|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Controlling N-doping type in carbon to boost single-atom site Cu catalyzed transfer hydrogenation of quinoline显示文摘Single-atom site(SA)catalysts on N-doped carbon(CN)materials exhibit prominent performance for their active sites being M-Nx.Due to the commonly random doping behaviors of N species in these CN,it is a tough issue to finely regulate their doping types and clarify their effect on the catalytic property of such catalysts.Herein,we report that the N-doping type in CN can be dominated as pyrrolic-N and pyridinic-N respectively through compounding with different metal oxides.It is found that the proportion of distinct doped N species in CN depends on the acidity and basicity of compounded metal oxide host.Owing to the coordination by pyrrolic-N,the SA Cu catalyst displays an enhanced activity(two-fold)for transfer hydrogenation of quinoline to access the valuable molecule tetrahydroquinoline with a good selectivity(99%)under mild conditions.The higher electron density of SA Cu species induced by the predominate pyrrolic-N coordination benefits the hydrogen transfer process and reduces the energy barrier of the hydrogenation pathway,which accounts for the improved catalytic effeciency. | Jian Zhang Caiyan Zheng Maolin Zhang Yajun Qiu Qi Xu Weng-Chon Cheong Wenxing Chen Lirong Zheng Lin Gu Zhengpeng Hu Dingsheng Wang Yadong Li | 2020 | Nano Research2020，13，11： | 29 |
| 2 | Plant microremains provide direct evidence for the functions of stone knives from the Lajia site, northwestern China显示文摘A large number of stone knives have been recovered from Neolithic archaeological sites in East Asia.However, direct evidence regarding the functions of the stone knives has been scarce, and hence, their functions have remained controversial. In this study, we recovered and analysed ancient starch grains and phytoliths from residues adhering to stone knives excavated from the Lajia site, Qinghai Province, northwest China, thus providing direct evidence for the functions of the knives. Our analyses were based on the following:(1) an assemblage of 278identifiable starch grains, representing grains from the stems of foxtail millet(Setaria italica) and broomcorn millet(Panicum miliaceum)(65.1 % of the total) and the stems of Hordeum and Triticum species(3.6 % of the total), and(2) an assemblage of 361 identifiable phytoliths,the majority of which were from the stems and leaves of plants such as Panicoideae and related taxa(96 % of the total). Our study demonstrates that one of the functions of the stone knives was the harvesting crops. In addition, a few starch grains from food legumes and roots(3.4 % of the total) indicate that the stone knives were also likely used to process, peel and cut some foods. | Zhikun Ma Quan Li Xiujia Huan Xiaoyan Yang Jingyun Zheng Maolin Ye | 2014 | Chinese Science Bulletin2014，59，11： | 5 |
| 3 | LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration显示文摘The adult mammalian heart is thought to be a terminally differentiated organ given the postmitotic nature of cardiomyocytes.Consequently,the potential for cardiac repair through cardiomyocyte proliferation is extremely limited.Low-density lipoprotein receptor-related protein 6(LRP6)is a Wnt co-receptor that is required for embryonic heart development.In this study we investigated the role of LRP6 in heart repair through regulation of cardiomyocyte proliferation.Lrp6 deficiency increased cardiomyocyte cell cycle activity in neonatal,juvenile and adult mice.Cardiomyocyte-specific deletion of Lrp6 in the mouse heart induced a robust regenerative response after myocardial infarction(MI),led to reduced