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| 1 | Psychosocial issues in evidence-based guidelines on inflammatory bowel diseases: A review显示文摘AIM:To study statements and recommendations on psychosocial issues as presented in international evidence-based guidelines on the management of inflammatory bowel diseases(IBD).METHODS:MEDLINE,guidelines International Network,National Guideline Clearing House and National Institute for Health and Care Excellence were searched from January 2006 to June 30,2013 for evidencebased guidelines on the management of IBD.RESULTS:The search yielded 364 hits.Thirteen guidelines were included in the review,of which three wereprepared in Asia,eight in Europe and two in the United States.Eleven guidelines made statements and recommendations on psychosocial issues.The guidelines were concordant in that mental health disorders and stress do not contribute to the aetiology of IBD,but that they can influence its course.It was recommended that IBD-patients should be screened for psychological distress.If indicated,psychotherapy and/or psychopharmacological therapy should be recommended.IBDcentres should collaborate with mental health care specialists.Tobacco smoking patients with Crohn’s disease should be advised to quit.CONCLUSION:Patients and mental health specialists should be able to participate in future guideline groups to contribute to establishing recommendations on psychosocial issues in IBD.Future guidelines should acknowledge the presence of psychosocial problems in IBD-patients and encourage screening for psychological distress. | Winfried Huser Gabriele Moser Petra Klose Antonina Mikocka-Walus | 2014 | World Journal of Gastroenterology2014，20，13： | 14 |
| 2 | 生态地质调查评价——以辽宁铁岭地区为例显示文摘参照俄罗斯生态地质调查评价方法,结合辽宁铁岭地区资源与环境状况,增加了土壤侵蚀、土壤厚度及植被发育状况等相关调查内容,建立了基于'土壤、植被、水文及地质灾害发育程度等'评价指标的'生态地质综合评价法'.由此将工作区划分出5类生态地质景观,提出了相应的资源开发与环境保护建议. | 陈树旺 邢德和 丁秋红 郑月娟 高飞 卞雄飞 张志斌 商翎 Antonina A.Zhukovskaya Irina V.Ershova Nadezhda A.Tomilovskaya | 2012 | 地质与资源2012，21，6： | 12 |
| 3 | Is the pancreas affected in patients with septic shock?——a prospective study显示文摘BACKGROUND:Hyperamylasemia can be observed anecdotally during the course of severe sepsis or septic shock.This study aimed to investigate the possibility of pancreatic involvement in patients with septic shock using serum pancreatic enzyme determinations and imaging techniques in 21 consecutive patients with septic shock and 21 healthy subjects as controls. METHODS:The serum activity of pancreatic amylase and lipase was assayed initially in all subjects and 24 and 48 hours after the initial observation in the 21 patients with septic shock All patients also underwent radiological examination to detect pancreatic abnormalities. RESULTS:The serum activity of pancreatic amylase was significantly higher in the 21 patients with septic shock than in the 21 control subjects during the study period while the serum activity of lipase was similar to that of the control subjects.Amylase and lipase serum activity did not significantly changed throughout the study period in the 21 patients with septic shock.None of the patients with pancreatic hyperenzymemia had clinical signs or morphological alterations compatible with acute pancreatitis CONCLUSION:The presence of pancreatic hyperenzymemia in septic shock patients is not a biochemical manifestation of acute pancreatic damage,and the management of these patients should be dependent on the clinical situation and not merely the biochemical results. | Raffaele Pezzilli Alessandra Barassi Andrea Imbrogno Dario Fabbri Antonina Pigna Antonio M.Morselli-Labate Roberto Corinaldesi Gianvico Melzi d'Eril | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 11 |
