathan N Bella | 2015 | World Journal of Gastroenterology2015，21，40： | 20 |
| 2 | Predicting the presence of adenomatous polyps during colonoscopy with National Cancer Institute Colorectal Cancer Risk-Assessment Tool显示文摘AIM To evaluate the National Cancer Institute(NCI)Colorectal Cancer(CRC)Risk Assessment Tool as a predictor for the presence of adenomatous polyps(AP) found during screening or surveillance colonoscopy.METHODS This is a retrospective single center observational study.We collected data of adenomatous polyps in each colonoscopy and then evaluated the lifetime CRC risk.We calculated the AP prevalence across risk score quintiles,odds ratios of the prevalence of AP across risk score quintiles,area under curves(AUCs)and Youden’s indexes to assess the optimal risk score cut off value for AP prevalence status.RESULTS The prevalence of AP gradually increased throughout the five risk score quintiles:i.e.,27.63%in the first and 51.35%in the fifth quintile.The odd ratios of AP prevalence in the fifth quintile compared to the first and second quintile were 2.76[confidence interval(CI):1.71-4.47]and 2.09(CI:1.32-3.30).The AUC for all patients was 0.62(CI:0.58-0.66).Youden’s Index indicated the optimal risk score cutoff value discriminating AP prevalence status was 3.60.CONCLUSION Patients with the higher NCI risk score have higher risk of AP and subsequent CRC;therefore,measures to increase the effectiveness of CRC detection in these patients include longer withdrawal time,early surveillance colonoscopy,and choosing flexible colonoscopy over other CRC screening modalities. | Hassan Tariq Muhammad Umar Kamal Harish Patel Ravi Patel Muhammad Ameen Shehi Elona Maram Khalifa Sara Azam Aiyi Zhang Kishore Kumar Ahmed Baiomi Danial Shaikh Jasbir Makker | 2018 | World Journal of Gastroenterology2018，24，34： | 3 |
| 3 | Prevalence of advanced liver fibrosis and steatosis in type-2 diabetics with normal transaminases:A prospective cohort study显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)and type-2 diabetes mellitus(T2DM)have an intricate bidirectional relationship.Individuals with T2DM,not only have a higher prevalence of non-alcoholic steatosis,but also carry a higher risk of progression to nonalcoholic steatohepatitis.Experts still differ in their recommendations of screening for NAFLD among patients with T2DM.AIM To study the prevalence of NAFLD and advanced fibrosis among our patient population with T2DM.METHODS During the study period(November 2018 to January 2020),59 adult patients with T2DM and 26 non-diabetic control group individuals were recruited prospectively.Patients with known significant liver disease and alcohol use were excluded.Demographic data and lab parameters were recorded.Liver elastography was performed in all patients.RESULTS In the study group comprised of patients with T2DM and normal alanine aminotransferase levels(mean 17.8±7 U/L),81%had hepatic steatosis as diagnosed by elastography.Advanced hepatic fibrosis(stage F3 or F4)was present in 12%of patients with T2DM as compared to none in the control group.Patients with T2DM also had higher number of individuals with grade 3 steatosis[45.8%vs 11.5%,(P<0.00001)and metabolic syndrome(84.7%vs 11.5%,P<0.00001)].CONCLUSION A significant number of patients with T2DM,despite having normal transaminase levels,have NAFLD,grade 3 steatosis and advanced hepatic fibrosis as measured by liver elastography. | Jasbir Makker Hassan Tariq Kishore Kumar Madhavi Ravi Danial Haris Shaikh Vivien Leung Umar Hayat Muhammad T Hassan Harish Patel Suresh Nayudu Sridhar Chilimuri | 2021 | World Journal of Gastroenterology2021，27，6： | 2 |
| 4 | Clinical relevance of oxidative stress in male factor infertility:an update显示文摘 | Aqarwal A Makker K Sharma R | 2008 | Am J Repord Immunol2008，59，1： | 1 |
| 5 | Cell phones and male infertility: dissecting the relationship显示文摘 | DEEPINDER F MAKKER K AGARWAL A | 2007 | Reprod Biomed Online2007，15，3： | 1 |
| 6 | Regulation of tumor progression by extracellular galectin-3显示文摘 | NANGIA MAKKER P BALAN V RAZ A | 2008 | Cancer Microenvironment2008，1，1： | 1 |
| 7 | Rare case of dysphagia, skin blis- tering,missing nails in a young boy显示文摘 | Makker J Baiantri B Remy P | 2015 | World J Gastrointest En- dosc2015，7，2： | 1 |
| 8 | Antioxidant defense system during endometrial receptivity in the guinea pig: effect of ormeloxifene, a selective estrogen receptor modulator 显示文摘 | Makker A Bansode FW Srivastava VM | 2006 | J Endoerino12006，188，1： | 1 |
| 9 | Effects of radiofrequency electromagnetic waves(RF-EMW)from celluar phones on human ejaculated semen:an in vitro pilot study显示文摘 | Agarwal A Desai N R Makker K | | 0，，04： | 1 |
| 10 | Ocimum gratissimum retards breast cancer growth and progression and is a natural inhibitor of matrix metalloproteases显示文摘 | Pratima Nangia-Makker Tirza Raz Larry Tait Malathy P.V. Shekhar Hong Li Vitaly Balan Hemanckur Makker Rafael Fridman Krishnarao Maddipati Avraham Raz | 2013 | Cancer Biology & Therapy2013，，： | 1 |
| 11 | Symptomatic gastreesophageal reflux in subjects with a breathing sleep disorder 显示文摘 | Valipour A Makker HK Hardy R | 2002 | Chest2002，121，6： | 1 |
| 12 | Albumin stimulates TGF-beta gene expression in cultured proximal tubular cells显示文摘 | Zhao J Oleinikova I Makker SP | | 0，，： | 1 |
| 13 | Clinical relevance of oxidative stress in male factor infertility: an update显示文摘 | Agarwal A Makker K Sharma R | 2008 | Am J Reprod Immunol2008，59，1： | 1 |
| 14 | PI3K-Akt-m TOR and MAPK signaling pathways in polycystic ovarian syndrome,uterine leiomyomas and endometriosis:an update显示文摘 | Makker A Goel MM Das V | 2012 | Gynecol Endocrinol2012，28，3： | 1 |
| 15 | Determination of both tannin and protein in a tannin-protein complex显示文摘 | Harinder Paul S Makker Rajinder K Dawra Bhupinder Singh | 1988 | J Agric Food Chem1988，36，： | 1 |
| 16 | Clinical relevance of oxidative stress in male factor infertility:An update显示文摘 | Agarwal A Makker K Sharma R | 2008 | Am J Reprod Immunol2008，59，1： | 1 |
| 17 | Symptomatic gastroesophageal reflux in subjects with a breathing sleep disorder显示文摘 | Valipour A Makker HK hardy R | 2002 | Chest2002，121，： | 1 |
| 18 | Concurrent carboplatin/paclitaxel and intravaginal radiation in surgical stage I-II serous endometrial cancer显示文摘 | Alektiar KM Makker V Abu-Rustum NR | 2009 | Gynecol Oncol2009，112，1： | 1 |
| 19 | Effects of radiofrequencyelec- tro magnetic waves ( RF - EMW ) from cellular phones onhumane jaculatedsem-en : An in vitro pilot study 显示文摘 | Agarwal A Desai NR Makker K | 2009 | Fertil Steril2009，92，4： | 1 |
| 20 | Uterine leiomyomas: effects onarchitectural, cellular, and molecular determinants ofendometrial receptivity显示文摘 | Makker A Goel MM | 2013 | Report Sci2013，20，6： | 1 |
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