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| 1 | A RELAXED HSS PRECONDITIONER FOR SADDLE POINT PROBLEMS FROM MESHFREE DISCRETIZATION*显示文摘在这,切开的纸,放松的 Hermitian 和 skew-Hermitian (RHSS ) preconditioner 从没有元素的 Galerkin (EFG ) discretization 方法为僵绳点问题被建议。EFG 方法是为解决部分微分方程的最广泛地使用的 meshfree 方法之一。RHSS preconditioner 比著名 HSS preconditioner 更近很被构造到系数矩阵,导致一次 RHSS 定点重复。RHSS 重复的集中被分析并且一个最佳的参数,它最小化光谱重复矩阵的半径被描述。使用 RHSS preconditioner 加速一些 Krylov subspace 方法(相似 GMRES ) 的集中也被学习。理论分析证明 RHSS preconditioned 矩阵的特征值在积极间隔真实、定位。特徵向量分发和 preconditioned 矩阵的最小的多项式的度的上面的界限被获得。一个实际参数在实现 RHSS preconditioner 被建议。最后,一些数字实验被说明显示出新 preconditioner 的有效性。[从作者抽象] | Yang Cao Linquan Yao Meiqun Jiang Qiang Niu | 2013 | Journal of Computational Mathematics2013，31，4： | 12 |
| 2 | Fructus Broussonetae extract improves cognitive function and endoplasmic reticulum stress in Alzheimer's disease models显示文摘This study investigated the effects and possible targets of Fructus Broussonetiae extract,a traditional Chinese medicinal herb,on a model of Alzheimer's disease induced by beta-amyloid peptide 25-35 and D-galactose.The results revealed that intragastric administration of Fructus Broussonetiae significantly increased the expression of immunoglobulin-binding protein,a key factor in the endoplasmic reticulum stress-signaling pathway in rat hippocampus.In contrast,the treatment significantly decreased expression levels of PKR-like endoplasmic reticulum kinase and C/EBP homologous protein,and substantially improved learning,memory and spatial recognition dysfunction in rats.This evidence indicates that Fructus Broussonetiae extract improves spatial learning and memory abilities in rats by affecting the regulation of hippocampal endoplasmic reticulum stress and activation of the apoptosis pathway. | Yinghong Li Li Hu Zhengzhi Wu Zhiling Yu Meiqun Cao Kehuan Sun Yu Jin Anmin Wu Andrew CJ Huang | 2011 | Neural Regeneration Research2011，6，30： | 7 |
| 3 | Identification of Pns12 as the second silencing suppressor of Rice gall dwarf virus显示文摘RNA silencing is a conserved mechanism found ubiquitously in eukaryotic organisms.It has been used to regulate gene expression and development.In addition,RNA silencing serves as an important mechanism in plants' defense against invasive nucleic acids,such as viruses,transposons,and transgenes.As a counter-defense,most plants,and some animal viruses,encode RNA silencing suppressors to interfere at one or several points of the silencing pathway.In this study,we showed that Pns12 of RGDV (Rice gall dwarf virus) exhibits silencing suppressor activity on the reporter green fluorescent protein in transgenic Nicotiana benthamiana line 16c.Pns12 of RGDV suppressed local silencing induced by sense RNA but had no effect on that induced by dsRNA.Expression of Pns12 also enhanced Potato virus X pathogenicity in N.benthamiana.Collectively,these results suggested that RGDV Pns12 functions as a virus suppressor of RNA silencing,which might target an upstream step of dsRNA formation in the RNA silencing pathway.Furthermore,we showed that Pns12 is localized mainly in the nucleus of N.benthamiana leaf cells. | WU JianGuo WANG ChunZheng DU ZhengGuo CAI LiJun HU MeiQun WU ZuJian LI Yi XIE LianHui | 2011 | Science China(Life Sciences)2011，54，3： | 7 |
| 4 | Association of long non-coding RNA HOTAIR and MALAT1 variants with cervical cancer risk in Han Chinese women显示文摘Long noncoding RNA(lncRNA) HOTAIR and MALAT1 are implicated in the development of multiple cancers. Genetic variants within HOTAIR and MALAT1 may affect the gene expression, thereby modifying genetic susceptibility to cervical cancer. A case-control study was designed, including 1 486 cervical cancer patients and 1 536 healthy controls. Based on RegulomeDB database, 11 SNPs were selected and genotyped by using Sequenom’s Mass ARRAY. Univariate and multivariate logistic regression models were