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| 1 | Innate immunity and hepatocarcinoma:Can toll-likereceptors open the door to oncogenesis?显示文摘Hepatocarcinoma(HCC) is a highly prevalent cancer worldwide and its inflammatory background was established long ago.Recent studies have shown that innate immunity is closely related to the HCC carcinogenesis.An effective innate immunity response relies on the tolllike receptors(TLR) found in several different liver cells which,through different ligands and many signaling pathways can elicit,not only a pro-inflammatory but also an oncogenic or anti-oncogenic response.Our aim was to study the role of TLRs in the liver oncogenesis and as a consequence their value as potential therapeutic targets.We performed a systematic review of PubMed searching for original articles studying the relationship between HCC and TLRs until March 2015.TLR2 appears to be a fundamental stress-sensor as its absence reveals an augmented tendency to accumulate DNAdamages and to cell survival.However,pathways are still not fully understood as TLR2 up-regulation was also associated to enhanced tumorigenesis.TLR3 has a wellknown protective role influencing crucial processes like angiogenesis,cell growth or proliferation.TLR4 works as an interesting epithelial-mesenchymal transition's inducer and a promoter of cell survival probably inducing HCC carcinogenesis even though an anti-cancer role has already been observed.TLR9's influence on carcinogenesis is also controversial and despite a potential anticancer capacity,a pro-tumorigenic role is more likely.Genetic polymorphisms in some TLRs have been found and its influence on the risk of HCC has been reported.As therapeutic targets,TLRs are already in use and have a great potential.In conclusion,TLRs have been shown to be an interesting influence on the HCCs microenvironment,with TLR3 clearly determining an antitumour influence.TLR4 and TLR9 are considered to have a positive relationship with tumour development even though,in each of them anti-tumorigenic signals have been described.TLR2 presents a more ambiguous role,possibly depending on the stage of the inflammationHCC axis. | Jorge AndréGomes Lopes Marta Borges-Canha Pedro Pimentel-Nunes | 2016 | World Journal of Hepatology2016，8，3： | 12 |
| 2 | No evidence of HPV DNA in esophageal squamous cell carcinoma in a population of Southern Brazil显示文摘AIM:To investigate the association between human papillomavirus(HPV)and esophageal squamous cell carcinoma(ESCC)in southern Brazil.METHODS:We studied 189 esophageal samples from125 patients from three different groups:(1)102 biopsies from 51 patients with ESCC,with one sample from the tumor and another from normal esophageal mucosa distant from the tumor;(2)50 esophageal biopsies from 37 patients with a previous diagnosis of head and neck squamous cell carcinoma(HNSCC);and(3)37 biopsies from esophageal mucosa with normal appearance from 37 dyspeptic patients,not exposed to smoking or alcohol consumption.Nested-polymerase chain reaction(PCR)with the MY09/11 and GP5/6 L1primers was used to detect HPV L1 in samples fixed in formalin and stored in paraffin blocks.All PCR reactions were performed with a positive control(cervicovaginal samples),with a negative control(Human Genomic DNA)and with a blank reaction containing all reagents except DNA.We took extreme care to prevent DNA contamination in sample collection,processing,and testing.RESULTS:The histological biopsies confirmed the diagnosis of ESCC in 52 samples(51 from ESCC group and 1 from the HNSCC group)and classified as well differentiated(12/52,23.1%),moderately differentiated(27/52,51.9%)or poorly differentiated(7/52,13.5%).One hundred twenty-eight esophageal biopsies were considered normal(51 from the ESCC group,42 from the HNSCC group and 35 from dyspeptic patients).Nine had esophagitis(7 from the HNSCC and 2 from dyspeptic patients).Of a total of 189 samples,only 6 samples had insufficient material for PCR analysis:1 from mucosa distant from the tumor in a patient with ESCC,3from patients with HNSCC and 2 from patients without cancer.In 183 samples(96.8%)GAPDH,G3PDH and/orβ-globin were amplified,thus indicating the adequacy of the DNA in those samples.HPV DNA was negative in all the 183 samples tested:52 with ESCC,9 with esophagitis and 122 with normal esophageal mucosa.CONCLUSION:There was no evidence of HPV infection in different ESCC from southern Brazil. | Luís Carlos Moreira Antunes Joo Carlos Prolla Antonio de Barros Lopes Marta Pires da Rocha Renato Borges Fagundes | 2013 | World Journal of Gastroenterology2013，19，39： | 4 |
