|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis显示文摘The sequence of events associated with the development of gastric cancer has been described as 'the gastric precancerous cascade'. This cascade is a dynamic process that includes lesions, such as atrophic gastritis, intestinal metaplasia and dysplasia. According to this model, Helicobacter pylori(H. pylori) infection targets the normal gastric mucosa causing non-atrophic gastritis, an initiating lesion that can be cured by clearing H. pylori with antibiotics or that may then linger in the case of chronic infection and progress to atrophic gastritis. The presence of virulence factors in the infecting H. pylori drives the carcinogenesis process. Independent epidemiological and animal studies have confirmed the sequential progression of these precancerous lesions. Particularly long-term follow-up studies estimated a risk of 0.1% for atrophic gastritis/intestinal metaplasia and 6% in case of dysplasia for the long-term development of gastric cancer. With this in mind, a better understanding of the genetic and epigenetic changes associated with progression of the cascade is critical in determining the risk of gastric cancer associated with H. pylori infection. In this review, we will summarize some of the mostrelevant mechanisms and focus predominantly but not exclusively on the discussion of gene promoter methylation and mi RNAs in this context. | Manuel A Valenzuela Jimena Canales Alejandro H Corvalán Andrew FG Quest | 2015 | World Journal of Gastroenterology2015，21，45： | 33 |
| 2 | Pancreatic cancer显示文摘 | Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo | 2002 | Current Problems in Cancer2002，，4： | 2 |
| 3 | Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and src activation 显示文摘 | Thomas H Manuel A Mark W | 2004 | J Biol Chem2004，22，23： | 1 |
| 4 | High rate membranelessmicrobial electrolysis cell for continuous hydrogen production显示文摘 | Tartakovsky B Manuel M F Wang H ei al | 2009 | International Journal of Hydrogen Energy2009，34，2： | 1 |
| 5 | Geographic localization of knowledge spillovers as evidenced by patent citations显示文摘 | Manuel T Rebecca H | 1993 | Quarterly Journal of Economics1993，108，3： | 1 |
| 6 | Effects of oxygen on the degradation of caroterloids in an aqueous model system 显示文摘 | Leolak H Liluh P N Manuel J G | 2000 | Journal of Agricultural and Food Chemistry2000，48，10： | 1 |
| 7 | Gradual distributed real-coded genetic algorithms显示文摘 | H Francisco L Manuel | 2000 | IEEE Transaction on Evolution Computation2000，，4： | 1 |
| 8 | Analyzing a fLrm' s In- ternational Portfolio of Technological Knowledge: A Declarative Ontology-based OWL Approach for Patent Documents显示文摘 | Maria B E Manuel N Nuria H T | 2013 | Ad- vanced Engineering Informatics2013，27，3： | 1 |
| 9 | The cryoglobulinaemias显示文摘 | Manuel Ramos-Casals John H Stone Maria C Cid Xavier Bosch | 2012 | The Lancet . 2012 (9813)2012，，9813： | 1 |
| 10 | The future of anti hypertension treatment 显示文摘 | Zafar H Rafael Hemandez Manuel Valaseo | 2007 | Am J Ther2007，14，： | 1 |
| 11 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 12 | The effeet of heat-moisture treat ment on the structure and physicochemical properties of nor- mal maize, waxy maize, dull waxy maize and amylomaize V starches显示文摘 | HOOVER R MANUEL H | 1996 | Journal of Cereal Science1996，23，2： | 1 |
| 13 | A new approach in the kinetic modeling of three-way catalytic reactions显示文摘 | MANUEL I THOMAS C COLAS H | 2004 | Topics in Catalysis2004，3031，： | 1 |
| 14 | Biosynthesis of saxitoxin analogues :The unpexpected pathway 显示文摘 | SHIMIZU Y MANUEL N AKIRA H | 1984 | J Am Chem Soc1984，106，21： | 1 |
| 15 | Phase I trial of EKB-569,an irreversible inhibitor of the epidermal growth factor receptor(EGFR),in patients with advanced solid tumors显示文摘 | Manuel H Charles E Eric K R | 2002 | Am Soc Clin Oncol2002，，： | 1 |
| 16 | Immediate application of positive-end expiratory pressure is more effective than delayed positive-end expiratory pressure to reduce extravascular lung water 显示文摘 | Manuel R Enrique F Benjamin H | 1999 | Cri Care Med1999，27，2： | 1 |
| 17 | Update on the diagnosis and treatment of bladder endometriosis显示文摘 | Héctor Pastor-Navarro José M. Giménez-Bachs María J. Donate-Moreno José M. Pastor-Guzman Rafael Ruíz-Mondéjar Manuel Atienzar-Tobarra Antonio S. Salinas-Sánchez Julio A. Virserda-Rodriguez | 2007 | International Urogynecology Journal2007，，8： | 1 |
| 18 | Partially Oxidized Poly- acrylonitrile Nanofibrous Membrane as a Thermally Stable Separator for Lithium Ion Batteries显示文摘 | Lee J H Manuel J Choi H | 2015 | Polymer2015，68，： | 1 |
| 19 | Production and partial characterization of extracellular peroxidases produced by Streptomyces avermitilis UAH30显示文摘 | ABDUL R MANUEL H | 1997 | Applied Biochemistry and Biotechnology1997，62，： | 1 |
| 20 | Phase study of gemcitabine and fluoronracil as a continuous infusion in patients with pancreatic cancer 显示文摘 | Manuel H Uaniel C Luis P | 1999 | Clinoncol1999，17，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员