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| 1 | Hepatic echinococcosis:Clinical and therapeutic aspects显示文摘Echinococcosis or hydatid disease(HD)is a zoonosis caused by the larval stages of taeniid cestodes belonging to the genus Echinococcus.Hepatic echinococcosis is a life-threatening disease,mainly differentiated into alveolar and cystic forms,associated with Echinoccus multilocularis(E.multilocularis)and Echinococcus granulosus(E.granulosus)infection,respectively.Cystic echinococcosis(CE)has a worldwide distribution,while hepatic alveolar echinococcosis(AE)is endemic in the Northern hemisphere,including North America and several Asian and European countries,like France,Germany and Austria.E.granulosus young cysts are spherical,unilocular vesicles,consisting of an internal germinal layer and an outer acellular layer.Cyst expan-sion is associated with a host immune reaction and the subsequent development of a fibrous layer,called the pericyst;old cysts typically present internal septations and daughter cysts.E.multilocularis has a tumorlike,infiltrative behavior,which is responsible for tissue destruction and finally for liver failure.The liver is the main site of HD involvement,for both alveolar and cystic hydatidosis.HD is usually asymptomatic for a long period of time,because cyst growth is commonly slow;the most frequent symptoms are fatigue and abdominal pain.Patients may also present jaundice,hepatomegaly or anaphylaxis,due to cyst leakage or rupture.HD diagnosis is usually accomplished with the combined use of ultrasonography and immunodiagnosis;furthermore,the improvement of surgical techniques,the introduction of minimally invasive treatments[such as puncture,aspiration,injection,re-aspiration(PAIR)]and more effective drugs(such as benzoimidazoles)have deeply changed life expectancy and quality of life of patients with HD.The aim of this article is to provide an up-todate review of biological,diagnostic,clinical and therapeutic aspects of hepatic echinococcosis. | Giuseppe Nunnari Marilia R Pinzone Salvatore Gruttadauria Benedetto M Celesia Giordano Madeddu Giulia Malaguarnera Piero Pavone Alessandro Cappellani Bruno Cacopardo | 2012 | World Journal of Gastroenterology2012，18，13： | 72 |
| 2 | Treatment of Helicobacter pylori infection in atrophic gastritis显示文摘Helicobacter pylori(Hp) is a major human pathogen causing chronic, progressive gastric mucosal damage and is linked to gastric atrophy and cancer. Hp-positive individuals constitute the major reservoir for transmission of infection. There is no ideal treatment for Hp. Hp infection is not cured by a single antibiotic, and sometimes, a combined treatment with three or more antibiotics is ineffective. Atrophic gastritis(AG) is a chronic disease whose main features are atrophy and/or intestinal metaplasia of the gastric glands, which arise from long-standing Hp infection. AG is reportedly linked to an increased risk for gastric cancer, particularly when extensive intestinal metaplasia is present. Active or past Hp infection may be detected by conventional methods in about two-thirds of AG patients. By immunoblotting of sera against Hp whole-cell protein lysates, a previous exposure to Hp infection is detected in all AG patients. According to guidelines, AG patients with Hp positivity should receive eradication treatment. The goals of treatment are as follows:(1) Cure of infection, resolution of inflammation and normalization of gastric functions;(2) possible reversal of atrophic and metaplastic changes of the gastric mucosa; and(3) prevention of gastric cancer. An ideal antibiotic regimen for Hp should achieve eradication rates of approximately 90%, and complex multidrug regimens are required to reach this goal. Amongst the factors associated with treatment failure are high bacterial load, high gastric acidity, Hp strain, smoking, low compliance, overweight, and increasing antibiotic resistance. AG, when involving the corporal mucosa, is linked to reduced gastric acid secretion. At a non-acidic intra-gastric p H, the efficacy of the common treatment regimens combining proton pump inhibitors with one or more antibiotics may not be the same as that observed in patients with Hp gastritis in an acid-producing stomach. Although the efficacy of these therapeutic regimens has been thoroughly tested in subjects with Hp infection, there is a paucity of evidence in the subgroupof patients with AG. Bismuth-based therapy may be an attractive treatment in the specific setting of AG, and specific studies on the efficacy of bismuth-based therapies are needed in patients with AG. | Edith Lahner Marilia Carabotti Bruno Annibale | 2018 | World Journal of Gastroenterology2018，24，22： | 57 |