| 3 | Survival of patients with hepatocellular carcinoma treated by transarterial chemoembolisation (TACE) using Drug Eluting Beads. Implications for clinical practice and trial design显示文摘 | Marta Burrel María Reig Alejandro Forner Marta Barrufet Carlos Rodríguez de Lope Silvia Tremosini Carmen Ayuso Josep M Llovet María Isabel Real Jordi Bruix | 2012 | Journal of Hepatology2012，，6： | 3 |
| 4 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 5 | Towards curative therapy in gastric cancer:Faraway, so close!显示文摘Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer(GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments. | Marília Cravo Catarina Fidalgo Rita Garrido Tania Rodrigues Gon?alo Luz Carolina Palmela Marta Santos Fábio Lopes Rui Maio | 2015 | World Journal of Gastroenterology2015，21，41： | 2 |
| 6 | Survival of patients with hepatocellular carcinoma treated by transarterial chemoembolisation (TACE) using Drug Eluting Beads. Implications for clinical practice and trial design显示文摘 | Marta Burrel María Reig Alejandro Forner Marta Barrufet Carlos Rodríguez de Lope Silvia Tremosini Carmen Ayuso Josep M Llovet María Isabel Real Jordi Bruix | 2012 | Journal of Hepatology2012，，6： | 1 |
| 7 | Effect of the treatment with achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by trypanosoma evansi显示文摘 | Guilherme M. Do Carmo Matheus D. Baldissera Rodrigo A. Vaucher Virginia Cielo Rech Camila B. Oliveira Michele Rorato Sagrillo Aline A. Boligon Margareth L. Athayde Marta P. Alves Raqueli T. Fran?a Sonia T.A. Lopes Claiton I. Schwertz Ricardo E. Mendes Sil | 2014 | Experimental Parasitology2014，，： | 1 |
| 8 | Bioucas-dias, nearinfrared hyperspectral unmixing based on a minimum volume criterion for fast and accurate chemometric characterization of counterfeit tablets显示文摘 | Marta B Lopes Jean-Claude W | 2010 | Anal Chem2010，82，： | 1 |
| 9 | Wheat nitrogen metabolism during grain filling: comparative role of glumes and the flag leaves 显示文摘 | Lopes Marta S Cortadellas Nuria Kichey T | 2006 | Planta2006，225，： | 1 |
| 10 | Impact of irrigation regime on berry development and flavonoids composition in Aragonez (Syn. Tempranillo) grapevine显示文摘 | Olfa Zarrouk Rita Francisco Marta Pinto-Marijuan Ricard Brossa Raquen Raissa Santos Carla Pinheiro Joaquim Miguel Costa Carlos Lopes Maria Manuela Chaves | 2012 | Agricultural Water Management2012，，： | 1 |
| 11 | Investigation into classification/sourcing of suspect counterfeit Heptodin? tablets by near infrared chemical imaging显示文摘 | Marta B. Lopes Jean-Claude Wolff | 2008 | Analytica Chimica Acta2008，，1： | 1 |
| 12 | QTL for yield and associated traits in the Seri/Babax population grown across several environments in Mexico, in the West Asia, North Africa, and South Asia regions显示文摘 | Marta S. Lopes Matthew P. Reynolds C. Lynne McIntyre Ky L. Mathews M. R. Jalal Kamali Moussa Mossad Yousef Feltaous Izzat S. A. Tahir Ravish Chatrath Francis Ogbonnaya Michael Baum | 2013 | Theoretical and Applied Genetics2013，，4： | 1 |
| 13 | “Love Is Strong, and You're so Sweet”: JAGGER Is Essential for Persistent Synergid Degeneration and Polytubey Block in Arabidopsis thaliana显示文摘在 flowering 植物的成功的双授精和随后的种子开发要求二个精子房间的交货,由一个花粉试管搬运了,进一颗小卵的胚胎囊。胚胎囊房间紧控制 synergid 房间死亡,并且作为结果 polyspermy 块。Arabinogalactan 蛋白质是高度,涉及几的 glycosylated 蛋白质思维繁殖过程走。我们给那 JAGGER,看 Arabinogalactan 蛋白质 4,是必要的一个重要分子在 Arabidopsis thaliana 阻止多重花粉试管的生长进一胚胎囊。在 jagger, AGP4 猛烈异种,雌蕊表演作为坚持的 synergid 的幸存的后果损害了花粉试管阻塞。JAGGER 似乎涉及导致花粉试管吸引力的阻塞的发信号的小径。我们的结果流负责在 Arabidopsis 阻止 polyspermy 并且为在一个雌蕊保卫所有小卵的成功的授精的轻在机制,保证种子集合和下一代。 | Ana Marta Pereira Margarida Sofia Nobre Sara Cristina Pinto Ana Lucia Lopes Mario Luis Costa Simona Masiero Silvia Coimbra | 2016 | Molecular Plant2016，9，4： | 1 |
