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| 1 | Liver transplantation and alcoholic liver disease:History,controversies,and considerations显示文摘Alcohol consumption accounts for 3.8% of annual global mortality worldwide, and the majority of these deaths are due to alcoholic liver disease(ALD), mainly alcoholic cirrhosis. ALD is one of the most common indications for liver transplantation(LT). However, it remains a complicated topic on both medical and ethical grounds, as it is seen by many as a 'self-inflicted disease'. One of the strongest ethical arguments against LT for ALD is the probability of relapse. However, ALD remains a common indication for LT worldwide. For a patient to be placed on an LT waiting list, 6 mo of abstinence must have been achieved for most LT centers. However, this '6-mo rule' is an arbitrary threshold and has never been shown to affect survival, sobriety, or other outcomes. Recent studies have shown similar survival rates among individuals who undergo LT for ALD and those who undergo LT for other chronic causes of end-stage liver disease. There are specific factors that should be addressed when evaluating LT patients with ALD because these patients commonly have a high prevalence of multisystem alcohol-related changes. Risk factors for relapse include the presence of anxiety or depressive disorders, short pre-LT duration of sobriety, and lack of social support. Identification of risk factors and strengthening of the social support system may decrease relapse among these patients. Family counseling for LT candidates is highly encouraged to prevent alcohol consumption relapse. Relapse has been associated with unique histopathological changes, graft damage, graft loss, and even decreased survival in some studies. Research has demonstrated the importance of a multidisciplinary evaluation of LT candidates. Complete abstinence should be attempted to overcome addiction issues and to allow spontaneous liver recovery. Abstinence is the cornerstone of ALD therapy. Psychotherapies, including 12-step facilitation therapy, cognitive-behavioral therapy, and motivational enhancement therapy, help support abstinence. Nutritional therapy helps to reverse muscle wasting, weight loss, vitamin deficiencies, and trace element deficiencies associated with ALD. For muscular recovery, supervised physical activity has been shown to lead to a gain in muscle mass and improvement of functional activity. Early LT for acute alcoholic hepatitis has been the subject of recent clinical studies, with encouraging results in highly selected patients. The survival rates after LT for ALD are comparable to those of patients who underwent LT for other indications. Patients that undergo LT for ALD and survive over 5 years have a higher risk of cardiorespiratory disease, cerebrovascular events, and de novo malignancy. | Claudio Augusto Marroni Alfeu de Medeiros Fleck Jr Sabrina Alves Fernandes Lucas Homercher Galant Marcos Mucenic Mario Henrique de Mattos Meine Guilherme Mariante-Neto Ajacio Bandeira de Mello Brandao | 2018 | World Journal of Gastroenterology2018，24，26： | 7 |
| 2 | Five Colletotrichum species are responsible for mango anthracnose in northeastern Brazil显示文摘Colletotrichum species are the most important and widespread form of decay affecting mango fruit worldwide.In this study,Colletotrichum species associated with fruit anthracnose isolated from mango in northeastern Brazil were subject to molecular and morphological analyses.The partial sequences of the glyceraldehyde-3-phosphate dehydrogenase gene of 143 Colletotrichum isolates was amplified,as an initial measure of genetic diversity.A subset of 47 isolates,selected to represent the range of genetic diversity and geographic origin,were further sequenced using the partial actin,β-tubulin,calmodulin,glutamine synthetase genes and rDNA-ITS region.The multilocus sequence analysis,together with a critical examination of the phenotypic characters,revealed four previously described species(Colletotrichum asianum,Colletotrichum fructicola,Colletotrichum tropicale and Colletotrichum karstii)and one new species.The new species is introduced as Colletotrichum dianesei and formally described,illustrated and compared with similar taxa.Only C.asianum and C.karstii have previously been reported from mango,while the other species represent the first report associated with the mango fruits worldwide.All species are reported for the first time associated with the mango fruits in Brazil. | Nelson B.Lima Marcus Vinicius de A.Batista Marcos A.De Morais Jr Maria A.G.Barbosa Sami J.Michereff Kevin D.Hyde Marcos P.S.Câmara | 2013 | Fungal Diversity2013，，4： | 7 |
