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| 1 | Effectiveness of an intervention for reducing social stigma towards mental illness in adolescents显示文摘AIM: To evaluate the effectiveness of an intervention for reducing social stigma towards mental illness in adolescents. The effect of gender and knowledge of someone with mental illness was measured. METHODS: Two hundred and eighty secondary school students were evaluated using the Community Attitudes towards Mental Illness(CAMI) questionnaire. The schools were randomized and some received the intervention and others acted as the control group. The programme consisted of providing information via a documentary film and of contact with healthcare staff in order to reduce the social stigma within the school environment. RESULTS: The intervention was effective in reducing the CAMI authoritarianism and social restrictiveness subscales. The intervention showed significant changes in girls in terms of authoritarianism and social restrictiveness, while boys only showed significant changes in authoritarianism. Following the intervention, a significant reduction was found in authoritarianism and social restrictiveness in those who knew someone with mental illness, and only in authoritarianism in those who did not know anyone with mental illness. CONCLUSION: The intervention was effective to reduce social stigma towards people with mental illness, especially in the area of authoritarianism. Some differences were found depending on gender and whether or not the subjects knew someone with mental illness. | Regina Vila-Badia Francisco Martínez-Zambrano Otilia Arenas Emma Casas-Anguera Esther García-Morales Raúl Villellas José Ramón Martín María Belén Pérez-Franco Tamara Valduciel Diana Casellas Mar García-Franco Jose Miguel Joaquim Balsera Gemma Pascual Eugènia Julia Susana Ochoa | 2016 | World Journal of Psychiatry2016，6，2： | 4 |
| 2 | Treatment of chronic hepatitis C with direct-acting antivirals: The role of resistance显示文摘The use of direct-acting antivirals(DAAs) to treat chronic hepatitis C has resulted in a significant increase in rates of sustained viral response(around 90%-95%) as compared with the standard treatment of peginterferon/ribavirin. Despite this, however, the rates of therapeutic failure in daily clinical practice range from 10%-15%. Most of these cases are due to the presence of resistant viral variants, resulting from mutations produced by substitutions of amino acids in the viral target protein that reduce viral sensitivity to DAAs, thus limiting the efficacy of these drugs. The high genetic diversity of hepatitis C virus has resulted in the existence of resistance-associated variants(RAVs), sometimes even before starting treatment with DAAs, though generally at low levels. These preexisting RAVs do not appear to impact on the sustained viral response, whereas those that appear after DAA therapy could well be determinant in virological failure with future treatments. As well as the presence of RAVs, virological failure to treatment with DAAs is generally associated with other factors related with a poor response, such as the degree of fibrosis, the response to previous therapy, the viral load or the viral genotype. Nonetheless, viral breakthrough and relapse can still occur in the absence of detectable RAVs and after the use of highly effective DAAs, so that the true clinical impact of the presence of RAVs in therapeutic failure remains to be determined. | Miguel Jiménez-Pérez Rocío González-Grande Pilar Espana Contreras Isabel Pinazo Martínez Jesús de la Cruz Lombardo Raúl Olmedo Martín | 2016 | World Journal of Gastroenterology2016，22，29： | 3 |
| 3 | E6 molecular variants of human papillomavirus (HPV) type 16: An updated and unified criterion for clustering and nomenclature显示文摘 | Antonio Huertas-Salgado Diana C. Martín-Gámez Pablo Moreno Raúl Murillo María Mercedes Bravo Luisa Villa Mónica Molano | 2010 | Virology2010，，： | 2 |
| 4 | Invasive aspergillosis in allogeneic stem cell transplant recipients:changes in epidemiology and risk factors 显示文摘 | Mart KA Carter RA Boeckh M | 2002 | Blood2002，100，13： | 1 |
| 5 | p21 and p27 ashared senescence history显示文摘 | Flores JM Martín-Caballero J García-Fernández RA | 2014 | Cell Cycle2014，13，11： | 1 |
| 6 | Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients 显示文摘 | Mart KA Carter RA Crippa F | 2002 | Clin Infect Dis2002，34，： | 1 |
| 7 | Experimental Translucent- Oriented Routing for Dynamic Lightpath Provisioning in GMPLS-Enabled Wavelength Switched Optical Networks显示文摘 | Ricardo Mart f nez Ramon Casellas Ra fi 1 Mufioz Takehiro Tsuritani | 2010 | LIGHTWAVE TECHNOLOGY2010，28，8： | 1 |
| 8 | Theoretical and experimental insights on the true impact of C 12 TAC cationic surfactant in enhanced oil recovery for heavy oil carbonate reservoirs显示文摘 | Mirna Pons-Jiménez Rocío Cartas-Rosado José Manuel Martínez-Magadán Raúl Oviedo-Roa Rodolfo Cisneros-Dévora Hiram I. Beltrán Luis S. Zamudio-Rivera | 2014 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2014，，： | 1 |