| 3 | Diagnostic and therapeutic management of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is an increasing health problem, representing the second cause of cancerrelated mortality worldwide. The major risk factorfor HCC is cirrhosis. In developing countries, viral hepatitis represent the major risk factor, whereas in developed countries, the epidemic of obesity, diabetes and nonalcoholic steatohepatitis contribute to the observed increase in HCC incidence. Cirrhotic patients are recommended to undergo HCC surveillance by abdominal ultrasounds at 6-mo intervals. The current diagnostic algorithms for HCC rely on typical radiological hallmarks in dynamic contrast-enhanced imaging, while the use of α-fetoprotein as an independent tool for HCC surveillance is not recommended by current guidelines due to its low sensitivity and specificity. Early diagnosis is crucial for curative treatments. Surgical resection, radiofrequency ablation and liver transplantation are considered the cornerstones of curative therapy, while for patients with more advanced HCC recommended options include sorafenib and trans-arterial chemoembolization. A multidisciplinary team, consisting of hepatologists, surgeons, radiologists, oncologists and pathologists, is fundamental for a correct management. In this paper, we review the diagnostic and therapeutic management of HCC, with a focus on the most recent evidences and recommendations from guidelines. | Francesco Bellissimo Marilia Rita Pinzone Bruno Cacopardo Giuseppe Nunnari | 2015 | World Journal of Gastroenterology2015，21，42： | 18 |
| 4 | Helicobacter pylori infection in obesity and its clinical outcome after bariatric surgery显示文摘The present review summarizes the prevalence and active clinical problems in obese patients with Helicobacter pylori(H.pylori)infection,as well as the outcomes after bariatric surgery in this patient population.The involvement of H.pylori in the pathophysiology of obesity is still debated.It may be that the infection is protective against obesity,because of the gastritis-induced decrease in production and secretion of the orexigenic hormone ghrelin.However,recent epidemiological studies have failed to show an association between H.pylori infection and reduced body mass index.H.pylori infection might represent a limiting factor in the access to bariatric bypass surgery,even if highquality evidence indicating the advantages of preoperative H.pylori screening and eradication is lacking.The clinical management of infection is complicated by the lower eradication rates with standard therapeutic regimens reported in obese patients than in the normalweight population.Prospective clinical studies to ameliorate both H.pylori eradication rates and control the clinical outcomes of H.pylori infection after different bariatric procedures are warranted. | Marilia Carabotti Chiara D'Ercole Angelo Iossa Enrico Corazziari Gianfranco Silecchia Carola Severi | 2014 | World Journal of Gastroenterology2014，20，3： | 3 |
| 5 | The application of electrochemical technology to the remediation of oily wastewater显示文摘 | Marcos R G Santos Marilia O F Goulart Josealdo Tonholo | 2006 | Chemosphere2006，64，3： | 1 |
| 6 | Metforminamplifies chemotherapy-induced AMPK activation and anti-tumoral growth 显示文摘 | Guilherme ZR Marilia MD Eduardo RR | 2011 | Clin Cancer Res2011，17，： | 1 |
| 7 | Leukopenia and thrombocytopenia induced byetanercept:two case reports and literature review显示文摘 | ValderilioFeijo Azevedo Marilia Barreto Gameiro Silva DeboraKarine Marinello | 2012 | Rev Bras Reumatol2012，52，1： | 1 |
| 8 | Survival of hemodialysis patients: modeling differences in risk of dialysis centers显示文摘 | Marilia S Robin H Silvia S | 2003 | Int J Qual Health Care2003，15，5： | 1 |
| 9 | Cloning and Characterization of ZmPIPI-5b,an aquaporin transparting water and urea显示文摘 | Marilia Gaspar Agnes Bousser Igor Sissoeff | 2003 | Plant Science2003，165，： | 1 |
| 10 | Metformin: an old but still the best treatment for type 2 diabetes显示文摘 | Lilian Beatriz Aguayo Rojas Marilia Brito Gomes | 2013 | Di- abetology &Metabolic Syndrome2013，5，： | 1 |
