|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The JAK/STAT signaling pathway:from bench to clinic显示文摘The Janus kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathway was discovered more than a quarter-century ago.As a fulcrum of many vital cellular processes,the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation.Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases.In this review,we discuss the current knowledge about the composition,activation,and regulation of the JAK/STAT pathway.Moreover,we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases. | Xiaoyi Hu Jing li Maorong Fu Xia Zhao Wei Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 21 |
| 2 | Precise Relative Orbit Determination of Twin GRACE Satellites显示文摘当形成飞时,太空船被用作站台获得土面向的观察,在这些太空船之间的精确基线总是是必要的。严肃恢复和气候实验(优雅) 使命针对印射全球严肃地和它的变化。优雅卫星的精确基线为当模特儿的严肃地是必要的。成双的卫星的运动学、减少的动态相对轨道的决心为动态相对轨道在 2 公里的这份报纸,和精确性被学习了,为运动学的 5 公里能被获得,大多数在 GPS 歧义上的双差别由此被解决。 | ZHAO Qile HU Zhigang GUO Jing LI Min GE Maorong | 2010 | Geo-Spatial Information Science2010，13，3： | 3 |
| 3 | Cognitive effects of atypical antipsychotic drugs in first-episode drug-nave schizophrenic patients显示文摘Cognitive impairment is a core feature of schizophrenia. The present randomized open study enrolled antipsychotic-nave patients who were experiencing their first episode of schizophrenia. After baseline neurocognitive tests and clinical assessment, subjects were randomly assigned to olanzapine, risperidone and aripiprazole treatment groups. A battery of neurocognitive tests showed that risperidone produced cognitive benefits in all five cognitive domains, including verbal learning and memory, visual learning and memory, working memory, processing speed, and selective attention; olanzapine improved processing speed and selective attention; and aripiprazole improved visual learning and memory, and working memory. However, the three atypical antipsychotic drugs failed to reveal any significant differences in the composite cognitive scores at the study endpoint. In addition, the three drugs all significantly improved clinical measures without significant differences between the drugs after 6 months. These results suggest that the atypical antipsychotics, olanzapine, risperidone and aripiprazole may improve specific cognitive domains with similar global clinical efficacy. In clinical practice, it may be feasible to choose corresponding atypical antipsychotics according to impaired cognitive domains. | Juan Wang Maorong Hu Xiaofeng Guo Renrong Wu Lehua Li Jingping Zhao | 2013 | Neural Regeneration Research2013，8，3： | 3 |
| 4 | PPP-RTK considering the ionosphere uncertainty with cross-validation显示文摘With the high-precision products of satellite orbit and clock,uncalibrated phase delay,and the atmosphere delay corrections,Precise Point Positioning(PPP)based on a Real-Time Kinematic(RTK)network is possible to rapidly achieve centimeter-level positioning accuracy.In the ionosphere-weighted PPP–RTK model,not only the a priori value of ionosphere but also its precision afect the convergence and accuracy of positioning.This study proposes a method to determine the precision of the interpolated slant ionospheric delay by cross-validation.The new method takes the high temporal and spatial variation into consideration.A distance-dependent function is built to represent the stochastic model of the slant ionospheric delay derived from each reference station,and an error model is built for each reference station on a fve-minute piecewise basis.The user can interpolate ionospheric delay correction and the corresponding precision with an error function related to the distance and time of each reference station.With the European Reference Frame(EUREF)Permanent GNSS(Global Navigation Satellite Systems)network(EPN),and SONEL(Système d’Observation du Niveau des Eaux Littorales)GNSS stations covering most of Europe,the efectiveness of our wide-area ionosphere constraint method for PPP-RTK is validated,compared with the method with a fxed ionosphere precision threshold.It is shown that although the Root Mean Square(RMS)of the interpolated ionosphere error is within 5 cm in most of the areas,it exceeds 10 cm for some areas with sparse reference stations during some periods of time.The convergence time of the 90th percentile is 4.0 and 20.5 min for horizontal and vertical directions using Global Positioning System(GPS)kinematic solution,respectively,with the proposed method.This convergence is faster than those with the fxed ionosphere precision values of 1,8,and 30 cm.The improvement with respect to the latter three solutions ranges from 10 to 60%.After integrating the Galileo navigation satellite system(Galileo),the convergence time of the 90th percentile for combined kinematic solutions is 2.0 and 9.0 min,with an improvement of 50.0%and 56.1%for horizontal and vertical directions,respectively,compared with the GPS-only solution.The average convergence time of GPS PPP-RTK for horizontal and vertical directions are 2.0 and 5.0 min,and those of GPS+Galileo PPP-RTK are 1.4 and 3.0 min,respectively. | Pan Li Bobin Cui Jiahuan Hu Xuexi Liu Xiaohong Zhang Maorong Ge Harald Schuh | 2022 | Satellite Navigation2022，3，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员