MI area and improvement in left ventricular systolic function.In vivo genetic lineage tracing revealed that the newly formed cardiomyocytes in Lrp6-deficient mouse hearts after MI were mainly derived from resident cardiomyocytes.Furthermore,we found that the pro-proliferative effect of Lrp6 deficiency was mediated by the ING5/P21 signaling pathway.Gene therapy using the adeno-associated virus(AAV)9 miRNAi-Lrp6 construct promoted the repair of heart injury in mice.Lrp6 deficiency also induced the proliferation of human induced pluripotent stem cell-derived cardiomyocytes(iPSC-CMs).Our study identifies LRP6 as a critical regulator of cardiomyocyte proliferation,which may lead to the development of a novel molecular strategy to promote myocardial regeneration and repair. | Yahan Wu Liping Zhou Hongyu Liu Ran Duan Huixing Zhou Fulei Zhang Xiaoyu He Dongbo Lu Ke Xiong Maolin Xiong Jinzhu Zhuang Yi Liu Li Li Dandan Liang Yi-Han Chen | 2021 | Cell Research2021，31，4： | 5 |
| 4 | Reverse Time Migration with Elastodynamic Gaussian Beams显示文摘Elastic migration has been widely paid attention by employing the vector processing of multicomponent seismic data.Ray based elastic Kirchhoff migration has such properties as high flexibility and high efficiency.However,it has failed to solve many problems caused by multipath.On the other hand,elastic reverse-time migration(RTM)based on the two-way wave equation is known to be capable of dealing with these problems,but it is extremely expensive when applied in 3D cases and velocity model building.Based on the elastic Kirchhoff-Helmholtz integral,we calculate decoupled backward-continued wavefields by introducing elastic Green functions for P-and S-waves,which is expressed by a summation of elastodynamic Gaussian beams.The PP and polarity-corrected PS images are obtained by calculating the correlation between downward and decoupled backward-continued vector wavefields,where polarity correction is performed by analyzing the relation between the polarization direction of converted PS waves and incident angle on the interface.To a large extent,our method combines the high efficiency of ray-based migration with the high accuracy of wave-equation based reverse-time migration.Application of this method to multicomponent synthetic datasets from the fault model and Marmousi 2 model demonstrates the validity,flexibility and accuracy of the new method. | Jianping Huang Maolin Yuan Qing Zhang Lingxiao Jia Zhenchun Li Jiguang Li Shengtian Zhao | 2017 | Journal of Earth Science2017，28，4： | 4 |
| 5 | Radiation synthesis and characteristics of PTFE-g-PSSA ion exchange membrane applied in vanadium redox battery显示文摘Radiation-induced grafting of styrene onto polytetrafluoroethylene (PTFE) membranes was studied by a simultaneous irradiation technique.Grafting was carded out usingγ-radiation from a ^(60)Co source at room temperature. Effects of absorbed dose,atmosphere,dose rate,and the concentration of initial monomer on the degree of grafting (DOG) were investigated and the most appropriate grafting condition was obtained.Subsequently,sulphonation of the grafted PTFE membrane (PTFE-g-PS) was carried out and a series of ion exchange membranes (PTFE-g-PSSA) was prepared.Further characterizations of FTIR,TGA,and SEM testified that grafting and sulphonation of the membranes were successfully processed;moreover,grafting of styrene not only occurred in the surface of PTFE membrane,but also in the micropores of the membrane.Ion exchange capacity (IEC) and conductivity were found increase with the grafting yield.The results suggest that at a low dose,such as 17 kGy,the ion exchange membrane (IEM) which will be suitable for vanadium redox battery (VRB) use can be obtained. | PENG Jinfen QIU Jinyi NI Jiangfeng ZHAI Maolin XU Peng PENG Jing ZHOU Henghui LI Jiuqiang WEI Genshuan | 2007 | Nuclear Science and Techniques2007，18，1： | 4 |
