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| 1 | Inflammatory colonic carcinogenesis: A review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis显示文摘Ulcerative colitis(UC)is characterized by repeated flare-ups of inflammation that can lead to oncogenic insults to the colonic epithelial.UC-associated carcinogenesis presents a different sequence of tumorigenic events compared to those that contribute to the development of sporadic colorectal cancer.In fact,in UC,the early events are represented by oxidative DNA damage and DNA methylation that can produce an inhibition of oncosuppressor genes,mutation of p53,aneuploidy,and microsatellite instability.Hypermethylation of tumor suppressor and DNA mismatch repair gene promoter regions is an epigenetic mechanism of gene silencing that contribute to tumorigenesis and may represent the first step in inflammatory carcinogenesis.Moreover,p53 is frequently mutated in the early stages of UC-associated cancer.Aneuploidy is an independentrisk factor for forthcoming carcinogenesis in UC.Epithelial cell-T-cell cross-talk mediated by CD80 is a key factor in controlling the progression from low to high grade dysplasia in UC-associated carcinogenesis. | Marco Scarpa Ignazio Castagliuolo Carlo Castoro Anna Pozza Melania Scarpa Andromachi Kotsafti Imerio Angriman | 2014 | World Journal of Gastroenterology2014，20，22： | 22 |
| 2 | A Regulatory Module Controlling CA-Mediated Endosperm Cell Expansion Is Critical for Seed Germination in Arabidopsis显示文摘A key component of seed germination is the interplay of mechanical forces governing embryo growth and the surrounding restraining endosperm tissue.Endosperm cell separation is therefore thought to play a critical role in the control of this developmental transition.Here we demonstrate that in Arabidopsis thaliana seeds,endosperm cell expansion is a key component of germination.Endosperm cells expand to accommodate embryo growth prior to germination.We show that this is an actively regulated process supported by spatiotemporal control of the cell expansion gene EXPANSIN 2 (EXPA2).The NAC transcription factors NAC25 and NACIL were identified as upstream regulators of EXPA2 expression,gibbereliinmediated endosperm expansion,and seed germination.The DELLA protein RGL2 repressed activation of the EXPA2 promoter by NAC25/NACIL.Taken together,our findings uncover a key role of the GA/ DELLA-NAC25/NACIL-EXPA2 network in regulating endosperm cell expansion to control the seed-toseedling transition. | Rocio Sanchez-Montesino Laura Bouza-Morcillo Julietta Marquez Melania Ghita Salva Duran-Nebreda Luis Gomez Michael J.Holdsworth George Bassel Luis Onate-Sanchez | 2019 | Molecular Plant2019，12，1： | 11 |
| 3 | Strategies for reducing speckle noise in digital holography显示文摘Digital holography(DH)has emerged as one of the most effective coherent imaging technologies.The technological developments of digital sensors and optical elements have made DH the primary approach in several research fields,from quantitative phase imaging to optical metrology and 3D display technologies,to name a few.Like many other digital imaging techniques,DH must cope with the issue of speckle artifacts,due to the coherent nature of the required light sources.Despite the complexity of the recently proposed de-speckling methods,many have not yet attained the required level of effectiveness.That is,a universal denoising strategy for completely suppressing holographic noise has not yet been established.Thus the removal of speckle noise from holographic images represents a bottleneck for the entire optics and photonics scientific community.This review article provides a broad discussion about the noise issue in DH,with the aim of covering the best-performing noise reduction approaches that have been proposed so far.Quantitative comparisons among these approaches will be presented. | Vittorio Bianco Pasquale Memmolo Marco Leo Silvio Montresor Cosimo Distante Melania Paturzo Pascal Picart Bahram Javidi Pietro Ferraro | 2018 | Light(Science & Applications)2018，7，1： | 8 |
| 4 | Endowing a plain fluidic chip with micro-optics: a holographic microscope slide显示文摘Lab-on-a-Chip(LoC)devices are extremely promising in that they enable diagnostic functions at the point-of-care.Within this scope,an important goal is to design imaging schemes that can be used out of the laboratory.In this paper,we introduce and test a pocket holographic slide that allows digital holography microscopy to be performed without an interferometer setup.Instead,a commercial off-the-shelf plastic chip is engineered and functionalized with this aim.The microfluidic chip is endowed with micro-optics,that is,a diffraction grating and polymeric lenses,to build an interferometer directly on the chip,avoiding the need for a reference arm and external bulky optical components.Thanks to the single-beam scheme,the system is completely integrated and robust against vibrations,sharing the useful features of any common path interferometer.Hence,it becomes possible to bring holographic functionalities out of the lab,moving complexity from the external optical apparatus to the chip itself.Label-free imaging and quantitative phase contrast mapping of live samples are demonstrated,along with flexible refocusing capabilities.Thus,a liquid volume can be analyzed in one single shot with no need for mechanical scanning systems. | Vittorio Bianco Biagio Mandracchia Valentina Marchesano Vito Pagliarulo Federico Olivieri Sara Coppola Melania Paturzo Pietro Ferraro | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 5 | Enhancing bioelectricity generation in microbial fuel cells and biophotovoltaics using nanomaterials显示文摘Microbial fuel cells and biophotovoltaics represent promising technologies for green bioelectricity generation.However,these devices suffer from low durability and efficiency that stem from their reliance on living organisms to act as catalysts.Such limitations can be overcome with augmented capabilities enabled by nanotechnology.This review presents an overview of the different nanomaterials used to enhance bioelectricity generation through improved light harvesting,extracellular electron transfer,and anode performance.The implementation of nanomaterials in whole-cell energy devices holds promise in developing bioelectrical devices that are suitable for industry. | Mohammed Mouhib Alessandra Antonucci Melania Reggente Amirmostafa Amirjani Alice J. Gillen Ardemis A.Boghossian | 2019 | Nano Research2019，12，9： | 4 |
