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| 1 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 2 | Long term outcome after bone marrow transplantation for severe aplastic anemia显示文摘 | Ades L mary JY robin M | 2004 | Blood2004，103，7： | 1 |
| 3 | Developing a practice doctorate in nursing: University of Washington perspectives and experience显示文摘 | Marie A B Mary AD Phyllis AZ | 2006 | Nursing Outlook2006，54，3： | 1 |
| 4 | Endoscopic appearance of proximal colorectal neoplasms and potential implications for colonoscopy in cancer prevention显示文摘 | Eveline J.A. Rondagh Mari?lle W.E. Bouwens Robert G. Riedl Bjorn Winkens Rogier de Ridder Tonya Kaltenbach Roy M. Soetikno Ad A.M. Masclee Silvia Sanduleanu | 2012 | Gastrointestinal Endoscopy2012，，6： | 1 |
| 5 | Yisfatin in obese children and adolescents and its association with insulin resistance and metabolic syndrome显示文摘 | Mitra Nourbakhsh Mona N ourbakhsh Zafar Gholinej ad Mary am Razzaghy-Azar | 2015 | Scandinavian Journal of Clinical & Laboratory Investigation2015，75，2： | 1 |
| 6 | Relapse following discontinuation of imatinib mesylate therapy for FIP1 L1/PDGFRA- positive chronic eosinophilic leukemia: implications for optimal dosing显示文摘 | Klion AD Robyn J Marie I | 2007 | Blood2007，110，10： | 1 |
| 7 | Development and evaluation of an interactive CD - ROM for children with leukemia and their families显示文摘 | Mary AD Patricia JB Judith KJ etal | 2002 | Patient Education and Conseling2002，46，： | 1 |
| 8 | Increased MRP expression is associated with resistance to radiation, anthracyclines and etoposide in cells treated with fractionated γ-radiation显示文摘 | Rozelle MH Mary WD Ross AD | 1997 | Int J Cancer1997，73，： | 1 |
| 9 | Development of a quantitative competitive PCR assays for detection and quantification of Esherichia coli O157:H7 cells 显示文摘 | Wenli L Mary AD | 2001 | Appl Environ Microbiol2001，67，7： | 1 |
| 10 | An assessment of factors contributing to treatment adherence and knowledge ot TB transmission among patients on TB treatment显示文摘 | Frederick AD Kaona Mary Tuba Seter Siziya | 2004 | BMC Public Health2004，4，1： | 1 |
| 11 | Relationship between attentional performance and corpus callosum morphometry in patients with Alzheimer's disease 显示文摘 | Marie S,Do minique H | 2002 | Neuropsychologia2002，40，： | 1 |
| 12 | A Phase I/II Study of Erlotinib in Combination with the Anti-Insulin-Like Growth Factor-1 Receptor Monoclonal Antibody IMC-A12 (Cixutumumab) in Patients with Advanced Non-small Cell Lung Cancer显示文摘 | Andrew Weickhardt Robert Doebele Ana Oton Janice Lettieri DeLee Maxson Michele Reynolds Amy Brown Mary K. Jackson Grace Dy Araba Adjei Gerald Fetterly Xian Lu Wilbur Franklin Marileila Varella-Garcia Fred R. Hirsch Murry W. Wynes Hagop Youssoufian Alex Ad | 2012 | Journal of Thoracic Oncology2012，，2： | 1 |
| 13 | Mycophenolate mofetil therapy in lupus nephritis: clinical observations显示文摘 | Mary AD Fernando GC Patrick H | 1999 | J Am Soc Nephrol1999，10，5： | 1 |
| 14 | Verapamil-stimulated glutathione transport by the multidrug resistance-associated protein (MRP1) in leukaemia cells显示文摘 | Karen VC Ross AD Mary WD | 2001 | Biochemical Pharmacology2001，62，4： | 1 |
| 15 | Mycophenolate Mofetil or Intravenous Cyclophosphamide for Lupus Nephritis显示文摘 | Ellen MG Mary AD Cynthia A | 2005 | N Engl J Med2005，353，： | 1 |
| 16 | Evaluation of graduates of an associate degree nursing program 显示文摘 | Salva F Mary AM Charles AD | 1999 | J Nurs Educ1999，38，2： | 1 |
| 17 | Long - term outcome after bone marrow transplantation for severe aplastic anemia显示文摘 | Ades L Mary JY Robin M | 2004 | Blood2004，103，7： | 1 |
| 18 | Relapse following discontinuation of imatinib mesylate therapy for FIP1LI/PDGFRA-positive chronic e- osinophilic leukemia: implications for optimal dosing 显示文摘 | Klion AD Robyn J Marie I | 2007 | Blood2007，110，10： | 1 |
| 19 | Incidence of 17p deletions and TP53 mutation in myelodysplastic syndrome and acute myeloid leukemia with 5q deletion显示文摘 | Amel Sebaa Lionel Ades Fanny Baran‐Marzack Marie‐Joelle Mozziconacci Dominique Penther Sophie Dobbelstein Aspasia Stamatoullas Christian Récher Thomas Prebet Soraya Moulessehoul Pierre Fenaux Virginie Eclache | 2012 | Genes Chromosom. Cancer2012，，12： | 1 |
| 20 | Long-term outcome after bone marrow transplantation for server aplastic anemia显示文摘 | Ades L Mary JY Robin M | 2004 | Blood2004，103，7： | 1 |
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