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| 1 | 胸苷酸合成酶和拓扑异构酶-1及Ki-67对伊立替康联合5-氟脲嘧啶治疗晚期大肠癌的预测价值显示文摘目的探讨胸苷酸合成酶(TS)、拓扑异构酶1(Topo1)和肿瘤增殖指标Ki67对伊立替康(CPT11)联合5氟脲嘧啶(5Fu)治疗晚期大肠癌患者的临床疗效和预后的预测价值。方法采用免疫组化方法检测了CPT11+5Fu一线治疗78例大肠癌患者的TS、Topo1和Ki67的表达,并与化疗疗效和患者的临床预后进行了分析。结果各检测指标的表达水平与临床疗效之间无关,但是临床预后不同。其中,TS低表达患者表现明显长的肿瘤进展时间(TTP,P<0.05)和存活期(OS,P<0.05);Ki67低表达也预示长的OS(P<0.05)。与单个指标相比较,两个指标的联合也不能预测临床疗效,但是对预后的判断作用明显提高。TS低表达、Ki67低表达以及TS和Ki67均低表达患者的中位TTP分别为9,8和17个月(P=0.02);TS低表达、Topo1低表达以及TS和Topo1均低表达患者的中位TTP分别为9,9和13个月(P=0.03);而Topo1低表达、Ki67低表达、Ki67和Topo1均低表达患者的中位TTP分别为8,9和11个月(P=0.05)。其中任何两个指标均低表达肿瘤的TTP和OS均明显长于高表达者(P<0.05)。结论TS、Topo1和Ki67不能预测大肠癌患者CPT11+5Fu的疗效,但对其临床预后有一定的预测作用。其中任何两个指标的联合,比单一指标对患者预后的预测价值明显提高。 | 徐建明 朱步东 Mangia Anita Simone Gianni Montemurro Severino Giuliani Francesco Maiello Evaristo Colucci Giuseppe Paradiso Angelo | 2005 | 中华肿瘤杂志2005，27，5： | 9 |
| 2 | H pylori status and angiogenesis factors in human gastric carcinoma显示文摘AIM: To investigate H pylori expression in gastric cancer patients in relation to primary tumor angiogenic markers, such as microvessel density (MVD), thymidine phospho- rylase (TP), vascular endothelial growth factor receptor-1 (VEGF-R1), p53 and circulating VEGF levels. METHODS: Angiogenic markers were analyzed immu- nohistochemically in 56 primary gastric cancers. H pylori cytotoxin (vacA) and the cytotoxin-associated gene (cagA) amplification were evaluated using PCR assay. Serum H pylori IgG antibodies and serum/plasma circulating VEGF levels were detected in 39 and 38 patients by ELI- SA, respectively. RESULTS: A total of 69% of patients were positive for circulating IgG antibodies against H pylori. cagA-positive H pylori strains were found in 41% of gastric patients. vacA was found in 50% of patients; s1 strains were more highly expressed among vacA-positive patients. The presence of the s1 strain was signifi cantly associ- ated with cagA (P = 0.0001). MVD was signifi cantly cor- related with both tumor VEGF expression (r = 0.361, P = 0.009) and serum VEGF levels (r = -0.347, P = 0.041).Conversely, neither VEGF-R1 expression nor MVD was related to p53 expression. However, H pylori was not related to any angiogenic markers except for the plasma VEGF level (P = 0.026). CONCLUSION: H pylori antigen is related to higher plasma VEGF levels, but not to angiogenic character- istics. It can be hypothesized that the toxic effects of H pylori on angiogenesis occurs in early preclinical dis- ease phase or in long-lasting aggressive infections, but only when high H pylori IgG levels are persistent. | Anita Mangia Annalisa Chiriatti Girolamo Ranieri Ines Abbate Maria Coviello Giovanni Simone Francesco Alfredo Zito Severino Montemurro Antonello Rucci Alfredo Di Leo Stefania Tommasi Pasquale Berloco Jian Ming Xu Angelo Paradiso | 2006 | World Journal of Gastroenterology2006，12，34： | 5 |
| 3 | Accurate mass measurements for the confirmation of Sudan azo-dyes in hot chilli products by capillary liquid chromatography–electrospray tandem quadrupole orthogonal-acceleration time of flight mass spectrometry显示文摘 | F. Calbiani M. Careri L. Elviri A. Mangia I. Zagnoni | 2004 | Journal of Chromatography A2004，，1： | 3 |
| 4 | Interleukin 28B polymorphisms as predictor of response in hepatitis C virus genotype 2 and 3 infected patients显示文摘Single nucleotide polymorphisms near the interleukin28B(IL-28B)gene have been identified as strong predictors of both spontaneous or Peg-interferon(Peg-IFN)and ribavirin(RBV)induced clearance of hepatitis C virus(HCV).Several studies have shown that,in patients with genotype 1(GT-1),rs12979860 C/C and rs8099917T/T substitutions are associated with a more than twofold increase in sustained virological response rate to Peg-IFN and RBV treatment.Although new treatment regimens based on combination of DAA with or without IFN are in the approval phase,until combination regimens with a backbone of Peg-IFN will be used,we can expect that IL28B holds its importance.The clinical relevance of IL28B genotyping in treatment of patients infected with HCV genotype 2(GT-2)and 3(GT-3)remains controversial.Therefore,after a careful examination of the available literature,we analyzed the impact of IL28B in GT-2 and-3.Simple size of the studies and GT-2 and GT-3 proportion were discussed.An algorithm for the practical use of IL28B in these patients was suggested at the aim of optimizing treatment. | Alessandra Mangia Leonardo Mottola Rosanna Santoro | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 5 | Sensory property relationship to chemical data of Italian-type dry-cured ham显示文摘 | Careri M Mangia A Barbieri G | 1993 | J Food Science1993，58，： | 2 |
