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| 1 | Resonance-enhanced multi-octave supercontinuum generation in antiresonant hollow-core fibers显示文摘Ultrafast supercontinuum generation in gas-filled waveguides is an enabling technology for many intriguing applications ranging from attosecond metrology towards biophotonics,with the amount of spectral broadening crucially depending on the pulse dispersion of the propagating mode.In this study,we show that structural resonances in a gas-filled antiresonant hollow core optical fiber provide an additional degree of freedom in dispersion engineering,which enables the generation of more than three octaves of broadband light that ranges from deep UV wavelengths to near infrared.Our observation relies on the introduction of a geometric-induced resonance in the spectral vicinity of the ultrafast pump laser,outperforming gas dispersion and yielding a unique dispersion profile independent of core size,which is highly relevant for scaling input powers.Using a krypton-filled fiber,we observe spectral broadening from 200 nm to 1.7μm at an output energy of B 23μJ within a single optical mode across the entire spectral bandwidth.Simulations show that the frequency generation results from an accelerated fission process of solitonlike waveforms in a non-adiabatic dispersion regime associated with the emission of multiple phase-matched Cherenkov radiations on both sides of the resonance.This effect,along with the dispersion tuning and scaling capabilities of the fiber geometry,enables coherent ultra-broadband and high-energy sources,which range from the UV to the mid‐infrared spectral range. | Rudrakant Sollapur Daniil Kartashov Michael Zürch Andreas Hoffmann Teodora Grigorova Gregor Sauer Alexander Hartung Anka Schwuchow Joerg Bierlich Jens Kobelke Mario Chemnitz Markus A Schmidt Christian Spielmann | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 2 | Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks显示文摘The systemic processes involved in the manifestation of life・threatening COVID-19 and in disease recovery are still incompletely understood,despite investigations focusing on the dysregulation of immune responses after SARS-CoV-2 infection.To define hallmarks of severe COVID-19 in acute disease(n=58)and in disease recovery in con valesce nt patie nts(n=28)from Han nover Medical School,we used flow cytometry and proteomics data with unsupervised clustering analyses.In our observational study,we combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and injury.ICU patients displayed an altered immune signature with prolonged lymphopenia but the expansion of granulocytes and plasmablasts along with activated and terminally differentiated T and NK cells and high levels of SARS-CoV-2-specific antibodies.The core signature of seven plasma proteins revealed a highly inflammatory microenvironment in addition to endothelial injury in severe COVID-19.Changes within this sign ature were associated with either disease progression or recovery.In summary,our data suggest that besides a strong inflammatory response,severe COVID-19 is driven by endothelial activation and barrier disruption,whereby recovery depends on the regeneration of the endothelial integrity. | Louisa Ruhl Isabell Pink Jenny F.Kiihne Kerstin Beushausen Jana Keil Stella Christoph Andrea Sauer Lennart Boblitz Julius Schmidt Sascha David Hans-Martin Jack Edith Roth Markus Cornberg Thomas F.Schulz Tobias Welte Marius M.Hoper Christine S.Falk | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 1 |
| 3 | Identification of degradation products of antioxidants in polyolefins by liquid chromatog-raphy combined with atmospheric pressure photoi-onisation mass spectrometry显示文摘 | Eva Reingruber Markus Himmelsbach Christian Sauer | | 0，，95： | 1 |
| 4 | Surgical Treatment of Primary Hepatic Epithelioid Hemangioendothelioma显示文摘 | Arianeb Mehrabi Arash Kashfi Peter Schemmer Peter Sauer Jens Encke Hamidreza Fonouni Helmut Friess Jürgen Weitz Jan Schmidt Markus W. Büchler Thomas W. Kraus | 2005 | Transplantation (S Suppl)2005，，1： | 1 |