| 6 | The human olfactory system in two proteinopathies: Alzheimer’s and Parkinson’s diseases显示文摘Alzheimer’s and Parkinson’s diseases are the most prevalent neurodegenerative disorders.Their etiologies are idiopathic,and treatments are symptomatic and orientated towards cognitive or motor deficits.Neuropathologically,both are proteinopathies with pathological aggregates(plaques of amyloid-β peptide and neurofibrillary tangles of tau protein in Alzheimer’s disease,and Lewy bodies mostly composed of α-synuclein in Parkinson’s disease).These deposits appear in the nervous system in a predictable and accumulative sequence with six neuropathological stages.Both disorders present a long prodromal period,characterized by preclinical signs including hyposmia.Interestingly,the olfactory system,particularly the anterior olfactory nucleus,is initially and preferentially affected by the pathology.Cerebral atrophy revealed by magnetic resonance imaging must be complemented by histological analyses to ascertain whether neuronal and/or glial loss or neuropil remodeling are responsible for volumetric changes.It has been proposed that these proteinopathies could act in a prion-like manner in which a misfolded protein would be able to force native proteins into pathogenic folding(seeding),which then propagates through neurons and glia(spreading).Existing data have been examined to establish why some neuronal populations are vulnerable while others are resistant to pathology and to what extent glia prevent and/or facilitate proteinopathy spreading.Connectomic approaches reveal a number of hubs in the olfactory system(anterior olfactory nucleus,olfactory entorhinal cortex and cortical amygdala)that are key interconnectors with the main hubs(the entorhinal–hippocampal–cortical and amygdala–dorsal motor vagal nucleus)of network dysfunction in Alzheimer’s and Parkinson’s diseases. | Isabel Ubeda-Bañon Daniel Saiz-Sanchez Alicia Flores-Cuadrado Ernesto Rioja-Corroto Melania Gonzalez-Rodriguez Sandra Villar-Conde Veronica Astillero-Lopez Juan Pablo Cabello-de la Rosa Maria Jose Gallardo-Alcañiz Julia Vaamonde-Gamo Fernanda Relea-Calatayud Lucia Gonzalez-Lopez Alicia Mohedano-Moriano Alberto Rabano Alino Martinez-Marcos | 2020 | Translational Neurodegeneration2020，9，2： | 4 |
| 7 | Gut Microbiota, Lipopolysaccharides, and Innate Immunity in the Pathogenesis of Obesity and Cardiovascular Risk显示文摘 | Melania Manco Lorenza Putignani Gian Franco Bottazzo | 2010 | Endocrine Reviews2010，，6： | 3 |
| 8 | Polymeriza- tion of propylene oxide by activated monomer mech- anism-kinetics显示文摘 | Melania B Przemyslaw K Stanislaw P | 1989 | Makromol Chem Suppl1989，15，： | 1 |
| 9 | Human Wharton’s Jelly Mesenchymal Stem Cells Maintain the Expression of Key Immunomodulatory Molecules When Subjected to Osteogenic, Adipogenic and Chondrogenic Differentiation In Vitro: New Perspectives for Cellular Therapy显示文摘 | Giampiero La Rocca Melania Lo Iacono Tiziana Corsello Simona Corrao Felicia Farina Rita Anzalone | 2013 | Current Stem Cell Research & Therapy2013，，： | 1 |
| 10 | Prog- ress in activated monomer polymerization: Kinet- ics of AM polymerization显示文摘 | Przemyslaw K Melania B Tadeusz B | 2000 | Macromol Symp2000，153，： | 1 |
| 11 | Effects of high pressure homogenization on the activity of lysozyme and lactoferrin against Listeria monocytogenes显示文摘 | I Luciana P Francesca V Melania | 2007 | FOOD CONTROL2007，18，： | 1 |
| 12 | The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity显示文摘 | Elena Gianchecchi Melania Palombi Alessandra Fierabracci | 2013 | Autoimmunity Reviews2013，，7： | 1 |
| 13 | IL-IO prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination ,Ileal defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-y 显示文摘 | Haouat G Melania AA Marital J | 1995 | Immunol1995，47，： | 1 |
| 14 | Phenols and lignans from Ckenopodium album显示文摘 | CUTILLO FRANCESCA DELLAGRECA MARINA GIONTI MELANIA | 2006 | Phytochemical Analysis2006，，： | 1 |
| 15 | How to define traceability显示文摘 | Petter Olsena Melania Borit | 2013 | Trends in Food Science & Technology2013，29，2： | 1 |
| 16 | Epigenetics: Concepts and relevance to IBD pathogenesis显示文摘 | Melania Scarpa Eleni Stylianou | 2012 | Inflamm Bowel Dis2012，，： | 1 |
| 17 | Optiomal Resource Allocation in Survey Designs显示文摘 | Melania Catinescu Sandjai Bhulai | 2013 | European Journal of Operational Research2013，226，1： | 1 |
| 18 | Cissaglaberrimine, an aporphine alkaloid from Cissampelos glaberrima 显示文摘 | JoseMaria B F Emidio V L D Melania L C | 1997 | Phytochemistry1997，44，5： | 1 |
| 19 | Effects of high pressure homogenization on the activity of lysozyme and lactoferrin against Listeria monocyto-genes显示文摘 | I Luciana P Francesca V Melania | | 0，，： | 1 |
| 20 | Development of a high-throughput transformation system for insertional mutagenesis in Magna-porthe oryzae显示文摘 | Melania F B Sara L T Natal la G | 2007 | Fungal Genet Biol2007，44，： | 1 |
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