| 9 | Targeting BACE 1with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model显示文摘 | Singer O Mart RA Rockenstein E | 2005 | Nat Neurosci2005，8，10： | 1 |
| 10 | HCV-specific immune responses induced by CIGB-230 in combination with IFN-α plus ribavirin显示文摘AIM:To analyze hepatitis C virus(HCV)-specific immune responses in chronically infected patients under triple therapy with interferon-α(IFN-α)plus ribavirin and CIGB-230.METHODS:CIGB-230 was administered in different schedules with respect to IFN-αplus ribavirin therapy.Paired serum and peripheral blood mononuclear cells(PBMC)samples from baseline and end of treatment were analyzed.The HCV-specific humoral response was tested by enzyme-linked immunosorbent assay,neutralizing antibodies were evaluated by cell culture HCV neutralization assays,PBMC proliferation was assayed by carboxyfluorescein succinimidyl ester staining and IFN-γsecretion was assessed by enzyme-linked immunospot.Data on virological and histological response and their association with immune variables are also provided.RESULTS:From week 12 to week 48,all groups of patients showed a significant reduction in mean leukocyte counts.Statistically significant reductions in antibody titers were frequent,but only individuals immunized with CIGB-230 as early add-on treatment sustained the core-IgG response,and the neutralizing antibody response was enhanced only in patients receiving CIGB-230.Cell-mediated immune responses also tended to decline,but significant reductions in IFN-γsecretion and total absence of core-specific lymphoproliferation were exclusive of the control group.Only CIGB-230-immunized individuals showed de novo induced lymphoproliferative responses against the structural antigens.Importantly,it was demonstrated that thequality of the CIGB-230-induced immune response depended on the number of doses and timing of administration in relation to the antiviral therapy.Specifically,the administration of 6 doses of CIGB-230 as late addon to therapy increased the neutralizing antibody activity and the de novo core-specific IFN-γsecretion,both of which were associated with the sustained virological response.CONCLUSION:CIGB-230,combined with IFN-α-based therapy,modifies the immune response in chronic patients.The study provides evidence for the design of more effective therapeutic vaccine interventions against HCV. | Yalena Amador-Caizares Gillian Martínez-Donato Liz lvarez-Lajonchere Claudia Vasallo Mariacarla Dausá Daylen Aguilar-Noriega Carmen Valenzuela Ivette Raíces Jean Dubuisson Czeslaw Wychowski Zurina Cinza-Estévez Marlén Castellanos Magdalys Núez Anny Armas Yaimé González Ismariley Revé Ivis Guerra ngel Pérez Aguiar Santiago Dueas-Carrera | 2014 | World Journal of Gastroenterology2014，20，1： | 1 |
| 11 | invasJve aspergillosis in allogeneie stem cell transplant recipients:changes in epidemiology and risk factors 显示文摘 | Mart KA Carter RA Boeekh M | 2002 | Blood2002，100，13： | 1 |
| 12 | Combination antifungal therapy for invasive aspergillosis 显示文摘 | Mart KA Boeckh M Carter RA | 2004 | Clin Infect Dis2004，39，6： | 1 |
| 13 | Clinical cellular and molecular factors that contribute to antifungal drug resistance 显示文摘 | White TC Mart KA Bowden RA | 1998 | Clin Microbiol Rev1998，，11： | 1 |
| 14 | Fungal enhancement of the antioxidant properties of grape waste显示文摘 | Guillermo Martínez-ávila Antonio Aguilera-Carbó Raúl Rodríguez-Herrera Cristóbal Aguilar | 2012 | Annals of Microbiology2012，，3： | 1 |
| 15 | Neprilysin regulates amyloid Beta Peptide levels显示文摘 | Mart RA Guan H Rockenstein E | 2004 | Mol Neurosci2004，22，： | 1 |
| 16 | Assessment of nonsteroidal anti-inflammatory drug-induced hepatotoxicity显示文摘 | José AG Agúndez María Isabel Lucena Carmen Martínez Raúl J Andrade Miguel Blanca Pedro Ayuso Elena García-Martín | 2011 | Expert Opinion on Drug Metabolism & Toxicology2011，，7： | 1 |
| 17 | Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer's disease显示文摘 | Dodart JC Mart RA | 2005 | Proc Natl Acad Sci USA2005，102，4： | 1 |
| 18 | Direct transformation of fungal biomass from submerged culturesinto biodiesel 显示文摘 | Vicente G Bautista LF Gutiérrez FJ Rodríguez R Martínez V Rodríguez-Frómeta RA Ruiz-Vázquez RM Torres-Martínez S GarreV | 2010 | Energy Fuels2010，24，5： | 1 |
| 19 | lnvasive aspergiillosis in allogeneie stem cell transplant recipients:changes in epidemiology and risk factors 显示文摘 | Mart KA Carter RA Boeckh M | 2002 | Blood2002，100，13： | 1 |
| 20 | In vitro regulation of B cell differentiation by interleukin-6 and soluble CD23 in systemic lupus erythematosus B cell subpopulations and antigeninduced normal B cells显示文摘 | Klashman DJ Martin RA Martínez-Maza O | 1991 | Arthritis Rheum1991，34，3： | 1 |
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