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| 1 | PDX1.1-dependent biosynthesis of vitamin B6 protects roots from ammonium-induced oxidative stress显示文摘Despite serving as a major inorganic nitrogen source for plants,ammonium causes toxicity at elevated con-centrations,inhibiting root elongation early on.While previous studies have shown that ammonium-inhibited root development relates to ammonium uptake and formation of reactive oxygen species(ROS)in roots,it remains unclear about the mechanisms underlying the repression of root growth and how plants cope with this inhibitory effect of ammonium.In this study,we demonstrate that ammonium-induced apo-plastic acidification co-localizes with Fe precipitation and hydrogen peroxide(H_(2)O_(2))accumulation along the stele of the elongation and differentiation zone in root tips,indicating Fe-dependent ROS formation.By screening ammonium sensitivity in T-DNA insertion lines of ammonium-responsive genes,we identified PDX1.1,which is upregulated by ammonium in the root stele and whose product catalyzes de novo biosyn-thesis of vitamin B6.Root growth of pdx1.1 mutants is hypersensitive to ammonium,while chemical complementation or overexpression of PDX1.1 restores root elongation.This salvage strategy requires non-phosphorylated forms of vitamin B6 that are able to quench ROS and rescue root growth from ammo-nium inhibition.Collectively,these results suggest that PDX1.1-mediated synthesis of non-phosphorylated B6 vitamers acts as a primary strategy to protect roots from ammonium-dependent ROS formation. | Ying Liu Rodolfo A.Maniero Ricardo F.H.Giehl Michael Melzer Priscille Steensma Gabriel Krouk Teresa B.Fitzpatrick Nicolaus von Wirén | 2022 | Molecular Plant2022，15，5： | 3 |
| 2 | CD4( + ) CD25( + ) FoxP'3 ( + ) regulatory T ceils suppress cytotoxicity of CD8 ( + ) effector T cells: implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level 显示文摘 | Gtibel K Bittner N Melzer N | 2012 | Journal of Neuroinflammation2012，9，2： | 1 |
| 3 | Comparison of 3,000 and 5,000 IU aXa/day certoparin in the prevention of deep-vein thrombosis after total hip replacement显示文摘 | Bramlage P Michaelis HC Melzer N | | 0，，01： | 1 |
| 4 | Developing quality indicators for older adults : transfer from the USA to the Uk is feasible 显示文摘 | Steel N Melzer D Shekelle PG | 2004 | Qual Saf Health Care2004，13，4： | 1 |
| 5 | Association between ankle muscle strength and limit of stability in older adults显示文摘 | MELZER I BENJUYA N KAPLANSKI J | 2009 | Age Ageing2009，38，： | 1 |
| 6 | Investigating associations between milk metabolite profiles and milk traits of Holstein cows显示文摘 | MELZER N WITTENBURG D HARTWIG S | 2013 | Joumal of Dairy Science2013，96，3： | 1 |
| 7 | CD8+ T cells and neuronal damage:direct and collateral mechanisms of cytotoxicity and impaired electrical excitability显示文摘 | Melzer N Meuth SG Wiendl H | | 0，，01： | 1 |
| 8 | Effects of regular walking on postural stability in the elderly 显示文摘 | Melzer I Benjuya N Kaplanski J | 2003 | Gerontology2003，49，4： | 1 |
| 9 | CD8+ T cells and neu-ronal damage:direct and col ateral mechanisms of cyto-toxicity and impaired electrical excitability显示文摘 | Melzer N Meuth SG Wiendl H | | 0，，11： | 1 |
| 10 | A pure cerebellar syndrome with corresponding ponto-cerebellar atrophy in acquired hepatocere- bral degeneration 显示文摘 | Melzer N Grimm A Meuth SG | 2010 | J Neurol Sci2010，292，： | 1 |
| 11 | CD4(+) T cells predominate in cerebrospinal fluid and leptomeningeal and parenchymal infiltrates in cerebral amyloid beta-related angiitis显示文摘 | Melzer N Harder A Gross CC | 2012 | Arch Neurol2012，69，： | 1 |
| 12 | De novo tumors after liver transplantation: a single-center experience显示文摘 | H Schmilovitz-Weiss E Mor J Sulkes N Bar-Nathan E Shaharabani E Melzer R Tur-Kaspa Z Ben-Ari | 2003 | Transplantation Proceedings2003，，2： | 1 |
| 13 | Urinary bis- phenol A concentration and risk of future coronary ar- tery disease in apparently healthy men and women 显示文摘 | Melzer D Osborne N J Henley W E | 2012 | Circulation2012，125，12： | 1 |
| 14 | Transient receptor potential melastatin subfamily member 2 cation channel regulates detrimental immune cel invasion in ischemic stroke显示文摘 | Gelderblom M Melzer N Schattling B G?b E Hicking G Arunachalam P | 2014 | Stroke2014，45，11： | 1 |
| 15 | Developing quality indicators for older adults:transfer from the USA to the Uk is feasible显示文摘 | Steel N Melzer D Shekelle PG | 2004 | Qual Saf Health Care2004，13，： | 1 |
| 16 | Prepregnancy Body Mass Index and Resting Metabolic Rate during Preg- nancy 显示文摘 | Melzer K Schutz Y Soehnchen N | 2010 | Ann Nutr Metab2010，57，： | 1 |
| 17 | A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis显示文摘 | Melzer N Meuth S G Torres-Salazar D | 2008 | PLoS One2008，3，9： | 1 |
| 18 | Excitotoxic neuronal cell death during an oligodendrocyte-directed CD8+T cell attack in the CNS gray matter显示文摘 | Melzer N Hicking G Bittner S | 2013 | J Neuroinflammation2013，10，2： | 1 |
| 19 | Association between serum perfluorooetanoic aeid (PFOA) and thyroid disease in the NHANES study 显示文摘 | Melzer D Rice N Depledgc M H | 2010 | Environmental Health Perspectives2010，118，5： | 1 |
| 20 | Collateral neuronal apoptosis in CNS gray matter during an oligodendrocyte-direeted CD8+ T cell attack显示文摘 | Gobel K Melzer N Herrmann A M | 2010 | Glia2010，58，4： | 1 |
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