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| 1 | Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-β and IGF-Ⅱ显示文摘 | Rosa Montes Gertrudis Ligero Laura Sanchez Purificacidn Catalina Teresa de la Cueva Ana Nieto Gustavo J Melen Ruth Rubio Javier Garcia-Castro Clara Bueno Pablo Menendez | 2009 | Cell Research2009，19，6： | 7 |
| 2 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 3 | Biological and genet- ic interaction between tenascin C and neuropeptide S receptor 1 in al- lergic diseases显示文摘 | Orsmark-Pietras C Melen E Vendelin J | 2008 | Hum Mol Genet2008，17，11： | 1 |
| 4 | Arginine/Lysine-rich Nuclear Localization signals mediate interactions between dimeric Stats and importin a5显示文摘 | Krister Melen Lena Kinnunnen | 2002 | J Biol Chem2002，277，30： | 1 |
| 5 | Interaction between variants in the interleukin -4 receptor alpha and interleukin -9 receptor genes in childhood wheezing:evidence from a birth cohort study 显示文摘 | Melen E Umerkajeff S Nyberg F | 2006 | Clin Exp Allergy2006，36，11： | 1 |
| 6 | MMP12,lung function, and COPD in high risk populations 显示文摘 | Hunninghake G M Cho M H Tesfaigzi Y Soto - Quiros M E Avila L Lasky - Su J Stidley C Melen E Soderhall C Hallberg J Kull I KercJ Svartengren M Pershagen G Wickman M Lange C Demeo D L Hersh C P Klanderman B J Raby B A Sparrow D Shapiro S D Silverman E K Litonjua A A Weiss S T Celedon J C | 2009 | New England Journal of Medicine2009，361，27： | 1 |
| 7 | Genome-wide association study of body mass index in 23 000 individuals with and without asthma 显示文摘 | Melen E Granell R Kogevinas M | 2013 | Clin Exp Allergy2013，43，4： | 1 |
| 8 | Nuclear and nucleolar targeting of influenza A virus NS1 proteinz striking differences between different virus subtypes 显示文摘 | Melen K Kinnunen L Fagerlund R | 2007 | J Virol2007，81，11： | 1 |
| 9 | Lumbar and Thoracic Epidural Blood Injections to Treat Spontaneous Intracranial Hypotension显示文摘 | Honorio T. Benzon Rimas Nemickas Robert E. Molloy Shireen Ahmad Onur Melen Bruce Cohen | 1996 | Anesthesiology1996，，4： | 1 |
| 10 | Qstial function in chronic sinnsitis显示文摘 | Melen I | 1986 | Acta Otolaryngol ( Stockh)1986，102，： | 1 |
| 11 | Haplotypes of G protein-coupled receptor 154 are associated with childhood allergy and asthma显示文摘 | Melen E Bruce S Doekes G | 2005 | Am J Respir Crit Care Med2005，171，： | 1 |
| 12 | Interferon-induced Mx protein form oligomers and contain a putative leucine zipper 显示文摘 | Krister Melen Tapani Rormi Barbara Broni | 1993 | Biolog Chem1993，267，25： | 1 |
| 13 | Analysis of influenza B virus NSI protein trafficking reveals a novel interaction with nuclear speckle domains 显示文摘 | Sehneider J Dauber B Melen K | 2009 | J Virol2009，83，2： | 1 |
| 14 | Agricultural nutrient losses to surface water in the Netherlands: Impact, strategies, and per- spective显示文摘 | Vander Melen D T Breeuwsma A Bcers P C M | 1998 | Journal of Environmental Quality1998，27，： | 1 |
| 15 | Susac syndrome with transient inverted vision 显示文摘 | Zeidman I A Melen O Gottardi-Littell N el al | 2004 | Neurology2004，63，3： | 1 |
| 16 | Interaction between variants in the interleukin-4 receptor alpha and interleukin-9 receptor genes in childhood wheezing:evidence from a birth cohort study显示文摘 | Melen E Umerkajeff S Nyberg F | 2006 | Clin Exp Allergy2006，36，11： | 1 |
| 17 | Preoperative hair removal to reduce surgical site infection显示文摘 | Tanner J Norrie P Melen K | 2011 | Cochrane Database of Syst Rev2011，，00： | 1 |
| 18 | Importin alpha nuclear localization signal binding sites for STAT1,STAT2,and influenza A virus nucleoprotein显示文摘 | Melen K Fagerlund R Franke J | 2003 | J Biol Chem2003，278，28： | 1 |
| 19 | Preoperative hair removal to reduce surgical site infection显示文摘 | Tanner J Norrie P Melen K | 2011 | Cochrane Collaboration2011，，00： | 1 |
| 20 | Interactions between gluta- thione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease 显示文摘 | Melen E Nyberg F Lindgren CM | 2008 | Environ Health Perspect2008，116，8： | 1 |
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