| 14 | Traits associated with winter wheat grain yield in Central and West Asia显示文摘Improved adaptation of winter wheat(Triticum aestivum L.) to drought and heat may be influenced by days to heading, plant height, biomass, canopy temperature(CT) at grain filling, and rate of senescence. This study shows that,under supplemental irrigation or rainfed conditions, days to heading and plant height together explain up to 68% of grain yield(GY) variation, and these associations were further confirmed in several locations across West and Central Asia.Days to heading can be slightly reduced below that of check line Karahan to further improve GY while avoiding the effect of late frosts. Plant height has been decreased in recent germplasm, but further reductions below that of check line Karahan could still improve GY in a wide range of environments. However, in Iranian sites, taller genotypes showed better adaptation with higher biomass and increased reservesfor grain filling. Canopy temperature and rate senescence were not associated with GY. A normalized difference vegetation index, used to estimate biomass(Feekes stages 4–5), had intermediate heritability across environments and correlated positively with GY under low plant density and should be explored further as a tool for early selection. | Marta Silva Lopes Didem Saglam Mutlu Ozdogan Matthew Reynolds | 2014 | Journal of Integrative Plant Biology2014，56，7： | 0 |
| 15 | Autoimmune hepatitis in a patient infected by HIV-1 and under highly active antiretroviral treatment:Case report and literature review显示文摘Liver disease has recently been described as an important cause of morbidity and mortality in patients infected with human immunodeficiency virus(HIV). Liver test changes are useful surrogates of the burden of liver disease. Previous studies have shown that transaminase elevations are frequent among these patients. The cause of those changes is harder to establish in HIV-patients. We present a 61-year-old caucasian male,diagnosed with HIV type 1 infection since 1998,under highly active antiretroviral treatment(HAART),with virological suppression and immunological recovery. He presented in a follow-up laboratory workup high values of transaminases,arthralgia at the hip joints and hepatomegaly. Liver function tests were normal. The antibodies to hepatitis viruses were negative. However,autoimmune study and liver biopsy were compatible with autoimmune hepatitis(AIH). The AIH is a rare di-agnosis in HIV-infected patients perhaps because the elevation of transaminases and changes in liver function tests are often associated to HAART or to other possible liver diseases,namely viral hepatitis and non-alcoholic steatohepatitis. The diagnosis may be underestimated. There are no specific recommendations available for the treatment of HIV-associated AIH although the immunosupression with slower tapering seems the most reasonable approach. | Marta Casal Moura Edite Pereira Vítor Braz Catarina Eloy Joanne Lopes Fátima Carneiro José Paulo Araújo | 2014 | World Journal of Immunology2014，4，3： | 0 |
| 16 | Isolated unilateral chorea:a diagnostic challenge显示文摘Movement disorders of paraneoplastic etiology are very rare,representing solely about 1%of all paraneoplastic neurological syndromes.^([1])The most frequently associated carcinoma is small-cell lung cancer,although several others are reported such as hematologic,bowel,breast,prostate and bladder.It was reported an association with CV2/CRMP5,Anti-Hu/ANNA,CASPR2 and Yo antibodies,which are detectable in serum in most cases,isolated or in association.^([1-4])However,in a minority of cases an autoantibody cannot be detected.^([1])The antibody most frequently associated with paraneoplastic chorea is CV2/CRMP5,followed by Anti-Hu/ANNA. | Marta Lopes Eva Brandão | 2016 | Neuroimmunology and Neuroinflammation2016，3，1： | 0 |
