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| 1 | Laparoscopic fundoplication for gastroesophageal reflux disease显示文摘Gastroesophageal reflux disease(GERD) is a condition that develops when the reflux of gastric contents into the esophagus leads to troublesome symptoms and/or complications. Heartburn is the cardinal symptom, often associated with regurgitation. In patients with endoscopy-negative heartburn refractory to proton pump inhibitor(PPI) therapy and when the diagnosis of GERD is in question, direct reflux testing by impedance-pH monitoring is warranted. Laparoscopic fundoplication is the standard surgical treatment for GERD. It is highly effective in curing GERD with a 80% success rate at 20-year follow-up. The Nissen fundoplication, consisting of a total(360°) wrap, is the most commonly performed antireflux operation. To reduce postoperative dysphagia and gas bloating, partial fundoplications are also used, including the posterior(Toupet) fundoplication, and the anterior(Dor) fundoplication. Currently, there is consensus to advise laparoscopic fundoplication in PPI-responsive GERD only for those patients who develop untoward side-effects or complications from PPI therapy. PPI resistance is the real challenge in GERD. There is consensus that carefully selected GERD patients refractory to PPI therapy are eligible for laparoscopic fundoplication, provided that objective evidence of reflux as the cause of ongoing symptoms has been obtained. For this purpose, impedance-pH monitoring is regarded as the diagnostic gold standard. | Marzio Frazzoni Micaela Piccoli Rita Conigliaro Leonardo Frazzoni Gianluigi Melotti | 2014 | World Journal of Gastroenterology2014，20，39： | 10 |
| 2 | Peritoneal carcinomatosis显示文摘Several gastrointestinal and gynecological malignancies have the potential to disseminate and grow in the peritoneal cavity.The occurrence of peritoneal carcinomatosis(PC)has been shown to significantly decrease overall survival in patients with liver and/or extraperitoneal metastases from gastrointestinal cancer.During the last three decades,the understanding of the biology and pathways of dissemination of tumors with intraperitoneal spread,and the understanding of the protective function of the peritoneal barrier against tumoral seeding,has prompted the concept that PC is a loco-regional disease:in absence of other systemic metastases,multimodal approaches combining aggressive cytoreductive surgery,intraperitoneal hyperthermic chemotherapy and systemic chemotherapy have been proposed and are actually considered promising methods to improve loco-regional control of the disease,and ultimately to increase survival.The aim of this review article is to present the evidence on treatment of PC in different tumors,in order to provide patients with a proper surgical and multidisciplinary treatment focused on optimal control of their locoregional disease. | Federico Coccolini Federico Gheza Marco Lotti Salvatore Virzì Domenico Iusco Claudio Ghermandi Rita Melotti Gianluca Baiocchi Stefano Maria Giulini Luca Ansaloni Fausto Catena | 2013 | World Journal of Gastroenterology2013，19，41： | 9 |
| 3 | Esophageal chemical clearance is impaired in gastro‐esophageal reflux disease – a 24‐h impedance‐pH monitoring assessment显示文摘 | M. Frazzoni R. Manta V. G. Mirante R. Conigliaro L. Frazzoni G. Melotti | 2013 | Neurogastroenterol Motil2013，，5： | 2 |
| 4 | Cystic fibrosis transmembrane conductance regulator functional evaluations in a G542X+/-IVS8Tn:T7/9 patient with acute recurrent pancreatitis显示文摘BACKGROUND Acute recurrent pancreatitis(ARP)is characterized by episodes of acute pancreatitis in an otherwise normal gland.When no cause of ARP is identifiable,the diagnosis of'idiopathic'ARP is given.Mutations in the cystic fibrosis transmembrane conductance regulator(CFTR)gene increase the risk of ARP by 3-to 4-times compared to the general population,while cystic fibrosis(CF)patients present with a 40-to 80-times higher risk of developing pancreatitis.CASE SUMMARY In non-classical CF or CFTR-related disorders,CFTR functional tests can help to ensure a proper diagnosis.We applied an individualized combination of standardized and new CFTR functional bioassays for a patient referred to the Verona CF Center for evaluation after several episodes of acute pancreatitis.The CFTR genotype was G542X+/-with IVS8Tn:T7/9 polymorphism.The sweat(Cl-)values