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| 1 | Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner显示文摘遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb,当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4E-BP 的 hypophosphorylated 状态相关,一个翻译抑压者。然而, seriesof 4E-BP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4E-BP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且,血缺氧的 repressiveeffect 类似于由 Torin 1,而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样,猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率,没能压制最高的 mRNAs 的调停氧的翻译激活。最后, TIA-1 和 TIAR co 击倒,二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有, failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此,近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。 | Rachel Miloslavski Elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith Kasir Rajini Mudhasani Stephen N. Jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas | 2014 | Journal of Molecular Cell Biology2014，8，3： | 3 |
| 2 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 3 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet2012，，9829： | 1 |
| 4 | New cooling approach and tool life improvement in cryogenic machining of titanium alloy of Ti- 6A1-4V 显示文摘 | Hong S Y Markus I Jeong W C | 2001 | International Journal of Machine Tools &Manufacture2001，41，15： | 1 |
| 5 | Occurrence and activity of natural antioxidants in herbal spirits 显示文摘 | Chistian I Markus K Stefan B | 2001 | Innovative Food Science Emerging Technologies2001，2，1： | 1 |
| 6 | Energetics of CdSe Quantum Dots Adsorbed on TiO2显示文摘 | Markus T Z Itzhakov S Akotzer Y I | | 0，，27： | 1 |
| 7 | Induction of connective tissue growth factor by angiotensin Ⅱ: integration of signaling pathways 显示文摘 | Dominika I Margot R Markus P | 2003 | Arterioscler Thromb Vasc Biol2003，23，： | 1 |
| 8 | MarketingR&D integration in the pharmaceutical industry显示文摘 | MARKUS C BECKER M I | 2006 | Research Policy2006，，35： | 1 |
| 9 | New cooling approach and tool life improvement in cryogenic machining of titanium alloy Ti-6A1- 4V显示文摘 | SHANE Y H MARKUS I JEONG W | 2001 | International Journal of Machine Tools & Manufacture2001，41，15： | 1 |
| 10 | Cerebral inflammstory response after fetal asphyxia and hyperoxic resuscitation in newborn sheep显示文摘 | Markus T Hansson S Amer-Wahlin I | 2007 | Pediatr Res2007，62，1： | 1 |
| 11 | New cooling approach and tool life improvement in cryogenic machining of titanium alloy Ti-6AI-4V显示文摘 | HONG S Y MARKUS I JEONG W C | 2001 | International Journal of Machine Tools & Manufacture2001，41，15： | 1 |
| 12 | New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects显示文摘 | Alimuddin I Zumla Stephen H Gillespie Michael Hoelscher Patrick P J Philips Stewart T Cole Ibrahim Abubakar Timothy D McHugh Marco Schito Markus Maeurer Andrew J Nunn | 2014 | The Lancet Infectious Diseases2014，，4： | 1 |
| 13 | Study ofdynamic multi-dimensional temperature and concentration distributionin liquid-sprayed fluidized beds 显示文摘 | Stefan H Jan B Markus H Matthias I Mirko P Lothar M | 2003 | Chemical Engineering Science2003，23，58： | 1 |
| 14 | The Internet of things显示文摘 | MICHAEL C MARKUS I ROGER R | 2010 | McKinsey Quarterly2010，，2： | 1 |
| 15 | Tissue Classification as a Potential Approach for Attenuation Correction in Whole-Body PET/MRI: Evaluation with PET/CT Data显示文摘 | Martinez-M?ller Axel Souvatzoglou Michael Delso Gaspar Bundschuh Ralph A Chefd’hotel Christophe Ziegler Sibylle I Navab Nassir Schwaiger Markus Nekolla Stephan G | 2009 | The Journal of Nuclear Medicine2009，，： | 1 |
| 16 | Induction of connective tissue growth factor by angiotensin Ⅱ:integration of signaling pathways显示文摘 | DOMINIKA I MARGOT R MARKUS P | 2003 | Arterioscler Thromb Vasc Biol2003，23，： | 1 |
| 17 | Stable transformation of sunflower (Helianthus annuus L,) using a non-meristematic regeneration protocol and green fluorescent protein as a vital marker显示文摘 | ALEXANDER M MARKUS I DIETER H | 2001 | Transgenic Research2001，10，： | 1 |
| 18 | Thermomechenical treatments on high strength Al-Zn-Mg(-Cu)alloys 显示文摘 | RUSSO E D I CONSERVA M GATTO F MARKUS H | 1973 | Metall Trans1973，4，4： | 1 |
| 19 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet2012，，9829： | 1 |
| 20 | The simultaneous re- duction of nitric oxide and soot in emissions from diesel en- gines显示文摘 | Markus S Abhijeet R Oliver I | 2009 | Carbon2009，47，： | 1 |
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