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| 1 | Clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal显示文摘AIM To determine the prevalence of epstein-barr virus(eb V)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics. METHODS We have performed a retrospective study including a total of 179 consecutive patients with gastric cancer(GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification. Tumour tissues were collected from the institutional tumour bank. eb V was detected by in situ hybridization for the detection of eb V-encoded small RNAs(ebe Rs) and eb V latent proteins(LMP1 and LMP2 A) were detected by immunohistochemistry.RESULTS The analysis showed that eb V-associated gastric carcinomas(eb Va GC) represents 8.4%(15/179) of all GC cases, with a significant differential distribution among histological types(P < 0.001): 100%(3/3) of medullary carcinomas, 100%(1/1) of adenosquamous carcinoma, 8.7%(8/92) of tubular adenocarcinomas, 8.0%(2/25) of mixed carcinomas and 2%(1/51) in poorly cohesive carcinomas. The analysis revealed a higher predominance of eb Va GC in the upper third and middle(cardia, fundus and body) of the stomach(P = 0.041), a significant lower number of regional lymph nodes invasion(P = 0.025) and a tendency for better prognosis(P = 0.222). eb V latent protein expression revealed that all eb Va GC cases were LMP1-negative, nevertheless 6 cases(40%) expressed LPM2 A, which reveals that these cases show a distinct eb V-Latency profile(latency II-like).CONCLUSION eb Va GC represents 8.4% of all GC in the North Region of Portugal. The eb V-infected patients have specific clinic-pathological features that should be further explored to develop new strategies of management and treatment. | Joana Ribeiro Andreia Oliveira Mariana Malta Claudia Oliveira Fernanda Silva Ana Galaghar Luís Pedro Afonso Maria Cassiano Neves Rui Medeiros Pedro Pimentel-Nunes Hugo Sousa | 2017 | World Journal of Gastroenterology2017，23，40： | 9 |
| 2 | Decision process in a water use conflict in Brazil显示文摘 | GETIRANA A C V MALTA V F de AZEYEDO J P S | 2008 | Water Resources Management2008，22，1： | 1 |
| 3 | Production of micro- and mesoporous activated carbon from paper mill sludge 显示文摘 | Nasrin R K Malta C Giselle S | 2000 | Carbon2000，38，14： | 1 |
| 4 | Emission quantum yield of europium (Ⅲ) mixed complexes with thenoyhriiluoroacetonate and some aromatic ligands 显示文摘 | Silva F R G E Menezes J F S Rocha G B Rocha G B Alves S Brito H F Longo R L Malta O L | 2000 | Journal of Alloys and Compounds2000，303，304： | 1 |
| 5 | The Psychophsiology of Aggressive Drivers: Comparison to Non- Aggressive Drivers and Pre-to Post-Treatment Change Following a Cognitive-Behavioural Treatment 显示文摘 | Galovski T E Blanchard E B Malta L S | 2003 | Behaviour Research and Therapy2003，41，10： | 1 |
| 6 | Free-floating Ulva in the southwest Netherlands: species or morphotypes? a morphological, molecular and ecological comparison显示文摘 | Malta E J Draisma S Kamermans P | 1999 | European Journal of Phycology1999，34，5： | 1 |
| 7 | Red wine polphenols prevent angiotensin Ⅱ-induced hypertension and endothelial dysfunction in rats ; role of NADPH oxidase 显示文摘 | Mamadou S Malta C Sandrine M | 2006 | Cardiovasc Res2006，71，： | 1 |
| 8 | Free-floating Ulva in the southwest Netherlands: species or morphotypes? a morphological, molecular and ecological comparison显示文摘 | Malta E Draisma S A Kamermans P | 1999 | European Journal of Phycology1999，34，5： | 1 |
| 9 | Free-floatingUlva in the southwest Netherlands: Species or morphotypes a morphological, molecular and ecological comparison显示文摘 | MALTA E DRAISMA S G A KAMERMANS P | 1999 | Europe- an Journal of Phycology1999，34，4： | 1 |
| 10 | A meta-analysis of structural brain abnormalities in PTSD显示文摘 | Karl A Schaefer M Malta L S | 2006 | Neurosci Biobehav Rev2006，30，7： | 1 |
| 11 | One-- and two-- year prospective follow up of cognitive behavior therapy or supportive psychotherapy显示文摘 | Blanchard E B Hiekling E J Malta L S | 2004 | Behaviour Research and Therapy2004，42，7： | 1 |
| 12 | The psychophsiology of aggressive drivers: comparison to non-aggressive drivers and pre-to post-treatment change following a cognitive-behavioural treatment 显示文摘 | Galovski T E Blanchard E B Malta L S | 2003 | Behaviour Research and Therapy2003，41，9： | 1 |
| 13 | Free-floating Ulva in the southwest Netherlands:species or morphotypes? A morphological, molecular and ecological comparison 显示文摘 | Malta E J Draisma S G A Kamermans P | 1999 | J Eur Phycol1999，34，： | 1 |
| 14 | ZmMPK6, a novel maize MAP kinase that interacts with 14-3-3 proteins显示文摘 | Lalle M Visconti S MalTa M | 2005 | Plant Moh Biol2005，59，5： | 1 |
| 15 | Sequential changes of oxyhaemoglobin in drained fluid of cisternal irrigation therapy-refenrence to the effect of ascorbic acid显示文摘 | Cocks T Malta E King S | 2001 | Acta Neurochir Suppl2001，77，： | 1 |
| 16 | Luminescent properties of diketonates of trivalent europium with dimethylsulfoxide显示文摘 | BRITO H F MALTA O L MENEZES J F S | 2000 | J Alloys Compounds2000，，： | 1 |
| 17 | Mechanical properties of amorphous nanosprings显示文摘 | Fonseca A F Malta C P Galvao D S | 2006 | Nanotechnology2006，17，22： | 1 |
| 18 | Adenosine 5' Monophos- phate inhibits the association of 14 - 3 - 3 protein with the plant plasma membrane H + - ATPase 显示文摘 | Camoni L Visconti S MalTa M | 2001 | Journal of Biological Chemis- try2001，276，31： | 1 |
| 19 | Relationship between bone mineral density and androgen-deprivation therapy in Japanese prostate cancer patients显示文摘 | Yuasa T Malta S Tsuchiya N | 2010 | Urology2010，75，5： | 1 |
| 20 | Limitations in doxorubicin production from Streptomyces peucetius显示文摘 | Malta S Niraula NP Singh B | 2010 | Microbiological Research2010，165，5： | 1 |
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