| 6 | Study of the volatile compounds useful for the characterisation of fresh and frozen-thawed cultured gilthead sea bream fish by solid-phase microextraction gas chromatography–mass spectrometry显示文摘 | J. Iglesias I. Medina F. Bianchi M. Careri A. Mangia M. Musci | 2009 | Food Chemistry2009，，4： | 2 |
| 7 | Relationship Between Steatosis, Inflammation, and Fibrosis in Chronic Hepatitis C: A Meta-Analysis of Individual Patient Data显示文摘 | Gioacchino Leandro Alessandra Mangia Jason Hui Paolo Fabris Laura Rubbia–Brandt Guido Colloredo Luigi E. Adinolfi Tarik Asselah Julie R. Jonsson Antonina Smedile Norah Terrault Valerio Pazienza Maria Teresa Giordani Emiliano Giostra Aurelio Sonzogni Giuse | 2006 | Gastroenterology2006，，6： | 2 |
| 8 | Fish and food safety: Determination of formaldehyde in 12 fish species by SPME extraction and GC–MS analysis显示文摘 | F. Bianchi M. Careri M. Musci A. Mangia | 2005 | Food Chemistry2005，，3： | 2 |
| 9 | Development and in-house validation of a liquid chromatography–electrospray–tandem mass spectrometry method for the simultaneous determination of Sudan I, Sudan II, Sudan III and Sudan IV in hot chilli products显示文摘 | F Calbiani M Careri L Elviri A Mangia L Pistarà I Zagnoni | 2004 | Journal of Chromatography A2004，，1： | 2 |
| 10 | Sensory properties relationships to chemical data of Italian-type dry-cured ham显示文摘 | CARERI M MANGIA A BARBIERI G | 1993 | J Food Science1993，58，5： | 1 |
| 11 | Knowledge creation and inter-organizational relationships: the development of innovation in the railway industry显示文摘 | Mario Pezzillo Iacono Marcello Martinez Gianluigi Mangia | 2012 | Jour- nal of Knowledge Management2012，16，4： | 1 |
| 12 | HLA class II favors clearance of HCV infection and progression of the chronic liver damage显示文摘 | Alessandra Mangia Raffaela Gentile Isabella Cascavilla Maurizio Margaglione Maria Rosaria Villani Francesco Stella Giovanni Modola Valeria Agostiano Carlo Gaudiano Angelo Andriulli | 1999 | Journal of Hepatology1999，，6： | 1 |
| 13 | Liquid Chromatography-UV Determination and Liquid Chromatography-Atmospheric Pressure Chemical Ionization Mass Spectrometric Characterization of Sitosterol and Sigmasterol in Soybean Oil显示文摘 | Careri M Elviri L Mangia A | 2001 | Journal Chromatography A2001，935，2： | 1 |
| 14 | Sensory property relationship to chemical data of Italian-type dry-cured ham显示文摘 | Careri M Mangia A Barbieri G | 1993 | Journal of Food Science1993，58，5： | 1 |
| 15 | Sensory propertyrelationships to chemical data of Italian-type dry-cured ham显示文摘 | CARERI M MANGIA A BARBIERI G | 1993 | Journalof Food Science1993，58，5： | 1 |
| 16 | External validation of biochemical indices for noninvasive evaluation of liver fibrosis in HCV chronic hepatitis显示文摘 | Iacobellis A Mangia A Leandro G | 2005 | Am J Gastroenterol2005，100，4： | 1 |
| 17 | Ultrasonographic and Biochemical Parameters in the Non-lnvasive Evaluation of Liver Fibrosis in Hepatitis C Virus Chronic Hepatitis显示文摘 | Iacobellis A Fusilli S Mangia A | 2005 | Aliment Pharmacol Ther2005，22，9： | 1 |
| 18 | Sofosbuvir for previ- ously untreated chronic hepatitis C infection显示文摘 | Lawitz E Mangia A Wyles D | 2013 | N Engl J Med2013，368，20： | 1 |
| 19 | Experimental design optimization for the ICP-AES determination of Li,Na,K,Al,Fe,Mn and Zn in human serum显示文摘 | Bianchi F Maffini M Mangia A | 2007 | J Pharm Biomed Anal2007，43，2： | 1 |
| 20 | Sofosbuvir for previ- ously untreated chronic hepatitis C infection 显示文摘 | Lawitz E Mangia A Wyles D | 2013 | N Engl J Med2013，368，20： | 1 |
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