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| 1 | Induction of Tetraploid Male Sterile Tagetes erecta by Colchicine Treatment and Its Application for Interspecific Hybridization显示文摘Tagetes erecta is an annual multifunctional plant which can be cultivated under a broad range of climatic conditions. Polyploidization and interspecific hybridization are applied to facilitate breeding cultivars of T. erecta with improved ornamental qualities. Colchicine treatment to the germinating seeds was proved to be a useful tool for chromosome doubling of the male sterile two-type line ‘M525AB', with the resulting frequency of polyploid seedlings ranging from 88.89%(following 0.05% w/v colchicine applied for a 3–6 h exposure period) to a maximum of100.00%(following 0.1% for 3–6 h, or 0.2% for 3 h). Morphological observation, stomatal size and density analysis, flow cytometric analysis and chromosome counting were conducted to identify the tetraploid plants. Distinctive morphological changes were observed in a notable proportion of polyploid plants. The colchicine-treated polyploid T. erecta plants showed dwarfed and more robust growth, thicker, larger and greener leaves, larger inflorescences and florets. The mutant plants identified through morphological observation all aligned as polyploid plants, thus morphological observation could be an effective method for the detection of polyploidy. The polyploid plants had significant larger stomata size over the abaxial leaf surface, whereas the density of stomata distribution was remarkably reduced. The survival rate of tetraploid cuttings(i.e. 38%)was greatly reduced compared to that of diploid plants. The fertility of tetraploid plants was also decreased, as shown by cross-pollination yields.Interspecific hybridizations between colchicine-induced tetraploid plants of a male sterile T. erecta line and the naturally tetraploid fully fertile Tagetes patula species resulted in hybrid progeny. Most of these hybrids displayed the dwarfed growth stature and compact, larger-flower morphology which is the typical ideotype of herbaceous flowers. Thus, polyploidization may be employed effectively as a means to facilitate interspecific hybridization, thereby contributing significantly to the improvement of quantitative traits of Tagetes spp. | HE Yanhong SUN Yalin ZHENG Riru AI Ye CAO Zhe BAO Manzhu | 2016 | Horticultural Plant Journal2016，2，5： | 5 |
| 2 | Big Earth data analytics:a survey显示文摘Big Earth data are produced from satellite observations,Internet-ofThings,model simulations,and other sources.The data embed unprecedented insights and spatiotemporal stamps of relevant Earth phenomena for improving our understanding,responding,and addressing challenges of Earth sciences and applications.In the past years,new technologies(such as cloud computing,big data and artificial intelligence)have gained momentum in addressing the challenges of using big Earth data for scientific studies and geospatial applications historically intractable.This paper reviews the big Earth data analytics from several aspects to capture the latest advancements in this fast-growing domain.We first introduce the concepts of big Earth data.The architecture,various functionalities,and supporting modules are then reviewed from a generic methodology aspect.Analytical methods supporting the functionalities are surveyed and analyzed in the context of different tools.The driven questions are exemplified through cutting-edge Earth science researches and applications.A list of challenges and opportunities are proposed for different stakeholders to collaboratively advance big Earth data analytics in the near future. | Chaowei Yang Manzhu Yu Yun Li Fei Hu Yongyao Jiang Qian Liu Dexuan Sha Mengchao Xu Juan Gu | 2019 | Big Earth Data2019，3，2： | 3 |
| 3 | Comparative transcriptome analysis of different heat stress responses between self-root grafting line and heterogeneous grafting line in rose显示文摘Rose is sensitive to high temperature which will make the rose go into a semi-dormancy state.Grafting is an excellent way to enhance rose heat tolerance.Here,heat-tolerant Rosa multiflora‘Huanong Wuci 1'(W)and heat-sensitive Rosa chinensis‘Old Blush’(X)were selected as experimental materials.The RNA-seq technique was used to investigate the transcriptomes of self-root grafting line(XX0),heterogeneous grafting line(XW0),self-root grafting line under 6 h heat stress(XX6),and heterogeneous grafting line under 6 h heat stress(XW6).Under high temperature stress,multiple signaling pathways were activated,moreover,a large number of transcription