used to calculate the odds ratio(OR) and 95% confidence interval(CI). We found that the A allele of rs35643724 in HOTAIR was associated with increased risk of cervical cancer, while the C allele of rs1787666 in MALAT1 was associated with decreased risk. Compared to individuals with 0–1 unfavorable allele, those with 3–4 unfavorable alleles showed18% increased odds of having cervical cancer. Our findings suggest that HOTAIR rs35643724 and MALAT1 rs1787666 might represent potential biomarkers for cervical cancer susceptibility. | Meiqun Jia Lulu Ren Lingmin Hu Hongxia Ma Guangfu Jin Dake Li Ni Li Zhibin Hu Dong Hang | 2019 | The Journal of Biomedical Research2019，33，5： | 2 |
| 5 | Root stoichiometric dynamics and homeostasis of invasive species Phyllostachys edulis and native species Cunninghamia lanceolata in a subtropical forest in China显示文摘The community species abundance and diversity declined with bamboo invasion had been widely reported worldwide.However,the physiological strategies used during root competition between native species and invasive bamboo are poorly understood.To clarify the mechanisms underlying such strategies,the stoichiometric dynamics and homeostasis of nitrogen,phosphorus,organic carbon in root orders of Phyllostachys edulis(I du[=Ⅰ-Pe,years 1 and 2];Ⅱdu[=Ⅱ-Pe,years 3 and 4]),Cunninghamia lanceolata in transition and pure forests were analyzed.With increasing intensity of bamboo invasion,N,P,and C content of C.lanceolata root orders declined,N and P content in P.edulis rhizome orders declined,while C increased,the stoichiometric ratios in mixed forest interface mainly increased,and the stoichiometric differences within native and invasive species root orders narrowed.Meanwhile,the stoichiometric homeostasis index(H)of elements in the same root order and even the same elements in different root orders were not consistent.H of most root orders(except some HP)was greater than 4,the H ranked order wasⅠ-Pe>Cl>Ⅱ-Pe in mixed interfaces,and the N:P ratio of most species root orders was greater than 16,despite being affected by invasion.Our research concluded that the bamboo invasion narrows stoichiometric differences within root orders,and the juvenile bamboo rhizome has a stronger capacity for homeostatic regulation than in adult bamboo and C.lanceolata,which is a key determinant of bamboo invasion success. | Chao Peng Jia Tu Ming Yang Yong Meng Meiqun Li Wensheng Ai | 2021 | Journal of Forestry Research2021，32，5： | 2 |
| 6 | LncRNA H19 inhibits oxidative stress injury of cochlear hair cells by regulating miR-653-5p/SIRT1 axis显示文摘Oxidative stress is one of the important mechanisms of inner ear cell damage,which can lead to age-related hearing loss(ARHL).LncRNA H19 is significantly downregulated in the cochlea of old mouse,however,the role of H19 in the development of ARHL remains unclear.In this study,we aim to investigate the expression and function of H19 in oxidative stress injury of cochlear hair cells induced by H_(2)O_(2).RT-qPCR and western blot analysis confirms that HEI-OC1 cells stimulated with H_(2)O_(2) decreases the expressions of H19 and SIRT1,but increases the expression of miR-653-5p.Overexpression of H19 could increase cell viability,ATP level and mitochondrial membrane potential,but reduce mitochondrial ROS generation and cell apoptosis ratio in H2O2-stimulated HEI-OC1 cells.MiR-653-5p is a target of H19,which can bind to the 3'-UTR of SIRT1.H19 is found to regulate the expression of SIRT1 through miR-653-5p.Further experiments demonstrates that H19 regulates HEI-OC1 cell viability,ATP level,mitochondrial membrane potential,mitochondrial ROS generation,and cell apoptosis ratio via the miR-653-5p/SIRT1 axis.In conclusion,lncRNA H19 inhibits oxidative stress injury of cochlear hair cells via the miR-653-5p/SIRT1 axis. | Wen Xie Ting Shu Haisen Peng Jiali Liu Chunhua Li Meiqun Wang Ping Wu Yuehui Liu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，3： | 2 |
