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| 1 | Treatment of laryngopharyngeal reflux disease: A systematic review显示文摘BACKGROUNG For a long time,laryngopharyngeal reflux disease(LPRD)has been treated by proton pump inhibitors(PPIs)with an uncertain success rate.AIM To shed light the current therapeutic strategies used for LPRD in order to analysis the rationale in the LPRD treatment.METHODS Three authors conducted a PubMed search to identify papers published between January 1990 and February 2019 about the treatment of LPRD.Clinical prospective or retrospective studies had to explore the impact of medical treatment(s)on the clinical presentation of suspected or confirmed LPRD.The criteria for considering studies for the review were based on the population,intervention,comparison,and outcome framework.RESULTS The search identified 1355 relevant papers,of which 76 studies met the inclusion criteria,accounting for 6457 patients.A total of 64 studies consisted of empirical therapeutic trials and 12 were studies where authors formally identified LPRD with pH-monitoring or multichannel intraluminal impedance-pH monitoring(MII-pH).The main therapeutic scheme consisted of once or twice daily PPIs for a duration ranged from 4 to 24 wk.The most used PPIs were omeprazole,esomeprazole,rabeprazole,lansoprazole and pantoprazole with a success rate ranging from 18%to 87%.Other composite treatments have been prescribed including PPIs,alginate,prokinetics,and H2 Receptor antagonists.CONCLUSION Regarding the development of MII-pH and the identification of LPRD subtypes(acid,nonacid,mixed),future studies are needed to improve the LPRD treatment considering all subtypes of reflux. | Jerome R Lechien Francois Mouawad Maria R Barillari Andrea Nacci Seyyedeh Maryam Khoddami Necati Enver Sampath Kumar Raghunandhan Christian Calvo-Henriquez Young-Gyu Eun Sven Saussez | 2019 | World Journal of Clinical Cases2019，7，19： | 9 |
| 2 | Immunogenetic phenotypes in inflammatory bowel disease显示文摘当前接受的 etiopathogenic 假设建议长期的肠的发炎和煽动性的肠疾病(IBD ) 的相关全身的表明特征由于对居民钠的过分好攻击或病理学的有免疫力的回答细菌的成分。预先安排的因素是粘膜免疫者回答或障碍功能的基因 dysregulation,与环境刺激触发的发作。这些因素和他们的相互作用可以也是疾病显型和疾病前进的重要决定因素。免疫的出现基因显型把支持借给不同免疫者处理的危险性基因调整的建议假设,由钠抗原开车,表示了接着在 IBD 影响临床的显型的同样特定的有免疫力的显型病人。 | Maria C Dubinsky Kent Taylor Stephan R Targan Jerome I Rotter | 2006 | World Journal of Gastroenterology2006，12，23： | 4 |
| 3 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 4 | Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial显示文摘 | David Laharie Arnaud Bourreille Julien Branche Matthieu Allez Yoram Bouhnik Jerome Filippi Frank Zerbib Guillaume Savoye Maria Nachury Jacques Moreau Jean-Charles Delchier Jacques Cosnes Elena Ricart Olivier Dewit Antonio Lopez-Sanroman Jean-Louis Dupas F | 2012 | The Lancet2012，，9857： | 2 |
| 5 | A change in the premitotic period of the cell cycle is associated with bradyzoite differentiation in Toxoplasma gondii显示文摘 | Jay R Radke Michael N Guerini Maria Jerome | 2003 | Mol Biochem Parasitol2003，131，： | 1 |
| 6 | Association of antibody responses to microbial antigens and complications of small bowel Crohn’s disease显示文摘 | William S. Mow Eric A. Vasiliauskas Ying-Chao Lin Phillip R. Fleshner Konstantinos A. Papadakis Kent D. Taylor Carol J. Landers Maria T. Abreu-Martin Jerome I. Rotter Huiying Yang Stephan R. Targan | 2004 | Gastroenterology2004，，： | 1 |
| 7 | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn’s disease显示文摘 | Maria T. Abreu Kent D. Taylor Ying-Chao Lin Tieu Hang Joanne Gaiennie Carol J. Landers Eric A. Vasiliauskas Lori Y. Kam Micha Rojany Konstantinos A. Papadakis Jerome I. Rotter Stephan R. Targan Huiying Yang | 2002 | Gastroenterology2002，，： | 1 |
| 8 | Determination of GSH, GSSG, and GSNO Using HPLC with Electrochemical Detection显示文摘 | Li-Peng Yap Harsh Sancheti Maria D. Ybanez Jerome Garcia Enrique Cadenas Derick Han | 2010 | Methods in Enzymology2010，，： | 1 |
