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| 1 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 2 | Robust face recognition for uncontrolled pose and illumination chan- ges显示文摘 | Maria D M Michele N Daniel R | 2013 | 1EEE Transactions on Systems Man and Cy- bernetics: Systems2013，43，1： | 1 |
| 3 | Efficient hydrogen peroxide decomposition on bimetallic Pt-Pd surfaces 显示文摘 | Hasnat M A Rahrnan M Maria Borhanuddin S M Siddiqua Ayesha Bahadur N M Karim M R | 2010 | Catalysis Communications2010，12，4： | 1 |
| 4 | A change in the premitotic period of the cell cycle is associated with bradyzoite differentiation in Toxoplasma gondii显示文摘 | Jay R Radke Michael N Guerini Maria Jerome | 2003 | Mol Biochem Parasitol2003，131，： | 1 |
| 5 | Drying and autogenous shrinkage of pastes and mortars with activated slag cement 显示文摘 | Antonio A M N Maria A C Wellington R | 2008 | Cement and Concrete Research2008，38，4： | 1 |
| 6 | An expeditious method for the determination of organochlorine pesticides residues in estuarine sediments using microwave assisted pre-extraction and automated headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry 显示文摘 | Pedro N C Pedro N R Filipe A Rafael E Maria C P Teresa M V | 2008 | Talanta2008，76，5： | 1 |
| 7 | Mechanical properties, dying and autogenous shrinkage of blast furnace slag activated with hydrated lime and gypsum显示文摘 | Antonio A M N Maria A C Wellington R | 2010 | Cement and Concrete Composites2010，32，4： | 1 |
| 8 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 9 | Age of male circumcision and risk of prevalent HIV infection in rural Uganda 显示文摘 | Kelly R Kiwanuka N Maria J W | 1999 | AIDS1999，13，3： | 1 |
| 10 | Hepatic apoptosis and proliferation in male and female rats fed alcohol: role of cytokines显示文摘 | Colantoni A Idilman R De Maria N | 2003 | Alcohol Clin Exp Res2003，27，7： | 1 |
| 11 | Pro up regulation: a diagn illicit use of oestrog ens in adult beef cattle显示文摘 | Divari S Mulasso C Spada F De Maria R gesterone receptor ostic tool for the Uslenghi F Cannizzo FT Brina N Biolatti B | 2011 | Tumour Biol2011，28，12： | 1 |
| 12 | Case 4-1994-a 38-year-old man with AIDS and the recent onset of diarrhea, hematochezia, fever, and pulmonary infiltrates显示文摘 | Basgoz N MaRia A R | 1994 | N Engl J Med1994，330，： | 1 |
| 13 | Gemcitabine,Paclitaxel,and cisplatin as induction chemotherapy for patients with biopsy-proven stage Ⅲ A (N2) nonsmall cell lung carcinoma显示文摘 | Filippo M Fabrizio N Maria R | 2003 | Cancer2003，98，5： | 1 |
| 14 | Aging effect on the refleetivity measurements of polyc hloroprene matrices containing carbon black and carbonyl-iron powder显示文摘 | Magali S P Maria L G Regina C R N | 2001 | Poly- mer Degradation and Stability2001，73，1： | 1 |
| 15 | Passivity-based control of nonlinear chemical processes显示文摘 | Hebertt S R Maria Isabel A N | 1997 | International J Control1997，68，5： | 1 |
| 16 | Design and study of piracetam-like nootropics,controve-rsial members of the problematic of congnition-enhancing drugs显示文摘 | Fulvio G Dina M Maria N R | 2002 | Current Pharmaceutical Design2002，8，2： | 1 |
| 17 | Extender and cryoprotectants for cooling and freezing of piracanjuba(Brycon orbignyanus) semen,an endangered Brazilian teleost fish显示文摘 | MARIA A N VIVERIOS A T M FREITAS R T F | 2006 | Aquaculture2006，26，14： | 1 |
| 18 | Role of endothelin-1 in neovascularation of ovarian carcinoma 显示文摘 | Debora S Valeriana D C Maria R N | 2000 | Am J Pathol2000，157，5： | 1 |
| 19 | Hepatic osteodystrophy: a review显示文摘 | Idilman R de Maria N Uzunalimoglu O | 1997 | Hepatogastroenterology1997，44，14： | 1 |
| 20 | Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study显示文摘 | Katarina Le Blanc Francesco Frassoni Lynne Ball Franco Locatelli Helene Roelofs Ian Lewis Edoardo Lanino Berit Sundberg Maria Ester Bernardo Mats Remberger Giorgio Dini R Maarten Egeler Andrea Bacigalupo Willem Fibbe Olle Ringdén | 2008 | The Lancet . 2008 (9624)2008，，： | 1 |
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