| 7 | Theory study on nonlinear control of ventilation network air flow of mine 显示文摘 | Zhu Hongqing Song Zeyang Yao Meiqun | 2011 | Proce- dia Engineering2011，26，： | 1 |
| 8 | Antiproliferative and apoptotic effects of paeonol on human hepatocellular显示文摘 | Zhang Chunhu Hu Suiyu Cao Meiqun | 2008 | Anticancer drugs2008，19，4： | 1 |
| 9 | On convergence of two-stage splitting methods for linear complementarity problems 显示文摘 | Meiqun Jiang Junliang Dong | 2005 | Journal of Computational and Applied Mathematics2005，，181： | 1 |
| 10 | Analysis of hippocampal gene expression profile of Alzheimer's disease model rats using genome chip bioinformatics显示文摘In this study,an Alzheimer's disease model was established in rats through stereotactic injection of condensed amyloid beta 1-40 into the bilateral hippocampus,and the changes of gene expression profile in the hippocampus of rat models and sham-operated rats were compared by genome expression profiling analysis.Results showed that the expression of 50 genes was significantly up-regulated(fold change ≥ 2),while 21 genes were significantly down-regulated in the hippocampus of Alzheimer's disease model rats(fold change ≤ 0.5) compared with the sham-operation group.The differentially expressed genes are involved in many functions,such as brain nerve system development,neuronal differentiation and functional regulation,cellular growth,differentiation and apoptosis,synaptogenesis and plasticity,inflammatory and immune responses,ion channels/transporters,signal transduction,cell material/energy metabolism.Our findings indicate that several genes were abnormally expressed in the metabolic and signal transduction pathways in the hippocampus of amyloid beta 1-40-induced rat model of Alzheimer's disease,thereby affecting the hippocampal and brain functions. | Yinghong Li Zhengzhi Wu Yu Jin Anmin Wu Meiqun Cao Kehuan Sun Xiuqin Jia Manyin Chen | 2012 | Neural Regeneration Research2012，7，5： | 1 |
| 11 | On Local Hermitian and Skew-Hermitian Splitting Iteration Methods for GeneralizedSaddle Point Problems 显示文摘 | JIANG Meiqun CAO Yang | 2009 | Journal Comput Appl Math2009，231，2： | 1 |
| 12 | Reactive Oxygen Species in Vascular Formation and Development显示文摘 | Yijiang Zhou Hui Yan Meiqun Guo Jianhua Zhu Qingzhong Xiao Li Zhang Sumitra Miriyala | 2013 | Oxidative Medicine and Cellular Longevity2013，，： | 1 |
| 13 | Effects of Different Picking Time and Different Geographical Provenances on Oil Content of Camellia oleifera显示文摘This paper studied effects of different picking time and different geographical provenances on oil content of Camellia oleifera. The results showed that different picking time had significant effects on the oil content of cold dew seeds and frost's descent seeds. With the delay of picking time,the oil content of cold dew seeds,frost's descent seeds,dry seeds and oil content of seed kernels were significantly increased.There was a significantly positive correlation between the oil content of fresh fruit of cold dew seeds and frost's descent seeds and the dry seed yield of fresh seeds and the oil content of fresh fruit( P < 0. 05),and the correlation coefficient was greater than 0. 85. Besides,the oil content of seed kernels of cold dew seeds was closely correlated with the seed yield of fresh seeds,oil content of fresh fruit,and oil content of fresh seeds. In the process of C. oleifera breeding,the thin coat,high seed yield and high oil content can be taken as the key research directions for future breeding. The oil content of ordinary C. oleifera seeds in 18 counties( cities) was 36. 42%-63. 33%,indicating that there were significant differences in the oil content of C. oleifera in different geographical provenances. In conclusion,according to the study of different picking time,the recommended picking time of cold dew seeds in Hunan area is around October 10,while the best picking time of frost's descent seeds is about October 30. The oil content of C. oleifera fruit in different geographical provenances is quite different. During the development of C. oleifera fruit,the cultivation and management of C. oleifera should be strengthened to increase the oil content of C. oleifera. | Xiaoqin MO Zhen ZHANG Yongzhong CHEN Yanming XU Yinghe PENG Longsheng CHEN Li MA Rui WANG Shaofeng PENG Zhigang LI Xiangnan WANG Meiqun LI Wei TANG | 2018 | Asian Agricultural Research2018，10，10： | 1 |
