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| 1 | Treatment modalities for early gastric cancer显示文摘Different treatment modalities have been proposed in the treatment of early gastric cancer(EGC). Endoscopic resection(ER) is an established treatment that allows curative treatment, in selected cases. In addition, ER allows for an accurate histological staging, which is crucial when deciding on the best treatment option for EGC. Recently, endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD) have become alternatives to surgery in early gastric cancer, mainly in Asian countries. Patients with 'standard' criteria can be successfully treated by EMR techniques. Those who meet 'expanded' criteria may benefit from treatment by ESD, reducing the need for surgery. Standardized ESD training system is imperative to promulgate effective and safe ESD technique to practices with limited expertise. Although endoscopic resection is an option in patients with EGC, surgical treatment continues to be a widespread therapeutic option worldwide. In this review we tried to point out the treatment modalities for early gastric cancer. | Jesús Espinel Eugenia Pinedo Vanesa Ojeda Maria Guerra del Rio | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，12： | 11 |
| 2 | Bone marrow-derived mesenchymal stem cells versus adipose-derived mesenchymal stem cells for peripheral nerve regeneration显示文摘Studies have confirmed that bone marrow-derived mesenchymal stem cells(MSCs) can be used for treatment of several nervous system diseases. However, isolation of bone marrow-derived MSCs(BMSCs) is an invasive and painful process and the yield is very low. Therefore, there is a need to search for other alterative stem cell sources. Adipose-derived MSCs(ADSCs) have phenotypic and gene expression profiles similar to those of BMSCs. The production of ADSCs is greater than that of BMSCs, and ADSCs proliferate faster than BMSCs. To compare the effects of venous grafts containing BMSCs or ADSCs on sciatic nerve injury, in this study, rats were randomly divided into four groups: sham(only sciatic nerve exposed), Matrigel(MG; sciatic nerve injury + intravenous transplantation of MG vehicle), ADSCs(sciatic nerve injury + intravenous MG containing ADSCs), and BMSCs(sciatic nerve injury + intravenous MG containing BMSCs) groups. Sciatic functional index was calculated to evaluate the function of injured sciatic nerve. Morphologic characteristics of nerves distal to the lesion were observed by toluidine blue staining. Spinal motor neurons labeled with Fluoro-Gold were quantitatively assessed. Compared with sham-operated rats, sciatic functional index was lower, the density of small-diameter fibers was significantly increased, and the number of motor neurons significantly decreased in rats with sciatic nerve injury. Neither ADSCs nor BMSCs significantly improved the sciatic nerve function of rats with sciatic nerve injury, increased fiber density, fiber diameters, axonal diameters, myelin sheath thickness, and G ratios(axonal diameter/fiber diameter ratios) in the sciatic nerve distal to the lesion site. There was no significant difference in the number of spinal motor neurons among ADSCs, BMSCs and MG groups. These results suggest that neither BMSCs nor ADSCs provide satisfactory results for peripheral nerve repair when using MG as the conductor for engraftment. | Marcela Fernandes Sandra Gomes Valente Rodrigo Guerra Sabongi Joao Baptista Gomes dos Santos Vilnei Mattioli Leite Henning Ulrich Arthur Andrade Nery Maria José da Silva Fernandes | 2018 | Neural Regeneration Research2018，13，1： | 10 |
| 3 | New-onset diabetes after kidney transplantation:Incidence and associated factors显示文摘AIM To determine the incidence and associated factors of new-onset diabetes after transplantation(NODAT) in a Portuguese central hospital. METHODS This single-center retrospective study involved consecutive adult nondiabetic transplant recipients, who had undergone kidney transplantation between January 2012 and March 2016. NODAT was diagnosed according to the criteria of the American Diabetes Association. Data were collected from an institutional database of the Nephrology and Kidney Transplantation Department(Santa Maria Hospital, Lisbon, Portugal) and augmented with data of laboratorial parameters collected from the corresponding patient electronic medical records. Exclusion criteria were preexisting diabetes mellitus, missing information and follow-up period