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| 1 | Clinical value of rapid urine trypsinogen-2 test strip, urinary trypsinogen activation peptide, and serum and urinary activation peptide of carboxypeptidase B in acute pancreatitis显示文摘AIM: To assess the usefulness of urinary trypsinogen-2 test strip, urinary trypsinogen activation peptide (TAP),and serum and urine concentrations of the activation peptide of carboxypeptidase B (CAPAP) in the diagnosisof acute pancreatitis.METHODS: Patients with acute abdominal pain and hospitalized within 24 h after the onset of symptoms were prospectively studied. Urinary trypsinogen-2 was considered positive when a clear blue line was observed (detection limit 50 μg/L). Urinary TAP was measured using a quantitative solid-phase ELISA, and serum and urinary CAPAP by a radioimmunoassay method.RESULTS: Acute abdominal pain was due to acute pancreatitis in 50 patients and turned out to be extrapancreatic in origin in 22 patients. Patients with acute pancreatitis showed significantly higher median levels of serum and urinary CAPAP levels, as well as amylase and lipase than extrapancreatic controls. Median TAP levels were similar in both groups. The urinary trypsinogen-2 test strip was positive in 68% of patients with acute pancreatitis and 13.6% in extrapancreatic controls (P<0.01). Urinary CAPAP was the most reliable test for the diagnosis of acute pancreatitis (sensitivity 66.7%, specificity 95.5%, positive and negative predictive values 96.6% and 56.7%, respectively), with a 14.6 positive likelihood ratio for a cut-off value of 2.32 nmol/L.CONCLUSION: In patients with acute abdominal pain,hospitalized within 24 h of symptom onset, CAPAP in serum and urine was a reliable diagnostic marker of acute pancreatitis. Urinary trypsinogen-2 test strip showed a clinical value similar to amylase and lipase.Urinary TAP was not a useful screening test for the diagnosis of acute pancreatitis. | Jesús Sáez Juan Martínez Celia Trigo José Sánchez-Payá Luis Compay Raquel Laveda Pilar Grió Cristina García Miguel Pérez-Mateo | 2005 | World Journal of Gastroenterology2005，11，46： | 21 |
| 2 | Direct-fed microbes: A tool for improving the utilization of low quality roughages in ruminants显示文摘For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restriction of antibiotics subtherapeutic uses from ruminant diets has amplified interest in improving nutrient utilization and animal performance and search for more safe alternatives. Some bacterial and fungal microorganisms as a direct-fed microbial(DFM) can be the most suitable solutions. Microorganisms that are commonly used in DFM for ruminants may be classified mainly as lactic acid producing bacteria(LAB), lactic acid utilizing bacteria(LUB), or other microorganism's species like Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Bacillus, Propionibacterium, Megasphaera elsdenii and Prevotellabryantii, in addition to some fungal species of yeast such as Saccharomyces and Aspergillus. A definitive mode of action for bacterial or fungal DFM has not been established; although a variety of mechanisms have been suggested. Bacterial DFM potentially moderate rumen conditions, and improve weight gain and feed efficiency. Fungal DFM may reduce harmful oxygen from the rumen, prevent excess lactate production, increase feed digestibility, and alter rumen fermentation patterns. DFM may also compete with and inhibit the growth of pathogens, immune system modulation, and modulate microbial balance in the gastrointestinal tract. Improved dry matter intake, milk yield, fat corrected milk yield and milk fat content were obtained with DFM administration. However, the response to DFM is not constant; depending on dosages, feeding times and frequencies, and strains of DFM. Nonetheless, recent studies have supported the positive effects of DFM on ruminant performance. | Mona M Y Elghandour Abdelfattah Z M Salem Jose S Martínez Castaeda Luis M Camacho Ahmed E Kholif Juan C Vázquez Chagoyán | 2015 | Journal of Integrative Agriculture2015，14，3： | 7 |
