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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Yttrium-90 microspheres for the treatment of hepatocellular carcinoma显示文摘 | Jean Francois H. Geschwind Riad Salem Brian I. Carr Michael C. Soulen Kenneth G. Thurston Kathleen A. Goin Mark van Buskirk Carol A. Roberts James E. Goin | 2004 | Gastroenterology2004，，： | 2 |
| 3 | Efficacy of polymeric encapsulated C5a peptidase–based group B streptococcus vaccines in a murine model显示文摘 | Donna A. Santillan Karishma K. Rai Mark K. Santillan Yogita Krishnamachari Aliasger K. Salem Stephen K. Hunter | 2011 | American Journal of Obstetrics and Gynecology2011，，3： | 2 |
| 4 | Waist-to-Hip Ratio, Body Mass Index, and Subsequent Kidney Disease and Death显示文摘 | Essam F. Elsayed Mark J. Sarnak Hocine Tighiouart John L. Griffith Tobias Kurth Deeb N. Salem Andrew S. Levey Daniel E. Weiner | 2008 | American Journal of Kidney Diseases2008，，1： | 1 |
| 5 | Cationic Colloidal Silica Membrane Perturbation as a Means of Examining Changes at the Sinusoidal Surface during Liver Regeneration显示文摘 | Donna Beer Stolz Mark A. Ross Hebah M. Salem Wendy M. Mars George K. Michalopoulos Katsuhiko Enomoto | 1999 | The American Journal of Pathology1999，，5： | 1 |
| 6 | Treatment of Unresectable Hepatocellular Carcinoma with Intrahepatic Yttrium 90 Microspheres: Factors Associated with Liver Toxicities显示文摘 | James E. Goin Riad Salem Brian I. Carr Janet E. Dancey Michael C. Soulen Jean Francois H. Geschwind Kathleen Goin Mark Van Buskirk Kenneth Thurston | 2005 | Journal of Vascular and Interventional Radiology2005，，2： | 1 |
| 7 | Use and barriers to chromoendoscopy for dysplasia surveillance in inflammatory bowel disease显示文摘Traditionally,patients with inflammatory bowel disease(IBD) have been thought to be at increased risk of developing colitis-associated colorectal cancer.Although there are recent data suggesting that rates of colitisassociated cancer in IBD patients is declining,current guidelines still recommend regular dysplasia surveillance for early detection and prevention of neoplasia in patients with IBD.White-light endoscopy with random biopsies has been the traditional approach for dysplasia detection;however,newer technologies and approaches have emerged.One method,dye-based chromoendoscopy,has the potential to detect more dysplasia.However,longitudinal data to showing a benefit in morbidity or mortality from the use of chromoendoscopy are still lacking.Many societies have included recommendation on the use of chromoendoscopy with targeted biopsies as a method of surveillance for colitis-associated colorectal cancer.This narrative review seeks to outline data on dysplasia detection as well as barriers to the implementation of dye-based chromoendoscopy for the prevention and early detection of colitis-associated colorectal cancer. | Richa Shukla Mark Salem Jason K Hou | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，8： | 1 |
| 8 | Waist-to-Hip Ratio and Body Mass Index as Risk Factors for Cardiovascular Events in CKD显示文摘 | Essam F. Elsayed Hocine Tighiouart Daniel E. Weiner John Griffith Deeb Salem Andrew S. Levey Mark J. Sarnak | 2008 | American Journal of Kidney Diseases2008，，1： | 1 |
| 9 | 湖泊沉积物磁学特征指示的埃及Faiyum盆地全新世以来的环境演变显示文摘利用埃及北部Faiyum盆地获得的高取芯率沉积物岩芯,进行沉积物多种磁性参数的测量,结合有机碳、介形虫、粒度等分析,在AMS14C加速器测年的基础上,建立全新世以来湖泊沉积物磁性特征变化的时间序列.结果表明,粒度效应以及沉积后的各种次生作用对沉积物的磁性特征没有明显的影响,磁性变化主要反映了沉积物不同来源组成的相对变化.全新世前沉积物磁性较弱,主要含不完全反铁磁性矿物,与周边沙漠的物质相似,结合其粒度特征,沉积物来源应以近源物质为主.全新世早中期(约10 5.4 ka BP)沉积物磁性变化相对稳定,有机质含量也较高,指示了来自尼罗河较为稳定的物质供应;而大约5.4 ka BP尤其最近约4.2 ka BP以来,磁性的明显变化反映了流域降水减少情况下,来自青尼河物质贡献的相对增加;最近约2.0 ka BP以来沉积物的磁性变化,则更多地与盆地人类活动的强化有关.总体而言,Faiyum盆地全新世以来的环境演变主要受控于全新世以来尼罗河与盆地的水力学联系.即:全新世前盆地未与尼罗河连通时,沉积物主要来源于周边沙漠的风成物质;而受全新世早-中期来流域季风降水增加的影响,泛滥的尼罗河为盆地提供了相对稳定的物质供应,湖泊也处于高湖面;全新世晚期以来,随着流域干旱化的加剧,尼罗河与盆地的连通性开始减弱,来自高磁性的青尼罗河物质贡献开始相对增加.最近约2.0 ka BP以来,虽然仍有人工运河连接尼罗河与盆地,但沉积物磁性的显著变化更多地反映了盆地人类活动的不断强化. | 江俊 Alaa Salem 赖晓鹤 张卫国 Leszek Marks Fabian Welc 徐立辰 陈静 陈中原 孙千里 | 2016 | 湖泊科学2016，28，6： | 0 |
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