| 6 | Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia显示文摘Type 2 diabetes mellitus(T2DM)and Alzheimer's disease(AD)share several common pathophysiological features.Rare variants of triggering receptor expressed on myeloid cells 2(TREM2)increase the risk of developing AD,suggesting the involvement of TREM2 and innate immunity in AD development.It is still unknown whether TREM2 is related to cognitive impairment in T2DM.Here,we investigated the effects of the hippocampal overexpression of TREM2 on cognitive in long-term high-fat diet(HFD)-fed mice.Male C57BL/6J mice were maintained on HFD for 50 weeks.TREM2 was overexpressed in the hippocampus 36 weeks after HFD feeding using adeno-associated virus vector(AAV)-mediated gene delivery.The results showed that the HFD feeding induced rapid and persistent weight gain,glucose intolerance and significant impairments in learning and memory.Compared with AAV-con,AAV-TREM2 significantly ameliorated cognitive impairment without altering body weight and glucose homeostasis in HFD mice.The overexpression of TREM2 upregulated the synaptic proteins spinophilin,PSD95 and synaptophysin,suggesting the improvement in synaptic transmission.Dendritic complexity and spine density in the CA1 region were rescued after TREM2 overexpression.Furthermore,TREM2 markedly increased the number of iba-1/Arg-1-positive microglia in the hippocampus,suppressed neuroinflammation and microglial activation.In sum,hippocampal TREM2 plays an important role in improving HFD-induced cognitive dysfunction and promoting microglial polarization towards the M2 anti-inflammatory phenotype.Our study also suggests that TREM2 might be a novel target for the intervention of obesity/diabetes-associated cognitive decline. | Min Wu Maolin Liao Rongfeng Huang Chunxiu Chen Tian Tian Hongying Wang Jiayu Li Jibin Li Yuxiang Sun Chaodong Wu Qifu Li Xiaoqiu Xiao | 2022 | Genes & Diseases2022，9，2： | 4 |
| 7 | Application of anterior decompression and reconstruction using titanium mesh with locking plates in the management of cervical spondylotic myelopathy显示文摘颈的 spondylotic myelopathy 被认为是在超过 55 的病人的最普通的针的绳索混乱。在手术后的经期,不能令人满意的神经结果经常被归因于疾病过程而非到足够的解压缩的失败,成像研究没被执行为失败决定原因。为这个目的,有 CSM 的 91 个病人临床上被检查,以及 radiologicaly 并且 electrophysiologicaly,并且在牛肉香肠的歌德大学的神经外科的神经外科, Kishinev 的医药大学,摩尔多瓦和部门的部门被操作,德国在从 1984-1996 的间隔期间。性比率是 male:female = 5.9:1。几乎所有病人被 MRI 扫描学习,常规 CT myelography 并且 electrophysiologically (SSEP 和 MEP ) 。SSEP 回答同等地与 CSM, pre- 和针的绳索的功能的手术后的状态在病人反映病理学的严厉。我们使用了操作的 5 种类型:没有熔化的前面的 discectomy 和 interbody 熔化,没有骨头 grafting 的前面的解压缩,利用 corpectomy 和 interbody 熔化的前面的解压缩, decompressive multilevel laminectomy 和部分 vertebrectomy。为在过程的不同类型以后评估外科的结果,我们使用了 Nurick 和 Crandall 规模。在 38 个病人手术后的结果:是 26 (68%)- 改善, 8 (21%)- 未改变,更坏 - 1 (3%) ,并且(8%) 3 死了。结论:1。有在有在 corpectomy 和 interbody 熔化以后的严重 CSM 的病人的好结果的流行。2。前面的 transdiscal 解压缩是在与 CSM 对待病人的选择的操作。 | Maolin He Zengming Xiao Shide Li Qianfen Chen | 2008 | Journal of Nanjing Medical University2008，22，4： | 3 |