| 4 | Doctor communication quality and Friends' attitudes influence complementary medicine use in inflammatory bowel disease显示文摘AIM: To examine the frequency of regular complementary and alternative therapy(CAM) use in three Australian cohorts of contrasting care setting and geography, and identify independent attitudinal and psychological predictors of CAM use across all cohorts. METHODS: A cross sectional questionnaire was administered to inflammatory bowel disease(IBD) patients in 3 separate cohorts which differed by geographical region and care setting. Demographics and frequency of regular CAM use were assessed, along with attitudes towards IBD medication and psychological parameters such as anxiety, depression, personality traits and quality of life(QOL), and compared across cohorts. Independent attitudinal and psychological predictors of CAM use were determined using binary logistic regression analysis. RESULTS: In 473 respondents(mean age 50.3 years, 60.2% female) regular CAM use was reported by45.4%, and did not vary between cohorts. Only 54.1%of users disclosed CAM use to their doctor. Independent predictors of CAM use which confirm those reported previously were: covert conventional medication dose reduction(P < 0.001), seeking psychological treatment(P < 0.001), adverse effects of conventional medication(P = 0.043), and higher QOL(P < 0.001).Newly identified predictors were CAM use by family or friends(P < 0.001), dissatisfaction with patient-doctor communication(P < 0.001), and lower depression scores(P < 0.001). CONCLUSION: In addition to previously identified predictors of CAM use, these data show that physician attention to communication and the patient-doctor relationship is important as these factors influence CAM use. Patient reluctance to discuss CAM with physicians may promote greater reliance on social contacts to influence CAM decisions. | Réme Mountifield Jane M Andrews Antonina Mikocka-Walus Peter Bampton | 2015 | World Journal of Gastroenterology2015，21，12： | 6 |
| 5 | 中华绒螯蟹不同生理阶段腹肢的结构变化及粘液腺的发育特征显示文摘用显微及亚显微方法研究了中华绒螯蟹雌体不同生理阶段 (幼蟹、未成熟蟹、成熟蟹、抱卵蟹和流产蟹 )腹肢的体壁结构变化和粘液腺发育特征。体壁的上皮细胞层常与粘液腺相连 ,粘液腺分泌物经导管穿过各层角膜排出。不同生理状况下中华绒螯蟹的腹肢体壁各角膜层结构的比例及致密度有明显的差异 ,粘液腺细胞及导管的数量不同 ,粘液腺与上皮细胞的连接程度也不同。粘液腺是否正常分泌、刚毛囊的开闭均与中华绒螯蟹的胚胎附着有关。比较研究发现 ,太湖抱卵蟹腹肢体腔内腺体比温州本地抱卵蟹腹肢内腺体发达 ,分泌的粘液也特别多。分析认为中华绒螯蟹腹肢组织结构。 | 应雪萍 杨万喜 许捷 林芳芳 Antonina dos SANTOS | 2004 | Zoological Research2004，25，3： | 5 |
| 6 | CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis显示文摘 | Matilde Todaro Miriam Gaggianesi Veronica Catalano Antonina Benfante Flora Iovino Mauro Biffoni Tiziana Apuzzo Isabella Sperduti Silvia Volpe Gianfranco Cocorullo Gaspare Gulotta Francesco Dieli Ruggero De Maria Giorgio Stassi | 2014 | Cell Stem Cell2014，，3： | 3 |
| 7 | Radioprotective thermally generated free-radical dextrins显示文摘Effect of doses of the X-ray radiation from 0 to 400 Gy upon granular cornstarch and dextrins (British gums, BG) thermally generated from it at 230-300℃ was recognized with quantitative EPR and IR ab-sorption spectroscopy, molecular mass distribution in the depolymerization products, Scanning Elec-tron Microscopy, and X-ray diffractometry. Fractal analysis of the profiles of molecular mass distribu-tion showed that the depolymerization involved debranching of amylopectin. Roasting of cornstarch produced BG which differed in concentration and EPR parameters of stable free radicals from BG generated by X-ray radiation. Two types of stable free radicals, with Gaussian and Lorentzian shapes of EPR signals, were recognized. The shapes of the signals and temperature dependence on free radical intensity indicated exchanging interactions of the antiferromagnetic type, causing partial quenching of the spins at-196℃ (77K). Upon X-ray irradiation, new radicals were generated, the number and stability of which strongly depended on the types of radicals present before irradiation. These radicals slowly ceased because of a repolymerization of BG on storage. | Piotr TOMASIK Oskar MICHALSKI Ewa BIDZINSKA Antonina CEBULSKA-WASILEWSKA Krystyna DYREK Maciej FIEDOROWICZ Pawe OLKO | 2008 | Chinese Science Bulletin2008，53，7： | 3 |
| 8 | Type 2 diabetes mellitus and chronic hepatitis C: Which is worse? Results of a long-term retrospective cohort study显示文摘 | Chiara Giordanino Simone Ceretto Simona Bo Antonina Smedile Alessia Ciancio Elisabetta Bugianesi Rinaldo Pellicano Sharmila Fagoonee Elisabetta Versino Giuseppe Costa Daniele Arese Marco Sacco Mario Rizzetto Giorgio Saracco | 2011 | Digestive and Liver Disease2011，，5： | 3 |
