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| 1 | Measurement of serum paraoxonase-1 activity in the evaluation of liver function显示文摘Paraoxonase-1 (PON1) is an esterase and lactonase synthesized by the liver and found in the circulation associated with high-density lipoproteins. The physiological function of PON1 seems to be to degrade specific oxidized cholesteryl esters and oxidized phospholipids in lipoproteins and cell membranes. PON1 is, therefore, an antioxidant enzyme. Alterations in circulating PON1 levels have been reported in a variety of diseases involving oxidative stress including chronic liver diseases. Measurement of serum PON1 activity has been proposed as a potential test for the evaluation of liver function. However, this measurement is still restricted to research and has not been extensively applied in routine clinical chemistry laboratories. The reason for this restriction is due to the problem that the substrate commonly used for PON1 measurement, paraoxon, is toxic and unstable. The recent development of new assays with non-toxic substrates makes this proposal closer to a practical development. The present editorial summarizes PON1 biochemistry and function, its involvement with chronic liver impairment, and some aspects related to the measurement of PON1 activity in circulation. | Jordi Camps Judit Marsillach Jorge Joven | 2009 | World Journal of Gastroenterology2009，15，16： | 3 |
| 2 | Paraoxonase-I inhibits oxidized low-density lipoprotein-induced metabolic alterations and apoptosis in endothelial cells: a nondirected metabolomic study 显示文摘 | Garcia-Heredia A Marsillach J Rull A | 2013 | Mediators Inflamm2013，2013，15： | 1 |
| 3 | Paraoxonase-1 is associated with oxidative stress,fibrosis and FAS expression in chronic liver diseases显示文摘 | Ferré N Marsillach J Camps J Mackness B Mackness M Riu F | 2006 | J Hepatol2006，45，1： | 1 |
| 4 | Immunohistochemical analysis of paraoxonases-1,2, and 3 expression in normal mouse tissues显示文摘 | Marsillach J Mackness B Mackness M Riu F Beltran R Joven J | 2008 | Free Radic Biol Med2008，45，2： | 1 |
| 5 | Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats显示文摘 | Judit Marsillach Natàlia Ferré Jordi Camps Anna Rull Raul Beltran Jorge Joven | 2008 | Molecular and Cellular Biochemistry (-)2008，，1： | 1 |
| 6 | Serum paraoxonase-1 in chronic alcoholics: relationship with liver disease 显示文摘 | Marsillach J Ferre N Vila MC | 2007 | Clin Biochem2007，40，910： | 1 |
| 7 | Immunohistochemical analysis of paraoxonases-1, 2, and 3 expression in normal mouse tissues显示文摘 | Judit Marsillach Bharti Mackness Michael Mackness Francesc Riu Raul Beltrán Jorge Joven Jordi Camps | 2008 | Free Radical Biology and Medicine2008，，2： | 1 |
| 8 | Paraoxonase-1is related toinflammation,fibrosis and PPAR delta in experimental liver dis-ease显示文摘 | Marsillach J Camps J FerréN | 2009 | BMC Gastroenterol2009，9，2： | 1 |
| 9 | Pharmacological and lifestyle factors modulating serum paraoxonase-1 activity显示文摘 | Camps J Marsillach J Joven J | 2009 | Mini Rev Med Chem2009，9，8： | 1 |
| 10 | Pharmacogenetics of paraoxonase activity: elucidating the role of high-density lipoprotein in disease 显示文摘 | Kim DS Marsillach J Furlong CE | 2013 | Pharmacogenomics2013，14，12： | 1 |
| 11 | Serum paraoxonase-1 in chronic alcoholics: relationship with liver disease 显示文摘 | Marsillach J Ferre N Vila MC et aI | 2007 | Clin Biochem2007，40，910： | 1 |
| 12 | Paraoxonase-1 is associated with oxidative stress,fibrosis and FAS expression in chronic liver diseases显示文摘 | MARSILLACH J CAMPS J | 2006 | J Hepatol2006，45，： | 1 |
| 13 | Pharmacogenetics of para-oxonase activity: elucidating the role of high-density lipoprotein indisease 显示文摘 | Kim DS Marsillach J Furlong CE | 2013 | Pharmacogenomics2013，14，12： | 1 |
| 14 | The paraoxonases :Role in human diseases and methodological difficulties in measurement显示文摘 | Camps J Marsillach J Joven J | 2009 | Crit Rev Clin Lab Sci2009，46，2： | 1 |
| 15 | Paraoxonase1 is associated with oxidative stress, fibrosis and FAS expression in chronic liver diseases 显示文摘 | FERRE N MARSILLACH J CAMPS J | 2006 | J Hepatol2006，45，1： | 1 |
| 16 | Immuno- histochemical analysis of paraoxonases-1, 2, and 3 ex- pression in normal mouse tissues 显示文摘 | Marsillach J Mackness B Mackness M | 2008 | Free Radic Biol Med2008，45，2： | 1 |
| 17 | Immuno- histochemical analysis of paraoxonases-1 and 3 in human atheromatous plaques 显示文摘 | Marsillach J Camps J Behran-Debon R | 2011 | Eur J Clin Invest2011，41，3： | 1 |
| 18 | Interrelationships between paraoxonase-1 and monocyte chemoattraetant protein-1 in the regulation of hepatic inflammation显示文摘 | Camps J Marsillach J Rull A | 2010 | Adv ExpMed Biol2010，660，： | 1 |
| 19 | The paraoxonaseg : Role in human diseases and methodological difficulties in measurement显示文摘 | Camps J Marsillach J Joven J | 2009 | Crit RevClinLabSei2009，46，2： | 1 |
| 20 | Paraoxonase - 1 isrelated to in- tlammation, fibrosisand PPAR delta in experimental liver disease 显示文摘 | Marsillach J Camps J Ferr N | 2009 | BMC Gastroenterol2009，9，2： | 1 |
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