| 8 | Analysis of Power Matching on Energy Savings of a Pneumatic Rotary Actuator Servo-Control System显示文摘When saving energy in a pneumatic system,the problem of energy losses is usually solved by reducing the air supply pressure.The power-matching method is applied to optimize the air-supply pressure of the pneumatic system,and the energy-saving effect is verified by experiments.First,the experimental platform of a pneumatic rotary actuator servo-control system is built,and the mechanism of the valve-controlled cylinder system is analyzed.Then,the output power characteristics and load characteristics of the system are derived,and their characteristic curves are drawn.The employed air compressor is considered as a constant-pressure source of a quantitative pump,and the power characteristic of the system is matched.The power source characteristic curve should envelope the output characteristic curve and load characteristic curve.The minimum gas supply pressure obtained by power matching represents the optimal gas supply pressure.The comparative experiments under two different gas supply pressure conditions show that the system under the optimal gas supply pressure can greatly reduce energy losses. | Yeming Zhang Hongwei Yue Ke Li Maolin Cai | 2020 | Chinese Journal of Mechanical Engineering2020，33，2： | 3 |
| 9 | Identification of ancient ceramics by digital shape characterization显示文摘Shapes are important clues for the identification of ancient ceramics.In this study,digital extraction methods of shape characterization were discussed,using samples of flared mouthed porcelain bowls produced in Jingdezhen Hutian Kiln from the Five Dynasties to the Song and Yuan period.By employing the techniques of image enhancement,edge detection and curve fitting of Matlab,the method using digital shape characterization has advanced accuracy and effectiveness of traditional identification which is based on visual and tactual inspections.Together with the increasingly applied compositional data analysis and thermoluminescence dating technique,the method will further improve and upgrade the scientific identification system for ancient ceramics. | WU Juan LIU YingChun XIONG Lu TANG Min ZHANG MaoLin WU JunMing LI QiJiang HUANG MengXuan LI JiaZhi | 2012 | Science China(Technological Sciences)2012，55，9： | 3 |
| 10 | Rabies virus co-localizes with early(Rab5) and late(Rab7) endosomal proteins in neuronal and SH-SY5Y cells显示文摘Rabies virus(RABV) is a highly neurotropic virus that follows clathrin-mediated endocytosis and p H-dependent pathway for trafficking and invasion into endothelial cells. Early(Rab5, EEA1) and late(Rab7, LAMP1) endosomal proteins play critical roles in endosomal sorting, maturity and targeting various molecular cargoes, but their precise functions in the early stage of RABV neuronal infection remain elusive. In this study, the relationship between enigmatic entry of RABV with these endosomal proteins into neuronal and SH-SY5 Y cells was investigated.Immunofluorescence, TCID_(50) titers, electron microscopy and western blotting were carried out to determine the molecular interaction of the nucleoprotein(N) of RABV with early or late endosomal proteins in these cell lines. The expression of N was also determined by down-regulating Rab5 and Rab7 in both cell lines through RNA interference. The results were indicative that N proficiently colocalized with Rab5/EEA1 and Rab7/LAMP1 in both cell lines at 24 and 48 h post-infection, while N titers significantly decreased in early infection of RABV. Down-regulation of Rab5 and Rab7 did not inhibit N expression, but it prevented productive infection via blocking the normal trafficking of RABV in a low pH environment. Ultrathin sections of cells studied by electron microscope also verified the close association of RABV with Rab5 and Rab7 in neurons. From the data it was concluded that primary entry of RABV strongly correlates with the kinetics of Rab-proteins present on early and late vesicles, which provides helpful clues to explain the early events of RABV in nerve cells. | Waqas Ahmad Yingying Li Yidi Guo Xinyu Wang Ming Duan Zhenhong Guan Zengshan Liu Maolin Zhang | 2017 | Virologica Sinica2017，32，3： | 3 |
