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| 1 | Transversus abdominis plane infiltration for laparoscopic gastric banding: A pilot study显示文摘AIM: To estimate an effect size for the transversus abdominis plane(TAP) infiltration on quality of recovery in patients undergoing laparoscopic gastric band surgery. METHODS: The pilot study was a randomized, double blinded, placebo controlled trial. Patients undergoing laparoscopic gastric band surgery were randomized to receive a bilateral TAP infiltration with 20 mL of 0.5% ropivacaine or saline. The evaluated outcomes included quality of recovery-40(QoR-40) at 24 h, postoperative opioid consumption and pain. Data was examined using the Mann-Whitney U test. RESULTS: Nineteen subjects were recruited. There was a positive trend favoring the TAP infiltration group in global QoR-40 scores at 24 h after surgery, median [interquartile range(IQR)] of 175.5(170-189) com-pared to 170(160-175) in the control group(P = 0.06). There also a positive trend toward a lower cumulative opioid consumption in the TAP infiltration group, median(IQR) of 7.5(2.5-11.5) mg iv morphine equivalents compared to 13(7-21.5) in the control group(P = 0.07). Correlation analysis(Spearman's Rho) demonstrated an inverse relationship between 24 h cumulative opioid consumption and global QoR-40 scores,-0.49(P = 0.03). CONCLUSION: The use of multimodal analgesic techniques to reduce opioid related side effects is particularly desirable in morbidly obese patients undergoing gastric reduction surgery. The TAP infiltration seems to have a clinically important effect in reducing postoperative opioid consumption and improve quality of recovery after laparoscopic gastric band surgery in morbid obese patients. Future studies to confirm the beneficial effects of the TAP infiltration in these patients are warranted. | Gildasio S De Oliveira Jr Paul Fitzgerald Shireen Ahmad John Kim Rohit Rahangdale Robert McCarthy | 2014 | World Journal of Gastrointestinal Surgery2014，6，2： | 4 |
| 2 | Extra-skeletal manifestations in mice affected by Clcn7-dependent autosomal dominant osteopetrosis type 2 clinical and therapeutic implications显示文摘Autosomal dominant osteopetrosis type 2 (ADO2) is a high-density brittle bone disease characterized by bone pain,multiple fractures and skeletal-related events,including nerve compression syndrome and hematological failure.We demonstrated that in mice carrying the heterozygous Clcn7^G213R mutation,whose human mutant homolog CLCN7^G215R affects patients,the clinical impacts of ADO2 extend beyond the skeleton,affecting several other organs.The hallmark of the extra-skeletal alterations is a consistent perivascular fibrosis,associated with high numbers of macrophages and lymphoid infiltrates.Fragmented clinical information in a small cohort of patients confirms extra-skeletal alterations consistent with a systemic disease,in line with the observation that the CLCN7 gene is expressed in many organs.ADO2 mice also show anxiety and depression and their brains exhibit not only perivascular fibrosis but also β-amyloid accumulation and astrogliosis,suggesting the involvement of the nervous system in the pathogenesis of the ADO2 extra-skeletal alterations.Extra-skeletal organs share a similar cellular pathology,confirmed also in vitro in bone marrow mononuclear cells and osteoclasts,characterized by an impairment of the exit pathway of the Clcn7 protein product,ClC7,through the Golgi,with consequent reduced ClC7 expression in late endosomes and lysosomes,associated with high vesicular pH and accumulation of autophagosome markers.Finally,an experimental siRNA therapy,previously proven to counteract the bone phenotype,also improves the extra-skeletal alterations.These results could have important clinical implications,supporting the notion that a systematic evaluation of ADO2 patients for extra-skeletal symptoms could help improve their diagnosis,clinical management,and therapeutic options. | Antonio Maurizi Mattia Capulli Annabel Curle Rajvi Patel Argia Ucci Juliana Alves Cotes Harriet Oxford Shireen R. Lamandé John F. Bateman Nadia Rucci Anna Teti | 2019 | Bone Research2019，7，2： | 3 |