| 5 | Bacteriobilia and fungibilia are associated with outcome in patients with endoscopic treatment of biliary complications after liver transplantation显示文摘 | Daniel Gotthardt Karl Weiss Christian Rupp Konrad Bode Isabella Eckerle Gerda Rudolph Janine Bergemann Petra Kloeters-Plachky Fadi Chahoud Markus Büchler Peter Schemmer Wolfgang Stremmel Peter Sauer | 2013 | Endoscopy2013，，： | 1 |
| 6 | A Trojan Horse for live-cell super-resolution microscopy显示文摘New peptide vehicles enable the efficient live-cell labeling of intracellular organelles with cell-impermeable fluorescent probes by simple coincubation,paving the way for refined multicolor super-resolution fluorescence imaging. | Gerti Beliu Markus Sauer | 2020 | Light(Science & Applications)2020，9，1： | 0 |
| 7 | Sharpening emitter localization in front of a tuned mirror显示文摘Single-molecule localization microscopy(SMLM)aims for maximized precision and a high signal-to-noise ratio1.Both features can be provided by placing the emitter in front of a metal-dielectric nanocoating that acts as a tuned mirror2–4.Here,we demonstrate that a higher photon yield at a lower background on biocompatible metal-dielectric nanocoatings substantially improves SMLM performance and increases the localization precision by up to a factor of two.The resolution improvement relies solely on easy-to-fabricate nanocoatings on standard glass coverslips and is spectrally and spatially tunable by the layer design and wavelength,as experimentally demonstrated for dual-color SMLM in cells. | Hannah S.Heil Benjamin Schreiber Ralph Götz Monika Emmerling Marie-Christine Dabauvalle Georg Krohne Sven Höfling Martin Kamp Markus Sauer Katrin G.Heinze | 2018 | Light(Science & Applications)2018，7，1： | 0 |
| 8 | A New Set of Reversibly Photoswitchable Fluorescent Proteins for Use in Transgenic Plants显示文摘荧光灯允许的记者蛋白质重复了切换在之间一荧光灯并且响应光的特定的波长的一个非荧光灯的状态是为在生活有机体蛋白质 trafficking 和超级决定的荧光显微镜学监视的新奇工具。这里,我们描述变体 reversibly photoswitchable 荧光灯为在转基因的 Arabidopsis 的使用是优化 codon 的蛋白质 rsFastLime, bsDronpa,和 Padron 种。合成蛋白质,指明的 rsFastLIME-s, bsDRONPA-s,和 PADRON C-s,显示出的 photophysical 性质和比得上那些的切换的行为为原来的蛋白质报导了。由把确实可切换的 PADRON C-s 与否定地可切换的 rsFastLIME-s 或 bsDRONPA-s 相结合,二不同荧光灯记者蛋白质能在 Nicotiana benthamiana 房间在短暂表示之上在一样的波长被想象。因此,合作本地化分析能用一条仅仅单个察觉隧道被执行。而且,蛋白质被用来标注 RNA 有约束力的蛋白质 AtGRP7 (Arabidopsis thaliana glycine 富有的 RNA 有约束力的蛋白质 7 ) 在转基因的 Arabidopsis 植物。因为新 reversibly photoswitchable 荧光灯蛋白质在每个 photoactivation 周期期间在信号力量显示出增加,我们能产生一样的区域的很多扫描并且重建在根尖端的 AtGRP7 表示的 3-D 图象。在在一条转基因的 Arabidopsis 根的一个定义区域的 AtGRP7:rsFastLIME-s 熔化蛋白质的 photoactivation 之上,荧光信号传播进邻近的区域被观察,显示到房间的从房间的那个运动能被监视。我们的结果证明 rsFastLIME-s, bsDRONPA-s,和 PADRON C-s 是万用的荧光灯在植物的标记。而且,蛋白质也包括 COS-7 和 HeLa 房间在哺乳动物的房间显示出强壮的荧光。 | Martina Lummer Fabian Humpert Matthias Wiedenubbert Markus Sauer Mark Schuttpelz Dorothee Staiger | 2013 | Molecular Plant2013，6，5： | 0 |
| 9 | Geoecological parameters indicate discrepancies between potential and actual forest area in the forest-steppe of Central Mongolia显示文摘Background:Forest distribution in the forest-steppe of Mongolia depends on relief,permafrost,and climate,and is highly sensitive to climate change and anthropogenic disturbance.Forest fires and logging decreased the forest area in the forest-steppe of Mongolia.The intention of this study was to identify the geoecological parameters that control forest distribution and living-tree biomass in this semi-arid environment.Based on these parameters,we aimed to delineate the area that forest might potentially occupy and to analyse the spatial patterns of actual and potential tree biomass.Methods:We used a combination of various geographic methods in conjunction with statistical analyses to identify the key parameters controlling forest distribution.In several field campaigns,we mapped tree biomass and ecological parameters in a study area within the Tarvagatai Nuruu National Park(central Mongolia).Forest areas,topographic parameters and vegetation indices were obtained from remote sensing data.Significant correlations between forest distribution and living-tree biomass on one hand,and topographic parameters,climate data,and environmental conditions on the other hand,were used to delineate the area of potential forest distribution and to estimate total living-tree biomass