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| 1 | 半胱氨酰白三烯拮抗剂治疗儿童哮喘(英文)显示文摘哮喘是一种梗阻性肺疾病,以支气管收缩、持续性气道炎症和气道重塑为特征。临床上常用吸入皮质激素和β2受体拮抗剂辅佐治疗儿童哮喘,但这些药物疗法的治疗效果不是很理想,而且不适当的大剂量皮质激素会导致骨质疏松,生长迟缓和青光眼等严重副作用。口服抗白三烯剂是一种治疗儿童哮喘的新方法。白三烯是由花生四烯酸通过5 脂肪氧化酶途径由肥大细胞、嗜酸粒细胞和肺泡巨噬细胞合成的脂质。它通过与气道平滑肌上的CysLT1受体结合参与哮喘的炎症反应而引起支气管收缩。最近的研究表明,半胱氨酰白三烯可以介导上皮下胶原沉着和平滑肌肥大增生,从而导致不可逆的气道重塑和气道阻塞。实验研究和初步的临床研究显示,白三烯拮抗剂孟鲁司特辅助治疗儿童哮喘,可以减少皮质激素和β2拮抗剂的用量,预防气道重塑、减轻哮喘症状。然而,抗白三烯药物的疗效还需通过随机、双盲和多中心的临床研究得到进一步证实。 | Robert KLEINMAN Marco MURA Ming-Yao LIU | 2005 | 中国当代儿科杂志2005，7，5： | 13 |
| 2 | Intrahepatic vascular changes in non-alcoholic fatty liver disease: potential role of insulin-resistance and endothelial dysfunction显示文摘Metabolic syndrome is a cluster of several clinical conditions characterized by insulin-resistance and high cardiovascular risk. Non-alcoholic fatty liver disease is the liver expression of the metabolic syndrome, and insulin resistance can be a frequent comorbidity in several chronic liver diseases, in particular hepatitis C virus infection and/or cirrhosis. Several studies have demonstrated that insulin action is not only relevant for glucose control, but also for vascular homeostasis. Insulin regulates nitric oxide production, which mediates to a large degree the vasodilating, antiinflammatory and antithrombotic properties of a healthy endothelium, guaranteeing organ perfusion. The effects of insulin on the liver microvasculature and the effects of IR on sinusoidal endothelial cells have been studied in animal models of non-alcoholic fatty liver disease. The hypotheses derived from these studies and the potential translation of these results into humans are critically discussed in this review. | Marcos Pasarín Juan G Abraldes Eleonora Liguori Beverley Kok Vincenzo La Mura | 2017 | World Journal of Gastroenterology2017，23，37： | 6 |
| 3 | The early responses of VEGF and receptors during acute lung injury: implication of VEGF in alveolar epithelial cell survival 显示文摘 | Marco Mura Bing Han Cristiano F | 2006 | Crit Care2006，10，5： | 1 |
| 4 | Microsurgical Clipping of Previously Coiled Aneurysms显示文摘 | Pablo Augusto Rubino Jorge Mura Martin Kitroser Juan Santiago Bottan Eduardo Salas Jorge Lambre Marcos Chiarullo Jorge Bustamante | 2014 | 2014 (1-2)2014，，1： | 1 |
| 5 | Randomized phase III clinical trial of a combined treatment with carnitine + celecoxib ± megestrol acetate for patients with cancer-related anorexia/cachexia syndrome显示文摘 | Clelia Madeddu Mariele Dessì Filomena Panzone Roberto Serpe Giorgia Antoni Maria Chiara Cau Lorenza Montaldo Quirico Mela Marco Mura Giorgio Astara Francesca Maria Tanca Antonio Macciò Giovanni Mantovani | 2011 | Clinical Nutrition2011，，2： | 1 |
| 6 | INTESTINAL ISCHEMIA-REPERFUSION-INDUCED ACUTE LUNG INJURY AND ONCOTIC CELL DEATH IN MULTIPLE ORGANS显示文摘 | Marco Mura Cristiano F. Andrade Bing Han Rashmi Seth Yu Zhang Xiao-Hui Bai Thomas K. Waddell David Hwang Shaf Keshavjee Mingyao Liu | 2007 | Shock2007，，2： | 1 |
| 7 | ANGIOTENSIN-CONVERTING ENZYME INHIBITOR CAPTOPRIL PREVENTS OLEIC ACID-INDUCED SEVERE ACUTE LUNG INJURY IN RATS显示文摘 | Xiaolin He Bing Han Marco Mura Shuyue Xia Shi Wang Tao Ma Mingyao Liu Zhi Liu | 2007 | Shock2007，，1： | 1 |
| 8 | A new drug nanocarrier consisting of chitosan and hydoxypropylcyclodextrin显示文摘 | Francesca Maestrelli Marcos Garcia-Fuentes Paola Mura | 2006 | European Journal of Pharmaceutics and Biopharmaceutics2006，63，2： | 1 |
| 9 | Suggestions on gut-eye cross-talk:about the chalazion显示文摘Dear Editor,We have studied with interest the publication'Effectiveness of oral probiotics supplementation in the treatment of adult small chalazion'by Filippelli et al[1].The conclusion of this work is exciting:the dialogue between gut and eye(brain)is now under the magnification lens and it deserves to continue the relationship studies,previously started by Filippelli et al[2]also on children. | Carla Enrica Gallenga Marco Mura Pier Enrico Gallenga | 2022 | International Journal of Ophthalmology(English edition)2022，15，9： | 0 |
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