| 3 | Endophytic species of Colletotrichum associated with mango in northeastern Brazil显示文摘Endophytic species of Colletotrichum associated with Mangifera indica(mango)are poorly understood.In this study,Colletotrichum species were isolated from mango in Pernambuco State,Brazil.There were significant differences in isolation frequencies of Colletotrichum species among sites and plant tissues.Mature leaf blades were colonized by most Colletotrichum isolates at the majority of sites.Partial sequences of glyceraldehyde-3-phosphate dehydrogenase(GAPDH)of 97 Colletotrichum isolates were amplified as an initial measure of genetic diversity.Phylogenetic analysis with a subset of 22 isolates were performed based on a multilocus dataset(ACT,TUB2,CAL,CHS-1,GAPDH,ITS)followed by Apn2/MAT IGS sequence-analysis for isolates within the C.gloeosporioides species complex.Molecular analysis associated with phenotypic characteristics revealed six previously described species[C.asianum,C.cliviae,C.dianesei(syn.C.melanocaulon),C.fructicola,C.karstii and C.tropicale]and one new species.This new species is introduced as C.endomangiferae.All species isolated were pathogenic on mango fruits but varied in their virulence.There was no distribution pattern of species among sites and plant tissues,although C.asianum was the most prevalent species at all sites and in all plant tissues studied.Five previously reported Colletotrichum species causing anthracnose in mango fruits in northeastern Brazil were also recovered as endophytes. | Willie A.S.Vieira Sami J.Michereff Marcos A.de Morais Jr Kevin D.Hyde Marcos P.S.Camara | 2014 | Fungal Diversity2014，，4： | 6 |
| 4 | Species of Lasiodiplodia associated with mango in Brazil显示文摘Mango(Mangifera indica)is a major tropical fruit species cultivated in Brazil.The objective of this study was to identify species of Lasiodiplodia associated with dieback and stem-end rot of mango in the semi-arid region of Northeastern Brazil,and compare the species in relation to mycelial growth,pathogenicity and virulence.A total of 120 isolates of Lasiodiplodia were used and identifications were made using a combination of morphology and phylogenetic analysis based on partial translation elongation factor 1-αsequence(EF1-α)and internal transcribed spacers(ITS).The following species were identified:Lasiodiplodia crassispora,L.egyptiacae,L.hormozganensis,L.iraniensis,L.pseudotheobromae,L.theobromae and Lasiodiplodia sp..Lasiodiplodia theobromae was the most frequently isolated species,which represented 41%of all the isolates.Only this species had been previously reported on mango in Brazil,while the other species represent the first report associated with mango tree diseases in this country.Lasiodiplodia crassispora is reported for the first time associated with mango diseases worldwide.There were significant differences in mycelial growth rates among the Lasiodiplodia species and also in the optimum temperature for growth.All species of Lasiodiplodia were pathogenic on mango fruit.There were significant differences in virulence among the species,wherein L.hormozganensis and Lasiodiplodia sp.were the most virulent,while the least virulent were L.iraniensis,L.pseudotheobromae,L.crassispora and L.egyptiacae. | Marília W.Marques Nelson B.Lima Marcos Antônio de Morais Jr Maria Angélica G.Barbosa Breno O.Souza Sami J.Michereff Alan J.L.Phillips Marcos P.S.Câmara | 2013 | Fungal Diversity2013，，4： | 2 |
| 5 | Photolu minescence and thermoanalytical studies of complexes based on 5-C1-8- hydroxyquinoline and calix arene ligands 显示文摘 | Marcos N Soares Jr Elder F | 2013 | Materials Science and Engineering C2013，，： | 1 |
| 6 | A Metaheuristic to solve the transmission expansion planning 显示文摘 | Rubenr Marcos JR | 2007 | IEEE transactions on Power Systems2007，22，4： | 1 |
