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| 1 | Superchiral near fields detect virus structure显示文摘Optical spectroscopy can be used to quickly characterise the structural properties of individual molecules.However,it cannot be applied to biological assemblies because light is generally blind to the spatial distribution of the component molecules.This insensitivity arises from the mismatch in length scales between the assemblies(a few tens of nm)and the wavelength of light required to excite chromophores(≥150 nm).Consequently,with conventional spectroscopy,ordered assemblies,such as the icosahedral capsids of viruses,appear to be indistinguishable isotropic spherical objects.This limits potential routes to rapid high-throughput portable detection appropriate for point-of-care diagnostics.Here,we demonstrate that chiral electromagnetic(EM)near fields,which have both enhanced chiral asymmetry(referred to as superchirality)and subwavelength spatial localisation(∼10 nm),can detect the icosahedral structure of virus capsids.Thus,they can detect both the presence and relative orientation of a bound virus capsid.To illustrate the potential uses of the exquisite structural sensitivity of subwavelength superchiral fields,we have used them to successfully detect virus particles in the complex milieu of blood serum. | Tarun Kakkar Chantal Keijzer Marion Rodier Tatyana Bukharova Michael Taliansky Andrew J.Love Joel J.Milner Affar S.Karimullah Laurence D.Barron Nikolaj Gadegaard Adrian J.Lapthorn Malcolm Kadodwala | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 2 | 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial显示文摘 | Ian Smith Marion Procter Richard D Gelber Sébastien Guillaume Andrea Feyereislova Mitch Dowsett Aron Goldhirsch Michael Untch Gabriella Mariani Jose Baselga Manfred Kaufmann David Cameron Richard Bell Jonas Bergh Robert Coleman Andrew Wardley Nadia Harbec | 2007 | The Lancet2007，，9555： | 1 |
| 3 | Porcine interleukin-3 enhances DNA vaccination against classical swine fever 显示文摘 | Marion Andrew Kirsten Morris Barbara Coupar | 2006 | Vaccine2006，24，： | 1 |
| 4 | Diverse functional outcomes of P lasmodium falciparum ligation of EPCR:potential implications for malarial pathogenesis显示文摘 | Mark RG Marion A Andrew J | 2015 | Cell Microbiol2015，17，12： | 1 |
| 5 | 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial显示文摘 | Ian Smith Marion Procter Richard D Gelber Sébastien Guillaume Andrea Feyereislova Mitch Dowsett Aron Goldhirsch Michael Untch Gabriella Mariani Jose Baselga Manfred Kaufmann David Cameron Richard Bell Jonas Bergh Robert Coleman Andrew Wardley Nadia Harbec | 2007 | The Lancet2007，，9555： | 1 |
| 6 | Transcytosis of retionol-binding protein across renal proximal tuble cells after megalin (gp330)mediated endocytosis显示文摘 | Marion M Andrews D Brown D | 2001 | Am Soc Nephrol2001，12，： | 1 |
| 7 | 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial显示文摘 | Ian Smith Marion Procter Richard D Gelber Sébastien Guillaume Andrea Feyereislova Mitch Dowsett Aron Goldhirsch Michael Untch Gabriella Mariani Jose Baselga Manfred Kaufmann David Cameron Richard Bell Jonas Bergh Robert Coleman Andrew Wardley Nadia Harbec | 2007 | 2007 (9555)2007，，9555： | 1 |
| 8 | Transcytosis of retionol-binding protein across renal proximal tuble cells after megalin (gp330) mediated endocytosis显示文摘 | Marion M Andrews D Brown D | 2001 | Am Soc Nephrol2001，12，： | 1 |
| 9 | Identification of a regulatory autophosphorylation site in the serine–threonine kinase RIP2显示文摘 | Marion Dorsch Anlai Wang Hong Cheng Chafen Lu Andrew Bielecki Kathryn Charron Karl Clauser Hong Ren Roberto D. Polakiewicz Tom Parsons Ping Li Tim Ocain Yajun Xu | 2006 | Cellular Signalling2006，，12： | 1 |
| 10 | Tropical forest canopies and their relationships with climate and disturbance: results from a global dataset of consistent field-based measurements显示文摘Background: Canopy structure, defined by leaf area index(LAI), fractional vegetation cover(FCover) and fraction of absorbed photosynthetically active radiation(f APAR), regulates a wide range of forest functions and ecosystem services. Spatially consistent field-measurements of canopy structure are however lacking, particularly for the tropics.Methods: Here, we introduce the Global LAI database: a global dataset of field-based canopy structure measurements spanning tropical forests in four continents(Africa, Asia, Australia and the Americas). We use these measurements to test for climate dependencies within and across continents, and to test for the potential of anthropogenic disturbance and forest protection to modulate those dependences.Results: Using data collected from 887 tropical forest plots, we show that maximum water deficit, defined across the most arid months of the year, is an important predictor of canopy structure, with all three canopy attributes declining significantly with increasing water deficit. Canopy attributes also increase with minimum temperature, and with the protection of forests according to both active(within protected areas) and passive measures(through topography). Once protection and continent effects are accounted for, other anthropogenic measures(e.g. human population) do not improve the model.Conclusions: We conclude that canopy structure in the tropics is primarily a consequence of forest adaptation to the maximum water deficits historically experienced within a given region. Climate change, and in particular changes in drought regimes may thus affect forest structure and function, but forest protection may offer some resilience against this effect. | marion pfeifer alemu gonsamo william woodgate luis cayuela andrew r.marshall alicia ledo timothy c.e.paine rob marchant andrew burt kim calders colin courtney-mustaphi aida cuni-sanchez nicolas j.deere dereje denu jose gonzalez de tanago robin hayward alvaro lau manuel j.macía pieter i.olivier petri pellikka hamidu seki deo shirima rebecca trevithick beatrice wedeux charlotte wheeler pantaleo k.t.munishi thomas martin abdul mustari philip j.platts | 2018 | Forest Ecosystems2018，5，1： | 1 |
| 11 | Multistate Outbreak of Fungal Infection Associated with Injection of Methylprednisolone Acetate Solution from a Single Compounding Pharmacy - United States, 2012显示文摘 | Kainer Marion Wiese Andrew D Benedict Kaitlin Braden Chris Brandt Mary Harris Julie Park Benjamin J Guh Alice Jernigan John Schaefer Melissa Weber J Todd Wise Matt Smith Rachel M Nguyen Duc | 2012 | EN2012，，41： | 1 |
| 12 | Transcytosis of retinol-binding protein across renal proixmal tuble cells after megalin(gp330)-mediated endocytosis显示文摘 | Marion M Andrews D Brown D et a1 | 2001 | Am Soc Nephrol2001，12，： | 1 |
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