| 9 | Etiology of chronic liver diseases in the Northwest of Italy, 1998 through 2014显示文摘AIM To assess the etiology of chronic liver diseases(CLD) from 1998 to 2014 at the outpatient clinic of Gastroenterology of the main hospital in Northwest of Italy among those dedicated to hepatology.METHODS A random sample of charts of patients referred to for increased liver enzymes between January 1998 and December 2006, and between January 2012 and December 2014 were reviewed. Etiology search included testing for hepatitis B virus(HBV), hepatitis C virus(HCV), autoimmune hepatitis, primary biliary cirrhosis, Wilson's disease and hereditary hemocromatosis. A risky alcohol consumption was also considered. Nonalcoholic fatty liver disease(NAFLD) was diagnosed in patients with histological and/or ultrasound evidence of steatosis/steatohepatitis, and without other causes of CLD.RESULTS The number of patients included was 1163. Of them, 528(45%) had positivity for HCV and 85(7%) for HBV. Among the virus-free patients, 417(36%) had metabolic disorders whereas the remaining had history of alcohol abuse, less prevalent causes of CLD or concomitant conditions. In comparison to 1998-2000(41%), a reduction of HCV alone-related cases was detected during the periods 2001-2003(35%, OR = 0.75, 95%CI: 0.53-1.06), 2004-2006(33%, OR = 0.70, 95%CI: 0.50-0.97) and 2012-2014(31%, OR = 0.64, 95%CI: 0.46-0.91). On the contrary, in comparison to 1998-2000(31%), metabolic-alone disorders increased in the period 2004-2006(39%, OR = 1.37, 95%CI: 0.99-1.91) and 2012-2014(41%, OR = 1.53, 95%CI: 1.09-2.16). The other etiologies remained stable. The increase of incidence of metabolic-alone etiology during the period 2004-2006 and 2012-2014 tended to be higher in older patients(≥ 50 years) compared to younger(P = 0.058).CONCLUSION In the Northwest of Italy, during this study period, the prevalence of HCV infection decreased notably whereas that of NAFLD increased. | Giorgio Maria Saracco Andrea Evangelista Sharmila Fagoonee Giovannino Ciccone Elisabetta Bugianesi Gian Paolo Caviglia Maria Lorena Abate Mario Rizzetto Rinaldo Pellicano Antonina Smedile | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 10 | Comparison of reversed-phase enantioselective HPLC methods for determining the enantiomeric purity of (S)-omeprazole in the presence of its related substances显示文摘A simple analytical high-performance liquid chromatography(HPLC) method was applied for the enantiomeric excess determination of esomeprazole((S)-OME), the enantiopure active ingredient contained in drug products, in the presence of its potential organic impurities A-E. The enantioselective separation was accomplished on the immobilized-type Chiralpak ID-3 chiral stationary phase(CSP)under reversed-phase conditions. The results were evaluated and compared with those obtained by the of fi cial enantioselective method of European Pharmacopoeia used as the reference for checking the enantiomeric excess of(S)-OME. It has been established that the use of the Chiralpak ID-3 CSP allows the determination of the enantiomeric purity of(S)-OME without any interference coming from its chiral and achiral related substances. The analytical procedure of the drug regulatory agencies based on the AGP CSP suffered instead from poor speci fi city due to overlap of the peaks pertinent to the achiral impurity A and the chiral impurity(R)-OME(impurity F). | Bruno Gallinella Rosella Ferretti Leo Zanitti Isabella Sestili Antonina Mosca Roberto Cirilli | 2016 | Journal of Pharmaceutical Analysis2016，6，2： | 2 |
| 11 | Synthesis, Structure, and Properties of N , N ′‐Dinitrourea显示文摘 | Sergey G. Il'yasov Gennady V. Sakovich Antonina A. Lobanova | 2013 | Propellants Explosives Pyrotechnics2013，，3： | 2 |
| 12 | Nitramide显示文摘 | Antonina A Lobanova S G Il'yasov Gennady V Sakovich | 2010 | Russian Chemical Reviews2010，，9： | 2 |
