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| 1 | Nonalcoholic fatty liver disease: Evolving paradigms显示文摘In the last years new evidence has accumulated on nonalcoholic fatty liver disease(NAFLD)challenging the paradigms that had been holding the scene over the previous 30 years.NAFLD has such an epidemic prevalence as to make it impossible to screen general population looking for NAFLD cases.Conversely,focusing on those cohorts of individuals exposed to the highest risk of NAFLD could be a more rational approach.NAFLD,which can be diagnosed with either non-invasive strategies or through liver biopsy,is a pathogenically complex and clinically heterogeneous disease.The existence of metabolic as opposed to genetic-associated disease,notably including'lean NAFLD'has recently been recognized.Moreover,NAFLD is a systemic condition,featuring metabolic,cardiovascular and(hepatic/extrahepatic)cancer risk.Among the clinico-laboratory features of NAFLD we discuss hyperuricemia,insulin resistance,atherosclerosis,gallstones,psoriasis and selected endocrine derangements.NAFLD is a precursor of type 2 diabetes(T2D)and metabolic syndrome and progressive liver disease develops in T2D patients in whom the course of disease is worsened by NAFLD.Finally,lifestyle changes and drug treatment options to be implemented in the individual patient are also critically discussed.In conclusion,this review emphasizes the new concepts on clinical and pathogenic heterogeneity of NAFLD,a systemic disorder with a multifactorial pathogenesis and protean clinical manifestations.It is highly prevalent in certain cohorts of individuals who are thus potentially amenable to selective screening strategies,intensive follow-up schedules for early identification of liver-related and extrahepatic complications and in whom earlier and more aggressive treatment schedules should be carried out whenever possible. | Amedeo Lonardo Fabio Nascimbeni Mauro Maurantonio Alessandra Marrazzo Luca Rinaldi Luigi Elio Adinolfi | 2017 | World Journal of Gastroenterology2017，23，36： | 33 |
| 2 | Precision and efficiency in solid-state pseudopotential calculations显示文摘Despite the enormous success and popularity of density-functional theory,systematic verification and validation studies are still limited in number and scope.Here,we propose a protocol to test publicly available pseudopotential libraries,based on several independent criteria including verification against all-electron equations of state and plane-wave convergence tests for phonon frequencies,band structure,cohesive energy and pressure.Adopting these criteria we obtain curated pseudopotential libraries(named SSSP or standard solid-state pseudopotential libraries),that we target for high-throughput materials screening(“SSSP efficiency”)and high-precision materials modelling(“SSSP precision”).This latter scores highest among open-source pseudopotential libraries available in theΔ-factor test of equations of states of elemental solids. | Gianluca Prandini Antimo Marrazzo Ivano E.Castelli Nicolas Mounet Nicola Marzari | 2018 | npj Computational Materials2018，，1： | 5 |
| 3 | Automated high-throughput Wannierisation显示文摘Maximally-localised Wannier functions(MLWFs)are routinely used to compute from first-principles advanced materials properties that require very dense Brillouin zone integration and to build accurate tight-binding models for scale-bridging simulations.At the same time,high-throughput(HT)computational materials design is an emergent field that promises to accelerate reliable and cost-effective design and optimisation of new materials with target properties.The use of MLWFs in HT workflows has been hampered by the fact that generating MLWFs automatically and robustly without any user intervention and for