were borderline.Intestinal current measurements were performed according to the European Cystic Fibrosis Society Standardized Operating Procedure.Recent nasal surgery for deviated septum did not allow for nasal potential difference measurements.Lung function and sputum cultures were normal;azoospermia was excluded.Pancreas divisum was excluded by imaging but hypoplasia of the left hepatic lobe was detected.Innovative tests applied in this case include sweat rate measurement by image analysis,CFTR function in monocytes evaluated using a membrane potential-sensitive fluorescent probe,and the intestinal organoids forskolin-induced swelling assay.CONCLUSION Combination of innovative CFTR functional assays might support a controversial diagnosis when CFTR-related disorders and/or non-classical CF are suspected. | Sara Caldrer Gabriella Bergamini Angela Sandri Silvia Vercellone Luca Rodella Angelo Cerofolini Francesco Tomba Filippo Catalano Luca Frulloni Mario Buffelli Gloria Tridello Hugo de Jonge Baroukh Maurice Assael Claudio Sorio Paola Melotti | 2019 | World Journal of Clinical Cases2019，7，22： | 2 |
| 5 | Performance of LCD iterative method in the finite element and finite difference solution of convection-diffusion equations显示文摘 | Catabriga L Vail A Melotti Z Pessoa M Coutinho A | | Communications in numerical methods in engineering0，22，6： | 1 |
| 6 | CT diagnosis of acute bowel and mesenteric injury显示文摘 | Melotti M | 2000 | Appl Radiol2000，29，4： | 1 |
| 7 | Activation of NF-kB mediates ICAM-1 induction in respiratory cells exposed to an adenovirus-derived vector 显示文摘 | Melotti P Nicolis E | 2001 | Gene Ther2001，8，18： | 1 |
| 8 | Gemcitabine (EM) (day 1-8) plus carboplatin (CBDCA) (days) for the treatment of advanced non-small cell lung cancer (ANSCLC) in elderly or poor performance status (PS) patients (pts)显示文摘 | Melotti B Martoni AA | 2007 | J Clin Oncol2007，25，18： | 1 |
| 9 | BMP signaling promotes the growth of primary human colon carcino- mas in vivo 显示文摘 | LORENTE-TRIGOS A VARNAT F MELOTTI A | 2010 | J Mol Cell Biol2010，2，6： | 1 |
| 10 | Laparoscopic distal pancreatectomy:results on a consecutive series of 58 patients显示文摘 | Melotti G Butturini G Piccoli M | | 0，，： | 1 |
| 11 | Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells显示文摘 | Cigana C Assael B M Melotti P | 2007 | Antimicrob Agents Chemother2007，51，： | 1 |
| 12 | Bioabsorbable Synthetic Plug in the Treatment of Anal Fistulas显示文摘 | Afshin Heydari Grazia Maria Attinà Enrico Merolla Micaela Piccoli Reza Fazlalizadeh Gianluigi Melotti | 2013 | Diseases of the Colon & Rectum2013，，6： | 1 |
| 13 | Pancreatic duct stenting for the duration of ERCP only does not prevent pancreatitis after accidental pancreatic duct cannulation: a prospective randomized trial显示文摘 | Rita Conigliaro Raffaele Manta Helga Bertani Mauro Manno Carmelo Barbera Angelo Caruso Giampiero Olivetti Gianluigi Melotti Marzio Frazzoni | 2013 | Surgical Endoscopy2013，，2： | 1 |
| 14 | High-dose epirubicin for untreated patients with advanced tumors: a phase Ⅰ study显示文摘 | MARTONI A MELOTTI B GUARALDI M | 1990 | Eur J Cancer1990，26，： | 1 |
| 15 | Laparoscopic distal pancreatomy: results on a consecutive series of 58 patients 显示文摘 | Melotti G Butturini G Piccoli M | 2007 | Ann Surg2007，246，： | 1 |
| 16 | Abdominal Wall Recurrences After Colorectal Resection for Cancer显示文摘 | G. Silecchia M.D. N. Perrotta M.D. G. Giraudo M.D. M. Salval M.D. U. Parini M.D. F. Feliciotti M.D. E. Lezoche M.D. M. Morino M.D. G. Melotti M.D. M. Carlini M.D. P. Rosato M.D. N. Basso M.D | 2002 | Diseases of the Colon & Rectum2002，，9： | 1 |
| 17 | Laparoscopic distal pancreatectomy: results on a consecutive series of 58 patients显示文摘 | Melotti G Butturini G Piccoli M | 2007 | Ann Surg2007，246，1： | 1 |
| 18 | Laparoscopic distal pancreatomy results on a consecutive series of 58 patients显示文摘 | Melotti G Butturini G Piccolim M | 2007 | Ann Surg2007，246，1： | 1 |
| 19 | Gemcitabine ( EM ) ( day 1 - 8 ) plus carboplatin (CBDCA) ( days ) for the treatment of advanced non-small cell lung cancer ( aNSCLC ) in elderly or poor performance status ( PS ) patients (pts) 显示文摘 | Melotti B Martoni AA | 2007 | J Clin Oncol2007，25，18： | 1 |
| 20 | Laparoscopic distal pancreatectomy results on a consecutive series of 58 patients显示文摘 | Melotti G Butturini G Piccoli M | 2007 | Ann Surg2007，246，1： | 1 |
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