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| 1 | Molecular underpinnings for microbial extracellular electron transfer during biogeochemical cycling of earth elements显示文摘Microbial extracellular electron transfer(EET) is electron exchanges between the quinol/quinone pools in microbial cytoplasmic membrane and extracellular substrates. Microorganisms with EET capabilities are widespread in Earth hydrosphere, such as sediments of rivers, lakes and oceans, where they play crucial roles in biogeochemical cycling of key elements, including carbon,nitrogen, sulfur, iron and manganese. Over the past 12 years, significant progress has been made in mechanistic understanding of microbial EET at the molecular level. In this review, we focus on the molecular mechanisms underlying the microbial ability for extracellular redox transformation of iron, direct interspecies electron transfer as well as long distance electron transfer mediated by the cable bacteria in the hydrosphere. | Yongguang Jiang Meimei Shi Liang Shi | 2019 | Science China(Life Sciences)2019，62，10： | 7 |
| 2 | Electromicrobiology and biotechnological applications of the exoelectrogens Geobacter and Shewanella spp.显示文摘Electromicrobiology is a sub-discipline of microbiology that investigates electrical interplay between microorganisms and redox active materials, such as electrodes and solid-phase minerals, and the mechanisms underlying microbial ability to exchange electrons with the redox active materials that are external to the microbial cells. The microorganisms with extracellular electron transfer capability are often referred to as exoelectrogens. Although exoelectrogens were documented in early 1900’s, discovery of the dissimilatory metal-reducing microorganisms Geobacter and Shewanella spp. in late 1980’s marked the beginning of modern electromicrobiology. Since then, thorough and rigorous studies have made Geobacter and Shewanella spp. the two best characterized groups of exoelectrogens. These include identification and characterization of the molecular mechanisms for exchanging electrons with electrodes by Geobacter sulfurreducens and Shewanella oneidensis. In addition, a variety of applications of Geobacter and Shewanella spp. in microbial fuel cells and electrobiosynthesis, such as maintenance of redox balance during fermentations and bioremediations, have also been developed. This review briefly discusses the molecular mechanisms by which G. sulfurreducens and S. oneidensis exchange electrons with electrodes and then focuses on biotechnological applications of Geobacter and Shewanella spp. in microbial fuel cells and electrobiosynthesis as well as the future directions of this research area. | SHI MeiMei JIANG YongGuang SHI Liang | 2019 | Science China(Technological Sciences)2019，62，10： | 4 |
| 3 | Additive-free non-fullerene organic solar cells with random copolymers as donors over 9% power conversion efficiency显示文摘In this study, a series of random conjugated polymers (PBDB-TBTn) as donors were designed and synthesized. In these polymers, benzodithiophene unit with thiophene conjugated side chains (BDT) are donor part, and two different content of benzo[1,2-c:4,5-c']dithiophene-4,8-dione (BDD) and difluorobenzothiadizole (BT) linked alkylthiophene are acceptor unit. Polymer solar cells (PSCs) were fabricated with ITIC as an acceptor, and over the power conversion efficiency (PCE) of 9%was obtained, with open circuit voltage (Voc) of 0.86 V, short-circuit current density (Jsc) of 16.84 mA/cm^2, and fill factor (FF) of 62.5%. These random conjugated polymers based solar cells are insensitive to solvent additives and thermal annealing. The performance of the device decreases gradually with the increasing of the proportion of fluorinated acceptor unit. The declining efficiency is due to the excessive fluorinated acceptor unit, which leads to over aggregated topography, destroys the effective charge transport pathways, and affects phase separation domain size between the donor and the acceptor. The phenomena are explained by the charge carrier recombination, atomic force microscope (AFM), and transmission electron microscope (TEM). These results indicate that proper addition of fluorinated acceptor units to build random copolymers can enhance the efficiency of organic photovoltaics toward additive-free and thermal annealing-free PSCs. | Meimei Wu Laitao Shi Yu Hu Lie Chen Ting Hu Youdi Zhang Zhongyi Yuan Yiwang Chen | 2019 | Chinese Chemical Letters2019，30，6： | 3 |
| 4 | Effect of metal–support interaction on the catalytic performance of Ni/Al 2 O 3 for selective hydrogenation of isoprene显示文摘 | Rong Wang Yonghong Li Ronghui Shi Meimei Yang | 2011 | Journal of Molecular Catalysis A Chemical2011，，1： | 1 |
