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| 1 | A Heterozygous Phospholamban Variant(p.R14del)Leads to Left Ventricular Involvement and Heart Failure Phenotypes in Arrhythmogenic Right Ventricular Cardiomyopathy显示文摘This study aimed to determine the prevalence and clinical features of Arrhythmogenic Right Ventricular Cardiomyopathy(ARVC)caused by pathogenic mutations in the Phospholamban(PLN)gene.The study included 170 patients who had a confrmed diagnosis of ARVC and underwent PLN genetic screening using next-generation sequencing.The fndings of this study provide valuable insights into the association between PLN mutations and ARVC,which can aid in the development of more efective diagnostic and treatment strategies for ARVC patients.Out of the patients evaluated,six had a rare pathogenic mutation in PLN with the same p.R14del variant.Family screening revealed that heterozygous carriers of p.R14del exhibited a defnite ARVC phenotype.In clinical studies,individuals with the p.R14del mutation experienced a similar rate of malignant arrhythmia events as those with classic desmosome mutations.After adjusting for covariates,individuals with PLN mutations had a two point one seven times greater likelihood of experiencing transplant-related risks compared to those who did not possess PLN mutations(95%CI 1.08–6.82,p=0.035).The accumulation of left ventricular fat and fbers is a pathological marker for ARVC patients with p.R14del mutations.In a cohort of 170 Chinese ARVC patients,three point fve percent of probands had the PLN pathogenic variant(p.R14del)and all were female.Our data shows that PLN-related ARVC patients are at high risk for ventricular arrhythmias and heart failure,which requires clinical diferentiation from classic ARVC.Furthermore,carrying the p.R14del mutation can be an independent prognostic risk factor in ARVC patients. | Han Mo Xiumeng Hua Mengni Bao Zhe Sun Xiao Chen Mengda Xu Jiangping Song | 2024 | Phenomics2024，4，1： | 0 |
| 2 | Molecular movements of trehalose inside a single network enabling a rapidly-recoverable tough hydrogel显示文摘It remains a challenge to achieve rapidly recoverable hydrogels by molecular hydrogen-bonding interaction because of its slow inter-action kinetics.This work for the first time reports a trehalose(Tre)-based molecular movement mechanism inside a single network of polyacrylamide(PAM)that accelerates the kinetics of hydrogenbonding interaction,and thereby endows the hydrogel with high toughness and rapid shape and mechanical recoverability.The resultant PAM@Tre hydrogel is capable of full shape recovery after 10,000 loading/unloading cycles at a strain of 500%.Even after being stretched at a strain of 2500%,it can recover to its original shape within 10 seconds.Moreover,the molecular movement of trehalose also endows the PAM@Tre hydrogel with fracture energy and toughness as high as~9000 J m^(-2) and~1600 kJ m^(-3),respec-tively,leading to strong resistance to both static and dynamic piercing.The PAM@Tre hydrogel is thus believed to have enormous potentials in protection devices,bionic skin,soft actuator,and stretchable electronics. | Xiaowen Huang Jimin Fu Huiyan Tan Yan Miu Mengda Xu Qiuhua Zhao Yujie Xie Shengtong Sun Haimin Yao Lidong Zhang | 2022 | International Journal of Smart and Nano Materials2022，13，4： | 0 |
| 3 | Performance Analysis of Cross⁃Site Scripting Based on Natural Language Processing显示文摘With the acceleration of network communication in the 5G era,the volume of data communication in cyberspace has increased unprecedentedly.The speed of data transmission will accelerate.Subsequently,the security of network communication data becomes more and more serious.Among them,malicious cross⁃site scripting leading to the leakage of user information is very serious.This article uses URL attribute analysis method and YARA rule to process data for cross⁃site scripting based on the long short⁃term memory(LSTM)characteristics of LSTM model.The results show that the LSTM classification model adopted in this paper has higher recall rate and F1⁃score than other machine learning methods,which proves that the method adopted in this paper is feasible. | Mengda Xu Luqun Li | 2022 | Journal of Harbin Institute of Technology(New Series)2022，29，4： | 0 |
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