arbitrary materials is,in general,very challenging.We address this problem directly by proposing a procedure for automatically generating MLWFs for HT frameworks.Our approach is based on the selected columns of the density matrix method and we present the details of its implementation in an AiiDA workflow.We apply our approach to a dataset of 200 bulk crystalline materials that span a wide structural and chemical space.We assess the quality of our MLWFs in terms of the accuracy of the band-structure interpolation that they provide as compared to the band-structure obtained via full first-principles calculations.Finally,we provide a downloadable virtual machine that can be used to reproduce the results of this paper,including all first-principles and atomistic simulations as well as the computational workflows. | Valerio Vitale Giovanni Pizzi Antimo Marrazzo Jonathan R.Yates Nicola Marzari Arash A.Mostofi | 2020 | npj Computational Materials2020，，1： | 4 |
| 4 | Zymographic detection and clinical correlations of MMP - 2 and MMP - 9 in breast cancer sear显示文摘 | La Rocca G Pucci - Minafra I Marrazzo A | 2004 | Br J Cancer2004，90，7： | 1 |
| 5 | Zymographic detection and clinical correlations of MMP-2 and MMP-9 in breast cancer sera显示文摘 | La Rocca G Pucci-minafra I Marrazzo A | 2004 | Br J Cancer2004，90，： | 1 |
| 6 | Diversity of human vaginal bacterial communities and associations with clinically de- fined bacterial vaginosis 显示文摘 | Oakley B B Fiedler T L Marrazzo J M | 2008 | Appl Environ Microbial2008，74，15： | 1 |
| 7 | Zymogrophic detection and clinical correlations of MMP-2 and MMP-9 in breast cancer sera显示文摘 | La Rocoa G Pacci-Minafra I Marrazzo A | | 0，，07： | 1 |
| 8 | Heme oxygen- ase-2 deletion impairs macrophage fimction: implication in wound healing 显示文摘 | Bellner L Marrazzo G van Rooijen N | 2015 | FASEB J2015，29，1： | 1 |
| 9 | Effects of aldose reductase inhibitors(tolreatat)on urinary albumin excretion rate and glomerular filtration rate IDDM subjects with nephro显示文摘 | Passariello N Sepe J Marrazzo C | 1993 | Diabetes Care1993，16，5： | 1 |
| 10 | Expression levels of p53 and p73 isoforms in stage I and stage m ovarian cancer 显示文摘 | Marabese M Marchini S Marrazzo E | 2008 | Eur J Cancer2008，44，1： | 1 |
| 11 | Expression levels of p53 and p73 isoforms in stage I and stage l]I ovarian cancer显示文摘 | Marabese M Marehini S Marrazzo E | 2008 | Eur J Cancer2008，44，1： | 1 |
| 12 | Anaemia in cancer: Pathophysiology and treatment显示文摘 | Mereadante S Gebbia V Marrazzo A | 2000 | Cancer Treat Rev2000，26，4： | 1 |
| 13 | A persistently enigmatic ecological mystery: bacterial vagi-nosis 显示文摘 | Marrazzo JM | 2006 | Infect Dis2006，19，3： | 1 |
| 14 | Interpreting the epidemiology and natural history of bacterial vaginosis: Are we still confused?显示文摘 | Jeanne M. Marrazzo | 2011 | Anaerobe2011，，4： | 1 |
| 15 | Thyroidectomy with l,igaSure versus traditional thyroidectomy : our experience 显示文摘 | Marrazzo A Casa L David M | 2007 | Chir Ital2007，59，3： | 1 |
| 16 | Common complementary and alternative therapies for yeast vaginitis and bacterial vaginosis: a systematic review显示文摘 | Van Kessel K Assefi N Marrazzo J | 2003 | Obstet Gynecol Surv2003，58，5： | 1 |
| 17 | Anaemia in cancer:pathophysiology and treatment显示文摘 | Mercadante S Gebbia V Marrazzo A | 2000 | Cancer treat Rev2000，26，4： | 1 |
| 18 | Management of women with cervicitis 显示文摘 | Marrazzo JM Martin DH | 2007 | Clin In-fect Dis2007，44，3： | 1 |
| 19 | Simultaneous determina- tion of amphetamine and one of its metabolites by HPLC with electro- chemical detection显示文摘 | Santagati NA Ferrara G Marrazzo A | 2002 | J Pharm Biomed Anal2002，30，2： | 1 |
| 20 | Vulvovaginal candidiasis显示文摘 | Marrazzo J | 2002 | Clin EVid2002，7，13： | 1 |
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