| 11 | Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication显示文摘HepatitisBvirus(HBV)infection causes acuteand chronic liver diseases,but is not directly cytopathic.Liver injury results fromrepeated attempts of the cellular immune response system to control the viral infection.Here,we investigate the roles of cellular factors and signaling pathways involved in the regulation of HBV replication to reveal the mechanism underlying HBV infection and pathogenesis.Weshowthat collagen triple helix repeat containing 1(CTHRC1)expression is elevated in HBV-infected patients andin HBV-transfected cells through epigenetic modification and transcriptional regulation.CTHRC1 facilitates HBV replication in cultured cells and BALB/c mice by activating the PKCa/ERK/JNK/c-Jun cascade to repress the IFN/JAK/STAT pathway.HBV-activated CTHRC1 downregulates the activityof typeI interferon(IFN),theproductionof IFN-stimulatedgenes(ISGs),andthephosphorylationofsignal transducerandactivator of transcription 1/2(STAT1/2),whereas it upregulates the phosphorylation and ubiquitination of type I IFN receptors(IFNARa/b).Thus,our results showthat HBV uses a novelmechanismto hijack cellular factors and signal cascades in order to evade host antiviral immunity and maintain persistent infection.We also demonstrate that CTHRC1 has a novel role in viral infection. | Lan Bai Wei Zhang Li Tan Hongchuan Yang Maolin Ge Chengliang Zhu Rui Zhang Yanhua Cao Junbo Chen Zhen Luo Wenzhe Ho Fang Liu Kailang Wu Jianguo Wu | 2015 | Journal of Molecular Cell Biology2015，7，6： | 2 |
| 12 | Study on the diversification of origins and primary development of Chinese porcelain glazes显示文摘With the support of the Origin Exploring of Chinese Civilization Projects (II) and National Natural Science Foundation of China,the close relationship among 'pottery coat','kiln sweat' and Chinese proto-porcelain glaze were studied,the characteristics and the key foundation of the origin of porcelain glaze were also discussed based on the relevant research results by Shanghai Institute of Ceramics,Chinese Academy of Sciences and Jingdezhen Ceramics Institute. | WU Juan ZHANG MaoLin WU JunMing LI QiJiang LI JiaZhi DENG ZeQun JIANG Xia | 2011 | Science China(Technological Sciences)2011，54，1： | 2 |
| 13 | On the pitch of dialogue in Chinese Putonghua显示文摘以便改进 TTS 讲话的自然以便代表自然讲话的韵律,在自发的讲话的沥青上有研究是必要的。基于 973 电话语料库,沥青范围和 1084 个语调短语的沥青寄存器被分析。语调短语能根据他们的范围和寄存器被分类,这被发现,并且这与他们在对话交换的位置有关。与读的讲话相比,在对话的沥青模式是更可变的。 | WANG Maolin LIN Maocan LI Aijun | 2009 | Chinese Journal of Acoustics2009，28，2： | 2 |
| 14 | Rce1 expression in renal cell carcinoma and its regulatory effect on 786-O cell apoptosis through endoplasmic reticulum stress显示文摘(Rce1 ) 地岬和 a-factor-converting 酶 1 位于 endoplasmic 蜂窝胃(嗯) 并且被认为为绝大多数 CAAX 蛋白质处理的 endoproteolytic 负责。Endoplasmic 蜂窝胃应力(ERS ) 在肾的房间癌(RCC ) 起一个重要作用;然而,在 RCC 的 Rce1 的表示和角色广泛地没被学习。我们试图在 RCC 786-O 房间在嗯导致 apoptosis 在 RCC 纸巾和它的分子的机制调查 Rce1 的表示。我们首先使用了检测在肾的癌纸巾和 paracancerous 纸巾的 Rce1 表示的西方的弄污,量的反向的 transcriptase 聚合酶链反应,和 immunohistochemistry。Rce1 表示是在 RCC 的 upregulated,这被发现纸巾,和它的积极表示水平强烈与 clinicopathologic 特征被联系。下次,我们在人的胚胎的肾房间线 HEK293 和人的肾的癌房间线 786-O 检测了 Rce1 的表示, ACHN,和 A498。Rce1 的更高的表示在人的肾的癌房间线被发现,特别在 786-O 房间。在 786-O 房间的 Rce1 击倒增加的 apoptosis | Jianjun Li Delin Wang Junnan Liu Yunlang Qin Liangliang Huang Qiangfeng Zeng Maolin Xiao Jie Hu Qixin Yang Jiang He Li Mai Ying Li Wujiang Liu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 2 |
| 15 | Earliest domestication of common millet(Panicummiliaceum)in East Asia extended to 10 000 years ago显示文摘 | Houyuan Lu Jianping Zhang Kam-biu Liu Naiqin Wu Yumei Li Kunshu Zhou Maolin Ye Tianyu Zhang Hai-jiang Zhang Xiaoyan Yang Licheng Shen Deke Xu Quan Li | 2009 | PNAS2009，106，18： | 1 |