| 17 | Needle knife fstulotomy in flat and diverticular papillae:Is it time for redemption?显示文摘Background: European Society of Gastrointestinal Endoscopy( ESGE) recommends needle-knife fstulotomy(NKF) as the preferred precut technique in cases when standard cannulation techniques fail. Despite scarce scientifc evidence, flat and diverticular papillae are thought not to be ideal for NKF, as they are associated with poor outcomes. The present study aimed to determine the outcomes of the use of NKF in relation to flat and intradiverticular papillae. Methods: This prospective multicenter study enrolled consecutive patients, evidencing na?ve flat(group A, n = 49) or diverticular papilla(group B, n = 28), who underwent NKF after failure of standard cannulation techniques. Diverticular morphology was subdivided into intradiverticular(group B1, n = 14) and diverticular border papillae(group B2, n = 14), using a previously validated endoscopic classifcation of the major papilla. The success of biliary cannulation at initial endoscopic retrograde cholangiopancreatography(ERCP), overall biliary cannulation, overall cannulation time, and the rate of adverse events were assessed in the study. Results: The initial cannulation rates were 93.9%, 64.3% and 71.4% for group A, B1, and B2, respectively( P = 0.005);overall cannulation rates after a second ERCP were 98.0%, 92.9% and 85.7%, respectively( P = 0.134). Adverse events occurred in 11.7% of patients, with post-ERCP pancreatitis(PEP) being the most common adverse event(10.4%). Although there was a trend towards a higher incidence of PEP in flat papillae, univariate and multivariate analyses did not show any signifcant relationship between pancreatitis and trainee involvement, papillary morphology, nor overall cannulation time. Conclusions: Although flat papillae are associated with high success rates of biliary cannulation using NKF, the rate of PEP is not negligible. NKF is feasible in diverticular papillae, but it is associated with a modest success rate in the initial ERCP. | João Fernandes Jorge Canena Marta Moreira Gonçalo Alexandrino Luísa Figueiredo Tarcísio Araújo Luís Lourenço David Horta Luís Lopes | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，2： | 0 |
| 18 | Metabolic-associated fatty liver disease is associated with low muscle mass and strength in patients with chronic hepatitis B显示文摘BACKGROUND Although the prognostic relevance of sarcopenia has been increasingly recognised in the context of liver disease,there is a paucity of data evaluating body composition in patients with chronic hepatitis B(CHB).Beyond virus-related factors,nutritional and metabolic aspects can be associated with skeletal muscle abnormalities in these patients and should not be disregarded.AIM To evaluate the association between components of sarcopenia and demographic,clinical,lifestyle,nutritional,and biochemical variables in CHB patients.METHODS Dual-energy X-ray absorptiometry(DXA)was used to assess muscle mass by quantifying appendicular lean mass(ALM)adjusted for body mass index(ALMBMI).Muscle function was evaluated by hand grip strength(HGS)and the timed up and go test.Metabolic-associated fatty liver disease(MAFLD)was defined according to the criteria proposed by an international expert panel.A body shape index and the International Physical Activity Questionnaire were used to assess central obesity and physical activity level,respectively.RESULTS This cross-sectional study included 105 CHB outpatients followed at the tertiary care ambulatory centre(mean age,48.5±12.0 years;58.1%males;76.2%without cirrhosis;23.8%with compensated cirrhosis).The DXA-derived fat mass percentage was inversely correlated with the ALMBMI(r=-0.87)and HGS(r=-0.63).In the multivariable analysis,MAFLD,sedentarism and central obesity were positively and independently associated with low ALMBMI.MAFLD and central obesity were independently associated with low HGS.CONCLUSION MAFLD and central obesity were associated with low muscle mass and strength in patients with chronic hepatitis B,independent of the liver disease stage. | Cecy Maria de Lima Santos Matheus Duarte Brito Pedro Alves Soares Vaz de Castro Thais Pontello de Vries Nataly Lopes Viana Marta Paula Pereira Coelho Olívio Brito Malheiro Tatiana Bering Maria Cristina Gonzalez Rosangela Teixeira Rodrigo Dias Cambraia Gifone Aguiar Rocha Luciana Diniz Silva | 2022 | World Journal of Hepatology2022，14，8： | 0 |
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