of less than 12 mo. Data on demographic and clinical characteristics as well as anthropometric and laboratorial parameters were also collected. Patients were divided into two groups: With and without NODAT-for statistical comparison.RESULTS A total of 156 patients received kidney transplantduring the study period, 125 of who were included in our analysis. NODAT was identified in 27.2% of the patients(n = 34; 53% female; mean age: 49.5 ± 10.8 years; median follow-up: 36.4 ± 2.5 mo). The incidence in the first year was 24.8%. The median time to diagnosis was 3.68 ± 5.7 mo after transplantation, and 76.5% of the patients developed NODAT in the first 3 mo. In the group that did not develop NODAT(n = 91), 47% were female, with mean age of 46.4 ± 13.5 years and median follow-up of 35.5 ± 1.6 mo. In the NODAT group, the pretransplant fasting plasma glucose(FPG) levels were significantly higher [101(96.1-105.7) mg/d L vs 92(91.4-95.8) mg/d L, P = 0.007] and pretransplant impaired fasting glucose(IFG) was significantly more frequent(51.5% vs 27.7%, P = 0.01). Higher pretransplant FPG levels and pretransplant IFG were found to be predictive risk factors for NODAT development [odds ratio(OR): 1.059, P = 0.003; OR: 2.772, P = 0.017, respectively]. CONCLUSION NODAT incidence was high in our renal transplant recipients, particularly in the first 3 mo posttransplant, and higher pretransplant FPG level and IFG were risk factors. | Vania Gomes Florbela Ferreira JoséGuerra Maria Joao Bugalho | 2018 | World Journal of Diabetes2018，9，7： | 8 |
| 4 | Slope Processes, Mass Movement and Soil Erosion: A Review显示文摘Soil erosion and land degradation are global problems and pose major issues in many countries.Both soil erosion and mass movement are two forms of land degradation and humans play important roles in these geomorphological processes.This paper reviews slope processes associated with mass movement and soil erosion and contributory factors,including physical and human agents.Acting together,these cause diverse geomorphological features.Slope processes are illustrated by reference to case studies from Brazil and UK.The causes and impacts of erosion are discussed,along with appropriate remedial bioengineering methods and the potential of the measures to prevent these types of environmental degradation.Although there are several agents of erosion,water is the most important one.Cultivation can promote soil erosion,due to ploughing and harvesting,which moves soil down slopes.Soil erosion and mass movement data would inform the viability of soil conservation practices.Integrated management of drainage basins offers a promising way forward for effective soil conservation and soil remedial bioengineering in Brazil and UK. | Antonio Jos Teixeira GUERRA Michael Augustine FULLEN Maria do Carmo Oliveira JORGE Joss Fernando Rodrigues BEZERRA Mohamed S. SHOKR | 2017 | Pedosphere2017，27，1： | 4 |
| 5 | Somatic Embryogenesis in Iberian Grapevine (Vitis vinifera) Cultivars Using Carpels as Initial Explants: Protocol Establishment and Histological Evaluation显示文摘Trincadeira and Aragonez are two important grapevine cultivars in the Iberian Peninsula, used for high quality red wines production. Both cultivars are strongly affected by fungal diseases, with consequent high loses on plant productivity and fruit quality. A successful protocol for plant regeneration via somatic embryogenesis (SE) was established for both cultivars allowing further plant improvement based on gene transfer technology. Several factors were evaluated during the three different phases which characterize an SE plant regeneration protocol. The culture room temperature during the induction phase, a parameter usually accepted as standard by most researchers, proved in these trials to significantly affect the embryo induction rates. Concerning embryo conversion, it was specially affected by the embryo developmental stage, by the intensity and duration of the chilling treatment and by the supplementation of conversion culture medium with activated charcoal. The responses obtained, both for induction and conversion, proved to be highly genotype dependent. Calli structure, as well as embryo integrity, was histologically observed, allowing to characterize embryonic and non-embryonic masses and to identify abnormalities on embryo development. | Hélia Guerra Cardoso Maria Catarina Campos Maria Salomé Pais Augusto Peixe | 2019 | Journal of Agricultural Science and Technology(B)2019，9，1： | 2 |
