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| 1 | Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis显示文摘AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy.METHODS We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were used.RESULTS A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were reported.CONCLUSION In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course. | Animesh Jain Evan J Lipson William H Sharfman Steven R Brant Mark G Lazarev | 2017 | World Journal of Gastroenterology2017，23，11： | 8 |
| 2 | Acute liver failure due to natural killer-like T-cell leukemia/ lymphoma: A case report and review of the Literature显示文摘尖锐的肝失败(ALF ) 是为肝移植要求立即的评估的一种医药紧急情况。我们描述与腹水,黄疸,和脑病介绍了并且被发现由于象 T 房间白血病 / 淋巴瘤一样的生来的杀手(NK ) 有 ALF 的一个病人的一个不平常的盒子。关键免疫显型是 CD2+ , CD3+ , CD7+ , CD56+ 。这诊断,在外部血和腹水基于调查结果,与肝活体检视被证实,并且是到肝移植的禁止徵候。hematologic 恶意是暴发性的肝的失败的一个不平常的原因的文学表演的评论,和那个象 NK 一样 T 房间白血病 / 淋巴瘤是一最近相对表示特性地认出了是的实体 CD3+ 和 CD56+ 。这个盒子证明那肝活体检视在与淋巴瘤 / 白血病能引起尖锐的肝失败的象 NK 一样 T 房间诊断肝的尖锐的肝失败,和那渗入的不平常的原因是必要的。 | Evan S Dellon Shannon R Morris Wozhan Tang Cherie H Dunphy Mark W Russo | 2006 | World Journal of Gastroenterology2006，12，25： | 5 |
| 3 | The chemistry and biology of febrifugine and halofuginone显示文摘 | Noel P. McLaughlin Paul Evans Mark Pines | 2014 | Bioorganic & Medicinal Chemistry2014，，： | 3 |
| 4 | Low-radiation and high image quality coronary computed tomography angiography in “real-world” unselected patients显示文摘AIM To determine the radiation dose and image quality in coronary computed tomography angiography(CCTA)using state-of-the-art dose reduction methods in unselected'real world'patients.METHODS In this single-centre study,consecutive patients in sinus rhythm underwent CCTA for suspected coronary artery disease(CAD)using a 320-row detector CT scanner.All patients underwent the standard CT acquisition protocol at our institute(Morriston Hospital)a combination of dose saving advances including prospective electrocardiogram-gating,automated tube current modulation,tube voltage reduction,heart rate reduction,and the most recent novel adaptive iterative dose reconstruction 3D(AIDR3D)algorithm.The cohort comprised real-world patients for routine CCTA who were not selected on age,body mass index,or heart rate.Subjective image quality was graded on a 4-point scale(4=excellent,1=non-diagnostic).RESULTS A total of 543 patients were included in the study with a mean body weight of 81±18 kg and a pre-scan mean heart rate of 70±11 beats per minute(bpm).When indicated,patients received rate-limiting medication with an oral beta-blocker followed by additional intravenous beta-blocker to achieve a heart rate below 65 bpm.The median effective radiation dose was 0.88 mSv(IQR,0.6-1.4 mSv)derived from a Dose Length Product of61.45 mGy.cm(IQR,42.86-100.00 mGy.cm).This also includes what we believe to be the lowest ever-reported radiation dose for a routine clinical CCTA(0.18 mSv).The mean image quality(SD)was 3.65±0.61,with a subjective image quality score of 3('good')or above for 93%of patient CCTAs.CONCLUSION Combining a low-dose scan protocol and AIDR3D with a 320-detector row CT scanner can provide high quality images at exceptionally low radiation dose in unselected patients being investigated for CAD. | Caryl Elizabeth Richards Stephen Dorman Patricia John Anthony Davies Sharon Evans Tishi Ninan David Martin Sriranj Kannoly Gail Roberts-Davies Mark Ramsey Daniel Rhys Obaid | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 5 | Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients with Acute Alcoholic Hepatitis显示文摘 | Lee J.L. Markwick Antonio Riva Jennifer M. Ryan Helen Cooksley Elena Palma Tom H. Tranah Godhev K. Manakkat Vijay Nikhil Vergis Mark Thursz Alex Evans Gavin Wright Sarah Tarff John O’Grady Roger Williams Debbie L. Shawcross Shilpa Chokshi | 2014 | Gastroenterology2014，，： | 2 |
| 6 | Genetic variation and potential coinfection of Wolbachia among widespread Asian citrus psyllid (Diaphorina citri Kuwayama) populations显示文摘Wolbachia can profoundly influence the survival, reproduction, and defenses of insect hosts. These interactions could potentially be harnessed for managing pests or insecttransmitted diseases. Diaphorina citri Kuwayama is a phloem-feeding pest capable of transmitting the putative causal agent of citrus greening, Candidatus Liberibacter asiaticus (CLas). Like many insects, D. citri is also infected with Wolbachia (wDi). Recent studies indicate that the relative abundance of wDi could be associated with the abundance of CLas, and that wDi may contribute to regulating expression of phage lytic cycle genes in CLas, suggesting the need for better understanding of wDi biology in general. This study investigated the genetic diversity of wDi among D. citri in populations spanning eleven