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| 1 | Current status in remnant gastric cancer after distal gastrectomy显示文摘Remnant gastric cancer(RGC) and gastric stump cancer after distal gastrectomy(DG) are recognized as the same clinical entity. In this review, the current knowledges as well as the non-settled issues of RGC are presented. Duodenogastric reflux and denervation of the gastric mucosa are considered as the two main factors responsible for the development of RGC after benign disease. On the other hand, some precancerous circumstances which already have existed at the time of initial surgery, such as atrophic gastritis and intestinal metaplasia, are the main factors associated with RGC after gastric cancer. Although eradication of Helicobacter pylori(H. pylori) in remnant stomach is promising, it is still uncertain whether it can reduce the risk of carcinogenesis. Periodic endoscopic surveillance after DG was reported useful in detecting RGC at an early stage, which offers a chance to undergo minimally invasive endoscopic treatment or laparoscopic surgery and leads to an improved prognosis in RGC patients. Future challenges may be expected to elucidate the benefit of eradication of H. pylori in the remnant stomach if it could reduce the risk for RGC, to build an optimal endoscopic surveillance strategy after DG by stratifying the risk for development of RGC, and to develop a specific staging system for RGC for the standardization of the treatment by prospecting the prognosis. | Masaichi Ohira Takahiro Toyokawa Katsunobu Sakurai Naoshi Kubo Hiroaki Tanaka Kazuya Muguruma Masakazu Yashiro Naoyoshi Onoda Kosei Hirakawa | 2016 | World Journal of Gastroenterology2016，22，8： | 15 |
| 2 | Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma显示文摘AIM To elucidate the effect of expression of doublecortin and Ca M kinase-like-1(DCLK1) in patients with pancreatic ductal adenocarcinoma(PDAC). METHODS Tumor specimens were obtained from 136 patients with pancreatic cancer who had undergone resection without preoperative therapy between January 2000 and December 2013 at the Department of Surgical Oncology, Osaka City University. The resected specimens were analyzed for associations with clinicopathological data, including DCLK1 expression, epithelial mesenchymal transition(EMT) marker expression, and cancer stem cell(CSC) marker expression. Univariate and multivariate survival analyses were performed and we assessed the association between DCLK1 expression and clinicopathological factors, including the EMT marker and CSC marker.RESULTS In total, 48.5%(66/136) of the pancreatic cancer samples were positive for DCLK1. Patients with DCLK1-positive tumors had significantly shorter survival times than those with DCLK1-negative tumors(median, 18.7 mo vs 49.5 mo, respectively; P < 0.0001). Positive DCLK1 expression correlated with histological grade(P = 0.0290), preoperative CA19-9 level(P = 0.0060), epithelial cell adhesion molecule(Ep CAM) expression(P = 0.0235), and the triple-positive expression of CD44/CD24/Ep CAM(P = 0.0139). On univariate survival analysis, five factors were significantly associated with worse overall survival: histological grade of G2 to G4(P = 0.0091), high preoperative serum SPan-1 level(P = 0.0034), R1/2(P < 0.0001), positive expression of DCLK1(P < 0.0001) or