| 16 | Sequential expression of cyclooxygenase-2, glutamate receptor-2, and platelet activating factor receptor in rat hippocampal neurons after fluid percussion injury显示文摘Traumatic brain injury causes gene expression changes in different brain regions. Occurrence and development of traumatic brain injury are closely related, involving expression of three factors, namely cyclooxygenase-2, glutamate receptor-2, and platelet activating factor receptor. However, little is known about the correlation of these three factors and brain neuronal injury. In this study, primary cultured rat hippocampal neurons were subjected to fluid percussion injury according to Scott's method, with some modifications. RT-PCR and semi-quantitative immunocytochemical staining was used to measure the expression levels of cyclooxygenase-2, glutamate receptor-2, and platelet activating factor receptor. Our results found that cyclooxygenase-2 expression were firstly increased post-injury, and then decreased. Both mRNA and protein expression levels reached peaks at 8 and 12 hours post-injury, respectively. Similar sequential changes in glutamate receptor 2 were observed, with highest levels mRNA and protein expression at 8 and 12 hours post-injury respectively. On the contrary, the expressions of platelet activating factor receptor were firstly decreased post-injury, and then increased. Both mRNA and protein expression levels reached the lowest levels at 8 and 12 hours post-injury, respectively. Totally, our findings suggest that these three factors are involved in occurrence and development of hippocampal neuronal injury. | Zhiqiang Li Qingming Shu Lingzhi Li Maolin Ge Yongliang Zhang | 2014 | Neural Regeneration Research2014，9，9： | 1 |
| 17 | A novel set of Wiener indices 显示文摘 | LI XINHUA LI ZUGUANG HU MAOLIN | 2003 | Journal of molecular graphics and modeling2003，，22： | 1 |
| 18 | Epoxy-POSS/silicone rubber nanocomposites with excellent thermal stability and radiation resistance显示文摘Due to the rigid Si-O-Si backbone,silicone rubber(SR)have a widespread application in extreme environment such as high temperature and high-level radiation.However,the radiation stability of SR still does not meet the practical needs in special radiation environments.Herein we prepared epoxy POSS(e POSS)/SR nanocomposites with excellent thermal stability and radiation resistance.As a physical crosslinking point in the SR,addition of small amount of ePOSS not only enhanced the mechanical properties of the matrix,but also improved its thermal stability greatly due to their good compatibility.e POSS/SR had higher radiation stability in air than SR owing to the inhibition of radiation oxidation by ePOSS,and the yield of main gaseous radiolysis products(CH_(4),H_(2),CO and CO_(2))of SR and ePOSS/SR nanocomposites was determined.By analyzing the changes of chemical structure,thermal properties and mechanical properties of the ePOSS/SR nanocomposite,combined with the characteristics of gas products afterγ-irradiation,the radiation induced crosslinking and degradation mechanism of the nanocomposites was proposed comprehensively. | Mengni Shi Yinyong Ao Lei Yu Lang Sheng Shuangxiao Li Jing Peng Hongbing Chen Wei Huang Jiuqiang Li Maolin Zhai | 2022 | Chinese Chemical Letters2022，33，7： | 1 |
| 19 | Pelvic floor images: anatomy of the levator cmi muscle显示文摘 | Maolin Guo Dawei Li | 2007 | Diseases of the Colon & Rectum2007，50，： | 1 |
| 20 | Morphology of the levator cmi muscle 显示文摘 | Dawei Li Maolin Guo | 2007 | Diseases of the Colon & Rectum2007，50，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员