factors and functional genes were induced,especially the HSFs and HSPs with remarkably upregulated expression levels.The GO analysis showed that the differences in the expressions of the genes related to fatty acids and carbohydrates were observed between self-root grafting line and heterogeneous grafting line.In addition,14 P450s were differentially expressed,and one lectin gene was up-regulated in XW0 vs XW6,but down-regulated in XX0 vs XX6.Considering physiological and biochemical traits such as relative electrolyte leakage,SOD activity,proline,and total soluble sugars,DEGs involved in these processes may be key factors to resist high temperature.The present study provides an insight into the complex mechanism underlying grafting in response to heat stress.Our results indicate that grafting is an effective way to improve rose heat resistance. | Wenquan Qi Chunling Zhang Wenjing Wang Zhe Cao Song Li Hang Li Wan Zhu Yongqi Huang Manzhu Bao Yanhong He Riru Zheng | 2021 | Horticultural Plant Journal2021，7，3： | 3 |
| 4 | Symmetry-enforced three-dimensional Dirac phononic crystals显示文摘Dirac semimetals,the materials featuring fourfold degenerate Dirac points,are critical states of topologically distinct phases.Such gapless topological states have been accomplished by a band-inversion mechanism,in which the Dirac points can be annihilated pairwise by perturbations without changing the symmetry of the system.Here,we report an experimental observation of Dirac points that are enforced completely by the crystal symmetry using a nonsymmorphic three-dimensional phononic crystal.Intriguingly,our Dirac phononic crystal hosts four spiral topological surface states,in which the surface states of opposite helicities intersect gaplessly along certain momentum lines,as confirmed by additional surface measurements.The novel Dirac system may release new opportunities for studying elusive(pseudo)and offer a unique prototype platform for acoustic applications. | Xiangxi Cai Liping Ye Chunyin Qiu Meng Xiao Rui Yu Manzhu Ke Zhengyou Liu | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 5 | Spatiotemporal event detection: a review显示文摘The advancements of sensing technologies,including remote sensing,in situ sensing,social sensing,and health sensing,have tremendously improved our capability to observe and record natural and social phenomena,such as natural disasters,presidential elections,and infectious diseases.The observations have provided an unprecedented opportunity to better understand and respond to the spatiotemporal dynamics of the environment,urban settings,health and disease propagation,business decisions,and crisis and crime.Spatiotemporal event detection serves as a gateway to enable a better understanding by detecting events that represent the abnormal status of relevant phenomena.This paper reviews the literature for different sensing capabilities,spatiotemporal event extraction methods,and categories of applications for the detected events.The novelty of this review is to revisit the definition and requirements of event detection and to layout the overall workflow(from sensing and event extraction methods to the operations and decision-supporting processes based on the extracted events)as an agenda for future event detection research.Guidance is presented on the current challenges to this research agenda,and future directions are discussed for conducting spatiotemporal event detection in the era of big data,advanced sensing,and artificial intelligence. | Manzhu Yu Myra Bambacus Guido Cervone Keith Clarke Daniel Duffy Qunying Huang Jing Li Wenwen Li Zhenlong Li Qian Liu Bernd Resch Jingchao Yang Chaowei Yang | 2020 | International Journal of Digital Earth2020，13，12： | 2 |
| 6 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 7 | Genome-wide identification and characterization of the bHLH gene family in an ornamental woody plant Prunus mume显示文摘The basic helix-loop-helix(bHLH)transcription factor family is the second-largest family in plants,where it plays essential roles in development,and the responses to multiple abiotic and biotic stressors.However,little information is available about this gene family in Prunus mume,which is widely cultivated in East Asia as an ornamental fruit tree.Here,100 PmbHLH genes were identified,and their evolution and functions were explored in P.mume for the first time.The PmbHLH genes were classified into 21 subfamilies.The chromosomal distribution,physicochemical properties,bHLH domain,conserved motif,and intron/exon compositions were also analyzed.Furthermore,the evolutionary pattern,divergence