for this area.Results:Presence of forest on slopes was controlled by the factors elevation,aspect,slope,mean annual precipitation,and mean growing-season temperature.Combining these factors allowed for estimation of potential forest area but was less suitable for tree-biomass delineation.No significant differences in mean living-tree biomass existed between sites exposed to different local conditions with respect to forest fire,exploitation,and soil properties.Tree biomass was reduced at forest edges(defined as 30m wide belt),in small fragmented and in large forest stands.Tree biomass in the study area was 20×10^(9) g(1,086 km^(2) forest area),whereas the potential tree biomass would reach up to 65×10^(9) g(>3168 km^(2)).Conclusions:The obtained projection suggests that the potential forest area and tree biomass under the present climatic and geoecological conditions is three times that of the present forest area and biomass.Forest fires,which mostly affected large forest stands in the upper mountains,destroyed 43% of the forest area and 45% of the livingtree biomass in the study area over the period 1986-2017. | Michael Klinge Choimaa Dulamsuren Florian Schneider Stefan Erasmi Uudus Bayarsaikhan Daniela Sauer Markus Hauck | 2021 | Forest Ecosystems2021，8，4： | 0 |
| 10 | Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus-response in spinal muscular atrophy显示文摘Background:Axonal degeneration and defects in neuromuscular neurotransmission represent a pathological hall-mark in spinal muscular atrophy(SMA)and other forms of motoneuron disease.These pathological changes do not only base on altered axonal and presynaptic architecture,but also on alterations in dynamic movements of organelles and subcellular structures that are not necessarily reflected by static histopathological changes.The dynamic inter-play between the axonal endoplasmic reticulum(ER)and ribosomes is essential for stimulus-induced local translation in motor axons and presynaptic terminals.However,it remains enigmatic whether the ER and ribosome crosstalk is impaired in the presynaptic compartment of motoneurons with Smn(survival of motor neuron)deficiency that could contribute to axonopathy and presynaptic dysfunction in SMA.Methods:Using super-resolution microscopy,proximity ligation assay(PLA)and live imaging of cultured motoneu-rons from a mouse model of SMA,we investigated the dynamics of the axonal ER and ribosome distribution and activation.Results:We observed that the dynamic remodeling of ER was impaired in axon terminals of Smn-deficient motoneu-rons.In addition,in axon terminals of Smn-deficient motoneurons,ribosomes failed to respond to the brain-derived neurotrophic factor stimulation,and did not undergo rapid association with the axonal ER in response to extracellular stimuli.Conclusions:These findings implicate impaired dynamic interplay between the ribosomes and ER in axon terminals of motoneurons as a contributor to the pathophysiology of SMA and possibly also other motoneuron diseases. | Chunchu Deng Sebastian Reinhard Luisa Hennlein Janna Eilts Stefan Sachs Sören Doose Sibylle Jablonka Markus Sauer Mehri Moradi Michael Sendtner | 2022 | Translational Neurodegeneration2022，11，1： | 0 |
| 11 | Variant signaling topology at the cancer cell–T-cell interface induced by a two-component T-cell engager显示文摘Bispecific T-cell-engaging antibodies(BiTEs)convey antigenic information from cancer to the T-lymphocyte-associated CD3 complex,thus redirecting immune effector cells to induce target cell lysis.Since antigenic information from transformed tissues is rarely unambiguous,we recently introduced novel T-cell-engaging antibody fragments called hemibodies for the combinatorial,ultraprecise targeting of cancer.1 Here,we report the unprecedented enhancement of the plasticity of immunological synapse(IS)formation and variant signaling topology at the cancer cell–T-cell interface induced by hemibodies compared to that induced by BiTEs. | Dina Kouhestani Maria Geis Saed Alsouri Thomas GPBumm Hermann Einsele Markus Sauer Gernot Stuhler | 2021 | Cellular & Molecular Immunology2021，18，6： | 0 |
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