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| 1 | Soluble ST2:A new and promising activity marker in ulcerative colitis显示文摘AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r = 0.76 and r = 0.67,P < 0.0001,respectively),and with the pro-inflammatory cytokine,tumor necrosis factor-α(r = 0.69 and r = 0.61,respectively,P < 0.0001).Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild(r = 0.44,P = 0.004),moderate(r = 0.59,P = 0.002) and severe disease(r = 0.82,P = 0.002).Only patients with inactive UC showed no significant correlation(r = 0.45,P = 0.267).CONCLUSION:sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker. | David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 2 | Tin-transition metal-carbon systems for lithium-ion battery negative electrodes显示文摘 | Todd A D W Mar R E Dahn J R | 2007 | Journal of the Electrochemical Society2007，154，6： | 1 |
| 3 | Effect of colored noise on stochastic resonance in sensorg neurons显示文摘 | Mar D J Magnasco M O | 1999 | Phys Rev1999，82，11： | 1 |
| 4 | Genetic,biochemical,and molecular characterization of the polypeptide transportassociated domain of Escherichia coli BamA显示文摘 | Workman P Heide K Giuliano N Lee N Mar J Vuong P Bennion D Misra R | | 0，，13： | 1 |
| 5 | Purification and Comparative Properties of the Cytosolic Isocitrate Dehydrogenases (NADP) from Pea (Pisum sativunz)Roots and Green Leaves显示文摘 | CHEN R D MAR(E)CHAL P L VIDAL J | 1988 | Eur J Biochem1988，175，： | 1 |
| 6 | Combinatorial study of tin-transition metal alloys as negative electrodes for lithiumion batteries显示文摘 | Todd A D W Mar R E Dahn J R | 2006 | J Electrochem Soc2006，153，10： | 1 |
| 7 | Modified singular value decomposition by means of independent component analysis显示文摘 | VRABIE V D MARS J I LACOUME J L | 2004 | Signal Processing2004，84，3： | 1 |
| 8 | How water droplets evaporate on a superhydrophobic substrate显示文摘 | Gelderblom H Marín (A) G Nair H Van Houselt A Lefferts L Snoeijer J H Lohse D | | 0，，02： | 1 |
| 9 | Combinatorial study of tin-tran- sition metal alloys as negative electrodes for lithium-ion batteries 显示文摘 | TOD A D W MAR R E DAHN J R | 2006 | Electrochemical Society2006，153，10： | 1 |
| 10 | Acyl transfer strategy for the bio-catalytical characterization of Candida rugosa lipases in organic solvents 显示文摘 | Mar'ia P D Sinisterra J V | 2006 | Enzyme and Microbial Technology2006，38，： | 1 |
| 11 | Modified singular value decomposition by means of independent component analysis显示文摘 | Vrabie V D Mars J I Lacoume J L | 2004 | Signal Processing2004，84，3： | 1 |
| 12 | The first record in the Americas of an autochthonous case of Leishmania ( Leishmania ) infantum chagasi in a domestic cat ( Felix catus ) from Cotia County, S?o Paulo State, Brazil显示文摘 | Elisa San Martin Mouriz Savani Maria Cec??lia Gibrail de Oliveira Camargo Mar??lia Russi de Carvalho Ricardo Andrade Zampieri Marcos Gonzaga dos Santos Sandra Regina Nicoletti D’áuria Jeffrey J Shaw Lucile Maria Floeter-Winter | 2004 | Veterinary Parasitology2004，，3： | 1 |
| 13 | Myoglobin diffusion in bovine heart muscle 显示文摘 | Livingston D J La Mar G N Brown W D | 1983 | Science1983，220，： | 1 |
| 14 | Mulficomponent wave separation using HOSVD/unimodal-ICA subspace method显示文摘 | VRABIE V D BIHAN N L MARS J | 2006 | Geophysics2006，71，5： | 1 |
| 15 | Tin-transition met- al-carbon systems for lithium-ion battery negative elec- trode 显示文摘 | Todd A D W Mar R E Dahn J R | 2007 | J Electrochem Soc2007，154，6： | 1 |
| 16 | Equivalent early sentitivity of myoglobin,creatine kinase MB mass,creatine Kinase isoform retion,and cardiac troponin I and T for myocardial infarction显示文摘 | Mar J Morandell D Genser N | 1995 | Clin Chem1995，41，9： | 1 |
| 17 | Treatment of a styrene-butadiene-styrene rubber with corona discharge to improve the adhesion to polyurethane adhesive显示文摘 | Romero-Sanchez M D Pastor-Blas M M Mar i n- Mart i nez J M | 2003 | IntJ Adhes Adhe2003，23，： | 1 |
| 18 | Influence of aging, training and acute physical exercise on plasma glutathione and lipidperoxides in man显示文摘 | KRETZSCH MAR M MULLER D HUBSCH ER J | 1991 | Int J Sports Med1991，12，2： | 1 |
| 19 | Wideband spectral matrix filtering显示文摘 | Gounon P Y Mars J I Goncalves D | 1998 | Expanded Abstracts of 68th Annual Internat SEG Mtg1998，，： | 1 |
| 20 | High sensitivity cardiac troponin T and interleukin-6 predict adverse cardiovascular events and mortality in anticoagulated patients with atrial fibrillation显示文摘 | Roldán V Marín F Díaz J | | 0，，08： | 1 |
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