| 13 | Reliability of transient elastography for the detection of fibrosis in Non-Alcoholic Fatty Liver Disease and chronic viral hepatitis显示文摘 | Silvia Gaia Silvia Carenzi Angela L. Barilli Elisabetta Bugianesi Antonina Smedile Franco Brunello Alfredo Marzano Mario Rizzetto | 2010 | Journal of Hepatology2010，，： | 2 |
| 14 | Relationship Between Steatosis, Inflammation, and Fibrosis in Chronic Hepatitis C: A Meta-Analysis of Individual Patient Data显示文摘 | Gioacchino Leandro Alessandra Mangia Jason Hui Paolo Fabris Laura Rubbia–Brandt Guido Colloredo Luigi E. Adinolfi Tarik Asselah Julie R. Jonsson Antonina Smedile Norah Terrault Valerio Pazienza Maria Teresa Giordani Emiliano Giostra Aurelio Sonzogni Giuse | 2006 | Gastroenterology2006，，6： | 2 |
| 15 | Novel MLH1 frameshift mutation in an extended hereditary nonpolyposis colorectal cancer family显示文摘AIM: To present novel frameshift mutation c.31delC [p.L11X] in the MLH1 gene identified in an extended Bulgarian hereditary non-polyposis colorectal cancer (HNPCC) family and to analyze the molecular and clinical findings within the pedigree concerning the proposal of adequate individual prophylactic strategy for all mutation carriers. METHODS: The pedigree of the family consists of 42 members in four generations. Search for mutations in the MLH1 and hMSH2 genes was performed in the pro-band. After PCR amplification of all exons including flanking intronic regions, amplicons were directly sequenced. RESULTS: The mutation was found in nine from the thirteen pedigree members who signed informed consent to participate in the study. In three adenocarcinomas, microsatellite instability and lack of the MLH1 protein expression were detected. The only one tubulovillous adenoma analyzed was microsatellite stable and the MLH1 protein showed an intact staining. CONCLUSION: The newly described mutation c.31delC is HNPCC causative. Besides the typical clinical features of the syndrome, we found a specific pathologic manifestation such as moderate to high differentiated adenocarcinomas of the colon. One of the mutation carriers developed a benign giant cell soft tissue tumor. The primary tumor localizations were frequently extracolonic and detailed yearly gastrointestinal and gynecological examinations have been proposed to the mutation carriers. We emphasize the importance of including the HNPCC genetic counseling and testing as well in the following surveillance of all patients at risk in the services covered by the health insurance in Bulgaria. | Tanya Kirilova Kadiyska Radka Petrova Kaneva Dimitar Georgiev Nedin Alexandrina Borisova Alexandrova Antonina Todorova Gegova Stoyan Ganchev Lalchev Tatyana Christova Vanio Ivanov Mitev Juergen Horst Nadja Bogdanova Ivo Marinov Kremensky | 2006 | World Journal of Gastroenterology2006，12，48： | 2 |
| 16 | Substance P selectively activates TNF-α mRNA in rat uterine immune cells: a neuroimmune link显示文摘 | Roberta Cocchiara Antonella Bongiovanni Giuseppe Albeggiani Antonina Azzolina Domenico Geraci | 1997 | NeuroReport1997，，13： | 1 |
| 17 | Outcome of chronic delta hepatitis in Italy: A long-term cohort study显示文摘 | Grazia Anna Niro Antonina Smedile Antonio Massimo Ippolito Alessia Ciancio Rosanna Fontana Antonella Olivero Maria Rosa Valvano Maria Lorena Abate Domenica Gioffreda Gian Paolo Caviglia Mario Rizzetto Angelo Andriulli | 2010 | Journal of Hepatology2010，，5： | 1 |
| 18 | Aerobic denitrification bacteria that produce low levels of nitrous oxide显示文摘 | Takaya N Maria Antonina B C S Yasushi S | 2003 | Appl Envir Microbio2003，69，6： | 1 |
| 19 | Feasibility and safety of G-CSF administration to induce bone marrow-derived cells mobilization in patients with end stage liver disease显示文摘 | Silvia Gaia Antonina Smedile Paola Omedè Antonella Olivero Fiorella Sanavio Federico Balzola Antonio Ottobrelli Maria Lorena Abate Alfredo Marzano Mario Rizzetto Corrado Tarella | 2006 | Journal of Hepatology2006，，1： | 1 |
| 20 | Particle swarm opti- mization for multimodal functions: a clustering approach 显示文摘 | ALESSANDRO P ANTONINA S | 2008 | Journal of Artificial Evolution and Applications- Particle Swarms: the Second Decade2008，2008，： | 1 |
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