| 14 | Effects of Fertilization on Soil CO_(2) Efflux in Chinese Hickory(Carya cathayensis)Stands显示文摘Chinese hickory(Carya cathayensis Sarg.)is a popular nut tree in China,but there is little information about the influences of fertilization on soil CO_(2) efflux and soil microbial biomass.This study evaluated the short-term effects of different fertilizer applications on soil CO_(2) efflux and soil microbial biomass in Chinese hickory stands.Four fertilizer treatments were established:control(CK,no fertilizer),inorganic fertilizer(IF),organic fertilizer(OF),and equal parts organic and inorganic N fertilizers(OIF).A field experiment was conducted to measure soil CO_(2) effluxes using closed chamber and gas chromatography techniques.Regardless of the fertilization practices,soil CO_(2) effluxes of all the treatments showed a similar temporal pattern,with the highest value in summer and the lowest in winter.The mean annual soil CO_(2) efflux in the IF treatment was significantly higher than that in the CK,OIF,and OF treatments.There was no significant difference in soil CO_(2) efflux between the OIF,OF,and CK treatments.Soil CO_(2) effluxes were significantly affected by soil temperature.Soil dissolved organic carbon(DOC)was positively correlated with soil CO_(2) efflux only in the CK treatment.Regression analysis,including soil temperature,moisture,and DOC,showed that soil temperature was the primary factor influencing soil CO_(2) effluxes.Both OF and OIF treatments increased concentrations of soil microbial biomass carbon(MBC)and microbial biomass nitrogen(MBN),but decreased the ratio of MBC:MBN.These results reveal that applying organic fertilizer,either alone or combined with inorganic fertilizer,may be the optimal strategy for mitigating soil CO_(2) emission and improving soil quality in Chinese hickory stands. | Juan Liu Meiqun Zheng Xueshuang Chen | 2023 | Phyton-International Journal of Experimental Botany2023，92，1： | 1 |
| 15 | Measuring ArticleQuality in Wikipedia:Models and Evaluation显示文摘 | Meiqun Hu Ee-Peng Lim Aixin Sun | 2007 | ACM2007，，： | 1 |
| 16 | Fe Nanoparticles Synthesized by Pomegranate Leaves for Treatment of Malachite Green显示文摘A green and convenient pathway of preparing iron nanoparticles(FeNPs)with pomegranate leaf(PG)extract for highly effective removal of malachite green(MG)was proposed under ambient conditions.The materials were characterized by scanning electron microscope(SEM),X-ray energy-dispersive spectrometer(EDS),Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS)techniques.The results show that their surfaces are capped and stabilized by PG extract with amorphous nature and without any detection of zero-valent iron.The size and surface valence state of FeNPs are the key factors that affect the MG removal efficiency.As the reagent volume ratio of PG extract to FeCl_(3) increases greater than 1,the cross-linked FeNPs become more obvious,having a homogeneous distribution with the size range from 30 to 40 nm,and show an increasing ratio ofFe(Ⅱ)/Fe(Ⅲ),which is in proportion to the degradation efficiency of MG,reaching higher than 95%in only 2 min by using 50 mg Fe/L FeNPs and 200 mg/L MG. | 胡玉 ZHOU Shiyu PAN Xiaobin ZHOU Fan SUN Yong LIU Meiqun ZHANG Dong 张玲帆 | 2022 | Journal of Wuhan University of Technology(Materials Science)2022，37，3： | 1 |