CD44(P = 0.0245). On multivariate survival analysis, R1/2 [odds ratio(OR) = 2.019, 95% confidence interval(CI): 1.380-2.933; P = 0.0004] and positive DCLK1 expression(OR = 1.848, 95%CI: 1.2854-2.661; P = 0.0009) were independent prognostic factors. CONCLUSION DCLK1 expression was found to be an independent prognostic factor and it may play a crucial prognostic role by promoting acquisition of stemness. | Kohei Nishio Kenjiro Kimura Ryosuke Amano Bunzo Nakata Sadaaki Yamazoe Go Ohira Kotaro Miura Naoki Kametani Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa Masaichi Ohira | 2017 | World Journal of Gastroenterology2017，23，31： | 3 |
| 3 | Vitamin D receptor expression is associated with colon cancer in ulcerativecolitis显示文摘 | Koji Wada Hiroaki Tanaka Kiyoshi Maeda Toru Inoue Eiji Noda Ryosuke Amano Naoshi Kubo Kazuya Muguruma Nobuya Yamada Masakazu Yashiro Tetsuji Sawada Bunzo Nakata Masaichi Ohira Kosei Hirakawa | 2009 | Oncology Reports2009，，5： | 2 |
| 4 | Carcinoid Tumor of the Kidney Presenting as a Large Abdominal Mass: Report of a Case显示文摘 | Hidemi Kawajiri Naoyoshi Onoda Masaichi Ohira Tatsuya Nakatani Kenichi Wakasa Tetsuro Ishikawa Kosei Hirakawa | 2004 | Surgery Today2004，，： | 2 |
| 5 | Electrostatic control of protein adsorption on UV-photofunctionalized titanium显示文摘 | Norio Hori Takeshi Ueno Hajime Minamikawa Fuminori Iwasa Fumihiko Yoshino Katsuhiko Kimoto Masaichi Chang-Il Lee Takahiro Ogawa | 2010 | Acta Biomaterialia2010，，10： | 1 |
| 6 | The Glasgow prognostic score is valuable for colorectal cancer withboth synchronous and metachronous unresectable liver metastases显示文摘 | Kenei Furukawa Hiroaki Shiba Koichiro Haruki Yuki Fujiwara Tomonori Iida Yoshinobu Mitsuyama Masaichi Ogawa Yuichi Ishida Takeyuki Misawa Katsuhiko Yanaga | 2012 | Oncology Letters2012，，2： | 1 |
| 7 | Acceleration of the oxidation of Fe ions by Fe(Ⅲ)-oxyhydroxides显示文摘 | Hirokin T Shizuo K Masaichi H | 1980 | Corrosion Science1980，20，： | 1 |
| 8 | Solanesol from tobacco leaf extracts显示文摘 | Takemare Masaichi Amaro | 1979 | Jpn Kokai to Kkgo Koho Appl1979，27，10： | 1 |
| 9 | Sa1654 Short- and Long-Term Prognosis of Patients With Early Gastric Cancer: Comparative Analysis Between Endoscopic Submucosal Dissection and Surgical Operation显示文摘 | Shusei Fukunaga Hirohisa Machida Kazunari Tominaga Hiroaki Tanaka Kazuya Muguruma Masaichi Ohira Yasuaki Nagami Satoshi Sugimori Hirotoshi Okazaki Tetsuya Tanigawa Hirokazu Yamagami Kenji Watanabe Toshio Watanabe Yasuhiro Fujiwara Kosei Hirakawa Tetsuo Ar | 2012 | Gastrointestinal Endoscopy2012，，4： | 1 |
| 10 | Role of the Stemness Factors Sox2, Oct3/4, and Nanog in Gastric Carcinoma显示文摘 | Junko Matsuoka Masakazu Yashiro Katsunobu Sakurai Naoshi Kubo Hiroaki Tanaka Kazuya Muguruma Tetsuji Sawada Masaichi Ohira Kosei Hirakawa | 2012 | Journal of Surgical Research2012，，1： | 1 |
| 11 | An Improved Intragastric Balloon Procedure Using a New Balloon: Preliminary Analysis of Safety and Efficiency显示文摘 | Gustavo L. Carvalho Cesar B. Barros Masaichi Okazaki Moacir L. Novaes Pedro C. Albuquerque Nair C. Almeida Pedro Paulo C. Albuquerque Chika Wakiyama Thiago G. Vila?a José Sergio N. Silva Rapahel M. Coelho | 2009 | Obesity Surgery2009，，2： | 1 |
| 12 | Solanesol from tobacco leaf exrracts显示文摘 | Takemare Masaichi Amaro | 1979 | Jpn Kokai to Kkgo Koho Appl1979，27，10： | 1 |
