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21篇 您的检索式：作者名="Masachika"

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	题名	作者	年代	出处	被引量
1	Induction of CD69 expression by cag PAI-positive Helicobacter pylori infection显示文摘AIM: To investigate and elucidate the molecular mechanism that regulates inducible expression of CD69 by Helicobacter pylori (H. pylori ) infection. METHODS: The expression levels of CD69 in a T-cell line, Jurkat, primary human peripheral blood mononuclear cells (PBMCs), and CD4 + T cells, were assessed by immunohistochemistry, reverse transcription polymerase chain reaction, and flow cytometry. Activation of CD69 promoter was detected by reporter gene. Nuclear factor (NF)-κB activation in Jurkat cells infected with H. pylori was evaluated by electrophoretic mobility shift assay. The role of NF-κB signaling in H. pylori-induced CD69 expression was analyzed using inhibitors of NF-κB and dominant-negative mutants. The isogenic mutants with disrupted cag pathogenicity island (cag PAI) and virD4 were used to elucidate the role of cag PAI-encoding type Ⅳ secretion system and CagA in CD69 expression.RESULTS: CD69 staining was detected in mucosal lymphocytes and macrophages in specimens of pa- tients with H. pylori-positive gastritis. Although cag PAI- positive H. pylori and an isogenic mutant of virD4 induced CD69 expression, an isogenic mutant of cag-PAI failed to induce this in Jurkat cells. H. pylori also induced CD69 expression in PBMCs and CD4 + T cells. The activation of the CD69 promoter by H. pylori was mediated through NF-κB. Transfection of dominant-negative mutants of IκBs, IκB kinases, and NF-κB-inducing kinase inhibited H. pylori-induced CD69 activation. Inhibitors of NF-κB suppressed H. pylori-induced CD69 mRNA expression. CONCLUSION: The results suggest that H. pylori induces CD69 expression through the activation of NF-κB. cagPAI might be relevant in the induction of CD69 expression in T cells. CD69 in T cells may play a role in H. pylori-induced gastritis.	Naoki Mori Chie Ishikawa Masachika Senba	2011	World Journal of Gastroenterology2011，17，32：	2
2	Biologi- cal properties and gene expression associated with metastatic po- tential of human osteosarcoma 显示文摘	TETSUHIRO N MASACHIKA T YASUNORI I etal	2003	Clin Exp Metast2003，20，7：	1
3	Biocontrol method in aquaculture for rearing the swimming crab larvae Portunus trituberculatus显示文摘	Kinya Nogami Katsuyuki Hamasaki Masachika Maeda Kazutsugu Hirayama	1997	Hydrobiologia (-)1997，，1：	1
4	Mitochondrial cytochrome C release and caspase-3-like protease activation during indomethacin-induced apoptosis in rat gastric mucosal cells显示文摘	Yasuyoshi F Tatsuya M Masachika K	2000	Soc Exp Biol Med2000，224，：	1
5	A new parameter for determination of the extent of staling in beer显示文摘	Shigeki Araki Masachika Takashio Ken Shinotsuka	2002	J Am Soc Brew Chem2002，60，1：	1
6	Mutation and expression of the p51gene in Human Lung Cancer显示文摘	Masachika Tani Kimihiro Shimizol	1999	Neoplasia1999，1，：	1
7	Naftopidil induces apoptosis in malignant mesothelioma cell lines independently of al-adrenoceptor blocking显示文摘	Masachika E Kanno T Nakano T	2013	Anticancer Res2013，33，3：	1
8	Why do chronic subdural hematomas continue to grow slowly and not coagulate?Role of thrombomodulin in the mechanism显示文摘	Murakami H Hirose Y Masachika S	2002	J Neurosurg2002，96，：	1
9	l Why do chronic subduralhema-tomas continue to grow slowly and notcoagulate? Role of thrombomodulinin themechanism显示文摘	HidekiM YuichiH Masachika S eta	2002	JNeurosurg2002，96，：	1
10	Ethyl Pyruvate-A New Indicator of Flavor Stability of Beer and Its Controlling Factors显示文摘	Chikako Shimizu Yasunobu Nara Masachika Takashio	2005	Am Soc Brew Chem2005，63，3：	1
11	A New Parameter for Determination of the Extent of Staling in Beer 显示文摘	Shigeki Araki Masachika Takashio Ken Shinotsuka	2002	Am Soc Brew Chem2002，60，1：	1
12	Properties of energy subtraction images obtained by X-rays with sharpened energy spectrum显示文摘	Masachika O Taku K Koji M	2009	IFMBE Proc2009，14，3：	1
13	Finite element analysis of the formability of an austenitic stainless steel sheet in warm deep drawing显示文摘	Takuda H Mori K Masachika T	2003	Journal of Materials Processing Technology2003，12，20：	1
14	Why do chronic subdural hematomas continue to grow slowly and not coagulate? Role of thrombomodulin in the mechanism显示文摘	Murakami H Hirose Y Masachika S	2002	J Neurosurg2002，96，5：	1
15	Orthotopic growth and metastasis of human non-small cell lung carcinoma cells injected into the pleural cavity of nude mice显示文摘	Yasuhiro N Masachika T Kimihiro S	1998	Cancer letters1998，127，1998：	1
16	Late hemorrhage from persistent pseudoaneurysm in vertebral artery dissection presenting with ischemia:case report显示文摘	Masachika S Yuichi H Hideki M	1999	Surgical Neurology1999，52，5：	1
17	Why do chronic subdural hematomas continue to grow slowly and not coagulate? Role of thrombomodulin in the mechanism显示文摘	Yuichi H Masachika S	2002	J Neurosurg2002，96，：	1
18	Peroxisome proliferator-activated receptor-γ activation with angiotensinⅡ type 1 receptor blockade is pivotal for the prevention of blood-brain barrier impairment and cognitive decline in type 2 diabetic mice显示文摘	Min LJ Masaki M Masachika SD	2012	Hypertension2012，59，23：	1
19	Loss of CDX2 Expression and Microsatellite Instability Are Prominent Features of Large Cell Minimally Differentiated Carcinomas of the Colon显示文摘	Takao Hinoi Masachika Tani Peter C. Lucas Karel Caca Rodney L. Dunn Ettore Macri Massimo Loda Henry D. Appelman Kathleen R. Cho Eric R. Fearon	2001	The American Journal of Pathology2001，，6：	1
20	Preliminary Analysis for Ground Structure around Source Region of 2008 Iwate-Miyagi Nairiku Earthquake显示文摘	Hitoshi Morikawa Masachika Tanigawa Taiyo Kobayashi Hiroko Matsuo	2011	Journal of Civil Engineering and Architecture2011，5，2：	0

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