| 9 | Fibrosis assessment using Fibro Meter combined to first generation tests in hepatitis C显示文摘AIM To evaluate the performance of FibroMeter^(Virus3G) combined to the first generation tests aspartate aminotransferase-to-platelet ratio index(APRI) or Forns index to assess significant fibrosis in chronic hepatitis C(CHC).METHODS First generation tests APRI or Forns were initially applied in a derivation population from Rio de Janeiro in Brazil considering cut-offs previously reported in the literature to evaluate significant fibrosis.FibroMeter^(Virus3G) was sequentially applied to unclassified cases from APRI or Forns.Accuracy of non-invasive combination of tests,APRI plus FibroMeter^(Virus3G) and Forns plus FibroMeter^(Virus3G) was evaluated in the Brazilian derivation population.APRI plus FibroMeter^(Virus3G) combination was validated in a population of CHC patients from Angers in France.All patients were submitted to liver biopsy staged according to METAVIR score by experienced hepatopathologists.Significant fibrosis was considered as METAVIR F≥2.The fibrosis stage classification was used as the reference for accuracy evaluation of non-invasive combination of tests.Blood samples for the calculation of serum tests were collected on the same day of biopsy procedure or within a maximum 3 mo interval and stored at-70 ℃.RESULTS Seven hundred and sixty CHC patients were included(222 in the derivation population and 538 in the validation group).In the derivation population,the FibroMeter^(Virus3G) AUROC was similar to APRI AUROC(0.855 vs 0.815,P=0.06) but higher than Forns AUROC(0.769,P<0.001).The best FibroMeter^(Virus3G) cut-off to discriminate significant fibrosis was 0.61(80% diagnostic accuracy;75% in the validation population,P=0.134).The sequential combination of APRI or Forns with FibroMeter^(Virus3G) in derivation population presented similar performance compared to FibroMeter^(Virus3G) used alone(79% vs 78% vs 80%,respectively,P=0.791).Unclassified cases of significant fibrosis after applying APRI and Forns corresponded to 49% and 54%,respectively,of the total sample.However,the combination of APRI or Forns with FibroMeter^(Virus3G) allowed 73% and 77%,respectively,of these unclassified cases to be correctly evaluated.Moreover,this combination resulted in a reduction of FibroMeter^(Virus3G) requirement in approximately 50% of the entire sample.The stepwise combination of APRI and FibroMeter^(Virus3G) applied to the validation population correctly identified 74% of patients with severe fibrosis(F≥3).CONCLUSION The stepwise combination of APRI or Forns with FibroMeter^(Virus3G) may represent an accurate lower cost alternative when evaluating significant fibrosis,with no need for liver biopsy. | Maria Chiara Chindamo Jerome Boursier Ronir Raggio Luiz Isabelle Fouchard-Hubert Vera Lúcia Nunes Pannain Joao Marcello de Araújo Neto Henrique Sérgio Moraes Coelho Renata de Mello Perez Paul Calès Cristiane Alves Villela-Nogueira | 2017 | World Journal of Hepatology2017，9，6： | 1 |
| 10 | Characteristics of ultrafiltration ceramic membranes derived from alumoxane nanoparticlcs 显示文摘 | Maria M C Jerome R Andrew R B | 2002 | J Membr Sci2002，205，： | 1 |
| 11 | Ceramic membranes derived from ferroxane nanoparticles: a new route for the fabrication of iron oxide ultrafiltration membranes显示文摘 | Maria M C Jerome R George F W | 2003 | J Membr Sci2003，227，： | 1 |
| 12 | NOD2 Variants and Antibody Response to Microbial Antigens in Crohn’s Disease Patients and Their Unaffected Relatives显示文摘 | Shane M. Devlin Huiying Yang Andrew Ippoliti Kent D. Taylor Carol J. Landers Xiaowen Su Maria T. Abreu Konstantinos A. Papadakis Eric A. Vasiliauskas Gil Y. Melmed Phillip R. Fleshner Ling Mei Jerome I. Rotter Stephan R. Targan | 2007 | Gastroenterology2007，，2： | 1 |
| 13 | An open-label pilot study of low-dose thalidomide in chronically active, steroid-dependent Crohn’s disease显示文摘 | Eric A. Vasiliauskas Lori Y. Kam Maria T. Abreu-Martin Philip V. Hassard Kostas A. Papadakis Huiying Yang Jerome B. Zeldis Stephan R. Targan | 1999 | Gastroenterology1999，，6： | 1 |