| 6 | EGF Receptor Signaling Is Essential for K- Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma显示文摘 | Carolina Navas Isabel Hernández-Porras Alberto J. Schuhmacher Maria Sibilia Carmen Guerra Mariano Barbacid | 2012 | Cancer Cell2012，，3： | 2 |
| 7 | Diversity of rotavirus strains circulating in Northern Brazil after introduction of a rotavirus vaccine: High prevalence of G3P[6] genotype显示文摘 | Luana da Silva Soares Sylvia de Fátima dos Santos Guerra Alessilva do Socorro Lima de Oliveira Fabiola da Silva dos Santos Euzeni Maria de Fátima Costa de Menezes Joana d’Arc Pereira Mascarenhas Alexandre C. Linhares | 2014 | Virol2014，，6： | 1 |
| 8 | Dynaamic microfihration with a vibrating hollow fiber membrane module: Filtration of yeast suspensions显示文摘 | Soren Prip Beier Maria Guerra Arvid Garde | 2006 | J Membr Sci2006，281，2： | 1 |
| 9 | Inhibition of Rho kinase mediates the neuroprotective effects of estrogen in the MPTP model of Parkinson’s disease显示文摘 | Ana I. Rodriguez-Perez Antonio Dominguez-Meijide Jose L. Lanciego Maria J. Guerra Jose L. Labandeira-Garcia | 2013 | Neurobiology of Disease2013，，： | 1 |
| 10 | Optimal reinsurance policy:The adjustment coefficient and the expected utility criteria显示文摘 | Manuel Guerra Maria de Lourdes Centeno | | 0，，： | 1 |
| 11 | New advances in the diagnosis of congenital cytomegalovirus infection显示文摘 | Tiziana Lazzarotto Brunella Guerra Marcello Lanari Liliana Gabrielli Maria Paola Landini | 2007 | Journal of Clinical Virology2007，，3： | 1 |
| 12 | Development of a multianalyte method based on micro-matrix-solid-phase dispersion for the analysis of fragrance allergens and preservatives in personal care products显示文摘 | Maria Celeiro Eugenia Guerra J. Pablo Lamas Marta Lores Carmen Garcia-Jares Maria Llompart | 2014 | Journal of Chromatography A2014，，： | 1 |
| 13 | Histological findings in foetuses congenitally infected by cytomegalovirus显示文摘 | Liliana Gabrielli Maria Paola Bonasoni Tiziana Lazzarotto Stefania Lega Donatella Santini Maria Pia Foschini Brunella Guerra Federica Baccolini Giulia Piccirilli Angela Chiereghin Evangelia Petrisli Giorgio Gardini Marcello Lanari Maria Paola Landini | 2009 | Journal of Clinical Virology2009，，： | 1 |
| 14 | JAK2 V617F Mutation in Patients with Splanchnic Vein Thrombosis显示文摘 | Sandra Guerra Xavier Telma Gadelha Glicínia Pimenta Angela Maria Eugenio Daniel Dias Ribeiro Fernanda Mendes Gomes Martin Bonamino Ilana Renault Zalcberg Nelson Spector | 2010 | Digestive Diseases and Sciences2010，，6： | 1 |
| 15 | Prenatal diagnosis of symptomatic congenital cytomegalovirus infection显示文摘 | Brunella Guerra Tiziana Lazzarotto Simona Quarta Marcello Lanari Luciano Bovicelli Alfredo Nicolosi Maria Paola Landini | 2000 | American Journal of Obstetrics and Gynecology2000，，2： | 1 |
| 16 | The E23K Variant of KCNJ11 Encoding the Pancreatic β-Cell Adenosine 5′-Triphosphate-Sensitive Potassium Channel Subunit Kir6.2 Is Associated with an Increased Risk of Secondary Failure to Sulfonylurea in Patients with Type 2 Diabetes显示文摘 | Giorgio Sesti Emanuela Laratta Marina Cardellini Francesco Andreozzi Silvia Del Guerra Concetta Irace Agostino Gnasso Maria Grupillo Renato Lauro Marta Letizia Hribal Francesco Perticone Piero Marchetti | 2006 | The Journal of Clinical Endocrinology & Metabolism2006，，6： | 1 |
| 17 | Antioxidant activities of sulfated polysaccharides from brown and red seaweeds显示文摘 | Micheline Cristiane Rocha de Souza Cybelle Teixeira Marques Celina Maria Guerra Dore Fernando Roberto Ferreira da Silva Hugo Alexandre Oliveira Rocha Edda Lisboa Leite | 2007 | Journal of Applied Phycology2007，，2： | 1 |
| 18 | Cytotoxic effect and apoptosis induction by Bothrops leucurus venom lectin on tumor cell lines显示文摘 | Erika S. Nunes Mary A.A. Souza Ant?nio F.M. Vaz Teresinha G. Silva Jaciana S. Aguiar André M. Batista Maria M.P. Guerra Miriam C. Guarnieri Luana C.B.B. Coelho Maria T.S. Correia | 2012 | Toxicon (-)2012，，7： | 1 |
| 19 | Histological alterations in the livers of Cx43-deficient mice submitted to a cholestasis model显示文摘 | Tarso Felipe Teixeira Tereza Cristina da Silva Heidge Fukumasu Cynthia Esteves de Lima Maria Lúcia Zaidan Dagli José Luiz Guerra | 2007 | Life Sciences2007，，5： | 1 |
| 20 | Dynamic microfiltration with a vibrating hollow fiber membrane module: Filtration of yeast suspensions 显示文摘 | Soren Prip Beier Maria Guerra Arvid Garde | 2006 | J Membr Sci2006，281，2： | 1 |
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