time of the PmbHLH family,and genetic relationships among P.mume,Arabidopsis thaliana,and Prunus persica and Fragaria vesca of Rosaceae were explored.The functional prediction analysis of these PmbHLHs indicated that their functions varied,and included participating in the formation of organs and tissues,responding to stress,and the biosynthesis and metabolism of hormones and other secondary metabolites.Interestingly,expression analyses of PmbHLHs also revealed diverse expression patterns.Most of the PmbHLH genes were highly expressed in roots and stems,and a few were highly expressed in leaves,buds,and fruits,indicating tissue expression specificity.Eight PmbHLH genes,which were upregulated during low-temperature stress,may have critical roles in the response to cold stress.Ten PmbHLHs were differentially expressed between weeping and upright branches in a P.mume F_(1) population.These results shed light on the structure and evolution of the PmbHLH gene family,and lay a foundation for further functional studies of the bHLH genes. | Yanyan Wu Sihui Wu Xueqin Wang Tianyu Mao Manzhu Bao Junwei Zhang Jie Zhang | 2022 | Horticultural Plant Journal2022，8，4： | 2 |
| 8 | Highly directional acoustic wave radiation based on asymmetrical two-dimensional phononic orystal resonant cavity显示文摘 | KE Manzhu LIU Zhengyou PANG Pei | 2006 | Applied PbysicsLetters2006，88，26： | 1 |
| 9 | Surface resonant-states-enhanced acoustic wave tunneling in two- dimensional phononic crystals显示文摘 | Ke Manzhu He Zhaojian Peng Shasha | 2007 | Physical Review Let- ters2007，99，04： | 1 |
| 10 | Deep learning for real-time social media text classification for situation awareness-using Hurricanes Sandy,Harvey,and Irma as case studies显示文摘Social media platforms have been contributing to disaster management during the past several years.Text mining solutions using traditional machine learning techniques have been developed to categorize the messages into different themes,such as caution and advice,to better understand the meaning and leverage useful information from the social media text content.However,these methods are mostly event specific and difficult to generalize for cross-event classifications.In other words,traditional classification models trained by historic datasets are not capable of categorizing social media messages from a future event.This research examines the capability of a convolutional neural network(CNN)model in cross-event Twitter topic classification based on three geo-tagged twitter datasets collected during Hurricanes Sandy,Harvey,and Irma.The performance of the CNN model is compared to two traditional machine learning methods:support vector machine(SVM)and logistic regression(LR).Experiment results showed that CNN models achieved a consistently better accuracy for both single event and crossevent evaluation scenarios whereas SVM and LR models had lower accuracy compared to their own single event accuracy results.This indicated that the CNN model has the capability of pre-training Twitter data from past events to classify for an upcoming event for situational awareness. | Manzhu Yu Qunying Huang Han Qin Chris Scheele Chaowei Yang | 2019 | International Journal of Digital Earth2019，12，11： | 1 |
| 11 | Negative-refraction imaging with two-dimensional phononic crystals显示文摘 | KE Manzhu LIU Zhengyou QIU Chunyin | 2005 | Physical Review B2005，72，06： | 1 |
| 12 | Geographic context-aware text mining:enhance social media message classification for situational awareness by integrating spatial and temporal features显示文摘To find disaster relevant social media messages,current approaches utilize natural language processing methods or machine learning algorithms relying on text only,which have not been perfected due to the variability and uncertainty in the language used on social media and ignoring the geographic context of the messages when posted.Meanwhile,a disaster relevant social media message is highly sensitive to its posting location and time.However,limited studies exist to explore what spatial features and the extent of how temporal,and especially spatial features can aid text classification.This paper proposes a geographic context-aware text mining method to incorporate spatial and temporal information derived from social media and authoritative datasets,along with the text information,for classifying disaster relevant social media posts.This work designed and demonstrated how diverse types of spatial and temporal features can be derived from spatial data,and then used to enhance text mining.The deep learning-based method and commonly used machine learning algorithms,assessed the accuracy of the enhanced text-mining method.The performance results of different classification models generated by various combinations of textual,spatial,and temporal features indicate that additional spatial and temporal features help improve the overall accuracy of the classification. | Christopher Scheele Manzhu Yu Qunying Huang | 2021 | International Journal of Digital Earth2021，14，11： | 1 |
