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| 1 | Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis显示文摘AIM:To investigate the association of macrophage migration inhibitory factor(MIF)promoter polymorphisms with inflammatory bowel disease(IBD)risk.METHODS:One thousand and six New Zealand Caucasian cases and 540 Caucasian controls were genotyped for the MIF SNP-173G>C(rs755622)and the repeat polymorphism CATT5-8(rs5844572)using a predesigned TaqMan SNP assay and capillary electrophoresis,respectively.Data were analysed for single site and haplotype association with IBD risk and phenotype.Meta-analysis was employed,to assess cumulative evidence of association of MIF-173G>C with IBD.All published genotype data for MIF-173G>C in IBD were identified using PubMed and subsequently searching the references of all PubMed-identified studies.Imputed genotypes for MIF-173G>C were generated from the Wellcome Trust Case Control Consortium(and National Institute of Diabetes and Digestive and Kidney Diseases).Separate meta-analyses were performed on Caucasian Crohn’s disease(CD)(3863 patients,6031controls),Caucasian ulcerative colitis(UC)(1260 patients,1987 controls),and East Asian UC(416 patients and 789 controls)datasets using the Mantel-Haenszel method.The New Zealand dataset had 93%power,and the meta-analyses had 100%power to detect an effect size of OR=1.40 atα=0.05,respectively.RESULTS:In our New Zealand dataset,single-site analysis found no evidence of association of MIF polymorphisms with overall risk of CD,UC,and IBD or disease phenotype(all P values>0.05).Haplotype analysis found the CATT5/-173C haplotype occurred at a higher frequency in New Zealand controls compared to IBD patients(0.6 vs 0.01;P=0.03,OR=0.22;95%CI:0.05-0.99),but this association did not survive bonferroni correction.Meta-analysis of our New Zealand MIF-173G>C data with data from seven additional Caucasian datasets using a random effects model found no association of MIF polymorphisms with CD,UC,or overall IBD.Similarly,meta-analysis of all published MIF-173G>C data from East Asian datasets(416UC patients,789 controls)found no association of this promoter polymorphism with UC. | James D Falvey Robert W Bentley Tony R Merriman Mark B Hampton Murray L Barclay Richard B Gearry Rebecca L Roberts | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Assessment of lymph node involvement in colorectal cancer显示文摘Lymph node metastasis informs prognosis and is a key factor in deciding further management, particularly adjuvant chemotherapy. It is core to all contemporary staging systems, including the widely used tumor node metastasis staging system. Patients with nodenegative disease have 5-year survival rates of 70%-80%, implying a significant minority of patients with occult lymph node metastases will succumb to disease recurrence. Enhanced staging techniques may help to identify this subset of patients, who might benefit from further treatment. Obtaining adequate numbers of lymph nodes is essential for accurate staging. Lymph node yields are affected by numerous factors, many inherent to the patient and the tumour, but others related to surgical and histopathological practice. Good lymph node recovery relies on close collaboration between surgeon and pathologist. The optimal extent of surgical resection remains a subject of debate. Extended lymphadenectomy, extra-mesenteric lymph node dissection, high arterial ligation and complete mesocolic excision are amongst the surgical techniques with plausible oncological bases, but which are not supported by the highest levels of evidence. With further development and refinement, intra-operative lymphatic mapping and sentinel lymph node biopsy may provide a guide to the optimum extent of lymphadenectomy, but in its present form, it is beset by false negatives, skip lesions and failures to identify a sentinel node. Once resected, histopathological assessment of the surgical specimen can be improved by thorough dissection techniques, step-sectioning of tissue blocks and immunohistochemistry. More recently, molecular methods have been employed. In this review, we consider the numerous factors that affect lymph node yields, including the impact of the surgical and histopathological techniques. Potential future strategies, including the use of evolving technologies, are also discussed. | Mark L H Ong John B Schofield | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 8 |
| 3 | Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis显示文摘 | Liu Weicheng Chen Yunzi Golan Maya Aharoni Annunziata Maria L Du Jie Dougherty Urszula Kong Juan Musch Mark Huang Yong Pekow Joel Zheng Changqing Bissonnette Marc Hanauer Stephen B Li Yan Chun | 2013 | Journal of Clinical Investigation2013，，9： | 2 |
| 4 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 5 | Extraction fraction and characterization of structural polysaccharides from wheat straw显示文摘 | MARK L J SUN Runcang BANKS W B | 1995 | Journal of Agricultural and Food Chemistry1995，43，3： | 1 |
| 6 | Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization显示文摘 | Lieben Liesbet Masuyama Ritsuko Torrekens Sophie Van Looveren Riet Schrooten Jan Baatsen Pieter Lafage-Proust Marie-Hélène Dresselaers Tom Feng Jian Q Bonewald Lynda F Meyer Mark B Pike J Wesley Bouillon Roger Carmeliet Geert | 2012 | EN2012，，5： | 1 |
| 7 | Amiodarone or an implant- able cardioverter-defibrillator for congestive heart failure 显示文摘 | Bardy G H Lee K L Mark D B | 2005 | N Engl J Med2005，352，3： | 1 |
| 8 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
| 9 | Choice of methodology for assessing genetic impacts of environmental stressors:Polymorphism and reproducibility of RAPD and AFLP fingerprints显示文摘 | Mark J B Susan L A Bernie M 2001 | 2001 | Ecotoxicology2001，10，： | 1 |
| 10 | Hemostatic function and progressing ischemic stroke D-dimer predicts early clinical progression显示文摘 | Mark B Peter L Ann R | 2004 | Stroke2004，35，： | 1 |
| 11 | Hemostatic function and progressing ischemic stroke D-dimer predicts early clinical progressi on显示文摘 | MARK B PETER L ANN R | 2004 | Stroke2004，35，6： | 1 |
| 12 | Patterns in nutrient availability and plant diversity of temperate North American wetlands显示文摘 | Barbara L B Mark RW Allison A | 1999 | Ecology1999，7，： | 1 |
| 13 | Using plasma transforming growth factor beta-1 during radiotherapy to select patients for dose escalation显示文摘 | Anscher M S Marks L B Shafman T D | | 0，，17： | 1 |
| 14 | Environ Sci Technol 显示文摘 | Snoeyink V L Weber W J Mark H B | 1969 | 3(10): 9181969，3，10： | 1 |
| 15 | Estimation of maximum interfer- ence-free transmit power level for opportunistic spec- trum access显示文摘 | Mark B L Nasif A O | 1999 | IEEE Tran Wireless Communication1999，8，5： | 1 |
| 16 | Role of aerobic fitness and aging on cerebral white matter integrity 显示文摘 | MARKS B L MADDEN D J BUCUR B | 2007 | Ann NY Acad Sci2007，1097，： | 1 |
| 17 | How limiting factors drive agricultural adaptation to climate change显示文摘 | Meredith T N Mark L Margaret B | 2015 | Agriculture Ecosystem&Environment2015，200，： | 1 |
| 18 | Vapor Recovery of Natural Gas Using Non - Mechanical Technology 显示文摘 | Mark A Alexandra L john B | 2003 | SPE 805992003，，： | 1 |
| 19 | Effect of stacking sequence on micro-cracking in a cryogenically cycled carbon/ bismaleimide composite 显示文摘 | Bethel V T Mark B F Steven L D | 2003 | Composites: Part A2003，34，7： | 1 |
| 20 | Hemostatic function and progress-ing ischemic stroke D-dimer predicts early clinical progression显示文摘 | Mark B Peter L Ann R | 2004 | Stroke2004，35，： | 1 |
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