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| 1 | Bone marrow-derived mesenchymal stem cells versus adipose-derived mesenchymal stem cells for peripheral nerve regeneration显示文摘Studies have confirmed that bone marrow-derived mesenchymal stem cells(MSCs) can be used for treatment of several nervous system diseases. However, isolation of bone marrow-derived MSCs(BMSCs) is an invasive and painful process and the yield is very low. Therefore, there is a need to search for other alterative stem cell sources. Adipose-derived MSCs(ADSCs) have phenotypic and gene expression profiles similar to those of BMSCs. The production of ADSCs is greater than that of BMSCs, and ADSCs proliferate faster than BMSCs. To compare the effects of venous grafts containing BMSCs or ADSCs on sciatic nerve injury, in this study, rats were randomly divided into four groups: sham(only sciatic nerve exposed), Matrigel(MG; sciatic nerve injury + intravenous transplantation of MG vehicle), ADSCs(sciatic nerve injury + intravenous MG containing ADSCs), and BMSCs(sciatic nerve injury + intravenous MG containing BMSCs) groups. Sciatic functional index was calculated to evaluate the function of injured sciatic nerve. Morphologic characteristics of nerves distal to the lesion were observed by toluidine blue staining. Spinal motor neurons labeled with Fluoro-Gold were quantitatively assessed. Compared with sham-operated rats, sciatic functional index was lower, the density of small-diameter fibers was significantly increased, and the number of motor neurons significantly decreased in rats with sciatic nerve injury. Neither ADSCs nor BMSCs significantly improved the sciatic nerve function of rats with sciatic nerve injury, increased fiber density, fiber diameters, axonal diameters, myelin sheath thickness, and G ratios(axonal diameter/fiber diameter ratios) in the sciatic nerve distal to the lesion site. There was no significant difference in the number of spinal motor neurons among ADSCs, BMSCs and MG groups. These results suggest that neither BMSCs nor ADSCs provide satisfactory results for peripheral nerve repair when using MG as the conductor for engraftment. | Marcela Fernandes Sandra Gomes Valente Rodrigo Guerra Sabongi Joao Baptista Gomes dos Santos Vilnei Mattioli Leite Henning Ulrich Arthur Andrade Nery Maria José da Silva Fernandes | 2018 | Neural Regeneration Research2018，13，1： | 10 |
| 2 | Purinergic Receptors in Basal Ganglia Diseases:Shared Molecular Mechanisms between Huntington’s and Parkinson’s Disease显示文摘Huntington’s(HD)and Parkinson’s diseases(PD)are neurodegenerative disorders caused by the death of GABAergic and dopaminergic neurons in the basal ganglia leading to hyperkinetic and hypokinetic symptoms,respectively.We review here the participation of purinergic receptors through intracellular Ca^2+signaling in these neurodegenerative diseases.The adenosine A2A receptor stimulates striatopallidal GABAergic neurons,resulting in inhibitory actions on GABAergic neurons of the globus pallidus.A2A and dopamine D2 receptors form functional heteromeric complexes inducing allosteric inhibition,and A2A receptor activation results in motor inhibition.Furthermore,the A2A receptor physically and functionally interacts with glutamate receptors,mainly with the mGlu5 receptor subtype.This interaction facilitates glutamate release,resulting in NMDA glutamate receptor activation and an increase of Ca2+influx.P2X7 receptor activation also promotes glutamate release and neuronal damage.Thus,modulation of purinergic receptor activity,such