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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Outcomes of critically ill cancer patients with Acinetobacter baumannii infection显示文摘AIM: To describe the intensive care unit(ICU) outcomes of critically ill cancer patients with Acinetobacter baumannii(AB) infection.METHODS: This was an observational study that included 23 consecutive cancer patients who acquired AB infections during their stay at ICU of the National Cancer Institute of Mexico(INCan), located in Mexico City. Data collection took place between January 2011, and December 2012. Patients who had AB infections before ICU admission, and infections that occurred during the first 2 d of ICU stay were excluded. Data were obtained by reviewing the electronic health record of each patient. This investigation was approved by the Scientific and Ethics Committees at INCan. Because of its observational nature, informed consent of the patients was not required.RESULTS: Throughout the study period, a total of 494 critically ill patients with cancer were admitted to the ICU of the INCan, 23(4.6%) of whom developed AB infections. Sixteen(60.9%) of these patients had hematologic malignancies. Most frequent reasons for ICU admission were severe sepsis or septic shock(56.2%) and postoperative care(21.7%). The respiratory tract was the most frequent site of AB infection(91.3%). The most common organ dysfunction observed in our group of patients were the respiratory(100%), cardiovascular(100%), hepatic(73.9%) and renal dysfunction(65.2%). The ICU mortality of patients with 3 or less organ system dysfunctions was 11.7%(2/17) compared with 66.6%(4/6) for the group of patients with 4 or more organ system dysfunctions(P = 0.021). Multivariate analysis identified blood lactate levels(BLL) as the only variable independently associated with inICU death(OR = 2.59, 95%CI: 1.04-6.43, P = 0.040). ICU and hospital mortality rates were 26.1% and 43.5%, respectively.CONCLUSION: The mortality rate in critically ill patients with both HM, and AB infections who are admitted to the ICU is high. The variable most associated with increased mortality was a BLL ≥ 2.6 mmol/L in the first day of stay in the ICU. | Silvio A ?amendys-Silva Paulina Correa-García Francisco J García-Guillén María O González-Herrera Américo Pérez-Alonso Julia Texcocano-Becerra Angel Herrera-Gómez Patricia Cornejo-Juárez Abelardo Meneses-García | 2015 | World Journal of Critical Care Medicine2015，4，3： | 3 |
| 3 | Effect of colored noise on stochastic resonance in sensorg neurons显示文摘 | Mar D J Magnasco M O | 1999 | Phys Rev1999，82，11： | 1 |
| 4 | Effect of calcium dips and chitosan coatings on postharvest life of strawberries (Fragaria x ananassa) 显示文摘 | Pilaf H M Eva A Mar'ia J O | 2006 | Postharvest Biology and Technology2006，，39： | 1 |
| 5 | Differentialexpression of m i R - 21 , m i R - 1 2 5 b a n d m i R - 191 in breastcancer tissue显示文摘 | Mar - Aguilar F L u n a - Aguirre C M M o r e n o - R o c h a J C | | Asia - Pacific J Clin Oncol0，9，1： | 1 |
| 6 | Evalution of color removal and degradation of a reactive textile azo dye on nanoporous TiO2 thin-film electrodes 显示文摘 | Patricia A C Marly E O Jeosadaque J S | 2004 | Electrochimica Acta2004，49，： | 1 |
| 7 | Controlling human striatal cognitive function via the frontal cortex显示文摘 | van Schouwenburg MR O'Shea J Mars RB | | 0，，： | 1 |
| 8 | AFLP: a new technique for DNA fingerprinting显示文摘 | Pieter V Reneh H Mar J O | 1995 | Nucleic Acids Research1995，，23： | 1 |
| 9 | Foaming of flat glass cullet using Si3N4and Mn O2powders显示文摘 | Alejandro S L María J O T Francisco J G T | 2009 | Ceramics International2009，35，5： | 1 |
| 10 | Telehealth in audiology: The need and potential to reach underserved communities 显示文摘 | SWANEPOEL D W CLARK J KOEKMOER D HALL III J W KRUMM M FERRARI D V MePHERSON B OLUSANYA B O MARS M RUSSO 1 BARAJAS J J | 2010 | International Journal of Audiology2010，49，： | 1 |
| 11 | Process flow model of solid oxide fuel cell system supplied with sewage biogas显示文摘 | J Van herle F Maréchal S Leuenberger Y Membrez O Bucheli D Favrat | 2004 | Journal of Power Sources2004，，1： | 1 |
| 12 | Nat Genet:科学家设计新方法找到抑制癌症发育的新基因显示文摘英国桑格研究院的研究人员和他们的合作者们最近发现了帮助阻止前列腺癌、皮肤癌和乳腺癌发育的新基因。这些基因能够与众所周知的肿瘤抑制基因PTEN配合发挥作用,该研究还发现这些基因与人类前列腺肿瘤存在相关性。相关研究结果发表在国际学术期刊Nature Genetics上。该研究揭示了一些参与癌症发育的新途径,这些基因有望成为治疗PTEN突变癌症的新药物靶点。这项研究开发的一些方法也可以用于发现其他协同抑制癌症生长的基因。 | Jorge de la Rosa, Mathias Josef Friedrich, Yilong Li, Lena Rad, Hannes Ponstingl, Qi Liang, Sandra Bernaldo de Quirós, Imran Noorani, Emmanouil Metzakopian, Alexander Strong, Meng Amy Li, Gary J Hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Allan Bradley Juan Cadiñanos Jorge de la Rosa Juan Cadiñanos Jorge de la Rosa Carlos López-Otín Julia Weber Roland Rad Julia Weber Roland Rad Aurora Astudillo María Teresa Fernández-García María Soledad Fernández-García Gary J Hoffman Carlos López-Otín | 2017 | 现代生物医学进展2017，17，15： | 0 |
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