| 11 | Genetic testing vs microforceps biopsy in pancreatic cysts:Systematic review and meta-analysis显示文摘BACKGROUND Carcinoembryonic antigen(CEA)and cytology in pancreatic cystic fluid are suboptimal for evaluation of pancreatic cystic neoplasms.Genetic testing and microforceps biopsy are promising tools for pre-operative diagnostic improvement but comparative performance of both methods is unknown.AIM To compare the accuracy of genetic testing and microforceps biopsy in pancreatic cysts referred for surgery.METHODS We performed a literature search in Medline,Scopus,and Web of Science for studies evaluating genetic testing of cystic fluid and microforceps biopsy of pancreatic cysts,with endoscopic ultrasound with fine-needle aspiration(EUSFNA)prior to surgery and surgical pathology as reference standard for diagnosis.We evaluated the diagnostic accuracy for:1-benign cysts;2-mucinous low-risk cysts;3-high-risk cysts,and the diagnostic yield and rate of correctly identified cysts with microforceps biopsy and molecular analysis.We also assessed publication bias,heterogeneity,and study quality.RESULTS Eight studies,including 1206 patients,of which 203(17%)referred for surgery who met the inclusion criteria were analyzed in the systematic review,and seven studies were included in the meta-analysis.Genetic testing and microforceps biopsies were identical for diagnosis of benign cysts.Molecular analysis was superior for diagnosis of both low and high-risk mucinous cysts,with sensitivities of 0.89(95%CI:0.79-0.95)and 0.57(95%CI:0.42-0.71),specificities of 0.88(95%CI:0.75-0.95)and 0.88(95%CI:0.80-0.93)and AUC of 0.9555 and 0.92,respectively.The diagnostic yield was higher in microforceps biopsies than in genetic analysis(0.73 vs 0.54,respectively)but the rates of correctly identified cysts were identical(0.73 with 95%CI:0.62-0.82 vs 0.71 with 95%CI:0.49-0.86,respectively).CONCLUSION Genetic testing and microforceps biopsies are useful second tests,with identical results in benign pancreatic cysts.Genetic analysis performs better for low-and high-risk cysts but has lower diagnostic yield. | Sandra Faias Luisa Pereira Angelo Luis Paula Chaves Marilia Cravo | 2019 | World Journal of Gastroenterology2019，25，26： | 1 |
| 12 | Reconstruction of large cranial defects in nonimmunosuppressed experimental design with human dental pulp stem cells显示文摘 | Andre DE Daniela F Marilia T | 2008 | J Cranio Surg2008，19，1： | 1 |
| 13 | The application of electrochemical technology to the remediation of oily wastewater显示文摘 | Marcos R.G. Santos Marilia O.F. Goulart Josealdo Tonholo Carmem L.P.S. Zanta | 2005 | Chemosphere2005，，3： | 1 |
| 14 | Impact of Diabetes on Cardiovascular Disease: An Update显示文摘 | Alessandra Saldanha de Mattos Matheus Lucianne Righeti Monteiro Tannus Roberta Arnoldi Cobas Catia C. Sousa Palma Carlos Antonio Negrato Marilia de Brito Gomes Mario Fritsch Neves | 2013 | International Journal of Hypertension2013，，： | 1 |
| 15 | Impact of Laparoscopic Sleeve Gastrectomy on Upper Gastrointestinal Symptoms显示文摘 | Marilia Carabotti Gianfranco Silecchia Francesco Greco Frida Leonetti Luca Piretta Marco Rengo Mario Rizzello John Osborn Enrico Corazziari Carola Severi | 2013 | Obesity Surgery2013，，10： | 1 |
| 16 | Influencec of particle size and reagent dosage on the performance of apatite flotation显示文摘 | Ricardo C S Ana C C F Marilia C C F | 2008 | Sep- aration and Purification Technology2008，64，： | 1 |
| 17 | Electrochemi- cal study of methyl 2-- acrylate, an anticancer drug, In the presence of GSH and dsD- NA 显示文摘 | Marilia O F Goulart A A de Souza E M Sales | 2007 | ECS Transactions2007，3，29： | 1 |
| 18 | Osmophore and elaiophores of Grobya amherstiae (Catasetinae, Orchidaceae)and their relatian to pollination显示文摘 | LUDMILA M P MARILIA D M C MARIJES S | 2009 | Botanical Journal of the Linnean Society2009，159，： | 1 |
| 19 | Xenotransplantation and other means of organ replacement显示文摘 | MARILIA C JEFFREY LP | 2001 | Nat Rev Immunol2001，1，2： | 1 |
| 20 | Development and Application of a Capillary Electrophoresis Based Method for the Simultaneous Screening of Six Antibiotics in Spiked Milk Samples显示文摘 | S'ergio M Santos Marilia Henrlques Armando C Duarte | 2007 | Talanta2007，71，： | 1 |
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