as A2A and P2X7 receptors,and subsequent aberrant Ca^2+signaling,might present interesting therapeutic potential for HD and PD. | Talita Glaser Roberta Andrejew Agatha Oliveira-Giacomelli Deidiane Elisa Ribeiro Lucas Bonfim Marques Qing Ye Wen-Jing Ren Alexey Semyanov Peter Illes Yong Tang Henning Ulrich | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 3 | From purines to purinergic signalling:molecular functions and human diseases显示文摘Purines and their derivatives,most notably adenosine and ATP,are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis.Besides,these purines support,as chemical messengers,purinergic transmission throughout tissues and species.Purines act as endogenous ligands that bind to and activate plasmalemmal purinoceptors,which mediate extracellular communication referred to as“purinergic signalling”.Purinergic signalling is cross-linked with other transmitter networks to coordinate numerous aspects of cell behaviour such as proliferation,differentiation,migration,apoptosis and other physiological processes critical for the proper function of organisms.Pathological deregulation of purinergic signalling contributes to various diseases including neurodegeneration,rheumatic immune diseases,inflammation,and cancer.Particularly,gout is one of the most prevalent purine-related disease caused by purine metabolism disorder and consequent hyperuricemia.Compelling evidence indicates that purinoceptors are potential therapeutic targets,with specific purinergic agonists and antagonists demonstrating prominent therapeutic potential.Furthermore,dietary and herbal interventions help to restore and balance purine metabolism,thus addressing the importance of a healthy lifestyle in the prevention and relief of human disorders.Profound understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases. | Zhao Huang Na Xie Peter Illes Francesco Di Virgilio Henning Ulrich Alexey Semyanov Alexei Verkhratsky Beata Sperlagh Shu-Guang Yu Canhua Huang Yong Tang | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 4 | The HLA-A2 Restricted T Cell Epitope HCV Core 35–44 Stabilizes HLA-E Expression and Inhibits Cytolysis Mediated by Natural Killer Cells显示文摘 | Jacob Nattermann Hans Dieter Nischalke Valeska Hofmeister Golo Ahlenstiel Henning Zimmermann Ludger Leifeld Elisabeth H. Weiss Tilman Sauerbruch Ulrich Spengler | 2005 | The American Journal of Pathology2005，，2： | 1 |
| 5 | Solid Layer Melt Crystallization显示文摘 | Ulrich J Bierwirth J Henning S | 1996 | Separation Purification Methods1996，25，1： | 1 |
| 6 | Solid Layer Melt Crystallization显示文摘 | Ulrich Bierwirth Henning | 1996 | Separation and Purification Methods1996，25，1： | 1 |
| 7 | Observation of supersymmetric pseudo-Landau levels in strained microwave graphene显示文摘Using an array of coupled microwave resonators arranged in a deformed honeycomb lattice,we experimentally observe the formation of pseudo-Landau levels in the whole crossover from vanishing to large pseudomagnetic field strengths.This result is achieved by utilising an adaptable setup in a geometry that is compatible with the pseudo-Landau levels at all field strengths.The adopted approach enables us to observe the fully formed flat-band pseudo-Landau levels spectrally as sharp peaks in the photonic density of states and image the associated wavefunctions spatially,where we provide clear evidence for a characteristic nodal structure reflecting the previously elusive supersymmetry in the underlying low-energy theory.In particular,we resolve the full sublattice polarisation of the anomalous 0th pseudo-Landau level,which reveals a deep connection to zigzag edge states in the unstrained case. | Matthieu Bellec Charles Poli Ulrich Kuhl Fabrice Mortessagne Henning Schomerus | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 8 | Solid layer melt crystallization 显示文摘 | ULRICH J BIERWIRTH J HENNING S | 1996 | Separation and Purification Methods1996，25，1： | 1 |
