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| 1 | Hepatic encephalopathy: Ever closer to its big bang显示文摘Hepatic encephalopathy(HE) is a neuropsychiatric disorder that commonly complicates the course of patients with liver disease. Despite the fact that the syndrome was probably first recognized hundreds of years ago, the exact pathogenesis still remains unclear. Minimal hepatic encephalopathy(MHE) is the earliest form of HE and is estimated to affect more that 75% of patients with liver cirrhosis. It is characterized by cognitive impairment predominantly attention, reactiveness and integrative function with very subtle clinical manifestations. The development of MHE is associated with worsen in driving skills, daily activities and the increase of overall mortality. Skeletal muscle has the ability to shift from ammonia producer to ammonia detoxifying organ. Due to its large size, becomes the main ammonia detoxifying organ in case of chronic liver failure and muscular glutaminesynthase becomes important due to the failing liver and brain metabolic activity. Gut is the major glutamine consumer and ammonia producer organ in the body. Hepatocellular dysfunction due to liver disease, results in an impaired clearance of ammonium and in its interorgan trafficking. Intestinal bacteria, can also represent an extra source of ammonia production and in cirrhosis, small intestinal bacterial overgrowth and symbiosis can be observed. In the study of HE, to get close to MHE is to get closer to its big bang; and from here, to travel less transited roads such as skeletal muscle and intestine, is to go even closer. The aim of this editorial is to expose this road for further and deeper work. | Pablo A Souto Ariel R Marcotegui Lisandro Orbea Juan Skerl Juan Carlos Perazzo | 2016 | World Journal of Gastroenterology2016，22，42： | 6 |
| 2 | A Gain of Function Mutation in JAK2 Is Frequently Found in Patientswith AML-M2 and Normal Karyotype显示文摘 | Marcotegui N | | 0，，： | 1 |
| 3 | Stepped-impedance lowpass filters with spurious pass-band suppression显示文摘 | J Garcia-Garcia J Bonache F Falcone J D Baena F Martin I Gil T Lopetegi M A G Laso A Marcotegui R Marques M Sorolla | 2004 | Electronic Letters2004，40，14： | 1 |
| 4 | Hole of fungi,bacteria,and invertebrates in leaf litter breakdown in a polluted riv-er 显示文摘 | PASCOAL C CASSIO F MARCOTEGUI A | 2005 | Journal of the North American Benthological Society2005，24，4： | 1 |
| 5 | Detection, segmentation andclassification of 3D urban objects using mathematicalmorphology and supervised learning显示文摘 | Serna A Marcotegui B | 2014 | ISPRS Journalof Photogrammetry and Remote Sensing2014，93，： | 1 |
| 6 | Silencing of hsa-miR-124 by EVI1 in cell lines and patients with acute myeloidleukemia 显示文摘 | Vazquez I Maicas M Marcotegui N | 2010 | Pro Natl Acad Sci U S A2010，107，44： | 1 |
| 7 | Pro- teins specified by African swine fever virus显示文摘 | Tabares E Marcotegui M A Fernandez M | 1980 | Arch Virol1980，66，： | 1 |
| 8 | Content-dependent image sampling using mathematical morphology:Application to texture mapping显示文摘 | Etienne Decencie're Marcotegui B Meyer F | 2001 | Signal Processing:Image Communication2001，16，： | 1 |
| 9 | Content-dependent image sampling using mathematical morphology:Application to texture mapping显示文摘 | Marcotegui B Meyer F | 2001 | Signal Processing:Image Communication (S0923-5965)2001，16，： | 1 |
| 10 | Silencing of hsa-miR-124 by EVI1 in cell lines and patients with acute myeloid leukemia显示文摘 | Vázquez I MaicasM Marcotegui N | 2010 | Proc Natl Acad Sci USA2010，107，44： | 1 |
| 11 | Content-dependent image sampling using mathematical morphology: Application to texture mapping显示文摘 | Marcotegui B Meyer F | 2001 | Signal Processing: Image Communication2001，16，： | 1 |
| 12 | Usefulness of echocardiography and Doppler echocardiography in endomyocardial fibrosis 显示文摘 | Berensztein CS Pineiro D Marcotegui M | 2000 | J Am Soc Echocardiogr2000，13，5： | 1 |
| 13 | Detection, segmentation and classification of 3D urban objects using mathematical morphology and supervised learning 显示文摘 | Serna A Marcotegui B | 2014 | ISPRS Journal of Photogrammetry and Remote Sensing2014，93，： | 1 |
| 14 | Detection, segmentation and classification of 3D urban objects using mathematical morphology and supervised learning 显示文摘 | ANDRES SERNA BEATRIZ MARCOTEGUI | 2014 | ISPRS Journal of Photogrammetry and Remote Sensing2014，93，： | 1 |
| 15 | Trichodinids (Ciliophora: Peritrichida) of Mugil platanus (Mugiliformes: Mugilidae) and Micropogonias furnieri (Perciformes: Sciaenidae) from Samborombon Bay, Argentina, with the description of a new species 显示文摘 | Marcotegui P S Martorelli S R | 2009 | Folia Parasitologica2009，56，3： | 1 |
| 16 | Discriminatory capacity of serum interleukin-6 between complicated and uncomplicated acute appendicitis in children:a prospective validation study显示文摘Background Serum interleukin-6(IL-6)has a moderate diagnostic performance in pediatric acute appendicitis(PAA).The evidence regarding its capacity to discern between complicated and uncomplicated PAA is scarce.Methods We designed a prospective observational study to validate serum IL-6 as a marker for diagnostic classification between complicated and uncomplicated PAA.This study included 205 patients divided into three groups:(1)patients who underwent major outpatient surgery(n=57);(2)patients with non-surgical abdominal pain(NSAP)in whom the diagnosis of PAA was excluded(n=53),and(3)patients with a confirmed diagnosis of PAA(n=95).The PAA patients were further classified as uncomplicated or complicated PAA.IL-6 concentration was determined in all patients at diagnosis.Comparative statistical analysis was performed using the Mann-Whitney U test,the Fisher exact test and the Kruskall Wallis test.The area under the receiver operating characteristic curves(AUC)were calculated.Results Median(interquartile range,IQR)serum IL-6 values were 2 pg/mL(2.0–3.4)in group 1,3.9 pg/mL(2.4–11.9)in group 2,and 23.9 pg/mL(11.1–61.0)in group 3(P<0.001).Among the participants in group 3,those with uncomplicated PAA had median(IQR)serum IL-6 values of 17.2 pg/mL(8.5–36.8),and those with complicated PAA had 60.25 pg/mL(27.1–169)serum IL-6(P<0.001).At the cut-off point of 19.55 pg/mL,the AUC for the discrimination between patients in group 2 vs.3 was 0.83[95%confidence interval(CI)0.76–0.90],with a sensitivity of 61.3%and a specificity of 86.8.The AUC for the discrimination between patients with uncomplicated and complicated PAA was 0.77(95%CI 0.68–0.86)and the cut-off point was 25.90 pg/mL,with a sensitivity and specificity of 84.6%and 65.6%,respectively.Conclusions Serum IL-6 has a good performance in discerning between complicated and uncomplicated PAA.A score including clinical and radiological variables may increase the diagnostic performance of this molecule. | Javier Arredondo Montero Giuseppa Antona Adriana Rivero Marcotegui Carlos BardajíPascual Mónica Bronte Anaut Raquel Ros Briones Amaya Fernández-Celis Natalia López-Andrés Nerea Martín-Calvo | 2022 | World Journal of Pediatrics2022，18，12： | 0 |
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