|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | On the utility of gambling: extending the approach of meginniss 显示文摘 | Ng C T Luce R D Marley A A J | 2008 | Aequationes Mathematicae2008，76，： | 1 |
| 3 | Utility of gambling I : entropy modified linear weighted utility 显示文摘 | Luce R D Ng C T Marley A A J | 2005 | Economic Theory2005，36，： | 1 |
| 4 | Utility of gambling II : risk, paradoxes, and data显示文摘 | Luce R D NgC T Marley A A J | 2008 | Economic Theory2008，36，： | 1 |
| 5 | Spectroscopic evidence for organic diacid complexation with silica in aqueous systems-I oxalic acid 显示文摘 | Marley N A Bennet P Janecky D R | 1989 | Organic Geochemistry1989，14，3： | 1 |
| 6 | Effect of root-knot nematodes on cajanol accumulation in the vascular tissues of pigeonpea after stem inoculation with Fusarium udum显示文摘 | MARLEY P S HILLOCKS R J | 1994 | Phytopathology1994，43，： | 1 |
| 7 | Fatigue Reassessment Applications:State-of-the-Art Paper显示文摘 | WILLIAM G B MARLEY M J MOHAMMADI J JIELSEN R J SARKANI S | 1997 | Journal of Structural Engineering1997，123，3： | 1 |
| 8 | Imrovement in renal function in hepatorenal syndrome with N-acetylcysteine 显示文摘 | Holt S Goodier D Marley R | 1999 | Lancet1999，353，： | 1 |
| 9 | Patient care after discharge from the ambulatory surgical center显示文摘 | MARLEY R A SWANSON J | 2001 | J Perianesth Nurs2001，16，6： | 1 |
| 10 | Distribution of transferring synthesis in brain and other tissues in the rat显示文摘 | Aldred A R Dickson P W Marley P D | 1987 | J Biol Chem1987，262，： | 1 |
| 11 | Review article:pharmacological treatment of the hepatorenal syndrome in cirrhotic patients显示文摘 | Dagher L Patoh D Marley R | 2000 | Alimen Pharmacol Therap2000，14，5： | 1 |
| 12 | Roller sheller: low damage cornshelling cylinder 显示文摘 | Brass R W Marley S J | 1973 | Trans of the ASAE1973，16，2： | 1 |
| 13 | Improvement in renal function in hepatorenal syndrome with N-acetylcysteine 显示文摘 | Holt S Goodier D Marley R | 1999 | Lancet1999，353，： | 1 |
| 14 | Photochemis- try in hoagland' s nutrient solution显示文摘 | Hothem S D Marley K A Larson R A | 2003 | Journal of Plant Nutrition2003，2，4： | 1 |
| 15 | Prevalence and Clonal Analysis of Porphyromonas gingivalis in Primary Endodontic Infections显示文摘 | José F. Siqueira Isabela N. R??as Marlei G. Silva | 2008 | Journal of Endodontics2008，，11： | 1 |
| 16 | Influence of temperature on the kinetics of adsorption and desorption of clavulanic acid by ionic exchange显示文摘 | Marlei Barboza Renata M R G Almeida Carlos O Hokka | 2003 | Biochemical Engineering Journal2003，14，： | 1 |
| 17 | The attenuation of ultraviolet radiation in high dissolved organic carbon waters of wetlands and lakes on northern Great Plains显示文摘 | Michael T A Richard D R Kasai F Marley J W Vijay P T Amanda J P Hakumat R Hendrika J D L | 2000 | Limnol Oceanogr2000，45，： | 1 |
| 18 | Ferric ion promoted photodecomposition of triazines显示文摘 | Larson R A Schlauch M B Marley K A | 1991 | Journal of Agricultural and Food Chemistry1991，39，11： | 1 |
| 19 | The effect of chlorhexidine gluconate as an endodontic irrigant on the apicalseal: long-term results显示文摘 | Ferguson D B Marley J T Hartwell G R | 2003 | J Endod2003，29，2： | 1 |
| 20 | Chromogranin A:secretion of processed products from the stimulated retrogradely perfused bovine adrenal gland显示文摘 | Helle K B Marley P D Angeletti R H | 1993 | Neuroendocrinology1993，5，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员