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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | On the utility of gambling: extending the approach of meginniss 显示文摘 | Ng C T Luce R D Marley A A J | 2008 | Aequationes Mathematicae2008，76，： | 1 |
| 3 | Utility of gambling I : entropy modified linear weighted utility 显示文摘 | Luce R D Ng C T Marley A A J | 2005 | Economic Theory2005，36，： | 1 |
| 4 | Utility of gambling II : risk, paradoxes, and data显示文摘 | Luce R D NgC T Marley A A J | 2008 | Economic Theory2008，36，： | 1 |
| 5 | Removing Volatile Contaminants from the Unsaturated Zone by Inducing Advective Air-Phase Transport显示文摘 | Baehr A L Hoag G E Marley M C | 1989 | Journal of Contaminant Hydrology1989，，4： | 1 |
| 6 | Spectroscopic evidence for organic diacid complexation with silica in aqueous systems-I oxalic acid 显示文摘 | Marley N A Bennet P Janecky D R | 1989 | Organic Geochemistry1989，14，3： | 1 |
| 7 | In-depth review of atmospheric mercury: Sources, transformations, and potential sinks 显示文摘 | Gaffney J S Marley N A | 2014 | Energy and Emis- sion Control Technologies2014，2，： | 1 |
| 8 | 查看详情显示文摘 | Ackerman A S Marley M | | 0，，： | 1 |
| 9 | Hospital delay in South Asian patients with acute ST-elevation myocardial infarction in the UK显示文摘 | Kendall H Marley A Patel JV | 2013 | European journal of preventive cardiology2013，20，5： | 1 |
| 10 | Bioactive properties of wild blueberry fruits显示文摘 | Smith M A L Marley K A scigler D | 2002 | Journal of Food Science2002，65，2： | 1 |
| 11 | The impact of combustion emission on air quality and climate from coal to biofuels and beyond显示文摘 | CAFFNEY J S MARLEY N A | | 0，，01： | 1 |
| 12 | The impact of hiogenic carbon sources on aerosol absorption in Mexico City显示文摘 | Marley N A Gaffney J S Tackett M | 2009 | Atmospheric Chemistry and Physics2009，9，5： | 1 |
| 13 | Bermard grofman:a general concept of majority rule显示文摘 | MARLEY A A J | 2002 | Mathematical Social Science2002，，43： | 1 |
| 14 | The impact of biogenic carbon sources on aerosol absorption in Mexico City 显示文摘 | MARLEY N A GAFFNEY J S TACKETT M | 2009 | Atmospheric Chemistry and Physics2009，9，5： | 1 |
| 15 | Incidence and recognition of peroneal tendon dislocation associated withcalcaneal fractures显示文摘 | Wong-Chung J Marley WD Tucker A | 2015 | Foot Ankle Surg2015，21，4： | 1 |
| 16 | Evaluation of nematicidal action of some botanicals on Meloidogyne incognita in vivo and in vitro 显示文摘 | AGBENIN N O EMECHEBE A M MARLEY P S | 2005 | Journal of Agriculture and Rural Development in the Tropics and Subtropics2005，106，1： | 1 |
| 17 | Patient care after discharge from the ambulatory surgical center显示文摘 | MARLEY R A SWANSON J | 2001 | J Perianesth Nurs2001，16，6： | 1 |
| 18 | Evaluation of nematicidal action of some botanicals on Meloidogyne incognita in viso and in vitro显示文摘 | Agbonin N O Emechebe A M Marley P S | 2005 | Journal of Agriculture and Rural Development in the Tropics and Subtropics2005，106，1： | 1 |
| 19 | Terbinafine in onyehomyeosis of the toenail:a novel treatment protocol 显示文摘 | Watson A Marley J Ellis D | 1995 | J Am Acad Dermatol1995，33，： | 1 |
| 20 | Distribution of transferring synthesis in brain and other tissues in the rat显示文摘 | Aldred A R Dickson P W Marley P D | 1987 | J Biol Chem1987，262，： | 1 |
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