| 13 | Plant regeneration from excised hypocotyl explants of Platanus acerifolia willd显示文摘 | Guofeng Liu Jun Huang Longqing Chen Manzhu Bao | 2002 | In Vitro Cellular & Developmental Biology - Plant2002，，6： | 1 |
| 14 | Research on Technology Development of Traditional Chinese Medicine Extraction Based on Patent Information显示文摘Objective To understand the development status of traditional Chinese medicine extraction technology,so as to provide a reference for enterprises and scientific research institutions to determine the direction of technological innovation.Besides,the government can formulate scientific and technological innovation strategies.Methods Based on patent information,statistical methods were applied to analyze the development of traditional Chinese medicine extraction technology.Then,the core technology was identified by constructing a patent citation network.Finally,the main path analysis method was applied to discover the technological evolution path.Results and Conclusion The extraction technology of traditional Chinese medicine is still in the growth stage.At present,its R&D is based on enterprises,supplemented by scientific research institutions.The core technologies are ultrasonic extraction and enzymatic extraction.The main path represented by enzymatic extraction technology reveals the evolution process of traditional Chinese medicine extraction technology.Based on this,relevant suggestions are put forward.Firstly,technological innovation cooperation should be strengthened to explore new models of achievement transformation and cooperation.Secondly,key enterprises of technology clusters should be cultivated to accelerate breakthroughs in core technologies.Thirdly,combined technologies can achieve high-efficiency enzyme-assisted extraction and open up new ways of extracting traditional Chinese medicine.Fourthly,traditional techniques should be improved to develop innovative modern techniques. | Liu Yue Fu Nan Shen Manzhu Yuan Hongmei | 2023 | Asian Journal of Social Pharmacy2023，18，1： | 0 |
| 15 | Low Frequency Dispersion Law for Two-Dimensional Metallic Photonic Crystals显示文摘Using the rigorous multiple-scattering theory, we study the dispersion relation of electromagnetic (EM) waves in two di- mensional dielectric photonic crystals (PCs) and metallic photonic crystals (MPCs) in the low-frequency limit. Analytic formula for the effective velocity of EM waves in PCs and MPCs is obtained. Accuracy of our formula is checked by comparing the results with rigorous calculations. For PCs, our result is exactly the same as the coherent potential approximation (CPA), which is accurate even when the filling fraction is high. But for MPCs, our approach demonstrates special advantages, while the CPA theory fails, in predicting the effective velocity of EM waves in MPCs at low frequency. | WANG Yun JIA Han TIAN Zhidong WANG Yong KE Manzhu | 2008 | Wuhan University Journal of Natural Sciences2008，13，1： | 0 |
| 16 | Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus显示文摘Dear editor,Swine influenza virus(SIV)is a member of the Orthomyxoviridae family,influenza A virus genus,which can cause the swine influenza—an acute and highly contagious respiratory disease in pigs(Brown,2000;Kothalawala et al.,2006).The SIV was first observed in 1918 in the United States and the progenitor of the SIV was the H1N1 influenza virus which caused the Spanish influenza pandemic of 1918(Shope,1931). | Shuaiyong Wang Manzhu Wang Lingxue Yu Juan Wang Jiecong Yan Xinli Rong Yanjun Zhou Tongling Shan Wu Tong Guoxin Li Hao Zheng Guangzhi Tong Hai Yu | 2022 | Virologica Sinica2022，37，4： | 0 |
| 17 | Effect of Preparation Atmosphere on the Structure and Properties of Vanadium Pentoxide Xerogel Films显示文摘In this article, the vanadium pentoxide sols are synthesized by two different routes (melted and quenched in oxygen atmosphere or in air). The structure and properties of the vanadium pentoxide xerogel films are characterized by XRD, ESR, cyclic voltammograms curves and UV-visible transmittance analysis. The results show that the sample prepared in oxygen has poorer crystallization, lower content of V4+ ions and higher Li+ insertion capacity compared with that prepared in air. | Wen CHEN Manzhu KB Qing XU Quanyao ZHU Liqiang MAI Li LI School of Materials Science and Engineering, Wuhan University of Technology,Wuhan 430070, China | 2004 | Journal of Materials Science & Technology2004，20，3： | 0 |