| 3 | Diagnostic yield and safety of jumbo biopsy forceps in patients with subepithelial lesions of the upper and lower GI tract显示文摘 | Jonathan M. Buscaglia Satish Nagula Vijay Jayaraman David H. Robbins Deepak Vadada Seth A. Gross Christopher J. DiMaio Shireen Pais Kal Patel Divyesh V. Sejpal Michelle K. Kim | 2012 | Gastrointestinal Endoscopy2012，，6： | 3 |
| 4 | Emergence and epidemic occurrence of enterovirus 68 respiratory infections in The Netherlands in 2010显示文摘 | Adam Meijer Sabine van der Sanden Bianca E.P. Snijders Giovanna Jaramillo-Gutierrez Louis Bont Cornelis K. van der Ent Pieter Overduin Shireen L. Jenny Edin Jusic Harrie G.A.M. van der Avoort Gavin J.D. Smith Gé A. Donker Marion P.G. Koopmans | 2011 | Virology2011，，1： | 2 |
| 5 | Rising trends in cholangiocarcinoma: Is the ICD classification system misleading us?显示文摘 | Shahid A. Khan Shireen Emadossadaty Nimzing G. Ladep Howard C. Thomas Paul Elliott Simon D. Taylor-Robinson Mireille B. Toledano | 2011 | Journal of Hepatology2011，，4： | 2 |
| 6 | Lipid peroxidation and antioxidant enzyme activity in different organs of mice exposed to low level of mercury显示文摘 | Mahboob M Shireen KF Atkinson A Khan AT | 2001 | J Environ Sci Health (B)2001，36，5： | 1 |
| 7 | A DSP-based active power filter for low voltage distribution systems显示文摘 | SHIREEN W LI Tao | 2008 | Electric Power Systems Research2008，，78： | 1 |
| 8 | The use of octyl cyanoacrylate (superglue) in hypospadias repair including its use as a fixator for urethral stents显示文摘 | Hock-Lim Tan Shireen A. Nah Iskandar I. Budianto Syariz Sehat Riana Tamba | 2012 | Journal of Pediatric Surgery2012，，12： | 1 |
| 9 | Lumbar and Thoracic Epidural Blood Injections to Treat Spontaneous Intracranial Hypotension显示文摘 | Honorio T. Benzon Rimas Nemickas Robert E. Molloy Shireen Ahmad Onur Melen Bruce Cohen | 1996 | Anesthesiology1996，，4： | 1 |
| 10 | A new technique to reject DC-link voltage ripple for inverters operating on programmed PWM waveforms显示文摘 | Enjeti P Shireen W | 1992 | IEEE Transactions on Power Electronics1992，，7： | 1 |
| 11 | A DSP-based active power filter for low voltage distribution systems显示文摘 | SHIREEN W TAO L I | 2008 | Electric Power Systems Reserch2008，78，： | 1 |
| 12 | Biohydrogen as a renewable energy resource-Prospects and potentials显示文摘 | Shireen Meher Kotay Debabrata Das | 2008 | International Journal of Hydrogen Energy2008，33，1： | 1 |
| 13 | Rising trends in cholangiocarcinoma: Is the ICD classification system misleading us?显示文摘 | Shahid A. Khan Shireen Emadossadaty Nimzing G. Ladep Howard C. Thomas Paul Elliott Simon D. Taylor-Robinson Mireille B. Toledano | 2011 | Journal of Hepatology2011，，4： | 1 |
| 14 | Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: Therapeutic implications for Parkinson's disease explained via in silico studies显示文摘 | Balusamy Jagatha Rajeswara Babu Mythri shireen Vali | 2008 | Free Radic Biol Med2008，44，： | 1 |
| 15 | A DSP-based active power filter for low voltage distribution systems显示文摘 | Wajiha Shireen Li Tao | 2008 | Electric Power Systems Research2008，，9： | 1 |
| 16 | Open-Source Learning Management with Moodle显示文摘 | Abhijeet Chavan Shireen Pavri | 2004 | Linux Journal2004，128，： | 1 |
| 17 | Innovation, Productivity and Foreign Direct Investment-induced R&D Spillovers显示文摘 | Shireen AlAzzawi | 2012 | The Journal of InternationalTrade & Economic Development2012，，： | 1 |
| 18 | Moving object detection in spatial domain using background removal techniques-state-of-art显示文摘 | SHIREEN Y ELHABIAN KHALED M | 2008 | Recent Patents on Computer Science2008，1，： | 1 |
| 19 | Potential of energy savings in the hotel sector in Jordan显示文摘 | Yahya Ali Mairna Mustafa Shireen A1-Mashaqbah | 2008 | Energy Conversion and Management2008，49，11： | 1 |
| 20 | Remifentanil versus alfentanil as analgesic adjuncts during placement of ophthalmologic nerve blocks显示文摘 | Shireen Ahmad Michael E. Leavell Robert J. Fragen Walter Jenkins Carl L. Roland | 1999 | Regional Anesthesia and Pain Medicine1999，，4： | 1 |
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