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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Failure in peripheral immuno- surveillance due to thymie atrophy: importance of thymoeyte maturation and apoptosis in adult tumor - bearer 显示文摘 | Mandal D Bhattacharyya A Lahiry L | 2005 | Life Sci2005，77，： | 1 |
| 3 | Identification and characterization of a bactericidal and proapoptotic peptide from cycas revoluta seeds with DNA binding properties显示文摘 | Mandal S M Migliolo L Das S | | 0，，： | 1 |
| 4 | Interaction between differentiating cell-and niche-derived signals in hematopoietic progenitor maintenance 显示文摘 | Mondal BC Mukherjee T Mandal L | 2011 | Cell2011，147，7： | 1 |
| 5 | Organizing pneu- monia and pulmonary lymphatic architecture in diffuse alveolar damage显示文摘 | MANDAL R V MARK E J KRADIN R L | 2008 | Human Pathology2008，39，8： | 1 |
| 6 | Techniques for microscale patterning of zeolite-based thin films显示文摘 | Mandal S Williams H L Hunt H K | 2015 | Microporous and Mesoporous Materials2015，203，： | 1 |
| 7 | Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells显示文摘 | Bandyopadhyay D Mandal M Adam L | 1998 | J Biol Chem1998，273，： | 1 |
| 8 | A Molecular Ruthenium Catalyst with Water-Oxidation Activity Comparable to that of Photosystem II显示文摘 | Duan L Bozoglian F Mandal S | 2012 | Nat Chem2012，4，5： | 1 |
| 9 | Long-term soil management effects on crop yields and soil quality in a dryland Alfisol显示文摘 | Sharma K L Uttam Kumar Mandal Srinivas K | 2005 | Soil and Tillage Research2005，83，： | 1 |
| 10 | d-Glucose transport in deeapod crustacean hepatopancreas 显示文摘 | Verri T Mandal A Zilli L | 2001 | Comparative Biochemistry & Physiology: Part A2001，130，3： | 1 |
| 11 | Long-term soil management effects on crop yields and soil quality in a dryland Alfisol显示文摘 | Sharma K L Mandal U K Srinivas K | | 0，，02： | 1 |
| 12 | Interaction of phosphorus and molybdenum in relation to uptake and utilization of molybdenum, phosphorus, zinc, copper and manganese by rice显示文摘 | Basak A Mandal L N Haldar M | 1982 | Plant Soil1982，68，2： | 1 |
| 13 | The missing link in plant histidine biosynthesis:Arabidopsis myoinositol monophosphatase-like 2 (IMPL2) encodes a functional histidinol-phosphate phosphatase显示文摘 | PETERSEN L N MARLNEO S MANDAL(A) S | 2010 | Plant Physiology2010，152，： | 1 |
| 14 | Stevia Rebaudiana Extract and related compounds-molecules of phmarmaceutical promise : a critical overview显示文摘 | Brahmachari G Mandal L C Roy R | 2011 | Arch Pharm Chem Life Sci2011，29，1： | 1 |
| 15 | Lipopeptides in microbial infection eontrol: Scope and reality for industry 显示文摘 | Mandal S M Barbosa A E Franco O L | 2013 | Biotechnology Advances2013，31，2： | 1 |
| 16 | Long-term soil management effects on crop yields and soil quality in a dryland Alfisol显示文摘 | Sharama K L Mandal U K Srinivas K | | 0，，02： | 1 |
| 17 | Effect of corn powder as filler in radial passenger tyre tread compound显示文摘 | Agrawal S L Mandot S K Mandal N | 2006 | Journal of Materials Science2006，41，17： | 1 |
| 18 | Nucleartargeting of Bax during epidermal growth factor receptor-induced apoptosis in colorectal cancer cells 显示文摘 | Adam L Mendelsohn J | 1998 | Oncogene1998，17，： | 1 |
| 19 | 显示文摘 | Mandal T K Bostanian L A Graves R A | 2001 | European Journal of Pharmaceutics and Biopharmaceutics2001，52，1： | 1 |
| 20 | Yeast as coupling agent for corn filler in tyre tread compound显示文摘 | Agrawal S L Mandot S K Mandal N | 2005 | Progress in Rubber Plastics and Recycling Technology2005，21，3： | 1 |
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