| 18 | The Development of DTP Pharmacy and Its Impact on Pharmaceutical Enterprises显示文摘Objective To summarize the development status of direct to patient(DTP)pharmacy and its impact on pharmaceutical enterprises in China and to provide a reference for the pharmaceutical industry.Methods Literature research method was used to research domestic and foreign journals and magazines.Then,all sorts of data were collected to make a comprehensive comparison.Combined with relevant national policies,the current situation and advantages of the DTP pharmacy were analyzed to study its impact on pharmaceutical enterprises.Results and Conclusion Although DTP pharmacies are in the exploratory stage in China,with the advancement of comprehensive medical and health reforms,several national policies have created a good environment for the development of DTP pharmacies.Therefore,DTP pharmacies are accelerating their construction with better market value.As DTP pharmacies gradually become mature,some pharmaceutical enterprises have deepened cooperation with DTP pharmacies to open new channels for drug management.However,from the perspective of some generic drug enterprises,DTP pharmacies have certain adverse effects on them. | Shen Manzhu Zeng Yingying Yuan Hongmei Fu Shuyong | 2022 | Asian Journal of Social Pharmacy2022，17，2： | 0 |
| 19 | Transcriptome and morphological analyses of double flower formation in Dianthus chinensis显示文摘The double flower developmental process is regulated via a complex transcriptional regulatory network.To understand this highly dynamic and complex developmental process of Dianthus spp.,we performed a comparative analysis of floral morphology and transcriptome dynamics in simple flowers and double flowers.We found that the primordium of double flowers of‘X’was larger in size compared to that of simple flowers of‘L’in Dianthus chinensis.RNA-seq and Weighted Gene Co-expression Network Analysis(WGCNA)during flower development,identified stage-specific gene network modules.Expression analysis by RNA-seq indicated that a group of genes related to floral meristem identity,primordia position and polarity were highly expressed in double flowers genotypes compared to simple flowers genotypes,suggesting their roles in double-petal formation.A total of 21 DEGs related to petal number were identified between simple and double flowers.The experiments of in situ hybridization revealed that DcaAP2L,DcaLFY and DcaUFO genes were expressed in the intra-sepal boundary and petal boundary.We proposed a potential transcriptional regulatory network for simple and double flower development.This study provides novel insights into the molecular mechanism underlying double flower formation in Dianthus spp. | Xiaoni Zhang Shengnan Lin Quanshu Wu Qijian Wang Chunmei Shi Manzhu Bao Mohammed Bendahmane Xiaopeng Fu Zhiqiang Wu | 2024 | Horticultural Plant Journal2024，10，1： | 0 |
| 20 | Research on Problems and Countermeasures of Patent Evaluation System in Pharmaceutical Enterprises显示文摘Objective To provide some suggestions and countermeasures for improving the patent evaluation system in pharmaceutical enterprises.Methods Literature research method was used to collect the relevant documents of pharmaceutical enterprises and patent evaluation system,and then the problems of traditional patent evaluation methods for pharmaceutical patents were studied.Results and Conclusion The evaluation of pharmaceutical patents plays an important role for pharmaceutical enterprises.However,it is urgent to improve the pharmaceutical patent evaluation system because there are many difficulties in evaluating pharmaceutical patents,such as large fluctuation of patent value,strong subjective interference,the incomplete pharmaceutical information,unapplicable traditional evaluation method,and the insufficient role of evaluation agencies.Therefore,some suggestions are put forward:(1)The application of the real option method;(2)Developing evaluation institutions and training evaluation personnel;(3)Improving the laws and policies related to the evaluation of pharmaceutical patents;(4)Building a pharmaceutical patent evaluation database. | Zeng Yingying Shen Manzhu Yuan Hongmei Han Xu | 2022 | Asian Journal of Social Pharmacy2022，17，3： | 0 |
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