| 3 | Novel nutraceutic therapies for the treatment of metabolic syndrome显示文摘Nutraceutic therapies such as berberine, bitter melon,Gymnema sylvestre, Irvingia gabonensis, resveratrol and ursolic acid have been shown to help control metabolic syndrome(MetS). The effect of berberine on glucose and lipid metabolism, hypertension, obesity and MetS has been evaluated in animal models and humans. Most clinical trials involving bitter melon have been conducted to evaluate its effect on glucose metabolism; nevertheless, some studies have reported favorable effects on lipids and blood pressure although there is little information about its effect on body weight. Gymnema sylvestre helps to decrease body weight and blood sugar levels; however, there is limited information on dyslipidemia and hypertension. Clinical trials of Irvingia gabonensis have shown important effects decreasing glucose and cholesterol concentrations as well decreasing body weight. Resveratrol acts through different mechanisms to decrease blood pressure, lipids, glucose and weight, showing its effects on the population with Met S. Finally, there is evidence of positive effects with ursolic acid in in vitro and in vivo studies on glucose and lipid metabolism and on body weight and visceral fat. Therefore, a review of the beneficial effects and limitations of the above-mentioned nutraceutic therapies is presented. | Esperanza Martínez-Abundis Miriam Mendez-del Villar Karina G Pérez-Rubio Laura Y Zuniga Marisol Cortez-Navarrete Alejandra Ramírez-Rodriguez Manuel González-Ortiz | 2016 | World Journal of Diabetes2016，7，7： | 3 |
| 4 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 5 | Review of the tectonics of the Levant Rift system:the structural significance of oblique continental breakup显示文摘 | Mart Y Ryan W B F Lunina O V | 2005 | Tectonophysics2005，395，： | 1 |
| 6 | Amyloid-13 and 'r biomarkers in Parkinson's disease-dementia显示文摘 | Buongiorno M Compta Y Mart MJ | 2011 | J Neurol Sci2011，310，： | 1 |
| 7 | 查看详情显示文摘 | Pavlenko Y V Rebolo R Martín E L | | 0，，： | 1 |
| 8 | Analogue experiments of propagation of oblique rifts显示文摘 | MART Y DAUTEUIL O | 2000 | Tectonophysics2000，316，1： | 1 |
| 9 | Tobacco yellow crinkle virus,a new bipartite begomovirusin infecting tobacco and pepper in Cuba显示文摘 | FIALLO-OLIVE RIVERA-BUSTAMANTE R F MARTNEZ-ZUBIAUR Y | 2009 | New disease reports2009，19，： | 1 |
| 10 | Modification of the surface properties of an activated carbon by oxygen plasma treatment显示文摘 | GARC(I)A Ana MART(I)NEZ-ALONSO Amelia LEON Carlos Leon Y | 1998 | Fuel1998，77，6： | 1 |
| 11 | The tectonic setting of the Seychelles,Mascarene and Amirante plateaus in the western equatorial Indian Ocean显示文摘 | Mart Y | 1988 | Marine Geology1988，79，3： | 1 |
| 12 | The EMT signaling pathways in endometrial carcinoma显示文摘 | Eva Colas Nuria Pedrola Laura Devis Tug?e Ertekin Irene Campoy Elena Martínez Marta Llauradó Marina Rigau Mireia Olivan Marta Garcia Silvia Cabrera Antonio Gil-Moreno Jordi Xercavins Josep Castellvi Angel Garcia Santiago Ramon y Cajal Gema Moreno-Bueno Xa | 2012 | Clinical and Translational Oncology2012，，： | 1 |
| 13 | Conservation of the salt overly sensitive pathway in rice 显示文摘 | Mart inez-Atienza J Jiang X Y Garciadeblas B | 2007 | Plant Physiol2007，143，2： | 1 |
| 14 | Robust motion estimation under varying illumination显示文摘 | Kim Y H Martínez A M Kak A C | 2005 | Image and Vision Computing2005，23，4： | 1 |
| 15 | Managing quality-of-control in network-based control systems by controller and message scheduling co-design显示文摘 | Pau Martí José Yépez Manel Velasco | 2004 | IEEE Tansaction on Industrial Electronics2004，51，6： | 1 |
| 16 | Executive dysfunction screening and intelectual coefficient measurement in children with attention deficit hyperactivity disorder显示文摘 | ZAMBRANO-S(A)NCHEZ E MART(I)NEZ-CORT(E)S J A RI-CARLOS Y D | 2010 | ARQ Neuropsiquiatr2010，68，4： | 1 |
| 17 | Integrated heterogeneous sono-photo Fenton processes for the degradation of phenolic aqueous solutions显示文摘 | Segura Y Molina R Martínez F | 2009 | Ultrasonics Sonochemistry2009，16，3： | 1 |
| 18 | Clean-up of triazines in vegetable extracts by molecular-ly imprinted solid-phase extraction using a propazine-imprinted polymer显示文摘 | CACHO C TURIEL E MART'(Y)N-ESTEBAN A | 2003 | Anal Bioanal Chem2003，376，： | 1 |
| 19 | Surface Analysis of NBR and HNBR Elastomers Modified with Different Plasma Treatments显示文摘 | Martínez L (A)lvarez L Huttel Y | 2007 | Vacuum2007，81，1112： | 1 |
| 20 | Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency显示文摘 | Nishigaki Y Martí R Copeland WC | | 0，，： | 1 |
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