| 17 | Nanomedicine in cancer therapy显示文摘Cancer remains a highly lethal disease in the world.Currently,either conventional cancer therapies or modern immunotherapies are non-tumor-targeted therapeutic approaches that cannot accurately distinguish malignant cells from healthy ones,giving rise to multiple undesired side effects.Recent advances in nanotechnology,accompanied by our growing understanding of cancer biology and nano-bio interactions,have led to the development of a series of nanocarriers,which aim to improve the therapeutic efficacy while reducing off-target toxicity of the encapsulated anticancer agents through tumor tissue-,cell-,or organelle-specific targeting.However,the vast majority of nanocarriers do not possess hierarchical targeting capability,and their therapeutic indices are often compromised by either poor tumor accumulation,inefficient cellular internalization,or inaccurate subcellular localization.This Review outlines current and prospective strategies in the design of tumor tissue-,cell-,and organelle-targeted cancer nanomedicines,and highlights the latest progress in hierarchical targeting technologies that can dynamically integrate these three different stages of static tumor targeting to maximize therapeutic outcomes.Finally,we briefly discuss the current challenges and future opportunities for the clinical translation of cancer nanomedicines. | Dahua Fan Yongkai Cao Meiqun Cao Yajun Wang Yongliang Cao Tao Gong | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 1 |
| 18 | Measuring ArticleQuality in Wikipedia : Models and Evaluation 显示文摘 | Meiqun Hu He - Peng Lim Aixin Sun | 2007 | ACM2007，，： | 1 |
| 19 | A Brief Discussion on the Marxist Theory of the Essence of Culture显示文摘Marxism holds that the internal essence of culture lies in the inherent identity of culture and man,and in the spiritual essence of man and that there would be no culture without man and man’s spirit.From the perspective of the source of culture,it is man’s transcendence over nature.From the point of view of the process of its evolution,it is the sum of all human social relationships.Culture has the characteristics of man’s sociality and is shared by an entire cultural community.The essential complexity of culture is the logical expression of human thinking,and the logic reflection of cultural practice.Cultural practice,i.e.,human practice,is influenced and constrained not only by external practice,but also by the consciousness of man himself.Such two-way internal and external effects determine the particular law and logic of culture itself in its development,i.e.,the dialectical unity between decisiveness and selectivity,and between nationality and cosmopolitanness,in the development of culture;the dialectical unity between the consistency of basic trends in terms of the law of cultural development and the diversity of choices of paths;and the dialectical unity between diversity and unity concerning paths for the development of culture. | Han Meiqun Huang Deyuan | 2019 | Contemporary Social Sciences2019，4，6： | 0 |
| 20 | Minimum and Maximum Resistance Status of Unicyclic Graphs显示文摘The resistance status of a vertex of a connected graph is the sum of the resistance distance between this vertex and any other vertices of the graph. The minimum(maximum,resp.) resistance status of a connected graph is the minimum(maximum, resp.) resistance status of all vertices of the graph. In this paper, we determine the extremal values and corresponding extremal graphs for the minimum(maximum, resp.) resistance status over all unicyclic graphs of fixed order, and we also discuss the dependence of the minimum(maximum, resp.) resistance status on the girth of unicyclic graphs. | Meiqun CHENG Bo ZHOU | 2022 | Journal of Mathematical Research with Applications2022，42，5： | 0 |
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