| 5 | Potentiation of synaptic strength and intrinsic excitability in the nucleus accumbens after 10 days of morphine withdrawal显示文摘 | Xiaobo Wu Meimei Shi Chunling Wei | | 0，，： | 1 |
| 6 | Role of methylation in vernalization and photoperiod pathway:a potential flowering regulator?显示文摘Recognized as a pivotal developmental transition,flowering marks the continuation of a plant’s life cycle.Vernalization and pho-toperiod are two major flowering pathways orchestrating numerous florigenic signals.Methylation,including histone,DNA and RNA methylation,is one of the recent foci in plant development.Considerable studies reveal that methylation seems to show an increasing potential regulatory role in plant flowering via altering relevant gene expression without altering the genetic basis.However,little has been reviewed about whether and how methylation acts on vernalization-and photoperiod-induced flowering before and after FLOWERING LOCUS C(FLC)reactivation,what role RNA methylation plays in vernalization-and photoperiod-induced flowering,how methylation participates simultaneously in both vernalization-and photoperiod-induced flowering,the heritability of methylation memory under the vernalization/photoperiod pathway,and whether and how methylation replaces vernalization/photoinduction to regulate flowering.Our review provides insight about the crosstalk among the genetic control of the flowering gene network,methylation(methyltransferases/demethylases)and external signals(cold,light,sRNA and phytohormones)in vernalization and photoperiod pathways.The existing evidence that RNA methylation may play a potential regulatory role in vernalization-and photoperiod-induced flowering has been gathered and represented for the first time.This review speculates about and discusses the possibility of substituting methylation for vernalization and photoinduction to promote flowering.Current evidence is utilized to discuss the possibility of future methylation reagents becoming flowering regulators at the molecular level. | Meimei Shi Chunlei Wang Peng Wang Fahong Yun Zhiya Liu Fujin Ye Lijuan Wei Weibiao Liao | 2023 | Horticulture Research2023，10，10： | 0 |
| 7 | Safety and activity of WX-0593(Iruplinalkib)in patients with ALK-or ROS1-rearranged advanced non-small cell lung cancer:a phase 1 dose-escalation and dose-expansion trial显示文摘WX-0593(Iruplinalkib)is a novel,highly selective oral ALK and ROS1 tyrosine kinase inhibitor(TKI).In this study,the safety,antitumor activity,and pharmacokinetics of WX-0593 were evaluated in advanced non-small cell lung cancer(NSCLC)patients with ALK or ROS1 rearrangement.In the dose-escalation phase and dose-expansion phase,patients were treated with WX-0593 until disease progression,unacceptable toxicity,or subject withdrawal.In the dose-escalation phase,the primary endpoints were maximum tolerated dose(MTD),dose-limiting toxicity(DLT),and safety assessed by investigators.In the dose-expansion phase,the primary endpoint was objective response rate(ORR)assessed by investigators.Between September 25,2017 and October 15,2018,a total of 153 patients received WX-0593 treatment.Two dose-limiting toxicities(DLTs)including one grade 3 QT interval prolonged and one grade 2 chronic heart failure were reported at the dose of 300 mg in one patient.MTD was not reached.Overall,140 of the 152(92%)patients experienced treatment-related adverse events(TRAEs)and 35 of the 152(23%)patients had TRAEs≥grade 3.The overall ORR was 59.3%(32 of 54)for the dose-escalation phase and 56.6%(56 of 99)for the dose-expansion phase.For patients who were ALK-rearranged and ALK TKI naive,the ORR were 81.0%(17 of 21)in the dose-escalation phase and 76.3%(29 of 38)in the dose-expansion phase,and for patients who previously received crizotinib as the only ALK TKI,the ORR were 38.1%(8 of 21)and 45.7%(21 of 46)for the two phases,respectively.For patients who were ROS1-rearranged,the ORR were 30.0%(3 of 10)in the dose-escalation phase and 44.4%(4 of 9)in the dose-expansion phase.WX-0593 showed favorable safety and promising antitumor activity in advanced NSCLC patients with ALK or ROS1 rearrangement. | Yuankai Shi Jian Fang Xuezhi Hao Shucai Zhang Yunpeng Liu Lin Wang Jianhua Chen Yi Hu Xiaosheng Hang Juan Li Chunling Liu Yiping Zhang Zhehai Wang Yanping Hu Kangsheng Gu Jian’an Huang Liangming Zhang Jinlu Shan Weiwei Ouyang Yanqiu Zhao Wu Zhuang Yan Yu Jun Zhao Helong Zhang Pei Lu Weidong Li Meimei Si Mingjing Ge Huaize Geng | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
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