| 7 | Red blood cell transfusion does not increase oxygen consumption in criti- cally ill septic patients显示文摘 | Fernandes CJ Jr Akamine N De Marco FV | 2001 | Crit Care2001，5，6： | 1 |
| 8 | Mutations in VANGL1 associated with neural -tube defects 显示文摘 | Kibar Z Torban E McDearmid JR Reynolds A Berghout J Mathieu M Kirillova I De Marco P Merello E Hayes JM Wall- ingford JB Drapeau P Capra V Gros P | 2007 | N Engl J Med2007，356，14： | 1 |
| 9 | Strong slime production is a marker of clinical significance in Staphylococcus epidermidis isolated from intravascular catheters 显示文摘 | Marco M Maestre JR Aguilar IJ | 2008 | Eur J Clin Microbiol Infect Dis2008，27，4： | 1 |
| 10 | Characterization and hydrotreating performance of NiMo catalysts supported on nanostmctured titanate 显示文摘 | Edisson Morgado Jr Jose L Zotin Marco A S de Abreu Danielle de Oliveira Rosas Paula M Jardim Bojan A Marinkovic | 2009 | Applied Catalysis A: General2009，357，2： | 1 |
| 11 | Botryosphaeria, Neofusicoccum, Neoscytalidium and Pseudofusicoccum species associated with mango in Brazil显示文摘Members of the Botryosphaeriaceae are well known fungi associated with dieback,canker and fruit rot on various hosts worldwide,including mango.The aim of this study was identify a large collection of Botryosphaeriaceae species associated with dieback and stem-end rot of mango in the semi-arid region of Northeastern Brazil,and compare the species in relation to mycelial growth,pathogenicity and virulence.A total of 115 isolates were sampled and based on morphology and DNA sequence data(ITS and EF1-α)seven taxa were identified,namely,Botryosphaeria dothidea,B.mamane,Fusicoccum fabicercianum,Neofusicoccum parvum,N.brasiliense sp.nov,Neoscytalidium dimidiatum and Pseudofusicoccum stromaticum.B.dothidea and P.stromaticum were the most commonly isolated species,which represented 37%and 33%of all isolates respectively.B.mamane is reported for the first time in association with mango diseases worldwide.There were significant differences among the species obtained in this study in relation to optimum temperature for mycelial growth and mycelial growth rates.All species were pathogenic on mango fruit.There were significant differences in virulence among the species,with Ne.dimidiatum and N.parvum being the most virulent species,while P.stromaticum was the least virulent. | Marília W.Marques Nelson B.Lima Marcos A.de Morais Jr Sami J.Michereff Alan J.L.Phillips Marcos P.S.Câmara | 2013 | Fungal Diversity2013，，4： | 1 |
| 12 | Experimental Determination of Chromatographic Separation Para- meters of Ketamine Enantiomers on MCTA显示文摘 | Ivanildo Jose da Silva Jr Marco Antonio Garcia dos Santos Vinicius de Veredas | 2005 | Separation and Purification Technology2005，43，1： | 1 |
| 13 | Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore显示文摘 | Marco T Ronald JR | | J Bio Chem0，274，31： | 1 |
| 14 | Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore 显示文摘 | John GP Marco T Ronald JR | 1999 | J Biol Chem1999，274，31： | 1 |
| 15 | Recombinant human MCP-1/JE induces chemotaxis,calcium flux,and the respiratory burst in human monocytes显示文摘 | Barrett JR Alfred W Marco B | 1991 | Blood1991，178，4： | 1 |
| 16 | Percutaneous trans- luminal angioplasty of the symptomatic atherosclerotic carotid arteries显示文摘 | Gil-Peralta A Mayol A Marcos JR | 1996 | Stroke1996，27，12： | 1 |
| 17 | Immunostimulatory effect of faecal Bifidobacteriumspecies of breast-fed and formula-fed infants in aperipheral blood mononuclear cell/Caco-2 co-culturesystem显示文摘 | Pozo- Rubio T Mujico JR Marcos A | 2011 | Br J Nutr2011，106，8： | 1 |
| 18 | 17p duplicated Charcot-Marie-Tooth 1A characteristics of a new population 显示文摘 | Ison Marques Jr Marcos R Freitas Osvaldo JM | 2005 | J Neurol2005，252，8： | 1 |
| 19 | Vohammetric determination of isoprenaline in pharmaceutical preparations using a copper (Ⅱ) hexacyanoferrate (Ⅲ) modified carbon paste electrode 显示文摘 | Viviane G Bonifa'cio Luiz H Marcolino Jr Marcos F S Teixeira | 2004 | Microchemical Journal2004，78，1： | 1 |
| 20 | Quantitative immunohistochemical analyses of the expression of E-cadherin,thrombomodulin,CD44H and CD44v6 in primary tumours of pharynx/larynx squamous cell carcinoma and their lymph node metastases 显示文摘 | Hernandez Gaspar R de los Toyos JR Alvarez Marcos C | 1999 | Anal Cell Pathol1999，18，： | 1 |
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