| 13 | Perioperative change in peripheral blood monocyte count may predict prognosis in patients with colorectal liver metastasis after hepatic resection显示文摘 | Koichiro Haruki Hiroaki Shiba Yuki Fujiwara Kenei Furukawa Shigeki Wakiyama Masaichi Ogawa Yuichi Ishida Takeyuki Misawa Katsuhiko Yanaga | 2012 | J. Surg. Oncol2012，，1： | 1 |
| 14 | Carcinoembryonic antigen and carbohydrate antigen 19-9 are prognosticpredictors of colorectal cancer with unresectable liver metastasis显示文摘 | Yoshinobu Mitsuyama Hiroaki Shiba Koichiro Haruki Yuki Fujiwara Kenei Furukawa Tomonori Iida Takenori Hayashi Masaichi Ogawa Yuichi Ishida Takeyuki Misawa Hideyuki Kashiwagi Katsuhiko Yanaga | 2012 | Oncology Letters2012，，4： | 1 |
| 15 | Role of the Stemness Factors Sox2, Oct3/4, and Nanog in Gastric Carcinoma显示文摘 | Junko Matsuoka Masakazu Yashiro Katsunobu Sakurai Naoshi Kubo Hiroaki Tanaka Kazuya Muguruma Tetsuji Sawada Masaichi Ohira Kosei Hirakawa | 2012 | Journal of Surgical Research2012，，1： | 1 |
| 16 | Role of the Stemness Factors Sox2, Oct3/4, and Nanog in Gastric Carcinoma显示文摘 | Junko Matsuoka Masakazu Yashiro Katsunobu Sakurai Naoshi Kubo Hiroaki Tanaka Kazuya Muguruma Tetsuji Sawada Masaichi Ohira Kosei Hirakawa | 2012 | Journal of Surgical Research2012，，1： | 1 |
| 17 | Insecticide Susceptibility of the Brown Planthopper and the White-backed Planthopper Collected from Southeast Asia显示文摘 | SHOZO ENDO MASAICHI TSURUMACHI | 2001 | Joumal of Pesticide Science2001，26，1： | 1 |
| 18 | Role of the Stemness Factors Sox2, Oct3/4, and Nanog in Gastric Carcinoma显示文摘 | Junko Matsuoka Masakazu Yashiro Katsunobu Sakurai Naoshi Kubo Hiroaki Tanaka Kazuya Muguruma Tetsuji Sawada Masaichi Ohira Kosei Hirakawa | 2012 | Journal of Surgical Research2012，，1： | 1 |
| 19 | Synergic antiproliferative effect of DNA methyhransferase inhibitor in combination with anticancer drugs in gastric carcinoma 显示文摘 | Zhang X T Masakazu Y Masaichi O | 2006 | Cancer Sci2006，97，9： | 1 |
| 20 | Discussion on the mechanism of ground improvement method at the excavation of shallow overburden tunnel in difficult ground显示文摘Tunnel construction opportunities involving shallow overburdens under difficult(e.g.,soft,unconsolidated)grounds have been increasing in Japan.Various auxiliary methods for excavating mountain tunnels have been developed and can satisfy stringent construction requirements.The ground improvement method,which is one of the auxiliary methods for shallow overburden tunnels,has demonstrated its ability to effectively control the amount of settlement under soft ground.However,the mechanism of the ground improvement method has not been clarified,nor has a suitable design code been established for it.Therefore,because the strength of the improved ground and the suitable length and width of the improved area have not been fully understood,an empirical design has been applied in every case.In this paper,the mechanical behavior during the excavation,including that of the stabilized ground,is evaluated through trapdoor experiments and numerical analyses.In addition,the enhancement of tunnel stability resulting from the application of the ground improvement method is discussed. | Kiyoshi Kishida Ying Cui Masaichi Nonomura Tomomi Iura Makoto Kimura | 2016 | Underground Space2016，1，2： | 0 |
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