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| 1 | Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats显示文摘AIM: To investigate the effects of ketamine anesthesia on the motility alterations and tissue injury caused by ischemia/reperfusion in rats. METHODS: Thirty male Wistar rats weighing 200-250 g were used. Ischemia was induced by ob-structing blood flow in 25% of the total small intesti-nal length (ileum) with a vascular clamp for 45 min, after which either 60 min or 24 h of reperfusion was allowed. Rats were either anesthetized with pento-barbital sodium (50 mg/kg) or ketamine (100 mg/kg). Control groups received sham surgery. After 60 min of reperfusion, the intestine was examined for mor-phological alterations, and after 24 h intestinal basic electrical rhythm (BER) frequency was calculated, and intestinal transit determined in all groups. RESULTS: The intestinal mucosa in rats that were anesthetized with ketamine showed moderate altera-tions such as epithelial lifting, while ulceration and hemorrhage was observed in rats that received pento-barbital sodium after 60 min of reperfusion. Quantita-tive analysis of structural damage using the Chiu scaleshowed significantly less injury in rats that received ketamine than in rats that did not (2.35 ± 1.14 vs 4.58 ± 0.50, P < 0.0001). The distance traveled by a mark-er, expressed as percentage of total intestinal length, in rats that received pentobarbital sodium was 20% ± 2% in comparison with 25.9% ± 1.64% in rats that re-ceived ketamine (P = 0.017). BER was not statistically different between groups. CONCLUSION: Our results show that ketamine anesthesia is associated with diminished intestinal injury and abolishes the intestinal transit delay induced by ischemia/reperfusion. | Carlos Rodrigo Cámara Francisco Javier Guzmán Ernesto Alexis Barrera Andrés Jesús Cabello Armando Garcia Nancy Esthela Fernández Eloy Caballero Jesus Ancer | 2008 | World Journal of Gastroenterology2008，14，33： | 5 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Nutritional characterization of tomato fiber as a useful ingredient for food industry显示文摘 | P. García Herrera M.C. Sánchez-Mata M. Cámara | 2010 | Innovative Food Science and Emerging Technologies2010，，4： | 1 |
| 4 | Structure of pyridoxalkinase from sheep brain and role of the tryptophanyl resi-dues显示文摘 | Maras B Valiante S Orru S | 1999 | J Protein Chem1999，18，： | 1 |
| 5 | Topological error eoection of GIS vector data显示文摘 | Maras S S Maras H H Aktug B | 2010 | International Journal of the Physical Sciences2010，5，5： | 1 |
| 6 | Naturalistic pharmacogenetic study of treatment resistance to typical neuroleptics in European–Brazilian schizophrenics显示文摘 | Fabiana B. Kohlrausch Clarissa S. Gama Maria Inês Lobato Paulo Belmonte-de-Abreu Sidia M. Callegari-Jacques Alejandro Gesteira Francisco Barros ángel Carracedo Mara H. Hutz | 2008 | Pharmacogenetics and Genomics2008，，7： | 1 |
| 7 | Sexing of in vitro-produced ovine embryos by duplex PCR 显示文摘 | MARA L PILICHI S SANNA A | 2004 | Mol Reprod Dev2004，69，1： | 1 |
| 8 | Ovarian cortex surrounding benign neoplasms:a histologic study显示文摘 | Maneschi F Marasá L Incandela S | | 0，，2： | 1 |
| 9 | Extending shelf-life and nutritive value of green beans(Phaseolus Vulgaris L ),by controlled atmosphere storage:macronutrients显示文摘 | Sánchez-Mata MC Cámara M D | | 0，，03： | 1 |
| 10 | Peripheral Blood Mononuclear Cells Immunophenotyping in Pulmonary Tuberculosis Patients before and after Treatment显示文摘 | Warly Barcelos Olindo Assis Martins‐Filho Tania Mara Pinto Dabés Guimar?es Márcio Hamilton Prostzner Oliveira Silvana Spíndola‐de‐Miranda Beatriz Nascimento Carvalho Vicente de Paulo Coelho Peixoto Toledo | 2006 | Microbiology and Immunology2006，，： | 1 |
| 11 | Changes in volatile com- position of Madeira wines during their oxidative ageing显示文摘 | Ci MARA J S ALVES M A MARQUES J C | 2006 | Anal Chim Acta2006，563，1： | 1 |
| 12 | Microwave-assisted methylation of phenols with tetramethylammonium chloride in the presence of K2CO3 or Cs2CO3 显示文摘 | Maras N Polanc S Kocevar M | 2008 | Tetrahedron2008，64，11： | 1 |
| 13 | Application of athree-dimensional network model to the coke formation in FAU,MFI and BEA zeolites 显示文摘 | Ca^mara L D T Cerqueira H S Aranda DAG | 2004 | Catalysis Today2004，，98： | 1 |
| 14 | Photodegradation and Removal of Diclofenac by the Green Alga Nannochloropsis oculata显示文摘The emerging contaminants(ECs)are organic compounds including pharmaceuticals.These products are consumed in large quantities,favoring their continuous entrance to the environment and affecting the health of living beings.Diclofenac is a non-steroidal anti-inflammatory drug with analgesic properties of prolonged release.It is the commonest postoperative analgesic,and it is highly consumed without prescription.In recent years,the capability of microalgae to remove pharmaceuticals in water has been tested as a promising tool.In this work,the removal efficiency of diclofenac(16µg/mL)by the microalga Nannochloropsis oculata CCAP 186/7 was evaluated.The major nutrient concentrations in Bold’s Basal Medium were modified(nitrogen and carbon:50 and 100%of their original concentration)to know their effect in the removal of diclofenac.Drug degradation by light was also evaluated.The maximum removal capacity of diclofenac in the medium was 68.8%.The percentage of diclofenac adsorbed on the cell wall was between 6 and 12.7%.Around 23.6%of diclofenac was degraded by light after 18 days.N.oculata did not show growth inhibition due to the presence of diclofenac.The results obtained point to the promissory application of N.oculata as a bioremediation system for diclofenac removal. | Danaé Samara Sánchez-Sandoval Omar González-Ortega Mara Fernanda Navarro-Martínez Juan Marcos Castro-Tapia Ramón Fernando García de la Cruz Ruth Elena Soria-Guerra | 2021 | Phyton-International Journal of Experimental Botany2021，90，5： | 1 |
| 15 | The chronic idiopathic neutropenia syndrome:correlation of clinical features with in vitro parameters of granulopoiesis显示文摘 | Greenberg PL Mara B Steed S | 1980 | Blood1980，55，6： | 1 |
| 16 | Sexing of in vitro produced ovine embryos by duplex PCR显示文摘 | Mara L Piliclli S Senna A | 2004 | Molecular Reproduetion and Development2004，69，3： | 1 |
| 17 | Inflammation in renal transplanta-tion显示文摘 | Abedini S Holme I Mara W | 2009 | Clin J Am Soc Nephrol2009，4，7： | 1 |
| 18 | Freiberg's disease in the Emergency Department显示文摘 | Love JN O'Mara S | 2010 | J Emerg Med2010，38，： | 1 |
| 19 | The Genome sequence of the SARS -associated coronavirus显示文摘 | Mara MA Jonel S J Astell CR | 2003 | Science2003，300，5624： | 1 |
| 20 | Studies on the evolution of ZnO morphologies in a thermohydrolysis technique and evaluation of their functional properties显示文摘 | ANASA S MANGALARAJAB R V ANANTHAKU- MARA S | 2010 | Journal of Hazardous Materials2010，175，： | 1 |
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