| 14 | Self-consistent Maxwell–Bloch model for highorder harmonic generation in nanostructured semiconductors显示文摘In pursuit of efficient high-order harmonic conversion in semiconductor devices,modeling insights into the complex interplay among ultrafast microscopic electron–hole dynamics,nonlinear pulse propagation,and field confinement in nanostructured materials are urgently needed.Here,a self-consistent approach coupling semiconductor Bloch and Maxwell equations is applied to compute transmission and reflection high-order harmonic spectra for finite slab and sub-wavelength nanoparticle geometries.An increase in the generated high harmonics by several orders of magnitude is predicted for gallium arsenide nanoparticles with a size maximizing the magnetic dipole resonance.Serving as a conceptual and predictive tool for ultrafast spatiotemporal nonlinear optical responses of nanostructures with arbitrary geometry,our approach is anticipated to deliver new strategies for optimal harmonic manipulation in semiconductor metadevices. | ANTON RUDENKO MARIA K.HAGEN JÖRG HADER STEPHAN W.KOCH JEROME V.MOLONEY | 2022 | Photonics Research2022，10，9： | 0 |
| 15 | Patterns of Gustatory Recovery in Patients Affected by the COVID-19 Outbreak显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a viral infection caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2).From March 2020,several studies indicate that many subjects affected by mild-to-moderate COVID-19 presented olfactory/gustatory dysfunction(OD/GD)that appeared strongly correlated between them but not with the other symptoms suggestive of upper airway infection(Lechien et al.2020a,b;Hopkins et al.2020;Paderno et al.2020). | Carlos M.Chiesa-Estomba Jerome R.Lechien Maria R.Barillari Sven Saussez | 2020 | Virologica Sinica2020，35，6： | 0 |
| 16 | 三大特色成就优良的PC TV解决方案显示文摘In-Stat/MDR分析公司预计.PC TV(电脑电视)调谐器卡将于2009年构成零售价值高达37亿美元的市场,复合年增长率达42.6%。这一预测的快速增长表明.数字家庭正迅速成为联网家庭。人们想要在家里的任何地方享受娱乐,不仅是在电视上,还要在电脑和移动电话上。 | Jerome Morris Maria de la Fuente | 2006 | 电子设计技术 EDN CHINA2006，13，12： | 0 |
| 17 | Physiological and druggable skipping of immunoglobulin variable exons in plasma cells显示文摘The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin(Ig)pre-mRNAs.We recently demonstrated that aberrant Ig chains lacking variable(V)domains can be produced after nonsense-associated altered splicing(NAS)events.Remarkably,the expression of these truncated Ig polypeptides heightens endoplasmic reticulum stress and shortens plasma cell(PC)lifespan.Many questions remain regarding the molecular mechanisms underlying this new truncated Ig exclusion(TIE-)checkpoint and its restriction to the ultimate stage of B-cell differentiation.To address these issues,we evaluated the extent of NAS of Ig pre-mRNAs using an Ig heavy chain(IgH)knock-in model that allows for uncoupling of V exon skipping from TIE-induced apoptosis.We found high levels of V exon skipping in PCs compared with B cells,and this skipping was correlated with a biallelic boost in IgH transcription during PC differentiation.Chromatin analysis further revealed that the skipped V exon turned into a pseudo-intron.Finally,we showed that hypertranscription of Ig genes facilitated V exon skipping upon passive administration of splice-switching antisense oligonucleotides(ASOs).Thus,V exon skipping is coupled to transcription and increases as PC differentiation proceeds,likely explaining the late occurrence of the TIE-checkpoint and opening new avenues for ASO-mediated strategies in PC disorders. | Mohamad Omar Ashi Nivine Srour Jean-Marie Lambert Anne Marchalot Ophelie Martin Sandrine Le Noir Eric Pinaud Maria Victoria Ayala Christophe Sirac Jerome Sauliere Jerome Moreaux Michel Cogne Laurent Delpy | 2019 | Cellular & Molecular Immunology2019，16，10： | 0 |
| 18 | Observatory science with eXTP显示文摘In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s. | Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig Alessandro Riggio Jerome Rodriguez Pablo Rodríguez-Gil Patrizia Romano Agata Rózańska Takanori Sakamoto Tuomo Salmi Ruben Salvaterra andrea Sanna andrea Santangelo Tuomas Savolainen Stéphane Schanne Hendrik Schatz LiJing Shao andy Shearer Steven N.Shore Ben W.Stappers Tod E.Strohmayer Valery F.Suleimanov Jirí Svoboda F.-K.Thielemann Francesco Tombesi Diego F.Torres Eleonora Torresi Sara Turriziani andrea Vacchi Stefano Vercellone Jacco Vink Jian-Min Wang JunFeng Wang Anna L.Watts ShanShan Weng Nevin N.Weinberg Peter J.Wheatley Rudy Wijnands Tyrone E.Woods Stan E.Woosley ShaoLin Xiong YuPeng Xu Zhen Yan George Younes WenFei Yu Feng Yuan Luca Zampieri Silvia Zane andrzej A.Zdziarski Shuang-Nan Zhang Shu Zhang Shuo Zhang Xiao Zhang Michael Zingale | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 0 |
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