countries and two U.S. territories. Six Wolbachia genes, wsp, coxA.fbpA.ftsZ, gatB, and hep A, were sequenced and compared across samples. Two prevalent wDi strains were identified across the samples, and screening of clone libraries revealed possible coinfection of wDi strains in specific populations. D. citri mitochondrial cytochrome oxidase subunit I gene (mtCOI) were more divergent between D. citri populations that were infected with different wDi strains or had different infection statuses (single infection vs. coinfection). While we could not eliminate the possibility that maternal transmission may contribute to such patterns, it is also possible that wDi may induce cytoplasmic incompatibility in their host. These fin dings should contribute to the understanding of wDi population ecology, which may facilitate manipulation of this endosymbiont for management of citrus greening disease worldwide. | Chia-Ching Chu Mark Hoffmann W. Evan Braswell Kirsten S. Pelz-Stelinski | 2019 | Insect Science2019，26，4： | 2 |
| 7 | Yttrium-90 microsphere selective internal radiation therapy for liver metastases following systemic chemotherapy and surgical resection for metastatic adrenocortical carcinoma显示文摘Adrenocortical carcinoma(ACC)is a rare malignancy with generally poor outcomes and limited treatment options.While surgical resection can be curative for early local disease,most patients present with advanced ACC owing to nonspecific symptoms.For those patients,treatment options include systemic chemotherapy and locoregional therapies including radiofrequency ablation and transarterial chemoembolization.We present the first reported case of utilizing yttrium-90 microsphere selective internal radiation therapy(SIRT)in combination with first line EDP-M(Etoposide,Doxorubicin,Cisplatin,Mitotane)chemotherapy and debulking surgical primary tumor resection for treatment of metastatic ACC.Stable complete radiologic response has been maintained after twelve months with resolution of clinical symptoms.These findings prompt the need for further consideration and studies to elucidate the role of SIRT in combination with systemic and surgical treatment for metastatic ACC. | Mina S Makary Lawrence S Krishner Evan J Wuthrick Mark P Bloomston Joshua D Dowell | 2018 | World Journal of Clinical Oncology2018，9，1： | 2 |
| 8 | Impact of surgery on immunologic function: comparison between minimally invasive techniques and conventional laparotomy for surgical resection of colorectal tumors显示文摘 | Charles Evans Christine Galustian Devinder Kumar Robert Hagger David M. Melville Mark Bodman-Smith Ian Jourdan Andrew M. Gudgeon Angus G. Dalgleish | 2009 | The American Journal of Surgery2009，，2： | 2 |
| 9 | Salary Caps And Competitve Balance In Professinal Sports Leagues显示文摘 | Evan S T Mark F O | 2011 | Joumal For Economic Education2011，，2： | 1 |
| 10 | The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels显示文摘 | Antony Galione A. Mark Evans Jianjie Ma John Parrington Abdelilah Arredouani Xiaotong Cheng Michael X. Zhu | | 0，2009，： | 1 |
| 11 | Bis(oxazoline)-copper complexes as chiral catalysts for the enantioselective aziridination of olefins 显示文摘 | DAVID A EVANS MARGARET M MARK T | 1993 | J Am Chem Soc1993，115，12： | 1 |
| 12 | Membrane compliance and liquefaction of sluiced gravel specimens显示文摘 | Evans Mark D Seed H Bnlton Seed Raymond B | 1995 | Journal of Geotechnical Engineering1995，118，6： | 1 |
| 13 | 显示文摘 | Mark D Mowery Amethyst Cook Smith Christine E Evans | 2000 | Langmuir2000，16，： | 1 |
| 14 | Ultrasound criteria for severe in-stent restenosis following carotid artery stenting显示文摘 | Wei Zhou Deborah D. Felkai Mark Evans Sally A. McCoy Peter H. Lin Panagiotos Kougias Hosam F. El-Sayed Alan B. Lumsden | 2008 | Journal of Vascular Surgery2008，，1： | 1 |
| 15 | Lead(Pb+2)promotes apoptosis in newborn rat cerebellar neurons:path-ologic implications显示文摘 | OBERTO A MARKS N EVANS H L | 1996 | J Pharmacol Exp Ther1996，279，1： | 1 |
| 16 | Hypoxic pulmonary vasoconstriction-in-vites article显示文摘 | Mark Evans A Ward J P | 2009 | Adv Exp Med Bio2009，648，： | 1 |
| 17 | Lead (Pb2+ ) promotes apoptosis in newborn rat cerebellar neurons: pathological implications显示文摘 | Oberto A Marks N Evans H | 1996 | J PharmacolExpTher1996，279，： | 1 |
| 18 | Prod- uct service systems and supply chain network relationships: an exploratory case study显示文摘 | Helen Lockett Mark Johnson Steve Evans Marko Bastl | 2011 | Journal of Manufacturing Tech- nology Management2011，22，3： | 1 |
| 19 | Liquefaction Behavior of Sand-Gravel Composites显示文摘 | Mark D. Evans Shengping Zhou | 1995 | Journal of Geotechnical Engineering1995，，3： | 1 |
| 20 | The UK Prospective Diabetes study 显示文摘 | Mark Evans | 1998 | The Lancet1998，352，： | 1 |
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