| 9 | Solid layer melt crystallization 显示文摘 | ULRICH BIERWIRTH HENNING | 1996 | Separation and Purification Methods1996，25，1： | 1 |
| 10 | Two independent pathways of regulated necrosis mediate ischemia–reperfusion injury显示文摘 | Andreas Linkermann Jan Hinrich Br?sen Maurice Darding Mi Kyung Jin Ana B. Sanz Jan-Ole Heller Federica De Zen Ricardo Weinlich Alberto Ortiz Henning Walczak Joel M. Weinberg Douglas R. Green Ulrich Kunzendorf Stefan Krautwald | 2013 | Proceedings of the National Academy of Sciences2013，，29： | 1 |
| 11 | Solid layer melt crystallization显示文摘 | Ulrich Bierwirth Henning | 1996 | Separation and Purification Methods1996，25，1： | 1 |
| 12 | Combined Pulmonary and Aortic Valve Stenosis - Prenatal Diagnosis and Postnatal Interventional Therapy显示文摘 | Herberg Ulrike Goltz Diane Weiss Henning Gembruch Ulrich Breuer Johannes | 2009 | Neonatology2009，，4： | 1 |
| 13 | Additive Utility in Prospect Theory显示文摘 | Hen Bleichrodt Ulrich Schmidt Horst Zank | 2009 | Management Science2009，55，5： | 1 |
| 14 | Peptide Receptor Radionuclide Therapy with Y-DOTATOC and 177Lu-DOTATOC in Advanced Neuroendocrine Tumors: Results from a Danish Cohort Treated in Switzerland显示文摘 | Pfeifer Andreas Klaus Gregersen Tine Gr?nb?k Henning Hansen Carsten Paln?s Müller-brand Jan Herskind Bruun Karin Krogh Klaus Kj?r Andreas Knigge Ulrich | 2011 | EN2011，，3： | 1 |
| 15 | Adjuvant treatment of clinical Stage I seminoma: is a single course of carboplatin sufficient?显示文摘 | Klaus-Peter Dieckmann Bernd Brüggeboes Uwe Pichlmeier Jens Küster Ulrich Müllerleile Henning Bartels | 2000 | Urology2000，，1： | 1 |
| 16 | The HLA-A2 Restricted T Cell Epitope HCV Core 35–44 Stabilizes HLA-E Expression and Inhibits Cytolysis Mediated by Natural Killer Cells显示文摘 | Jacob Nattermann Hans Dieter Nischalke Valeska Hofmeister Golo Ahlenstiel Henning Zimmermann Ludger Leifeld Elisabeth H. Weiss Tilman Sauerbruch Ulrich Spengler | 2005 | The American Journal of Pathology2005，，2： | 1 |
| 17 | L1 is a potential marker for poorly-differentiated pancreatic neuroendocrine carcinoma显示文摘瞄准:在胰腺的神经内分泌肿瘤决定 L1 的表示并且相关它与这个肿瘤的分类。方法:我们回顾地在原发性瘤或转移的石蜡节上由免疫组织化学在胰腺的神经内分泌肿瘤的 63 种情况中分析了 L1 表示。染色被过氧化物酶技术对人的 L1 与单音的同种细胞的抗体 UJ127.11 执行。所有肿瘤被分类根据分类同样区分得好的神经内分泌肿瘤和癌或糟糕区分的神经内分泌癌。结果:L1 在 5 被检测(7.9%) 63 个胰腺的神经内分泌肿瘤。(44.4%) 四 9 糟糕区分的癌表示了 L1。相反,仅仅(1.9%) 1 为 L1 54 个区分得好的肿瘤或癌是积极的。没有表示在正常胰腺的织物的 Langerhans 小岛房间被发现。生气桌子分析显示出在 L1 表示和胰(P<0.01 ) 的神经内分泌肿瘤的分类之间的一个重要协会。结论:L1 明确地在被知道有最糟的预后的糟糕区分的胰腺的神经内分泌癌被表示。L1 可能是为与胰腺的神经内分泌癌诊断的病人的风险预言的一个标记。 | Jussuf T Kaifi Ulrich Zinnkann Emre F Yekebas Paulus G Schurr Uta Reichelt Robin Wachowiak Henning C Fiegel Susann Petri Melitta Schachner Jakob RIzbicki | 2006 | World Journal of Gastroenterology2006，12，1： | 1 |
| 18 | 显示文摘 | Ulrich Bierwirth Henning | 1996 | Separation and Purification Methods1996，25，1： | 1 |
| 19 | Solid layer melt crystallization显示文摘 | Ulrich Bierwirth Henning | 1996 | Separation and Purification Methods1996，25，1： | 1 |
| 20 | Spinal cord stimulation in postherpetic neuralgia and in acute herpes zoster pain显示文摘 | Henning Harke Peter Gretenkort Hans Ulrich Ladleif | 2002 | Anesth Analg2002，94，3： | 1 |
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